cMyc Cancer Research Results

cMyc, cellular-MYC oncogene: Click to Expand ⟱
Source:
Type: oncogene
The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell. The c-Myc oncogene is a ‘master regulator’ of both cellular growth and metabolism in transformed cells.
-C-myc is a common oncogene that enhances aerobic glycolysis in the cancer cells by transcriptionally activating GLUT1, HK2, PKM2 and LDH-A

Inhibitors (downregulate):
Curcumin
Resveratrol: downregulate c-Myc expression.
Epigallocatechin Gallate (EGCG)
Quercetin
Berberine: decrease c-Myc expression and repress its transcriptional activity.
Scientific Papers found: Click to Expand⟱
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, EGFR↓, ROS↑,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
5222- TQ,    Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB
- in-vitro, CRC, COLO205 - in-vitro, CRC, HCT116
tumCV↓, ChemoSen↑, p‑p65↓, NF-kB↓, VEGF↓, cMyc↓, Bcl-2↓, ROS↑,
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT/SLC7A11↓, ROS↑, Synergy↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT/SLC7A11↓, eff↑,
1020- UA,    Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
- in-vitro, Melanoma, RPMI-8226
β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,
942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231
Cav1↑, Glycolysis↓, cMyc↓, LDHA↓, Nrf1↓, PGC-1α↓, Sp1/3/4↑, TumCG↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
3136- VitC,    Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- in-vitro, Colon, SW48 - in-vitro, Colon, LoVo
ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, Var, MCF7 - in-vivo, Var, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 151 to 166 of 166
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 166

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 4,   GSH↓, 11,   GSH↑, 5,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 6,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   Nrf1↓, 1,   NRF2↓, 8,   NRF2↑, 8,   p‑NRF2↓, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 13,   ROS↑, 73,   ROS⇅, 3,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 2,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   Bfl-1↓, 1,   CDC16↓, 1,   CDC2↓, 1,   CDC2↑, 1,   CDC25↓, 3,   EGF↓, 2,   mitResp↓, 2,   mtDam↑, 4,   OCR↓, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↑, 1,   PGC-1α↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 3,   ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AMPK↑, 9,   ATP↓, 6,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ECAR↓, 3,   ECAR↝, 1,   FASN↓, 2,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 3,   GLS↑, 1,   GlucoseCon↓, 11,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   Glycolysis↓, 30,   Glycolysis↑, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 5,   HK2↓, 18,   HK2↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 12,   LDHA↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 10,   p‑PKM2↓, 1,   PKM2:PKM1↓, 2,   PPP↓, 2,   Pyruv↑, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SIRT2↓, 2,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 65,   ASK1↑, 1,   BAD↑, 2,   Bak↑, 3,   BAX↓, 5,   BAX↑, 36,   Bax:Bcl2↑, 15,   Bcl-2↓, 50,   Bcl-2↑, 3,   Bcl-xL↓, 22,   BID↑, 1,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 9,   Casp10↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 47,   cl‑Casp3↑, 8,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7↑, 12,   cl‑Casp7↑, 1,   Casp8↑, 10,   cl‑Casp8↑, 3,   Casp9↑, 30,   cl‑Casp9↑, 4,   cFLIP↓, 4,   Cyt‑c↑, 21,   Diablo↑, 4,   DIDO1/DIO-1↑, 1,   DR5↓, 1,   DR5↑, 10,   FADD↑, 1,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 3,   GSDME-N↑, 1,   IAP1↓, 7,   IAP2/BIRC3↓, 6,   ICD↑, 1,   iNOS↓, 5,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 7,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↑, 9,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 5,   Pyro↑, 1,   survivin↓, 43,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 3,   XIAP?, 1,   XIAP↓, 17,   YAP/TEAD↓, 4,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 49,   Akt↑, 4,   p‑Akt↓, 9,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   CDC7↓, 1,   CK2↓, 2,   cMET↓, 3,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 17,   ERK↓, 19,   ERK↑, 3,   p‑ERK↓, 6,   FGFR1↓, 4,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   IKKα↓, 6,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 4,   JAK1↓, 4,   JAK2↓, 8,   JNK↓, 1,   JNK↑, 8,   p‑JNK↓, 1,   MAPK↓, 9,   MAPK↑, 2,   p‑MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 2,   mTOR↓, 29,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   P90RSK↓, 1,   PI3K↓, 38,   PI3K↑, 1,   PKA↓, 1,   PKCδ↓, 5,   PTEN↑, 14,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 6,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3↓, 45,   p‑STAT3↓, 9,   STAT6↓, 2,   STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 3,   ATF4↝, 1,   BRD4↓, 1,   CBP↑, 1,   cJun↓, 4,   cJun↑, 2,   cMyc↓, 158,   cMyc↑, 4,   cMyc↝, 1,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 2,   FOXO1↑, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HES1↓, 1,   IRF1↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-130a↓, 1,   miR-134↑, 1,   miR-192-5p↑, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-200b↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 2,   miR-221↑, 1,   miR-222↑, 1,   miR-27a-3p↓, 2,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-34a↑, 5,   miR-34b-5p↑, 2,   miR-384↑, 1,   miR-99↑, 1,   Myc↓, 3,   n-MYC↓, 1,   OCT4↓, 10,   other↓, 1,   other↑, 2,   other↝, 3,   SOX2↓, 8,   SOX4↓, 1,   SOX4↑, 1,   tumCV?, 1,   tumCV↓, 16,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 15,   GRP78/BiP↑, 7,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP90↓, 3,   IRE1↑, 1,   PERK↑, 3,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 4,   p62↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 11,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   CUL4B↑, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 20,   mt-DNAdam↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   MSH2↑, 1,   p16↑, 2,   P53↓, 1,   P53↑, 41,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↓, 2,   PARP↑, 7,   cl‑PARP↑, 28,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 4,   cl‑PARP1↑, 1,   PCNA↓, 19,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 2,   TOP2↓, 5,   TP53↑, 2,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

BRD4↓, 1,   CDK1↓, 7,   CDK2↓, 17,   CDK2↑, 1,   CDK4↓, 25,   CDK4/6↓, 2,   CDK6↓, 12,   CDK8↓, 3,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 67,   CycD3↓, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 2,   cycE1↓, 1,   cycF↓, 1,   E2Fs↓, 3,   Ki-67↓, 8,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 29,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↑, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   TumCCA↓, 1,   TumCCA↑, 68,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 5,   Axin2↑, 1,   CD133↓, 8,   CD133↑, 1,   CD24↓, 1,   cFos↓, 5,   CSCs↓, 23,   CSCs↑, 1,   EP300↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 8,   Let-7↑, 2,   LGR5↓, 1,   LRP6↓, 1,   mTORC1↓, 6,   Nanog↓, 12,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 8,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 3,   PTCH2↓, 1,   SFRP5↑, 1,   Shh↓, 8,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 39,   TumCP↓, 54,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 21,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 4,   APC↑, 1,   Ca+2↑, 10,   Ca+2↝, 2,   Cav1↑, 2,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 7,   E-cadherin↑, 22,   EMT↓, 31,   EMT↝, 1,   FAK↓, 2,   p‑FAK↓, 2,   Fibronectin↓, 2,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LEF1↓, 2,   MALAT1↓, 1,   MET↓, 1,   MET↑, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 33,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 42,   MMP9↑, 1,   MMPs↓, 15,   N-cadherin↓, 15,   NCAM↑, 1,   PDGF↓, 3,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 8,   Smad1↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   Snail↓, 14,   TET1↑, 1,   TGF-β↓, 8,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 2,   TIMP2↑, 4,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↑, 1,   TumCI↓, 26,   TumCMig↓, 26,   TumCMig↑, 1,   TumMeta↓, 22,   TumMeta↑, 2,   Twist↓, 11,   TXNIP↑, 1,   uPA↓, 10,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 23,   Zeb1↓, 6,   α-SMA↓, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 35,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 26,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 3,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 48,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CellMemb↑, 1,   CLDN2↓, 1,   GLUT1↓, 10,   GLUT1↑, 1,   GLUT3↓, 1,   KCNH2/hERG↓, 1,   MMP↓, 21,   MPT↑, 1,   NHE1↓, 1,   SLC12A5↓, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 10,   cDC2↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCR4↓, 11,   DR4↑, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 6,   IL12↓, 2,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 3,   IL4↑, 1,   IL6↓, 23,   IL7↓, 1,   IL8↓, 5,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 10,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   NF-kB↓, 57,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   p50↓, 1,   p65↓, 4,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   TCF↓, 5,   TCF7/TCF1↓, 1,   TLR4↓, 1,   TNF-α↓, 13,   TNF-α↑, 1,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   ER(estro)↓, 1,   PPARγ↓, 2,   PPARγ↑, 2,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 12,   BioAv↝, 3,   BioEnh?, 1,   BioEnh↑, 4,   CBR1↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 45,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 3,   Dose↝, 6,   Dose∅, 1,   eff↓, 12,   eff↑, 26,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 8,   Half-Life↑, 1,   Half-Life↝, 4,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 7,   P450↓, 3,   RadioS↑, 19,   selectivity↑, 22,   Synergy↑, 38,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 8,   AST↓, 2,   BRAF↓, 1,   BRCA1↑, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 17,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 1,   Myc↓, 3,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 13,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 3,   neuroP↑, 2,   Obesity↓, 1,   OS↑, 5,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 1,   Strength↑, 1,   TGFβR1↑, 1,   toxicity↓, 5,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 678

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 18,   Catalase↑, 8,   GPx↑, 6,   GSH↑, 12,   GSTs↑, 1,   H2O2↓, 1,   HO-1?, 1,   HO-1↑, 7,   lipid-P↓, 8,   MDA↓, 10,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 11,   ROS↓, 21,   ROS↑, 1,   SOD↑, 11,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ALAT↓, 4,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   LDHA↑, 1,   NAD↑, 1,   PDK1 / PDPK1↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 3,   Casp↓, 1,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GSDMD↓, 1,   iNOS↓, 3,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   ERK↑, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   PI3K↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 2,   cMyc↑, 1,   p‑cMyc↑, 1,   HDAC2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP9↓, 2,   MUC1↑, 1,   TGF-β↓, 2,   TumCI↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   eNOS↓, 1,   eNOS↑, 1,   Hif1a↓, 2,   NO↓, 2,   NO↑, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   IL10↓, 1,   IL10↑, 3,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 6,   IL4↓, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 25,   Inflam↑, 2,   IRF3↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 7,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 9,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 5,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 5,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 4,   BMD↑, 2,   BP↓, 2,   CRP↓, 3,   IL6↓, 7,   LDH↓, 3,   NOS2↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 4,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 2,   AntiDiabetic↑, 4,   cardioP↑, 12,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 15,   memory↑, 6,   motorD↑, 1,   neuroP↑, 22,   Obesity↓, 2,   Pain↓, 1,   RenoP↑, 4,   Stroke↓, 2,   toxicity↓, 4,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 1,   Bacteria↑, 1,   GutMicro↑, 1,  
Total Targets: 176

Scientific Paper Hit Count for: cMyc, cellular-MYC oncogene
12 Curcumin
10 Quercetin
9 Thymoquinone
8 Resveratrol
6 Baicalein
5 Luteolin
4 Artemisinin
4 Berbamine
4 Berberine
4 Lycopene
4 Piperlongumine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 EGCG (Epigallocatechin Gallate)
3 lambertianic acid
2 Apigenin (mainly Parsley)
2 Aspirin
2 Betulinic acid
2 Boswellia (frankincense)
2 brusatol
2 Chrysin
2 Ellagic acid
2 Sulforaphane (mainly Broccoli)
2 Emodin
2 Ferulic acid
2 Fisetin
2 Gambogic Acid
2 mebendazole
2 Magnetic Fields
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phenethyl isothiocyanate
2 Piperine
2 Pterostilbene
2 Ursolic acid
2 Urolithin
2 Vitamin K2
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Boron
1 Chemotherapy
1 Caffeic acid
1 Metformin
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Propolis -bee glue
1 Crocetin
1 Cucurbitacin
1 Gemcitabine (Gemzar)
1 Cynaropicrin
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Genistein (soy isoflavone)
1 Estrogen
1 Evodiamine
1 flavonoids
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Honokiol
1 Indole-3-carbinol
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Inositol
1 Ivermectin
1 Kaempferol
1 Licorice
1 Magnolol
1 Matrine
1 Methyl salicylate / Sweet Birch oil
1 Melatonin
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 Phenylbutyrate
1 Cisplatin
1 salinomycin
1 Shikonin
1 Aflavin-3,3′-digallate
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:35  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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