GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1/SREBF1↓,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
2311- MFrot,  MF,    Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
- in-vivo, Nor, HaCaT
*COX2/PTGS2↓, *Inflam↓, *MMP9↑, *GPx↑, *Diff↑,
1777- MLT,    Melatonin as an antioxidant: under promises but over delivers
- Review, Var, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
6419- MLT,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
8672- MLT,    Glioblastoma and Melatonin’s Effects: A Narrative Review
- Review, GBM, NA
selectivity↑, *ROS↓, *DNAdam↓, *SOD↑, *Catalase↑, *GPx↑, *Inflam↓, *EGF↓, *HIF-1↓, Pyruv↓, Glycolysis↓, ROS↑, TumCG↓, IL1β↓, ICAM-1↓, VCAM-1↓, NRF2↓, RadioS↑, OS↑, NAD↓, LDHA↓, MCT4↓, pH↝, ChemoSen↑, Synergy↑, TRPV1↓, Pain↓, Synergy↑, Dose↑,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3839- MO,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
- in-vitro, AD, NA
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
8908- MO,    Water Extracts of Moringa oleifera Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *GPx↑, *Catalase↑, *SOD↑, *Bcl-2↓, *BAX↓, *Casp3↓, *BDNF↑, *p‑Akt↑, *p‑CREB↑, *neuroP↑,
8875- MOR,    Neuroprotective Effect of Morin Against Chemical-Induced Neurotoxicities and Neurodegenerative Disease Models
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *chemoP↑, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *ROS↓, *MDA↓, *NO↓, *TLR4↓, *NF-kB↓, *ERK↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓,
8884- MOR,    Morin Reactivates Nrf2 by Targeting Inhibition of Keap1 to Alleviate Deoxynivalenol-Induced Intestinal Oxidative Damage
- in-vivo, Nor, NA
*other↑, *other↑, *TAC↑, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *Keap1↓, *NRF2↑, *Dose↝,
8882- MOR,  Cisplatin,    Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose?, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑, *MDA↓, *other↑, *Ferroptosis↓, *Iron↓, *ROS↓, *other↓, ChemoSen↑, *chemoP↑, *selectivity↑,
8770- MSM,  Cisplatin,    Methylsulfonylmethane (MSM) Mitigates Cisplatin-Induced Early Oxidative Testicular Dysfunction Through Modulation of Antioxidant Defense and GPX4 Response
- in-vivo, Nor, NA
*Dose?, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *testos↑, *GPx4↓, *chemoP↑,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
8964- mushLions,    Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review
- Review, Nor, NA - Review, AD, NA
*Ingr↝, *ROS↓, *antiOx↑, *AntiBio↑, *NGF↑, *neuroG↑, *memory↑, *neuroP↑, *NF-kB↓, *COX2/PTGS2↓, *NeuroI↓, *cognitive↑, *NRF2↑, *SOD↑, *GPx↑, *GutMicro↑, *BBB↑, *BioAv↝,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1683- PBG,  Rad,    Protective effect of propolis in protecting against radiation-induced oxidative stress in the liver as a distant organ
- in-vivo, Nor, NA
GPx↑, SOD↓, RadioS↑,
4954- PEITC,    Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
- vitro+vivo, Ovarian, SKOV3
ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, Synergy↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
2956- PL,    Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- in-vitro, PC, NA
ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *Synergy↑, *ROS↓, *cognitive↑, *Synergy↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, Var, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
*Inflam↓, *COX2/PTGS2↓, *5LO↓, *antiOx↑, *BioAv↝, *GPx↑, *SOD↑, *Ach↑, *4-HNE↓, *CREB↑, *BDNF↑, *ROS↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
*antiOx↑, *Keap1↓, *NRF2↑, *HO-1↑, *GPx↑, *SOD↑,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,

Showing Research Papers: 151 to 200 of 252
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 9,   Catalase↓, 12,   Catalase↑, 13,   GPx↓, 20,   GPx↑, 28,   GPx4↓, 3,   GSH↓, 20,   GSH↑, 9,   GSH⇅, 1,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 2,   HO-1↑, 8,   Iron↑, 4,   Iron↝, 1,   lipid-P↓, 5,   lipid-P↑, 11,   MDA?, 1,   MDA↓, 5,   MDA↑, 6,   MPO↓, 2,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 12,   ROS↓, 15,   ROS↑, 71,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↑, 1,   SOD↓, 12,   SOD↑, 15,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↓, 1,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↑, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compIV↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 10,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 3,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 2,   ATP↓, 6,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 6,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 3,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 3,   Pyruv↓, 2,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 49,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 2,   Bcl-2↓, 29,   Bcl-2↑, 5,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 7,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 39,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 12,   Casp9↑, 27,   cl‑Casp9↑, 1,   Cyt‑c↑, 18,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 6,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 5,   Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 8,   TumCD↑, 5,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 33,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 6,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 5,   MAPK↑, 6,   MAPK↝, 1,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   mTOR↝, 1,   p‑mTOR↓, 3,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 25,   PI3K↑, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 2,   RAS↓, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 3,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 1,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 3,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 1,   tumCV↓, 14,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 9,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 6,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↑, 1,   P53↓, 3,   P53↑, 28,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 9,   cl‑PARP∅, 1,   PCNA↓, 13,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↑, 5,   pRB↓, 1,   pRB↑, 1,   RB1↑, 1,   TumCCA↑, 45,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 3,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 10,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 34,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 2,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 8,   EMT↓, 12,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 22,   MMP9↑, 2,   MMPs↓, 5,   N-cadherin↓, 9,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 18,   TumMeta↓, 17,   TumMeta↑, 3,   Twist↓, 2,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 18,   NO↓, 2,   NO↑, 2,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 18,   MMP↑, 2,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 2,   IL6↓, 15,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 8,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 5,   PSA↓, 2,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 14,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ER-α36↓, 1,   Estro↝, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 6,   BioAv↝, 4,   BioEnh?, 1,   ChemoSen↑, 43,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 5,   Dose↝, 15,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 1,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 13,   selectivity↑, 23,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 6,   AST↓, 2,   BP↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 6,   EGFR↑, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 15,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 2,   PSA∅, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 20,   antiNeop↑, 1,   AntiTum↑, 6,   Appetite↑, 1,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 7,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 8,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 10,   RenoP↑, 2,   Risk↓, 9,   Sleep↑, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 565

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 4,   antiOx↑, 102,   ARE↑, 2,   Bil↓, 2,   Catalase↓, 4,   Catalase↑, 123,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 6,   GPx↑, 202,   GPx↝, 1,   GPx∅, 1,   GPx4↓, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 89,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 25,   GSSG↓, 3,   GSTs↓, 2,   GSTs↑, 24,   H2O2↓, 9,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 5,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 8,   Keap1↝, 1,   lipid-P↓, 62,   MDA↓, 84,   MDA↑, 3,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 11,   NRF2↓, 1,   NRF2↑, 82,   Prx↓, 1,   Prx↑, 2,   RNS↓, 1,   ROS?, 2,   ROS↓, 164,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 5,   SOD?, 1,   SOD↓, 2,   SOD↑, 160,   SOD↝, 1,   SOD1↑, 4,   SOD2↑, 6,   TAC↑, 15,   TBARS↓, 3,   TBARS↑, 1,   Thiols↑, 2,   Trx↑, 3,   Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 7,   VitE↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTL↓, 1,   IronCh↑, 4,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   EGF↓, 1,   ETC↑, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN1↑, 1,   MFN2↑, 2,   mtDam↓, 2,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   mt-ACC⇅, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 25,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 11,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↑, 1,   glucose↓, 7,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 10,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 13,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDKs↑, 1,   PFK↓, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PONs↑, 1,   PPP↓, 1,   SCFAs↑, 2,   SIRT1↑, 14,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 18,   BAD↓, 1,   BAX↓, 15,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 11,   Bcl-2↝, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 26,   cl‑Casp3↓, 2,   proCasp3↑, 1,   Casp8↓, 1,   Casp9↓, 11,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 4,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 4,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 2,   IκB?, 1,   JAK2↓, 1,   JNK↓, 7,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 3,   PI3K↑, 4,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ?, 1,   PP2A↑, 1,   PTEN↓, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 2,   HDAC?, 1,   HDAC↓, 1,   miR-34a↓, 1,   other?, 1,   other↓, 7,   other↑, 12,   other↝, 3,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   P53↓, 1,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CHIP↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↑, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   AP-1↑, 1,   ATPase↑, 1,   Ca+2↓, 8,   Ca+2↝, 2,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MUC1↑, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 2,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Vim↓, 3,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 22,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   GastroP↑, 4,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 1,   MMP↑, 10,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPM7⇅, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 42,   COX2/PTGS2↑, 2,   Eos↓, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↓, 5,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 1,   IL10↓, 7,   IL10↑, 12,   IL12↓, 2,   IL12↑, 1,   IL13↓, 1,   IL17↓, 5,   IL18↓, 1,   IL1β↓, 43,   IL2↓, 3,   IL2↑, 2,   IL23↓, 2,   IL4↓, 4,   IL4↑, 3,   IL5↓, 2,   IL6↓, 44,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↓, 1,   Imm↑, 6,   INF-γ↓, 2,   Inflam↓, 106,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   NF-kB↓, 49,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 8,   p65↓, 1,   PGE2↓, 14,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 13,   TNF-α↓, 60,   TNF-α↑, 2,   TRAF6↓, 1,   TRIF↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 6,   Ach↑, 9,   AChE↓, 31,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 18,   BDNF⇅, 1,   ChAT↑, 8,   GABA↑, 3,   MAOA↓, 3,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 2,   BACE/β-secretase↓, 9,   tau↓, 8,   p‑tau↓, 8,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 5,   GR↝, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 40,   BioAv⇅, 1,   BioAv↝, 23,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 23,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 7,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 25,   ALAT↑, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 27,   AST↑, 1,   BG↓, 3,   Bil↓, 2,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BP↝, 1,   BUN↓, 3,   Calcium↑, 1,   CEA↓, 2,   creat↓, 5,   CRP↓, 8,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 44,   IL6↑, 1,   IRes↝, 1,   LDH↓, 10,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 5,   Urea↓, 3,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 12,   AntiArt↑, 4,   AntiCan↑, 12,   AntiDiabetic↑, 18,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↑, 1,   BOLD↑, 1,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 36,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 44,   Learn↑, 2,   memory↑, 37,   motorD↑, 6,   neuroP↑, 82,   NP/CIPN↓, 1,   Obesity↓, 12,   OS↑, 2,   Pain↓, 4,   radioP↑, 3,   RenoP↑, 14,   Risk↓, 7,   Sleep↑, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity↓, 14,   toxicity↝, 8,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 10,   GutMicro↑, 24,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 2,  
Total Targets: 535

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Lycopene
9 Thymoquinone
8 Melatonin
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Hydrogen Gas
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Sulforaphane (mainly Broccoli)
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hyperoside
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Luteolin
3 Moringa oleifera
3 Morin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Berberine
2 Phenethyl isothiocyanate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Sesame seeds and Oil
2 doxorubicin
2 isoorientin
2 Kaempferol
2 Matrine
2 Cisplatin
2 Methylsulfonylmethane
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Cichoric acid / Chicoric acid
1 Citicoline, CDP-Choline
1 Citric Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 Butein
1 Scopoletin
1 Isothiocyanates
1 Juglone
1 Lactoferrin/Talactoferrin
1 Vitamin E
1 Magnolol
1 Mung Bean Sprouts
1 methylseleninic acid
1 Magnetic Field Rotating
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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