cMyc Cancer Research Results

cMyc, cellular-MYC oncogene: Click to Expand ⟱
Source:
Type: oncogene
The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell. The c-Myc oncogene is a ‘master regulator’ of both cellular growth and metabolism in transformed cells.
-C-myc is a common oncogene that enhances aerobic glycolysis in the cancer cells by transcriptionally activating GLUT1, HK2, PKM2 and LDH-A

Inhibitors (downregulate):
Curcumin
Resveratrol: downregulate c-Myc expression.
Epigallocatechin Gallate (EGCG)
Quercetin
Berberine: decrease c-Myc expression and repress its transcriptional activity.
Scientific Papers found: Click to Expand⟱
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 151 to 153 of 153
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 153

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   i-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 1,   LDHA↑, 1,   PDH↓, 1,   PFK↓, 1,   PKM2↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   MAPK↓, 1,   p27/CDKN1B↑, 1,   p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

p‑P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,   p‑mTOR↓, 1,   mTORC1↓, 1,   PI3K↑, 1,   RAS↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   TumCI↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IKKα↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   eff↓, 5,   eff↑, 4,  

Functional Outcomes(tgid=23) ⓘ

ChemoSideEff↓, 1,   toxicity∅, 1,  
Total Targets: 57

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cMyc, cellular-MYC oncogene
12 Curcumin
10 Quercetin
9 Thymoquinone
8 Resveratrol
6 Baicalein
4 Artemisinin
4 Berbamine
4 Berberine
4 Luteolin
4 Piperlongumine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 EGCG (Epigallocatechin Gallate)
3 Lycopene
2 Apigenin (mainly Parsley)
2 Aspirin
2 Betulinic acid
2 Boswellia (frankincense)
2 brusatol
2 Chrysin
2 Ellagic acid
2 Sulforaphane (mainly Broccoli)
2 Emodin
2 Ferulic acid
2 Fisetin
2 Gambogic Acid
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phenethyl isothiocyanate
2 Piperine
2 Pterostilbene
2 Ursolic acid
2 Urolithin
2 Vitamin K2
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Boron
1 Chemotherapy
1 Caffeic acid
1 Metformin
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Propolis -bee glue
1 Crocetin
1 Cucurbitacin
1 Gemcitabine (Gemzar)
1 Cynaropicrin
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Genistein (soy isoflavone)
1 Estrogen
1 Evodiamine
1 flavonoids
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Honokiol
1 Indole-3-carbinol
1 Isobavachalcone
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Inositol
1 lambertianic acid
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Fields
1 Mushroom Chaga
1 Neem
1 Phenylbutyrate
1 Cisplatin
1 salinomycin
1 Shikonin
1 Aflavin-3,3′-digallate
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:35  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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