STAT3 Cancer Research Results

STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Scientific Papers found: Click to Expand⟱
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2/PTGS2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2/PTGS2↓,
1409- CUR,    Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma
- in-vivo, CCA, Walker256
TumCG↓, ROS↑, MMP↓, STAT3↓, TumCCA↑, eff↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2/PTGS2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
4656- CUR,  EGCG,    Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
CSCs↓, CD44↓, p‑STAT3↓, NF-kB↓, TumCI↓,
4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
CSCs↓, TumCG↓, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, Shh↓, NOTCH↓, DNMT1↓, STAT3↓, NF-kB↓, EGFR↓, IGFR↓, TumCCA↓, cl‑PARP↑, BAX↑, ECM/TCF↓,
4676- CUR,    Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway
- vitro+vivo, Lung, H460
CSCs↓, JAK2↓, STAT3↓, TumCP↓, TumCG↓,
3861- CUR,    Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
- Review, Var, NA
*antiOx↑, *Inflam↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, NF-kB↓, HH↓, NOTCH↓, JAK↓, STAT3↓, ADAM10↓,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- in-vitro, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
7448- CYN,    Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs
- in-vitro, Pca, DU145
GSH↓, STAT3↓, Bcl-2↓, survivin↓, cl‑PARP↑, ChemoSen↑,
7447- CYN,    Antiproliferative Effects of Cynaropicrin on Anaplastic Thyroid Cancer Cells
- in-vitro, Thyroid, 8505C - in-vitro, Thyroid, CAL62 - in-vitro, Thyroid, SW1736
tumCV↓, TumCCA↑, NF-kB↓, p‑STAT3↓, lipid-P↑, ROS∅,
7445- CYN,    Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
- vitro+vivo, CRC, RKO - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
tumCV↓, STAT↓, LIFR/CD118↓, STAT3↓, STAT4↑, TumCG?, cl‑PARP1↑, Bcl-2↓, BAX↑, STAT3↓, Dose↝, TumVol↓, TumW↓, toxicity↓,
7437- CYN,    Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma
- in-vitro, Mye, AMO1 - in-vivo, Mye, NA - in-vitro, Mye, KMS11 - in-vitro, Mye, JJN3 - in-vitro, Mye, MolP8 - in-vitro, Mye, L363 - in-vitro, Mye, H929
tumCV↓, cMyc↓, STAT3↓, Akt↓, ERK↓, TumCCA↑, DNAdam↑, PARP1↑, AIF↑, TumCG↓,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
6285- DL,    Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
VEGF↓, *STAT3↓, TumCP↓, TumMeta↓, p‑STAT3↓, MMP9↓, SHP1↑, angioG↓,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, Var, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2/KDR/Flk1↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,
668- EGCG,    The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
- Review, BC, MCF7 - Review, BC, MDA-MB-231
HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,
684- EGCG,    Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation
- in-vitro, CRC, NA
eff↑, Akt↓, VEGFR2/KDR/Flk1↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, Var, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
7045- EMD,  TSG,    Synergic effects and possible mechanism of emodin and stilbene glycosides on colorectal cancer
- vitro+vivo, CRC, NA
Apoptosis↑, TumCMig↓, TumVol↓, IL6↓, TGF-β↓, i-P53↓, i-STAT3↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
- Review, Nor, NA
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6833- EMD,    Anticancer potential of emodin
- Review, Var, NA
Inflam↓, angioG↓, TumCCA↑, Apoptosis↑, HIF-1↓, TumCI↓, TumCMig↓, HER2/EBBR2↓, CK2↓, ROS↑, AR↓, JAK2↓, STAT3↓, Mcl-1↓, NAT↓, ChemoSen↑, survivin↓, XIAP↓, NF-kB↓, *neuroP↑, *hepatoP↑,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓, *antiAll↑,
1320- EMD,  SRF,    Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7 - vitro+vivo, Hepat, SK-HEP-1
SREBF2↓, Akt↓, TumCCA↑, TumCG↓, STAT3↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
2853- FIS,    Fisetin Inhibits Cell Proliferation and Induces Apoptosis via JAK/STAT3 Signaling Pathways in Human Thyroid TPC 1 Cancer Cells
- in-vitro, Thyroid, TPC-1
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, JAK1↓, STAT3↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
1113- FIS,    Fisetin suppresses migration, invasion and stem-cell-like phenotype of human non-small cell lung carcinoma cells via attenuation of epithelial to mesenchymal transition
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, MMP2↓, CD44↓, CD133↓, β-catenin/ZEB1↓, NF-kB↓, EGFR↓, STAT3↓, CSCs↓,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6965- Form,    Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
- in-vitro, CRC, HCT116
TumCP↓, TumCI↓, cycD1/CCND1↓, TumCCA↑, MMP2↓, MMP9↓, miR-149↑, tumCV↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓,
6966- Form,    Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model
- vitro+vivo, MM, NA
tumCV↓, Apoptosis↑, STAT3↓, STAT5↓, JAK1↓, JAK2↓, cSrc↓, ROS↑, Casp3↑, cl‑PARP↑,
6968- Form,    Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation
- in-vitro, Cerv, NA
PD-1↓, Myc↓, STAT3↓,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7031- GA,  Cisplatin,    Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, ChemoSen↑, JAK↓, STAT3↓,

Showing Research Papers: 151 to 200 of 428
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 428

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 9,   Catalase↓, 7,   Catalase↑, 4,   Copper↓, 1,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 4,   GPx1↓, 1,   GPx4↓, 7,   GSH↓, 22,   GSH↑, 2,   GSR↓, 2,   GSR↑, 2,   GSTs↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 12,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 4,   Iron↝, 1,   i-Iron↑, 1,   Keap1↑, 2,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 11,   MDA↓, 2,   MDA↑, 6,   MPO↓, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 22,   NRF2↑, 14,   NRF2↝, 1,   p‑NRF2↓, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 2,   ROS↓, 19,   ROS↑, 185,   ROS⇅, 7,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 6,   SOD↑, 4,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC?, 1,   TBARS↑, 1,   Trx↓, 2,   Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 6,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 2,   ETC↑, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 7,   MKK7↓, 1,   mtDam↑, 17,   OCR↓, 8,   OXPHOS↓, 6,   SIRT3↓, 2,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 4,   ALAT↝, 1,   ALDOA↓, 1,   AMPK↓, 2,   AMPK↑, 25,   AMPK↝, 1,   ATP↓, 14,   mt-ATP↓, 1,   BMAL1↝, 1,   CAIX/CA9↑, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 2,   GLS↓, 1,   glucose↓, 4,   GlucoseCon↓, 13,   GlucoseCon↑, 1,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 29,   GSK‐3β↓, 9,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 5,   HK2↓, 16,   HMG-CoA↓, 1,   HSD17B4↓, 1,   lactateProd↓, 16,   lactateProd↑, 1,   LAR↓, 1,   LDHA↓, 8,   LDL↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 14,   PKM2↑, 1,   p‑PKM2↓, 1,   PLA2↓, 1,   PPP↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↓, 2,   SREBF2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 2,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 157,   mt-Apoptosis↑, 3,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 4,   Bak↑, 4,   BAX↓, 4,   BAX↑, 82,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 19,   Bcl-2↓, 105,   Bcl-2↑, 6,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 3,   BIM↑, 5,   BNIP3↑, 3,   Casp↑, 26,   Casp↝, 1,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp10↑, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 106,   cl‑Casp3↑, 15,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7?, 1,   Casp7↑, 12,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 22,   cl‑Casp8↑, 3,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↑, 63,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 9,   Cyt‑c↑, 44,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 22,   FADD↑, 3,   Fas↓, 1,   Fas↑, 15,   FasL↑, 3,   Ferroptosis↑, 12,   GranB/GZMB↑, 1,   GranB/GZMB↝, 1,   HEY1↓, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 5,   ICAD↓, 1,   iNOS↓, 13,   iNOS↑, 1,   Mcl-1↓, 27,   Mcl-1↑, 2,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 3,   p38↓, 5,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 6,   Perforin↑, 1,   Perforin↝, 1,   PUMA↑, 4,   Pyro↑, 1,   survivin↓, 67,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD?, 1,   TumCD↑, 12,   XIAP?, 1,   XIAP↓, 25,   XIAP↑, 1,   YAP/TEAD↓, 3,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 31,   AMPKα↓, 1,   AMPKα↑, 1,   Brk/PTK6↓, 1,   CaMKII ↓, 2,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 6,   p‑cMET↑, 1,   cSrc↓, 8,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   EphB4↓, 1,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 18,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HGF/c-Met↝, 1,   Hippo↓, 1,   IGF-1R↓, 6,   IGFR↓, 2,   IKKα↓, 7,   p‑IKKα↓, 1,   IR↓, 2,   IκB↑, 1,   JAK↓, 18,   JAK↝, 1,   p‑JAK↓, 1,   JAK1?, 1,   JAK1↓, 18,   JAK1↑, 2,   p‑JAK1↓, 3,   JAK2↓, 54,   p‑JAK2↓, 9,   p‑JAK3↓, 2,   JNK↓, 2,   JNK↑, 21,   p‑JNK↓, 1,   p‑JNK↑, 3,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAPK↓, 20,   MAPK↑, 15,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 5,   MKK4↓, 1,   mTOR↓, 73,   mTOR↝, 1,   p‑mTOR↓, 10,   mTORC2↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PDGFR-BB↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 76,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PP2A↑, 1,   PRAS40↓, 1,   PTEN↓, 1,   PTEN↑, 26,   PTPN6↑, 2,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 8,   RAS↑, 1,   RET↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 7,   Sp1/3/4↓, 14,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 5,   p‑STAT2↓, 1,   STAT3↓, 321,   STAT3↑, 13,   STAT3⇅, 1,   STAT3↝, 3,   p‑STAT3↓, 74,   p‑STAT3↑, 4,   i-STAT3↓, 1,   mt-STAT3↓, 1,   STAT4↓, 2,   STAT4↑, 1,   STAT5↓, 8,   p‑STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   TK1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 3,   cJun↑, 3,   cMyc↓, 50,   DNMT1↓, 9,   DNMT3A↓, 2,   DNMTs↓, 4,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 5,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↓, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 3,   HES1↓, 1,   IRF1↑, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-148a↓, 1,   miR-148a↑, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 7,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-422a↑, 1,   miR-592↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 13,   other↓, 3,   other↑, 1,   other↝, 5,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 12,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFE3↑, 1,   tumCV↓, 49,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 5,   ER Stress↑, 31,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP27↓, 3,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 15,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 11,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 1,   LC3II↓, 2,   LC3II↑, 9,   LC3s↑, 1,   MitoP↓, 1,   p62↓, 7,   SESN2↑, 2,   TumAuto↑, 24,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 37,   DNArepair↓, 2,   DNArepair↑, 1,   hTERT/TERT↓, 9,   NKX3.1↑, 1,   p16↑, 3,   P53?, 1,   P53↓, 3,   P53↑, 65,   P53↝, 2,   p‑P53↓, 1,   i-P53↓, 1,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↑, 58,   proPARP↓, 1,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 23,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 9,   TOP1↓, 7,   TOP2↓, 4,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 14,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 28,   CDK4↓, 32,   CDK4↑, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 4,   CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 21,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 91,   cycD1/CCND1↑, 1,   CycD3↓, 3,   cycE/CCNE↓, 15,   cycE1↓, 1,   E2Fs↓, 4,   E2Fs↑, 1,   GADD45A↑, 1,   Ki-67↓, 26,   P21?, 1,   P21↓, 4,   P21↑, 46,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 20,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 6,   TumCCA↓, 4,   TumCCA↑, 150,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 3,   Axin2↑, 1,   BMPs↑, 1,   CD133↓, 10,   CD24↓, 1,   CD34↓, 2,   cFos↓, 5,   cFos↑, 1,   CSCs↓, 42,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↓, 2,   Diff↑, 1,   EIF4E↓, 2,   FGF↓, 3,   Gli↓, 1,   Gli1↓, 5,   HH↓, 5,   HMGCR↓, 1,   IGF-1↓, 4,   IGFBP1↑, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   JAG1↓, 1,   Ki-67↓, 26,   Let-7↑, 3,   LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 5,   NOTCH↓, 19,   NOTCH⇅, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 8,   Smo↓, 3,   STAT1↓, 3,   p‑STAT1↓, 1,   TumCG?, 2,   TumCG↓, 74,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 120,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 37,   Wnt↑, 1,   Wnt/(β-catenin)↓, 6,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 16,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   CD11b↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 8,   E-cadherin↑, 37,   EM↑, 1,   EMT↓, 68,   EMT↑, 2,   FAK↓, 16,   FAK↑, 1,   p‑FAK↓, 4,   fascin↓, 1,   Fibronectin↓, 2,   GIT1↓, 1,   GLI2↓, 1,   ITGA2↓, 1,   ITGA5↓, 3,   ITGA6↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 2,   LAMs↓, 2,   LEF1↓, 2,   MALAT1↓, 2,   MET↓, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP15↓, 1,   MMP16↓, 1,   MMP2?, 1,   MMP2↓, 82,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 8,   MMP9?, 1,   MMP9↓, 90,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 24,   MUC4↓, 1,   N-cadherin↓, 25,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 2,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 2,   TIMP2↑, 4,   TRIB3↑, 2,   TSP-1↑, 3,   TumCI↓, 73,   TumCI↑, 1,   TumCMig↓, 70,   TumCMig↑, 1,   TumMeta↓, 52,   TumMeta↑, 8,   Twist↓, 22,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   Vim↓, 31,   Vim↑, 1,   Zeb1↓, 10,   ZEB2↓, 2,   α-SMA↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 52,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 69,   angioG↑, 3,   CD31/PECAM-1↓, 4,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↝, 2,   Hypoxia↓, 1,   NO↓, 5,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 109,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 7,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 3,   GLUT1↓, 10,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 3,   IBI↑, 1,   MMP?, 1,   MMP↓, 67,   MMP↑, 1,   MMP↝, 1,   MPT↑, 3,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 3,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 10,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 69,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 1,   CXCR4↓, 14,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↓, 2,   Gal-3↓, 2,   HCAR1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 8,   IL10↑, 1,   IL12↓, 2,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 64,   IL6↑, 1,   IL7↓, 1,   IL8↓, 10,   Imm↑, 6,   Imm↝, 2,   Inflam↓, 33,   M2 MC↓, 3,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 3,   MIP2↓, 2,   NF-kB↓, 130,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 5,   NLRP3↑, 2,   p65↓, 8,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 15,   PGE2↓, 15,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 2,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 1,   Th17↓, 1,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 32,   TNF-α↑, 4,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 16,   AR↑, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 35,   BioAv↑, 33,   BioAv↝, 7,   BioEnh↑, 3,   chemoR↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 110,   ChemoSen⇅, 1,   CompStab↓, 3,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 6,   Dose↝, 34,   Dose∅, 11,   eff?, 1,   eff↓, 28,   eff↑, 55,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 14,   Half-Life↑, 1,   Half-Life↝, 11,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   NAT↓, 1,   P-gp/ABCB1↓, 13,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS↑, 39,   selectivity↑, 46,   selectivity∅, 1,   Synergy↑, 81,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 4,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 16,   AR↑, 1,   ascitic↓, 2,   AST↓, 3,   AST↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   FOXM1↓, 6,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 64,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 5,   LDH↝, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 15,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 2,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 29,   antiD↑, 1,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 8,   cachexia↓, 4,   cardioP↑, 9,   CardioT↑, 1,   chemoP↑, 19,   chemoPv↑, 17,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 7,   NKG2D↑, 1,   Obesity↓, 2,   OS↑, 7,   Pain↓, 2,   QoL↑, 4,   radioP↑, 6,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 1,   toxicity↓, 15,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   TumVol↓, 21,   TumVol∅, 1,   TumW↓, 13,   TumW∅, 1,   Weight↑, 1,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 1,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 982

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 52,   ARE↑, 2,   Catalase↑, 29,   DUOX1↓, 1,   Fenton↓, 1,   GPx↑, 18,   GPx4↑, 1,   GSH↑, 28,   GSR↑, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HNE↑, 1,   HO-1↑, 16,   i-Iron↓, 1,   Keap1↓, 2,   lipid-P↓, 17,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 4,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 29,   Prx↑, 1,   RNS↓, 1,   ROS?, 3,   ROS↓, 67,   SOD↑, 36,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 3,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 2,   PINK1↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 1,   Buty↑, 1,   CRM↑, 1,   FASN↓, 2,   GSK‐3β↓, 1,   H2S↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 3,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 3,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp9↓, 4,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   GSDMD↓, 1,   iNOS↓, 13,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 5,   Akt↝, 1,   p‑Akt↑, 1,   AKT1↓, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 3,   JAK2↑, 4,   p‑JAK2↓, 2,   JNK↓, 2,   p‑JNK↓, 2,   LPAR1/EDG2↑, 1,   MAPK↓, 9,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 1,   mTOR↑, 3,   PI3K↓, 3,   PI3K↑, 5,   PTEN↑, 1,   STAT↓, 1,   STAT3?, 1,   STAT3↓, 18,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 4,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 3,   HDAC2↓, 1,   HOTAIR↑, 1,   OCT4↓, 1,   other↑, 2,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 3,   LC3B↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 2,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 2,   neuroG↑, 2,   p300↓, 1,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   p‑Rac1↓, 1,   ROCK1↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SPARC↓, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 1,   α-SMA↓, 4,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   NO↓, 12,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB∅, 2,   IBI↑, 1,   MMP↑, 4,   OATPs↓, 1,   TJ↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 3,   IFN-γ↓, 4,   IL1↓, 1,   IL10↓, 4,   IL10↑, 4,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 23,   IL2↓, 3,   IL22↓, 3,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 2,   IL6↓, 25,   IL8↓, 5,   Imm↓, 1,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 65,   Inflam↑, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 30,   NF-kB↑, 1,   NLRP3↓, 7,   NLRP3↑, 1,   PGE2↓, 12,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 33,   TNF-α↑, 1,   Treg lymp↝, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 1,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   DHT↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 29,   BioAv↑, 13,   BioAv↝, 12,   BioEnh↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 9,   eff↑, 7,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 1,   AST↓, 9,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   creat↓, 2,   CRP↓, 1,   EGFR↓, 1,   IL6↓, 25,   LDH↓, 2,   NOS2↓, 1,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 1,   antiAll↑, 14,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 10,   AntiDiabetic↑, 7,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↑, 18,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 9,   diuretic↑, 3,   hepatoP↑, 30,   Learn↑, 2,   memory↑, 10,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 41,   Obesity↓, 2,   OS↑, 2,   radioP↑, 2,   RenoP↑, 6,   Stroke↓, 4,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 5,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiP↑, 1,   AntiViral↑, 10,   Bacteria↓, 8,   GutMicro↑, 9,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 340

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
27 Curcumin
15 Thymoquinone
13 Cucurbitacin
13 Quercetin
12 Apigenin (mainly Parsley)
12 Luteolin
10 Resveratrol
9 EGCG (Epigallocatechin Gallate)
9 Baicalein
9 Capsaicin
9 Chrysin
9 Garcinol
9 Honokiol
8 Ashwagandha(Withaferin A)
8 Betulinic acid
8 Emodin
8 Ginkgetin
8 Silymarin (Milk Thistle) silibinin
7 Lycopene
6 Berberine
6 brusatol
6 Kaempferol
5 Artemisinin
5 Beta-Caryophyllene
5 Caffeic acid
5 Matrine
5 Pterostilbene
4 Cisplatin
4 Radiotherapy/Radiation
4 Berbamine
4 Sorafenib (brand name Nexavar)
4 Carnosic acid
4 Celastrol
4 Cynaropicrin
4 Ellagic acid
4 Fisetin
4 Formononetin
4 Sulforaphane (mainly Broccoli)
4 Ginger/6-Shogaol/Gingerol
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Ivermectin
4 Magnolol
4 Morin
4 Niclosamide (Niclocide)
4 Piperine
4 Piperlongumine
3 Gemcitabine (Gemzar)
3 Melatonin
3 Chemotherapy
3 Boswellia (frankincense)
3 Propolis -bee glue
3 Magnetic Fields
3 chaetocin
3 Dandelion Root
3 Gambogic Acid
3 Paclitaxel/Taxol
3 isoorientin
3 lambertianic acid
3 Licorice
3 Methylsulfonylmethane
3 Nimbolide
3 Oleocanthal
3 Phenethyl isothiocyanate
3 Rosmarinic acid
3 Shikonin
3 Ursolic acid
2 Andrographis
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Brucea javanica
2 borneol
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Cinnamon
2 immunotherapy
2 methylseleninic acid
2 Fucoidan
2 Gallic acid
2 Genistein (soy isoflavone)
2 Geraniol
2 Indole-3-carbinol
2 Juglone
2 Lasiodin
2 Licochalcone A
2 Modified Citrus Pectin
2 Metformin
2 Vitamin C (Ascorbic Acid)
2 Sanguinarine
2 Vitamin K2
1 5-Hydroxytryptophan
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Astaxanthin
1 Biochanin A
1 Atorvastatin
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Black Rice, Oryza sativa
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Trastuzumab
1 Hydroxycinnamic-acid
1 Crocetin
1 Carvone
1 Oxygen, Hyperbaric
1 CUSP9
1 Deguelin
1 D-limonene
1 Tetrahydroxystilbene glucoside
1 Ferulic acid
1 Ginkgolic acids
1 Ginseng
1 Hydrogen Gas
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hyperoside
1 Isobavachalcone
1 Inositol
1 isoflavones
1 isoquercitrin
1 L-Theanine
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 mebendazole
1 Moringa oleifera
1 doxorubicin
1 tamoxifen
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Oleuropein
1 Orlistat
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Parthenolide
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Urolithin
1 Usnic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:373  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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