Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
5482- BM,    Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways
- in-vitro, Nor, NA
*neuroP↑, *ERK↑, *Akt↑, *MAPK↑, *PI3K↑, *Inflam↓, antiOx↑,
5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
*memory↑, *neuroP↑, *cognitive↑, *hepatoP↑, *antiOx↑, *AntiDiabetic↑, *fatigue↓, *GSK‐3β↓, *PI3K↑, *Akt↑, *tau↓, *ROS↓, *Inflam↓,
5677- BML,    Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
- in-vitro, Melanoma, A431 - in-vitro, Melanoma, A375
TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, NA, NA
COX2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5673- Bor,    Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice
- in-vivo, Nor, NA
HRAS↓, Hif1a↓, Akt↓, PTEN↓,
750- Bor,    Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis
- in-vitro, CRC, Caco-2
Bcl-2↓, BAX↑, Akt↓, p70S6↓, PTEN↑, TSC2↑,
725- Bor,    Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway
- in-vitro, HCC, NA
tumCV↓, Apoptosis↑, TumAuto↑, p‑Akt↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1420- Bos,    Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway
- vitro+vivo, GC, BGC-823
TumCP↓, TumCG↓, PTEN↑, BAX↑, Bcl-2↓, p‑Akt↓, COX2↓,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5691- BRU,    Brusatol Inhibits Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, H1975
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EGFR↓, β-catenin/ZEB1↓, Akt↓, STAT3↓, TumMeta↓, ChemoSen↑, NRF2↓, Akt↓, mTOR↓,
5693- BRU,    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
- in-vivo, HCC, NA
NRF2↓, eff↑, p‑MAPK↑, p‑Akt↑, p‑ERK↑, p‑JNK↑,
5699- BRU,  BJ,    Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay
- in-vitro, Lung, A549
EGFR↓, ChemoSen↑, NRF2↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ROCK1↓, Hif1a↓,
6548- BSB,    Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway
- in-vitro, NSCLC, A549
AntiCan↑, Dose↝, TumCCA↑, mt-Apoptosis↑, TumCMig↓, PI3K↓, Akt↓,
6547- BSB,    Antitumor effects of a-bisabolol against pancreatic cancer
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, KLM1 - in-vitro, PC, KP4 - in-vitro, Nor, ACBRI515
TumCP↓, selectivity↑, Apoptosis↑, Akt↓, EGR1↑, TumCG↓, Dose↝, PI3K↓, PDK1↓, mTORC2↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6559- BSB,    AktPI3K_Signaling_pathways_in_MCF-7_breast_cancer_cells">Modulatory effect of α-Bisabolol on induced apoptosis via mitochondrial and NF-κB/Akt/PI3K Signaling pathways in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, TumCP↓, Apoptosis↓, ROS↑, Bcl-2↓, BAX↑, BAD↑, Casp3↑, Casp9↑, Cyt‑c↑, NF-kB↓, p‑PI3K↓, p‑Akt↓,
1230- CA,  Caff,    Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - Human, NA, NA
TumVol↓, TumCG↓, ER(estro)↓, cycD1/CCND1↓, IGF-1R↓, p‑Akt↓,
5750- CA,    Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells
- in-vitro, MM, NA
eff↑, selectivity↑, Ki-67↓, PCNA↓, TumCP↓, p‑ERK↓, Akt↓, p27↑, P21↑, TumCCA↑, Bax:Bcl2↑, cl‑Casp3↑, mt-Apoptosis↑,
5747- CA,    Caffeic Acid Enhances Anticancer Drug-induced Apoptosis in Acid-adapted HCT116 Colon Cancer Cells
- in-vitro, CRC, NA
TumCP↓, Apoptosis↑, ChemoSen↑, PI3K↓, Akt↓, ERK↓,
5870- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF7
ROS↑, cJun↑, p38↑, eff↓, TumCP↓, glucose↓, Apoptosis↑, BAX↑, PARP↑, Bcl-2↓, TumCG↑, Ki-67↓, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, eff↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
1101- CA,  Tras,    Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
- in-vitro, BC, NA
ChemoSen↑, HER2/EBBR2↓, PI3K↓, Akt↓, mTOR↓, p62↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5841- CAP,    The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
- in-vitro, HCC, HepG2
AMPK↑, CaMKII ↑, tumCV↓, Akt↓, mTOR↓, ROS↑,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5848- CAP,  SRF,    Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
ChemoSen↑, Apoptosis↑, Casp9↑, PARP↑, Akt↓, AMPK↑, p‑ACC↑,
5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, miR-126↑, Ki-67↓, PI3K↓, mTOR↓, Akt↑, eff↑, Casp3↑,
1260- CAP,    Capsaicin inhibits in vitro and in vivo angiogenesis
- vitro+vivo, NA, NA
VEGF↓, angioG↓, TumCCA↑, cycD1/CCND1↓, Akt↓,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5767- CAPE,    Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer
- Review, Oral, NA
TumCP↓, tumCV↓, TumMeta↓, Akt↓, NF-kB↓, MMPs↓, EGFR↓, COX2↓, TumCCA?,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5886- CAR,    Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo
- in-vivo, GBM, U87MG - in-vivo, GBM, U251
TRPM7↓, TumVol↓, p‑Akt↓, p‑GSK‐3β↑, Dose↝,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5882- CAR,    Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, pRB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, PI3K↓, p‑Akt↓, Apoptosis↑, Bcl-2↓, BAX↑,
5905- CAR,  HCQ,    Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets
- in-vitro, Melanoma, NA
eff↑, tumCV↑, IGF-1R↓, SIRT2↓, HSP90↓, TumCP↓, Akt↓,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, eff↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
5912- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, p‑Cofilin↑, RAS↓, MEK↓, MAPK↓, PI3K↓, Akt↓,
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
5963- CEL,    Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
Akt↓,
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2↓, ChemoSen↑, MDR1↓, MRP1/ABCC1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp↓, PI3K↓, Akt↓,

Showing Research Papers: 151 to 200 of 663
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 663

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GSH↓, 2,   MDA↓, 1,   MDA↑, 1,   NRF2↓, 3,   ROS↓, 1,   ROS↑, 15,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   CDC25↓, 1,   MEK↓, 2,   MMP↓, 6,   MPT↑, 2,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑ACC↑, 1,   AMPK↓, 1,   AMPK↑, 3,   glucose↓, 2,   Glycolysis↓, 2,   PDK1↓, 1,   PIK3CA↓, 1,   SIRT2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 36,   Akt↑, 1,   p‑Akt↓, 8,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 18,   mt-Apoptosis↑, 2,   BAD↑, 2,   Bak↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   BID↑, 1,   Casp↑, 4,   Casp3↑, 8,   cl‑Casp3↑, 1,   Casp8↑, 3,   Casp9↑, 5,   Cyt‑c↑, 7,   Diablo↑, 1,   DR5↑, 1,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 1,   ICAD↓, 1,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↑, 2,   MAPK↓, 6,   p‑MAPK↑, 1,   p27↑, 1,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 1,   TRPV1↑, 2,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1,   HER2/EBBR2↓, 2,   p70S6↓, 1,   SOX9↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   other↝, 1,   pRB↓, 1,   tumCV↓, 7,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   LC3B↓, 1,   LC3II↑, 1,   p62↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↑, 4,   PARP↑, 4,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   CDK4↓, 3,   cycD1/CCND1↓, 4,   P21↑, 4,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EIF4E↓, 1,   ERK↓, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   FGF↓, 1,   FOXM1↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   HRAS↓, 1,   IGF-1R↓, 2,   Let-7↑, 1,   mTOR↓, 13,   mTORC1↓, 1,   mTORC2↑, 1,   NOTCH↓, 1,   PI3K↓, 20,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   Smo↓, 1,   Src↓, 1,   STAT3↓, 6,   p‑STAT3↑, 1,   TOP2↓, 1,   TRPM7↓, 5,   TumCG↓, 5,   TumCG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   ATPase↓, 1,   AXL↓, 1,   Ca+2↑, 2,   i-Ca+2?, 1,   cal2↓, 1,   CEA↓, 1,   p‑Cofilin↑, 2,   COL1↓, 1,   COL4↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   F-actin↓, 2,   Fibronectin↓, 1,   Ki-67↓, 4,   MMP2↓, 4,   MMP2↑, 1,   MMP9↓, 5,   MMPs↓, 1,   ROCK1↓, 1,   Snail↑, 1,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 15,   TumMeta↓, 5,   Vim↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 5,   EGFR↑, 1,   EGR1↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   miR-126↑, 1,   VEGF↓, 7,   VEGFR2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 8,   CXCR4↓, 2,   IL1↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 11,   Dose↝, 4,   eff↓, 3,   eff↑, 14,   eff↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 1,   CEA↓, 1,   EGFR↓, 5,   EGFR↑, 1,   FOXM1↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 2,   IL6↓, 1,   Ki-67↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoPv↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity↝, 2,   TumVol↓, 3,   Weight↑, 1,  
Total Targets: 208

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 5,   GPx↑, 2,   GSH↑, 5,   GSR↑, 1,   HNE↓, 1,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 4,   lipid-P↑, 1,   MDA↓, 2,   NOX4↓, 1,   NRF2↑, 4,   ROS↓, 8,   ROS↑, 1,   SOD↑, 7,   TBARS↓, 1,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 1,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   LDH↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 5,   p‑Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3∅, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   iNOS↓, 3,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   PI3K↑, 5,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Ca+2↑, 1,   MMP13↓, 1,   MMP3↓, 2,   Na+↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2↓, 5,   IL1β↓, 3,   IL6↓, 5,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 10,   Inflam↑, 1,   NF-kB↓, 3,   NF-kB↑, 1,   PGE2↓, 1,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   GABA↝, 1,   tau↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 5,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↓, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 2,   memory↑, 3,   motorD↑, 1,   neuroP↑, 9,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 112

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
28 Quercetin
24 Thymoquinone
24 Apigenin (mainly Parsley)
21 Baicalein
19 Resveratrol
16 Berberine
16 Chrysin
15 Fisetin
14 Shikonin
13 Alpha-Lipoic-Acid
12 Emodin
11 Magnetic Fields
11 Lycopene
11 Sulforaphane (mainly Broccoli)
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 Magnolol
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Piperlongumine
8 Urolithin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 HydroxyTyrosol
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 5-fluorouracil
6 Celastrol
6 Dandelion Root
6 Luteolin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Celecoxib
4 Ferulic acid
4 Gambogic Acid
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Cucurbitacin
3 Radiotherapy/Radiation
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Gallic acid
3 Garcinol
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 3-bromopyruvate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 Hydroxycinnamic-acid
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geraniol
2 Ginseng
2 Hydrogen Gas
2 Huperzine A/Huperzia serrata
2 Melatonin
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 Camptothecin
1 chemodynamic therapy
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fucoidan
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Grapeseed extract
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Psoralidin
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 statins
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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