Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱

Source:

Type: proliferation marker

A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.

Scientific Papers found: Click to Expand⟱

7150-

RES,

Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

-

Review,

Var,

NA

AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,

2440-

RES,

Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway

-

in-vitro,

Lung,

H460

-

in-vivo,

Lung,

NA

xenograft mouse model

-

in-vitro,

Lung,

H1650

-

in-vitro,

Lung,

HCC827

AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,

3081-

RES,

Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?

-

Review,

CRC,

NA

NF-kB↓, FAK↓, Ki-67↓, MMP9↓, CSCs↓, CD44↓, CD133↓, ALDH1A1↓, EMT↓, ChemoSen↑, Hif1a↓, ITGB1↓, Inflam↓,

3092-

RES,

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

-

Review,

BC,

MDA-MB-231

-

Review,

BC,

MCF7

TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,

3010-

RosA,

Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation

-

in-vitro,

Lung,

A549

-

in-vivo,

NA,

NA

TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,

9278-

SES, SSM,

Antitumor Effects of Sesamin via the LincRNA-p21/STAT3 Axis in Human Bladder Cancer: Inhibition of Metastatic Progression and Enhanced Chemosensitivity

-

vitro+vivo,

Bladder,

UMUC3

Six-week-old male BALB/c nude mice

-

in-vitro,

Bladder,

5637

tumCV↓, MMP2↓, STAT3↓, TumCMig↓, TumCI↓, ChemoSen↑, TumVol↓, TumW↓, Ki-67↓, Synergy↑,

1434-

SFN,

GEM,

Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity

-

in-vitro,

CCA,

HuCCT1

 SFN (0–80 μM) or GEM (0–10 μM) for 24 h

27.4uM(SFN),0.57 μM(GEM)

-

in-vitro,

CCA,

HuH28

34.2 μM(SFN), 0.71um(GEM)

-

in-vivo,

NA,

NA

50 mg/kg/day

tumors of SFN- and GEM-treated mice

HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,

1483-

SFN,

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

-

in-vitro,

OS,

143B

0-10uM

-

in-vitro,

Nor,

HEK293

-

in-vivo,

OS,

NA

25-50mg/kg

subcutaneous tumor-bearing nude mouse model

AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

1730-

SFN,

Sulforaphane: An emergent anti-cancer stem cell agent

-

Review,

Var,

NA

BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,

1140-

SIL,

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

-

in-vitro,

PC,

AsPC-1

10 μM to 250 μM

~75uM

-

in-vivo,

PC,

NA

mouse

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

PC,

PANC1

-

in-vitro,

PC,

Bxpc-3

TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,

5102-

SK,

GEM,

Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway

-

vitro+vivo,

PC,

NA

TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,

6436-

T4O,

Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression

-

in-vitro,

Melanoma,

A431

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,

5332-

TFdiG,

Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway

-

vitro+vivo,

OS,

143B

mice

-

in-vitro,

OS,

U2OS

tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,

1931-

TQ,

doxoR,

Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms

-

in-vivo,

AML,

NA

Dox  50-750 nM, TQ 5-40uM

mice

ChemoSen↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↓, TumVol↓, eff↑, Ki-67↓,

2121-

TQ,

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,

3422-

TQ,

Thymoquinone, as a Novel Therapeutic Candidate of Cancers

-

Review,

Var,

NA

selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

3425-

TQ,

Advances in research on the relationship between thymoquinone and pancreatic cancer

-

in-vitro,

PC,

NA

Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,

3573-

TQ,

Chronic diseases, inflammation, and spices: how are they linked?

-

Review,

Var,

NA

NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,

2411-

UA,

Ursolic acid in health and disease

-

Review,

Var,

NA

Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

1216-

VitC,

Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer

-

in-vitro,

Laryn,

FaDu

-

in-vitro,

SCC,

SCC-154

Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,

115-

VitD3,

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

-

in-vivo,

RCC,

NA

-

in-vivo,

BCC,

NA

HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

1913-

Xyl,

Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer

-

in-vivo,

Oral,

NA

mice

TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,

9131-

ZYF,

Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets

-

vitro+vivo,

PC,

NA

orthotopic mouse model

TumCP↓, ChemoSen↑, Apoptosis↑, NF-kB↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, Bcl-2↓, IAP1↓, VEGF↓, survivin↓, ICAM-1↓, CXCR4↓, TumCG↓, Ki-67↓, MMP9↓,

Showing Research Papers: 151 to 173 of 173
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 173

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 1, antiOx↑, 5, Catalase↓, 2, GPx↑, 2, GPx4↓, 7, GSH↓, 12, GSH↑, 2, GSTs↑, 1, H2O2↓, 1, H2O2↑, 1, HO-1↓, 1, HO-1↑, 4, Iron↑, 1, Iron↝, 1, i-Iron↑, 1, lipid-P↓, 1, lipid-P↑, 5, MDA↑, 4, MPO↓, 1, NOX↓, 1, NOX4↓, 1, NQO1?, 1, NQO1↑, 1, NRF2↓, 4, NRF2↑, 5, NRF2↝, 1, ox-PrxI↑, 1, PYCR1↓, 1, ROS↓, 7, ROS↑, 56, mt-ROS↑, 2, SOD↓, 3, SOD↑, 2, SOD1↑, 1, SOD2↑, 2, TAC↓, 1, Trx1↑, 1, TrxR↓, 1, TrxR1↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, CDC25↝, 1, compI↓, 4, compII↓, 1, compIII↓, 1, compV↓, 1, ETC↓, 3, HSP60/HSPD1↓, 1, mitResp↓, 1, mtDam↑, 5, OCR↓, 1, OCR↑, 1, OXPHOS↓, 1, OXPHOS↑, 1, PDH↝, 1, PINK1↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1, ACSL4↑, 1, Alanine↓, 1, ALAT↓, 1, AMPK↓, 1, AMPK↑, 5, ATP↓, 4, ATP↑, 1, mt-ATP↓, 1, CAIX/CA9↓, 1, ENO1↓, 1, FABP4↑, 1, FAO↑, 1, FASN↓, 3, FBI-1↓, 1, glucose↓, 3, GlucoseCon↓, 5, GlutMet↓, 1, Glycine↓, 1, Glycolysis↓, 11, Glycolysis↝, 1, GPI↓, 1, GSK‐3β↑, 2, p‑GSK‐3β↓, 1, HK1↓, 1, HK2↓, 7, lactateProd↓, 7, LDHA↓, 3, PCK1↓, 1, PDK1 / PDPK1↓, 1, PDK3↑, 1, PFK↓, 2, PFK1↓, 1, PGE3↑, 1, PKM2↓, 7, PPP↓, 1, p‑S6↓, 1, SIRT1↓, 2, SIRT1↑, 2, TCA↑, 1, TPI↓, 1, Warburg↓, 3,

Cell Death(tgid=5) ⓘ

AIF↑, 1, Apoptosis↓, 2, Apoptosis↑, 55, mt-Apoptosis↑, 1, BAD↓, 1, BAD↑, 1, Bak↑, 1, BAX↑, 38, Bax:Bcl2↑, 9, Bcl-2↓, 43, Bcl-xL↓, 7, BIM↑, 1, Casp↑, 7, proCasp↑, 1, cl‑Casp12↑, 1, Casp3↓, 1, Casp3↑, 36, cl‑Casp3↑, 19, Casp7↑, 7, cl‑Casp7↑, 1, Casp8↑, 4, cl‑Casp8↑, 1, proCasp8↑, 1, Casp9↑, 14, cl‑Casp9↑, 2, cFLIP↓, 1, Cyt‑c↑, 16, Diablo↑, 4, DR5↑, 6, FADD↑, 2, Fas↑, 3, Ferroptosis↑, 6, GSDMD↑, 1, IAP1↓, 4, IAP2/BIRC3↓, 1, ICD↑, 1, iNOS↓, 3, Mcl-1↓, 8, MDM2↓, 1, MDM2↑, 2, p‑MDM2↓, 1, p38↑, 5, p‑p38↓, 1, p‑p38↑, 3, PUMA↑, 1, Pyro↑, 1, survivin↓, 19, TRAIL⇅, 1, TRAILR↑, 1, TumCD↑, 2, TUNEL↑, 1, XIAP↓, 7, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 45, Akt↑, 1, p‑Akt↓, 7, AMPKα↓, 1, CIP2A↓, 1, CK2↓, 1, cMET↓, 1, p‑CREB↑, 1, cSrc↓, 2, EGFR↓, 13, p‑EGFR↓, 1, ERK↓, 10, ERK↑, 3, p‑ERK↓, 5, p‑ERK↑, 1, FGFR1↓, 1, HER2/EBBR2↓, 1, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 2, HRAS↓, 1, IGF-1R↓, 1, IGF-2R↑, 1, IGFR↓, 1, IKKα↓, 1, IκB↓, 1, p‑IκB↓, 1, JAK1↓, 2, JAK2↓, 7, JNK↓, 1, JNK↑, 8, p‑MAP2K1/MEK1↓, 1, MAPK↓, 9, MAPK↑, 1, MAPK↝, 1, p‑MAPK↓, 1, p‑MAPK↑, 2, mTOR↓, 24, p‑mTOR↓, 2, mTORC2↓, 1, P70S6K↓, 1, p‑P70S6K↓, 1, PI3K↓, 30, PI3K↝, 1, p‑PI3K↓, 3, PI3K/Akt↓, 2, PKCδ↓, 2, PTEN↑, 8, RAS↓, 1, p‑RSK↑, 1, SHP1↓, 1, Sp1/3/4↓, 2, STAT3↓, 25, STAT3↑, 2, p‑STAT3↓, 5, STAT6↓, 2,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1, CBP↓, 1, cJun↑, 2, cMyc↓, 9, DNMT1↓, 2, DNMT3A↓, 1, DNMTs↓, 2, EZH2↓, 1, FOXM1↓, 2, FOXO1↓, 1, p‑FOXO3↓, 1, FOXO4↓, 1, p‑H3↓, 1, ac‑H3↑, 2, H3K27ac∅, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 1, HDAC↓, 7, HDAC1↓, 2, HDAC2↓, 1, HDAC3↓, 2, miR-106b↓, 1, miR-107↑, 1, miR-126↑, 1, miR-139-5p↑, 1, miR-155↓, 1, miR-19b↓, 1, miR-21↓, 1, miR-224↓, 1, miR-29b↑, 1, miR-30a-5p↑, 1, miR-340↓, 1, miR-34a↓, 1, miR-34a↑, 2, miR-384↑, 1, miR-422a↑, 1, OCT4↓, 4, other↑, 1, other↝, 3, SD↑, 1, SOX2↓, 2, SUV39H↓, 1, tumCV↓, 19,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5, p‑eIF2α↑, 1, ER Stress↑, 7, GRP78/BiP↑, 1, HSP70/HSPA5↓, 1, PERK↑, 1, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 4, LC3B↑, 1, LC3B-II↓, 1, LC3II↑, 3, LC3s↑, 1, p62↓, 1, p62↑, 3, PARK2↑, 1, TumAuto↑, 10, TumAuto⇅, 1,

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1, ATM↑, 2, BRCA1↓, 1, BRCA2↓, 1, DNAdam↑, 12, DNArepair↓, 1, ERCC1↓, 1, ERCC3↑, 1, hTERT/TERT↓, 2, NKX3.1↓, 1, P53↓, 2, P53↑, 24, p‑P53↑, 2, PARP↑, 5, cl‑PARP↑, 18, PARP1↑, 1, PCNA↓, 31, PCNA↑, 1, POLD1↓, 1, TOP1↓, 1, TOP2↓, 2, TP53↑, 1, XRCC1↓, 1, γH2AX↑, 5, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 2, CDK1↑, 2, CDK1↝, 1, CDK2↓, 12, CDK2↑, 1, CDK4↓, 9, CDK6↓, 6, CDK8↓, 1, CHK1↓, 1, CHK1↑, 1, CHK1↝, 1, p‑CHK1↑, 1, Chk2↑, 1, p‑Chk2↑, 1, cycA1/CCNA1↓, 4, CycB/CCNB1↓, 5, CycB/CCNB1↝, 1, cycD1/CCND1↓, 28, cycD1/CCND1↑, 1, CycD3↓, 1, cycE/CCNE↓, 4, GADD45A↓, 1, Ki-67↓, 164, Ki-67↑, 3, MAD↓, 1, P21↓, 3, P21↑, 15, p27/CDKN1B↓, 1, p27/CDKN1B↑, 4, RB1↓, 1, TumCCA↓, 1, TumCCA↑, 54,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1, ALDH1A1↓, 2, AXIN1↑, 2, BMPs↑, 1, CD133↓, 5, CD34↓, 2, cFos↓, 1, CSCs↓, 9, CSCsMark↓, 1, Diff↑, 1, FGF↓, 1, Gli1↓, 5, HH?, 1, HH↓, 6, IGF-1↓, 2, IGFBP3↓, 1, Jun↓, 1, Ki-67↓, 164, Ki-67↑, 3, MCM2↓, 1, mTORC1↓, 2, Nanog↓, 3, NOTCH↓, 6, NOTCH1↓, 2, NOTCH1↑, 2, OGFr↑, 1, p300↓, 1, SCF↓, 1, Shh↓, 1, TumCG↓, 56, TumCG↑, 2, TumCG∅, 1, TumCP?, 1, TumCP↓, 66, tyrosinase↓, 1, Wnt↓, 7, Wnt↝, 1,

Migration(tgid=13) ⓘ

AntiAg↓, 1, AP-1↓, 2, AXL↓, 1, Ca+2↑, 5, i-Ca+2↓, 1, CAFs/TAFs↓, 1, cal2↑, 1, Cdc42↓, 1, E-cadherin↑, 17, EMT?, 1, EMT↓, 22, EpCAM↓, 1, FAK↓, 7, p‑FAK↓, 2, Fibronectin↓, 2, Furin↓, 1, GLI2↓, 2, GLI3↑, 1, ITGA5↓, 1, ITGB1↓, 2, KRAS↓, 1, L-sel↑, 1, MALAT1↓, 1, MMP13↓, 2, MMP16↓, 1, MMP2↓, 19, MMP3↓, 2, MMP7↓, 5, MMP9↓, 30, MMP9↑, 1, MMPs↓, 5, MTA1↓, 1, MUC4↓, 1, N-cadherin↓, 11, pax↓, 2, PDGF↓, 1, Rac1↓, 1, Rho↓, 3, ROCK1↓, 1, Slug↓, 4, SMAD2↓, 2, SMAD2↑, 1, SMAD3↓, 2, SMAD4↓, 1, Snail?, 1, Snail↓, 5, TET1↑, 1, TGF-β↓, 7, TGF-β↑, 2, TIMP1↑, 2, TIMP2↑, 2, TIMP3↑, 1, TRIB3↑, 1, TSP-1↑, 1, TumCI↓, 33, TumCMig?, 1, TumCMig↓, 26, TumCMig↑, 1, TumMeta↓, 23, TumMeta↑, 2, TumPF↓, 2, Twist↓, 4, uPA↓, 4, Vim?, 1, Vim↓, 10, Zeb1↓, 3, ZEB2↓, 2, β-catenin/ZEB1↓, 10, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23, CD31/PECAM-1↓, 9, eNOS↓, 1, HIF-1↓, 1, Hif1a↓, 12, LymphAG↓, 1, NO↓, 1, NO↑, 1, PGI2↓, 1, VEGF↓, 27, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 9,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2, CLDN2↓, 1, EPR↑, 2, GLUT1↓, 6, GLUT3↓, 1, IBI↑, 1, MMP↓, 20, MMP↑, 1, SLC12A5↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3, CD8+↑, 1, p‑cDC2↓, 1, COX2/PTGS2↓, 20, CXCL12↓, 1, CXCR3↓, 1, CXCR4↓, 4, DR4↑, 3, FOXP3↑, 1, Gal-3↓, 1, HMGB1↓, 1, ICAM-1↓, 2, IFN-γ↑, 1, IL10↓, 1, IL1β↓, 10, IL1β↑, 1, IL2↑, 1, IL4↓, 1, IL5↓, 1, IL6↓, 10, IL8↓, 4, Inflam↓, 13, M2 MC↓, 1, MCP1/CCL2↓, 2, MIP2↓, 1, NF-kB↓, 36, NF-kB↑, 1, NLRP3↑, 1, p50↓, 1, p65↓, 3, p‑p65↓, 1, PD-1↓, 2, PD-1↝, 1, PD-L1↓, 5, PGE2↓, 3, PSA↓, 3, Th1 response↑, 1, TIM-3↑, 1, TNF-α↓, 14, TNF-α↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1, AR↓, 4, COMT↓, 2, DHT↓, 1, ENL↑, 1, ER-α36↓, 1, FGF21↓, 1, PPARα↑, 1, PPARγ↓, 1, PPARγ↑, 2, testos↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9, BioAv↑, 10, BioAv↝, 4, CBR1↓, 1, ChemoSen↑, 39, CompStab↓, 1, CompStab↝, 1, CYP1A1↓, 1, CYP1A1↑, 1, CYP3A4↓, 1, Dose?, 2, Dose↑, 1, Dose⇅, 1, Dose↝, 31, Dose∅, 1, eff↓, 11, eff↑, 20, eff↝, 3, eff∅, 1, GSTA1↑, 1, Half-Life↓, 4, Half-Life↝, 1, MDR1↓, 1, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 5, P450↓, 1, RadioS↑, 12, selectivity↑, 15, Synergy↑, 41, Synergy↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2, ALAT↓, 1, ALP↓, 1, AR↓, 4, ascitic↓, 1, AST↓, 1, BG↓, 1, BRCA1↓, 1, CA125↓, 1, CA19-9↓, 1, CEA↓, 1, CRP↓, 2, EGFR↓, 13, p‑EGFR↓, 1, EZH2↓, 1, FOXM1↓, 2, HER2/EBBR2↓, 1, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 2, IL6↓, 10, KRAS↓, 1, LDH↓, 3, LDH↑, 1, PD-L1↓, 5, PSA↓, 3, TG/TAG↓, 1, TP53↑, 1, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10, antiNeop↑, 1, AntiTum↓, 2, AntiTum↑, 7, cachexia↓, 1, cardioP↑, 2, chemoP?, 1, chemoP↑, 6, chemoPv↑, 6, ChemoSideEff↓, 2, hepatoP↑, 4, K17↓, 1, neuroP↑, 2, OS↑, 9, OS∅, 1, PFS∅, 1, radioP↑, 1, RenoP↑, 1, Risk↓, 9, Strength↑, 1, toxicity↓, 10, toxicity↝, 2, TumNum↓, 3, TumVol↓, 23, TumW↓, 12, Weight↓, 1, Weight∅, 4,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↑, 2, Ingr↝, 2,
Total Targets: 600

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↑, 15, Bil↓, 1, Catalase↑, 9, GPx↑, 9, GSH↑, 11, GSR↑, 2, GSTs↑, 2, H2O2↓, 1, HO-1↑, 5, Keap1↓, 1, lipid-P↓, 6, MDA↓, 9, NQO1↑, 2, NRF2↑, 11, ROS↓, 20, SOD↑, 14, TAC↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1, adiP↑, 1, ALAT↓, 5, AMPK↓, 1, AMPK↑, 1, ATP↓, 1, ATP↑, 2, FASN↓, 1, glucose↓, 3, GSK‐3β↓, 2, LDL↓, 2, lipidLev↓, 1, NAD↓, 1, NAD↑, 1, PFK↓, 1, SCFAs↑, 1, SIRT1↑, 3, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2, BAX↓, 1, Bax:Bcl2↓, 1, Bcl-2↓, 1, Bcl-2↑, 1, Casp3↓, 1, cl‑Casp8↑, 1, Casp9↓, 1, Cyt‑c↓, 1, iNOS↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, AKT1↓, 1, Akt2↓, 1, CREB↑, 1, p‑CREB↑, 1, EGFR↓, 1, ERK↓, 1, ERK↑, 1, IKKα↓, 1, MAPK↓, 1, PI3K↑, 1, PP2A↑, 1, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1, HDAC↓, 1, HDAC3↓, 1, SOX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, LC3II↓, 1, MitoP↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1, PCNA↓, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, GADD34↓, 1, Ki-67↓, 4, Ki-67↑, 3, P21↓, 1, RB1↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1, IGF-1↑, 1, Ki-67↓, 4, Ki-67↑, 3, Nestin↑, 1, NOTCH1↑, 1, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 1, Ca+2↓, 1, Cartilage↑, 1, MLC2/MYL9↝, 1, MMP2↑, 1, ROCK1↓, 1, TGF-β1↑, 1, α-SMA↓, 1, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, CD31/PECAM-1↓, 1, NO↓, 3, VCAM-1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, GLUT1↑, 1, MMP↑, 1, OCLN↝, 1, TJ↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3, Eos↓, 1, ICAM-1↓, 1, IFN-γ↓, 1, IFN-γ↑, 1, IL10↓, 2, IL10↑, 1, IL17↓, 2, IL1β↓, 6, IL22↓, 2, IL6↓, 6, Imm↓, 1, INF-γ↑, 1, Inflam↓, 18, Inflam↑, 1, NF-kB↓, 7, p‑NF-kB↓, 1, NK cell↑, 1, NLRP3↓, 1, NLRP3↑, 1, PGE2↓, 2, PSA↓, 1, TLR2↓, 1, TLR4↓, 1, TNF-α↓, 11,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, Ach↑, 1, AChE↓, 2, AChE↑, 1, BDNF↓, 1, BDNF↑, 4, GABA↑, 2, MAOA↓, 2, MAOB↓, 1, NGF↑, 1, PSD95↑, 1, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 2, Aβ42↓, 2, tau↓, 2,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1, Estro↓, 1, FGF21↑, 1, PPARγ↓, 1, PPARγ↑, 1, testos↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8, BioAv↑, 7, BioAv↝, 7, Dose↑, 1, Dose↝, 7, Half-Life↓, 1, Half-Life↝, 1, P450↑, 1, selectivity↑, 1, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5, ALP↓, 2, AST↓, 5, Bil↓, 1, BP↝, 1, CEA↓, 1, CRP↓, 3, EGFR↓, 1, hs-CRP↓, 1, IL6↓, 6, LDH↓, 3, PSA↓, 1, TC↓, 2, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 2, antiAll↑, 1, AntiArt↑, 2, AntiCan↑, 3, AntiDiabetic↑, 6, AntiTum↑, 1, cardioP↑, 14, chemoP↑, 2, chemoPv↑, 1, cognitive↑, 5, hepatoP↑, 8, memory↑, 6, neuroP↑, 16, Obesity↓, 3, OS↑, 1, radioP↑, 1, RenoP↑, 3, Risk↓, 1, Sleep↑, 1, Stress↓, 1, Stroke↓, 1, toxicity↓, 8, toxicity↝, 5, toxicity∅, 2, Weight↓, 1, Weight∅, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, AntiViral↑, 1, Bacteria↓, 3, GutMicro↑, 6, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1, Ingr↑, 3, Ingr↝, 4,
Total Targets: 213

Scientific Paper Hit Count for: Ki-67, Ki-67 protein

6 Benzyl isothiocyanate
5 Melatonin
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
5 Flaxseed/Linseed
5 Magnolol
5 Thymoquinone
4 Berberine
4 itraconazole
4 Luteolin
4 Lycopene
4 Resveratrol
3 Capsaicin
3 Formononetin
3 Phenethyl isothiocyanate
3 doxorubicin
3 L-Theanine
3 SDG/lignans
3 Linalool
3 Sulforaphane (mainly Broccoli)
2 Açaí, Euterpe oleracea
2 Silver-NanoParticles
2 Cisplatin
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Carnosic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chrysin
2 Docetaxel
2 Eugenol
2 Ferulic acid
2 Fisetin
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Ivermectin
2 Kaempferol
2 Metformin
2 Piperlongumine
2 Gemcitabine (Gemzar)
1 Astragalus
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Black Rice, Oryza sativa
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Cat’s Claw
1 Chlorogenic acid
1 Propolis -bee glue
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 D-limonene
1 Ellagic acid
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Bortezomib
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Licochalcone A
1 low dose naltrexone
1 Curcumin
1 Radiotherapy/Radiation
1 Matrine
1 mebendazole
1 Sulindac
1 Modified Citrus Pectin
1 immunotherapy
1 Lemon Balm/Melissa officinalis
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Phycocyanin
1 Piperine
1 Psoralidin
1 Pterostilbene
1 Rosmarinic acid
1 Sesamin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Xylitol
1 Zyflamend

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:425  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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