Wnt Cancer Research Results

Wnt, Wingless-related integration site: Click to Expand ⟱
Source:
Type:
The Wnt signaling pathway is a complex network of proteins that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and migration. It is particularly important during embryonic development and tissue homeostasis. Dysregulation of the Wnt pathway has been implicated in various cancers, making it a significant area of research in oncology.
Wnt Ligands
Wnt1: Often overexpressed in breast cancer and some types of leukemia.
Wnt Receptors
Frizzled (Fzd) Receptors: Different Fzd receptors (e.g., Fzd1, Fzd2, Fzd7) have been implicated in various cancers:
Fzd1: Overexpressed in colorectal cancer.
Fzd2: Associated with breast cancer and prostate cancer.
Fzd7: Linked to gastric cancer and glioblastoma.
Scientific Papers found: Click to Expand⟱
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
5121- Sal,    Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, BC, NA
CSCs↓, Wnt↓, selectivity↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
5001- Sal,    Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex
- in-vitro, CRC, NA
CSCs↓, β-catenin/ZEB1↓, Wnt↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
- in-vitro, Var, NA
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP/DDIT3↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, Synergy↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
- Review, Var, NA
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
6446- SAO,    Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
- in-vitro, BC, NA
Wnt↓, β-catenin/ZEB1↓, TumCMig↓, Wound Healing↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,

Showing Research Papers: 151 to 177 of 177
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 177

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 1,   GPx↑, 4,   GPx4↓, 7,   GPx4↝, 1,   GSH↓, 6,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 9,   Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   NADH↓, 1,   NRF2↓, 4,   NRF2↑, 10,   p‑NRF2↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 67,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↑, 3,   mt-SOD↑, 1,   TAC?, 1,   TrxR↓, 2,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 5,   compI↓, 3,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 6,   OCR↓, 3,   OXPHOS↓, 4,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 1,   AMPK?, 1,   AMPK↑, 16,   ATP↓, 9,   FAO↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 10,   GSK‐3β↓, 10,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 3,   HK1↓, 1,   HK2↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   PKM2↓, 2,   PKM2↑, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 67,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 5,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 4,   Bcl-2↓, 33,   Bcl-2↑, 2,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 2,   BIM↑, 5,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 11,   cl‑Casp↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 39,   cl‑Casp3↑, 11,   Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 12,   cl‑Casp8↑, 2,   Casp9↑, 21,   cl‑Casp9↑, 5,   cFLIP↓, 1,   Cyt‑c↑, 28,   Diablo↑, 3,   DR5↑, 17,   FADD↑, 1,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 10,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICD↑, 3,   iNOS↓, 4,   Mcl-1↓, 14,   MDM2↓, 7,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 1,   p38↓, 2,   p38↑, 7,   p‑p38↓, 1,   PUMA↓, 2,   Pyro↑, 1,   survivin↓, 19,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 3,   XIAP↓, 6,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 70,   p‑Akt↓, 10,   CIP2A↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   DDIT4↑, 1,   EGFR↓, 25,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   FGFR1↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 2,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 7,   JAK1↓, 3,   JAK2↓, 2,   JNK↓, 3,   JNK↑, 8,   p‑JNK↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 18,   MAPK↑, 8,   MAPK↝, 1,   p‑MAPK↓, 1,   MEK↓, 2,   Mst1↑, 1,   mTOR↓, 46,   p‑mTOR↓, 4,   mTORC2↓, 2,   p‑p70S6↓, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 60,   PI3K↑, 1,   PI3K↝, 1,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↑, 16,   Raf↓, 1,   e-Raf↓, 1,   RAS↓, 7,   RET↓, 1,   Sp1/3/4↓, 3,   STAT↓, 3,   STAT3↓, 32,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 5,   CBP↓, 1,   cJun↓, 5,   cMyc↓, 20,   p‑cMyc↑, 1,   DNMT1↓, 9,   DNMT3A↓, 4,   DNMTs↓, 5,   EZH2↓, 4,   FOXM1↓, 3,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↑, 1,   FOXO4↑, 1,   H3K9↓, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-330-5p↑, 1,   miR-340↓, 2,   miR-34a↓, 1,   miR-34a↑, 4,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 2,   Myc↓, 5,   MYCN↓, 1,   MYCN↑, 1,   OCT4↓, 6,   OLIG2↓, 1,   other↑, 2,   other↝, 5,   PCAF↓, 1,   SOX2↓, 6,   SOX4↓, 4,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 3,   TFE3↑, 1,   tumCV↓, 13,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 12,   eIF2α↓, 3,   eIF2α↑, 1,   ER Stress↑, 17,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 3,   IRE1↑, 3,   PERK↑, 2,   UPR↑, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 9,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   p62↓, 2,   p62↑, 1,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 5,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 29,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 17,   cl‑PARP↝, 1,   PCNA↓, 7,   SIRT6↓, 1,   Telomerase↓, 4,   TOP1↓, 2,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 5,   CDK1↑, 3,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 15,   CDK6↓, 5,   CDKN1C/p57↓, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 35,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 3,   Ki-67↓, 7,   P21↑, 26,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 2,   Securin↓, 2,   TumCCA↓, 4,   TumCCA↑, 59,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 6,   ALDH1A1↓, 4,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 7,   CD24↓, 2,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 45,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 3,   FGF↓, 1,   Gli1↓, 8,   HH↓, 7,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 7,   Let-7↓, 1,   Let-7↑, 2,   LRP6↓, 5,   p‑LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 9,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 16,   NOTCH⇅, 1,   NOTCH↝, 1,   NOTCH1↓, 9,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 5,   TAZ↓, 1,   TumCG↓, 29,   TumCP?, 1,   TumCP↓, 59,   Wnt?, 1,   Wnt↓, 165,   Wnt↑, 2,   Wnt↝, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   AGRN↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 12,   CCN2/CTGF↓, 2,   Chl↓, 1,   Chl↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 23,   EMT↓, 43,   FAK↓, 6,   FAK↑, 1,   FAK↝, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 5,   GLI3↑, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LEF1↓, 2,   MALAT1↓, 3,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 7,   MMP14↓, 1,   MMP16↓, 2,   MMP2↓, 39,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 42,   MMPs↓, 11,   N-cadherin↓, 15,   PAK1↓, 2,   PDGF↓, 4,   Rho↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   Slug↓, 7,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 19,   TET1↑, 2,   TGF-β↓, 10,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 2,   TIMP2↑, 3,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 29,   TumCMig↓, 31,   TumMeta↓, 26,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 5,   uPA↓, 16,   uPAR↓, 2,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 8,   Zeb1↑, 1,   β-catenin/ZEB1↓, 120,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   CCN1/CYR61↓, 1,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 14,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 1,   VEGF↓, 41,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   GLUT1↓, 4,   MMP↓, 30,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 15,   COX1↓, 2,   COX2/PTGS2↓, 38,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 9,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 3,   IL12↓, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↑, 4,   IL4↑, 1,   IL6↓, 16,   IL8↓, 2,   Imm↑, 8,   Imm↝, 1,   Inflam↓, 14,   IRAK1↓, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MIP2↓, 1,   NF-kB?, 1,   NF-kB↓, 77,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↑, 2,   p65↓, 3,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 14,   PSA↓, 5,   TCF↓, 5,   TCF↑, 1,   TCF7/TCF1↓, 3,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 12,   EstroRS/ERS↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 19,   BioAv↑, 13,   BioAv↝, 8,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 57,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose↑, 4,   Dose↝, 17,   eff↓, 8,   eff↑, 20,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 5,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 10,   P450↓, 3,   P450↝, 1,   RadioS↑, 20,   selectivity↑, 21,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 29,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALB↑, 1,   ALP↓, 1,   AR↓, 12,   ascitic↓, 1,   AST?, 1,   CEA↓, 1,   CRP↓, 1,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 25,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 5,   IBIL↓, 1,   IL6↓, 16,   IRes↓, 1,   KRAS↓, 1,   LDH↑, 1,   Myc↓, 5,   PD-L1↓, 5,   PSA↓, 5,   TBIL↓, 1,   TP53↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 20,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 5,   chemoP↑, 10,   chemoPv↑, 8,   ChemoSideEff↓, 2,   hepatoP↑, 2,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 6,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 6,   toxicity↓, 6,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 4,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 704

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 3,   Fenton↓, 1,   GPx↑, 1,   GPx4↑, 2,   GSH↑, 5,   GSTs↑, 3,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 9,   i-Iron↓, 1,   lipid-P↓, 4,   MDA↓, 5,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 16,   RNS↓, 1,   ROS?, 1,   ROS↓, 24,   ROS↑, 2,   SOD↑, 5,   SOD1↑, 2,   TAC↑, 1,   TBARS↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   glucose↓, 1,   GSK‐3β↓, 3,   LDL↓, 2,   NADPH↓, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   JAK2↑, 1,   JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   mTOR↑, 1,   PI3K↑, 2,   STAT↓, 2,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↝, 1,   RUNX2∅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   Diff↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   NOTCH↓, 1,   TumCP↓, 1,   Wnt↓, 3,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2?, 1,   Ca+2↑, 2,   Ca+2↝, 1,   COL1∅, 1,   FAK↑, 1,   MMP9↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   MUC19↓, 1,   MUC2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 3,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 3,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 6,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 24,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 10,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 5,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 9,   BioAv↝, 7,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   eff↑, 3,   eff↝, 1,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP∅, 1,   AST↓, 1,   BMD↑, 1,   CRP↓, 1,   IL6↓, 6,   IRes↑, 1,   LDH↑, 1,   OCN∅, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 4,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↑, 2,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 10,   Learn↑, 1,   memory↑, 7,   neuroP↑, 17,   OS↑, 1,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 10,   toxicity↝, 2,   toxicity∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 3,   Bacteria↓, 4,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 208

Scientific Paper Hit Count for: Wnt, Wingless-related integration site
16 Curcumin
12 salinomycin
11 Fisetin
8 Matrine
8 Resveratrol
7 Ivermectin
5 EGCG (Epigallocatechin Gallate)
5 Sulforaphane (mainly Broccoli)
4 Astragalus
4 Honokiol
4 HydroxyTyrosol
4 Luteolin
4 Lycopene
4 Nimbolide
3 Baicalein
3 Garcinol
3 Ginkgetin
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnetic Fields
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Deguelin
2 Diindolylmethane
2 Indole-3-carbinol
2 Dandelion Root
2 Hydrogen Gas
2 Isobavachalcone
2 isoorientin
2 Lemongrass Extract/Citral
2 Morin
2 Niclosamide (Niclocide)
2 Silymarin (Milk Thistle) silibinin
2 Urolithin
1 1,8-Cineole
1 Isovitexin
1 Chemotherapy
1 Artemisinin
1 Baicalin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Caffeic Acid Phenethyl Ester (CAPE)
1 chaetocin
1 Chrysin
1 Coenzyme Q10
1 Cucurbitacin
1 5-fluorouracil
1 Dipyridamole
1 Juglone
1 Licochalcone A
1 Magnetic Field Rotating
1 Melatonin
1 Zeolite
1 Naringin
1 Piperine
1 Parthenolide
1 Quercetin
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:377  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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