Bax:Bcl2 Cancer Research Results

Bax:Bcl2, Bax:Bcl2 ratio: Click to Expand ⟱

Source:

Type:

Bax and Bcl-2 are the major members of Bcl-2 family that play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction.
Bax/Bcl-2 ratio is typically significantly lower in tumors.

Scientific Papers found: Click to Expand⟱

5002-

Sal,

SFN,

Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo

-

in-vivo,

CRC,

Caco-2

-

vitro+vivo,

CRC,

CX-1

Apoptosis↑, PI3K↓, Akt↓, P53↑, BAX↑, Bax:Bcl2↑, p‑PARP↑, TumCMig↓,

1458-

SFN,

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

-

Review,

Bladder,

NA

HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

1474-

SFN,

Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway

-

in-vitro,

Colon,

SW480

5, 10, 15 and 20 µM

TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,

1508-

SFN,

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

-

Review,

Var,

NA

*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

-

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1735-

SFN,

Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane

-

in-vitro,

GBM,

T98G

 20 μM and 40 μM SFN for 24 h

-

in-vitro,

GBM,

U87MG

Apoptosis↑, Ca+2↑, Bax:Bcl2↑, cal2↑, Casp12↑, Casp9↑, Cyt‑c↑,

6431-

T4O,

Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo

-

vitro+vivo,

NSCLC,

A549

TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,

5221-

TQ,

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

-

in-vitro,

AML,

HL-60

chemoPv↑, Apoptosis↑, MMP↓, Casp8↑, Casp9↑, Bax:Bcl2↑, Cyt‑c↑,

2112-

TQ,

Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells

-

in-vitro,

BC,

MCF7

45 mg/ml@72hr

Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,

2114-

TQ,

Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice

-

in-vivo,

Nor,

NA

0.1, 0.2 and 0.5 mL/kg

male mice for 42 days

*ALAT↓, *AST↓, *lipid-P↓, *GSH↑, *Bax:Bcl2↓, *proCasp3↓, *cl‑Casp3↓, *antiOx↑,

2124-

TQ,

Thymoquinone: an emerging natural drug with a wide range of medical applications

-

Review,

Var,

NA

hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,

2129-

TQ,

doxoR,

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells

-

in-vitro,

BC,

MCF7

25, 50 or 100 µM TQ

ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,

2085-

TQ,

Anticancer Activities of Nigella Sativa (Black Cumin)

-

Review,

Var,

NA

MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,

2095-

TQ,

Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ChemoSen↑,

2097-

TQ,

Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells

-

in-vitro,

Cerv,

HeLa

 IC50 values for 25, 50, 75 and 100 ug/ml were observed after 72, 48, 24 and 24 h

Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, P53↑, P21↑, TumCP↓, Apoptosis↓, selectivity↑,

2108-

TQ,

Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa

-

Review,

Var,

NA

HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,

5911-

TV,

Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway

-

vitro+vivo,

CRC,

NA

TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,

1313-

VitD3,

MLT,

The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line

-

in-vitro,

BC,

MCF7

 optimum dose of melatonin (5 nM) and vitamin D3 (0.5 nM

BAX↑, Bcl-2↓, Bax:Bcl2↑, Synergy↑,

7914-

VT,

Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells

-

vitro+vivo,

Lung,

A549

tumCV↓, selectivity↑, Cyt‑c↑, MMP↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, TumCG↓, mtDam↑, LDH↑, Bax:Bcl2↑, cl‑Casp3↑,

Showing Research Papers: 151 to 169 of 169
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 169

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 3, Catalase↓, 1, Catalase↑, 1, Fenton↑, 2, GPx1↓, 1, GSH↓, 9, mt-GSH↓, 1, GSH/GSSG↓, 1, GSSG↑, 1, HO-1↓, 3, HO-1↑, 2, HO-2↓, 1, Iron↓, 1, Iron↑, 1, lipid-P↑, 2, MDA↑, 3, NRF2↓, 4, NRF2↑, 4, NRF2⇅, 1, p‑NRF2↑, 1, OSI↑, 1, PYCR1↓, 1, ROS?, 1, ROS↓, 11, ROS↑, 68, ROS⇅, 1, i-ROS↑, 1, mt-ROS↑, 1, SOD↓, 5, SOD↑, 1, SOD2↓, 1, SOD2↑, 1, TAC↓, 1, TBARS↑, 1, TOS↑, 1, Trx2↓, 1, TrxR↓, 1, TrxR1↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, CDC25↑, 1, HSP60/HSPD1↓, 1, mitResp↓, 1, mtDam↑, 8, OCR↓, 1, mt-OXPHOS↓, 1, PINK1↑, 1, SIRT3↓, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 1, ALAT↓, 1, AMPK↑, 6, ATP↓, 5, CAIX/CA9↓, 1, CholSyn↓, 1, ECAR↝, 1, FASN↓, 2, GlucoseCon↓, 4, Glycolysis↓, 8, GSK‐3β↓, 2, GSK‐3β↑, 1, p‑GSK‐3β↓, 5, HK2↓, 4, lactateProd↓, 1, LDHA↓, 2, NADPH↓, 1, NADPH↑, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 2, PKM2↓, 2, PKM2↑, 1, PPP↓, 1, SIRT1↓, 2, SIRT1↑, 2, TS↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 2, APAF1↑, 3, Apoptosis?, 1, Apoptosis↓, 2, Apoptosis↑, 93, mt-Apoptosis↑, 4, BAD↓, 2, BAD↑, 1, BAX↑, 21, Bax:Bcl2↓, 2, Bax:Bcl2↑, 149, Bcl-2↓, 25, Bcl-xL↓, 8, Casp↑, 12, Casp12?, 1, Casp12↑, 3, Casp3?, 1, Casp3↓, 2, Casp3↑, 67, cl‑Casp3↑, 16, proCasp3↓, 1, Casp6↑, 1, Casp7↑, 5, cl‑Casp7↑, 2, Casp8↑, 12, Casp8∅, 2, cl‑Casp8↑, 1, Casp9↓, 1, Casp9↑, 45, cl‑Casp9↑, 9, proCasp9↓, 1, Cyt‑c↓, 1, Cyt‑c↑, 47, Diablo↑, 2, DR5↑, 4, FADD↑, 1, Fap1↓, 1, Fas?, 1, Fas↓, 1, Fas↑, 5, FasL↑, 2, Ferroptosis↑, 1, IAP1↓, 4, IAP2/BIRC3↓, 3, cl‑IAP2/BIRC3↑, 1, iNOS↓, 3, Mcl-1?, 1, Mcl-1↓, 1, MDM2↓, 4, MDM2↑, 1, MLKL↑, 1, Necroptosis↑, 1, necrosis↑, 1, NOXA↑, 1, p38↓, 2, p38↑, 5, p‑p38↑, 2, PUMA↑, 2, Pyro↑, 1, p‑RIP3↑, 1, survivin↓, 16, TRAIL↑, 2, TumCD↑, 3, XIAP↓, 8, β-TRCP↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 36, Akt↑, 2, p‑Akt↓, 17, AMPKα↓, 1, CIP2A↓, 1, CK2↓, 4, p‑cMET↑, 1, CREB2↓, 1, EGFR↓, 12, ERK↓, 11, ERK↑, 6, p‑ERK↓, 6, p‑ERK↑, 1, p‑ERK⇅, 1, e-ERK↑, 1, FGFR1↓, 1, HER2/EBBR2↓, 5, IKKα↓, 1, IκB↓, 1, JAK↓, 1, JAK2↓, 2, JAK3↓, 1, JNK↑, 4, p‑JNK↓, 3, LIMK1↓, 1, MAPK↓, 5, MAPK↑, 4, MEK↓, 4, MKK4↓, 1, mTOR↓, 11, p‑mTOR↓, 6, p70S6↓, 1, P70S6K↓, 1, PI3K↓, 23, p‑PI3K↓, 2, PI3K/Akt↓, 3, PKCδ↓, 2, PP2A↑, 1, PRAS40↓, 1, PRAS40↑, 1, PTEN↑, 5, p‑PTEN↓, 1, Raf↓, 2, RAS↓, 1, p‑S6K↓, 1, Sp1/3/4↓, 1, Src↓, 1, STAT3↓, 17, p‑STAT3↓, 4, p‑STAT3↑, 1, STAT6↓, 1, THEM4/CTMP↑, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1, ChrMod↝, 1, cJun↓, 1, cJun↑, 1, cMyc↓, 15, DNMTs↓, 1, FOXM1↓, 1, FOXO3↓, 1, FOXO3↑, 3, FOXO4↑, 2, HATs↓, 2, HDAC↓, 7, HDAC1↓, 2, HDAC2↓, 1, HDAC3↓, 2, HES1↓, 1, miR-148a↓, 1, miR-19b↓, 1, miR-200c↑, 1, miR-21↓, 1, miR-34a↓, 1, miR-34a↑, 1, miR-34b-5p↑, 1, miR-384↑, 1, Myc↓, 1, n-MYC↓, 2, NDRG1↑, 1, OCT4↓, 2, other↑, 1, other↝, 3, PCAF↓, 1, SOX2↓, 3, SOX4↓, 1, tumCV?, 1, tumCV↓, 25,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4, eIF2α↓, 1, ER Stress↑, 8, ERStress↑, 1, HSP90↓, 2, HSPs↓, 1, HTRA↓, 1, PERK↑, 1, UPR↑, 2,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 1, ATG5↑, 5, ATG7↑, 2, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 8, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3II↑, 7, LC3s↑, 1, lysosome↓, 1, MitoP↑, 1, p62↓, 3, p62↑, 5, PARK2↑, 1, RUBCN↓, 1, TumAuto↑, 15, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1, DNA-PK↑, 1, DNAdam↓, 2, DNAdam↑, 22, mt-DNAdam↑, 1, hTERT/TERT↓, 4, MGMT↓, 1, NKX3.1↑, 1, p16↑, 1, P53↓, 1, P53↑, 29, P53∅, 1, p‑P53↑, 1, PARP↓, 1, PARP↑, 3, p‑PARP↑, 2, cl‑PARP↓, 1, cl‑PARP↑, 37, cl‑PARP1↑, 2, PCNA↓, 6, SIRT6↓, 1, SIRT6↑, 1, Telomerase↓, 8, TOP2↓, 1, TP53↑, 1, γH2AX↑, 4, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK2↓, 11, CDK4↓, 14, CDK4↑, 1, CDK6↓, 5, CDK6↑, 1, CDK8↓, 1, Chk2↑, 1, Cyc↓, 1, cycA1/CCNA1↓, 4, CycB/CCNB1↓, 5, cycD1/CCND1↓, 30, CycD3↓, 1, cycE/CCNE↓, 8, Ki-67↓, 10, mitA↑, 1, p19↑, 1, P21↓, 1, P21↑, 35, p27/CDKN1B↑, 15, p‑pRB↓, 1, RB1↑, 1, p‑RB1↓, 1, TumCCA?, 2, TumCCA↓, 2, TumCCA↑, 67,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, BMP2↓, 1, CD133↓, 3, cFos↓, 2, cMYB↓, 1, CSCs↓, 13, Diff↓, 1, Diff↑, 1, FGF↓, 1, Gli↓, 1, Gli1↓, 1, HH↓, 3, HMGCR↓, 1, IGF-1↓, 3, IGFBP3↑, 1, p‑Jun↓, 1, Ki-67↓, 10, p‑mTORC1↓, 1, Nanog↓, 3, Nestin↓, 2, NOTCH↓, 4, NOTCH1↓, 1, NOTCH1↑, 1, NOTCH2↓, 1, p300↓, 1, SCF↓, 1, Shh↓, 2, TumCG?, 1, TumCG↓, 32, TumCP↓, 41, TumCP↑, 1, TumCP∅, 1, Wnt↓, 3, Wnt↑, 1, Wnt/(β-catenin)↓, 3,

Migration(tgid=13) ⓘ

AntiAg↑, 1, AP-1↓, 1, APC↑, 1, Ca+2↑, 10, Ca+2↝, 1, i-Ca+2?, 1, cal2↑, 2, Cav1↓, 1, COL1↓, 1, E-cadherin↓, 2, E-cadherin↑, 8, EMT↓, 17, EMT↝, 1, F-actin↓, 1, FAK↓, 4, p‑FAK↓, 2, p‑FAK↑, 1, Fibronectin↓, 1, ITGB4↓, 1, MMP-10↓, 1, MMP1↓, 1, MMP16↓, 1, MMP2↓, 21, MMP3↓, 3, MMP7↓, 2, MMP9↓, 24, MMPs↓, 5, MUC4↓, 1, N-cadherin↓, 3, NCAM↓, 1, SMAD3↓, 2, Snail↓, 1, TET1↑, 1, TGF-β↓, 3, TIMP1↑, 1, TIMP2↓, 2, TIMP2↑, 2, TSC1↑, 1, TSP-1↑, 1, TumCA↓, 1, TumCA↑, 1, TumCI↓, 14, TumCMig↓, 19, TumCMig↑, 1, TumMeta↓, 11, Twist↓, 2, uPA↓, 2, Vim↓, 3, β-catenin/ZEB1↓, 13,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22, angioG↑, 1, Endoglin↑, 1, HIF-1↓, 2, Hif1a↓, 13, NO↓, 1, NO↑, 1, VEGF↓, 26, VEGF↑, 1, VEGFR1↓, 3, VEGFR2/KDR/Flk1↓, 3,

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1, CellMemb↑, 1, CLDN1↑, 1, EPR↑, 1, GLUT1↓, 5, GLUT4↓, 2, IBI↑, 1, MMP?, 1, MMP↓, 55, MMP↑, 1, MPT↑, 2, NHE1↓, 1, OCLN↑, 1, TJ↑, 1, TRPV1↑, 1, TRPV1↝, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD44↓, 6, CD59↑, 1, cDC2↓, 1, COX1↓, 1, COX2/PTGS2↓, 21, COX2/PTGS2↑, 1, CXCR4↓, 1, DR4↑, 2, IFN-γ↓, 1, IFN-γ↑, 1, IL10↑, 1, IL1β↓, 5, IL2↓, 1, IL2↑, 2, IL4↑, 1, IL6↓, 7, IL8↓, 2, IL8↑, 1, Imm↑, 1, Imm↝, 1, Inflam↓, 7, M2 MC↓, 1, MCP1/CCL2↓, 2, NF-kB↓, 42, NF-kB↑, 1, p‑NF-kB↓, 1, NK cell↑, 1, p65↓, 1, p‑p65↓, 1, PD-L1↓, 3, PGE2↓, 7, PSA↓, 2, TNF-α↓, 9, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5, COMT↓, 2, ER-α36↓, 1, ER(estro)↓, 1, ERα/ESR1↓, 1, ERβ/ESR2↑, 1, PPARα↓, 1, PPARγ↑, 4,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 6, BioAv↑, 9, BioAv↝, 2, BioEnh↑, 3, CBR1↓, 1, chemoR↓, 1, ChemoSen↑, 34, CompStab↓, 1, CompStab↑, 1, CYP1A1↑, 1, Dose?, 2, Dose↓, 1, Dose↑, 1, Dose↝, 8, Dose∅, 5, eff↓, 23, eff↑, 24, eff↝, 6, eff∅, 2, Half-Life↓, 3, Half-Life↝, 1, MDR1↓, 4, MDR1↑, 1, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 5, RadioS↑, 13, selectivity↑, 29, Synergy↑, 31,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, ALP↓, 2, AR↓, 5, AST↓, 1, EGFR↓, 12, ERα/ESR1↓, 1, FOXM1↓, 1, HER2/EBBR2↓, 5, hTERT/TERT↓, 4, IL6↓, 7, LDH↓, 3, LDH↑, 1, LDH↝, 1, Myc↓, 1, PD-L1↓, 3, PSA↓, 2, TP53↑, 1, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13, antiNeop↑, 3, AntiTum↑, 4, cardioP↑, 1, chemoP↑, 5, chemoPv↑, 9, ChemoSideEff↓, 4, hepatoP↑, 4, memory↑, 1, OS↑, 2, Pain↓, 1, radioP↑, 1, Risk↓, 1, toxicity↓, 2, toxicity↝, 2, TumVol↓, 6, TumVol↑, 1, TumW↓, 5,

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 536

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17, i-antiOx↑, 1, Catalase↑, 5, GCLC↝, 1, GCLM↝, 1, GPx↑, 3, GPx4↑, 1, GSH↑, 6, GSR↑, 1, GSSG↓, 1, GSTs↑, 3, H2O2↑, 1, HO-1↑, 10, Iron↓, 1, i-Iron↓, 1, Keap1↝, 1, lipid-P↓, 5, MDA↓, 11, NOX↓, 1, NQO1↑, 1, NQO1↝, 1, NRF2↑, 11, p‑NRF2↑, 1, ROS↓, 23, ROS↑, 2, SOD↑, 11, TAC↑, 1, Trx1↑, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3, AMPK↑, 1, ATP↑, 2, glucose↓, 1, GSK‐3β↓, 3, p‑GSK‐3β↑, 1, LDL↓, 2, lipidLev↓, 1, NADPH↓, 1, PLA2↓, 1, SCFAs↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6, mt-Apoptosis↓, 1, ASK1↓, 1, BAX↓, 1, Bax:Bcl2↓, 14, Bax:Bcl2↑, 3, Bax:Bcl2↝, 1, Bcl-2↑, 3, Casp↓, 1, Casp3↓, 4, Casp3↑, 2, Casp3∅, 1, cl‑Casp3↓, 5, cl‑Casp3↑, 1, proCasp3↓, 1, Casp8↑, 1, cl‑Casp8↑, 2, Casp9↓, 2, Casp9↑, 2, cl‑Casp9↑, 1, Cyt‑c↓, 1, Cyt‑c∅, 1, Fas↑, 2, Ferroptosis↓, 1, p‑p38↓, 1, Pyro↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 4, Akt2↓, 1, CREB↑, 1, ERK↓, 2, IKKα↓, 1, JNK↓, 2, p‑JNK↓, 1, MAPK↓, 2, mTOR↑, 1, PI3K↑, 4, PKCδ↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↑, 1, HSP70/HSPA5↑, 1, UPR↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, MitoP↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1, P53↑, 2, cl‑PARP↓, 1, cl‑PARP↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, P21↓, 1, P21↑, 2, TumCCA↑, 2,

Migration(tgid=13) ⓘ

AntiAg↑, 1, Ca+2↓, 1, LAMs↑, 1, LRP1↑, 1, MLC2/MYL9↝, 1, MUC1↑, 1, Smad1↑, 1, TGF-β↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, Hif1a↓, 1, NO↓, 1, VCAM-1↓, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, IBI↑, 1, MMP↓, 2, MMP↑, 3, MMP∅, 1, OCLN↝, 1, TJ↑, 1, TRPC1↓, 1, ZO-1↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4, IFN-γ↑, 1, IL1↓, 1, IL10↓, 1, IL10↑, 1, IL12↓, 1, IL1β↓, 4, IL33↓, 1, IL4↓, 1, IL5↓, 1, IL6↓, 7, IL8↓, 2, Imm↑, 1, Imm⇅, 1, Inflam↓, 17, MIP‑1α/CCL3↓, 1, MIP2↓, 1, NeuroI↓, 1, NF-kB↓, 9, NK cell↑, 1, NLRP3↓, 2, p65↓, 1, PGE2↓, 1, RAGE↓, 1, TLR4↓, 1, TNF-α↓, 9,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2, BDNF↑, 6, GABA↑, 1, PSD95↑, 3, SYP↑, 1, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 6, BACE/β-secretase↓, 2, tau↓, 2, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7, BioAv↑, 5, BioAv↝, 1, ChemoSen↑, 1, Dose↝, 1, eff↑, 3, Half-Life↓, 1, Half-Life∅, 1, selectivity↑, 1, Synergy↑, 6,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3, AST↓, 3, BloodF↑, 1, BMD↑, 1, BP↓, 1, BP↝, 1, CRP↓, 2, hs-CRP↓, 1, IL6↓, 7, LDH↓, 3, RAGE↓, 1, TC↓, 1, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, antiAll↑, 3, AntiArt↑, 3, AntiCan↑, 2, AntiDiabetic↑, 7, antiPs↑, 1, cardioP↑, 9, CardioT↓, 1, chemoP↑, 3, chemoPv↑, 1, cognitive↑, 6, hepatoP↑, 9, Learn↑, 1, memory↑, 5, motorD↑, 1, Mucositis↓, 1, neuroP↑, 15, Obesity↓, 1, radioP↑, 3, RenoP↑, 7, Stroke↓, 1, toxicity↓, 9, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1, AntiViral↑, 3, Bacteria↓, 2, GutMicro↑, 3, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1, Ingr↝, 4,
Total Targets: 215

Scientific Paper Hit Count for: Bax:Bcl2, Bax:Bcl2 ratio

9 Thymoquinone
7 Apigenin (mainly Parsley)
6 Baicalein
6 Berberine
6 Emodin
6 Lycopene
6 Sulforaphane (mainly Broccoli)
5 Quercetin
4 Isoliquiritigenin
4 Luteolin
3 Cisplatin
3 EGCG (Epigallocatechin Gallate)
3 Curcumin
3 Caffeic acid
3 Carvacrol
3 Crocetin
3 Ellagic acid
3 Formononetin
3 Garcinol
3 iodine
3 isoorientin
3 Ivermectin
3 Melatonin
2 Silver-NanoParticles
2 Arctigenin
2 Docetaxel
2 Berbamine
2 Beta-Caryophyllene
2 Propolis -bee glue
2 Chlorogenic acid
2 Coenzyme Q10
2 D-limonene
2 Dandelion Root
2 Gambogic Acid
2 Graviola
2 HydroxyTyrosol
2 Licochalcone A
2 Magnolol
2 Myricetin
2 Phycocyanin
1 2-DeoxyGlucose
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Paclitaxel/Taxol
1 Betulinic acid
1 borneol
1 Boswellia (frankincense)
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Diclofenac
1 Radiotherapy/Radiation
1 Ginkgo biloba-EGb 761
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Flaxseed/Linseed
1 Fucoidan
1 Gallic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginkgetin
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Indole-3-carbinol
1 isoquercitrin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Juglone
1 Kaempferol
1 Matrine
1 Magnetic Fields
1 Morin
1 Naringin
1 Nimbolide
1 Plumbagin
1 Rosmarinic acid
1 salinomycin
1 Terpinen-4-ol / Tea Tree Oil
1 doxorubicin
1 Thymol-Thymus vulgaris
1 Vitamin D3
1 Vitexin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:352  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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