Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
Scientific Papers found: Click to Expand⟱
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8063- KAE,    Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways
- in-vitro, Ovarian, NA
Dose↓, selectivity↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, TumCCA↑, MEK↓, ERK↓, STAT3↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
8152- lamb,  TRAIL/rTRAIL,    Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
TumCD↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, cFLIP↓, XIAP↓, BID↑, DR4↑, p‑NF-kB↓, p‑IκB↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8241- LCA,    Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells
- in-vitro, NPC, NA
tumCV↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ERK↑, p38↑, JNK↑, *antiAll↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiCan↑,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2917- LT,  Rad,    Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- in-vitro, Lung, NA
Bcl-2↓, Casp3↑, Casp8↑, Casp9↑, p‑p38↑, ROS↑, RadioS↑,
8347- Lut,    Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
- in-vitro, BC, NA
TumCG↓, TumCCA↑, selectivity↑, ROS↑, eff↓, P53↑, HSP60/HSPD1↑, cycF↑, CDC25↑, CDK6↑, ANAPC2↑, AURKB↑, GADD45A↑, BAX↑, Casp3↑, CASP4↑, Casp8↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR6↑, ChemoSen↑,
8524- MAG,    Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
Apoptosis↑, Akt?, BAD↑, Cyt‑c↑, cl‑Casp8↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, NA⇅, selectivity↑, p‑EGFR↓, p‑PI3K↓, p‑Akt↓,
8511- MAG,    Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo
- vitro+vivo, CRC, HT-29 - in-vitro, Colon, CT26
p‑PKCδ↓, p‑NF-kB↓, TumCI↓, Fas↓, FasL↓, TumCG?, toxicity↓, cl‑Casp8↑, MMP↓, Casp9↑, ChemoSen↑,
1314- MAG,    Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑,
4534- MAG,    Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
- in-vitro, Liver, HepG2 - in-vitro, CRC, COLO205
AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8715- MeJa,    Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells
- in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, memfluid↓, TNFR 1↑, MAPK↑, Casp8↑, MMP↓, Apoptosis↑, p38↑, ERK↑, Casp3↑,
4092- MF,    Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology
- Review, Var, NA
Apoptosis↑, selectivity↑, ROS↑, Catalase↓, TumVol↓, angioG↓, Ca+2↝, eff↝, angioG↓, Imm↝, TNF-α↑, Casp8↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
9087- MGF,    Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
- Review, Var, NA
TumCP↓, TumCI↓, angioG↓, *BioAv↓, *neuroP↑, *Inflam↓, *AntiCan↑, *ROS↓, *BioAv↑, *BioAv↝, *Half-Life↝, *BBB↓, CDK1↑, CycB/CCNB1↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, PI3K↓, Akt↓, mTOR↓, MMP↓, MOMP↑, Apoptosis↑, lipid-P↑, TCA↓, NRF2↑, NQO1↑, ROS↓, RadioS↑,
8863- MOR,    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
- in-vitro, Colon, SW48
TumCP↓, Apoptosis↑, ROS↑, MMP↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, ATP↓, GlucoseCon↓, GLUT1↓, Warburg↓, Dose↝, Catalase↓, GSH↓, ADP:ATP↑, AMP↑,
8862- MOR,    The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells
- in-vitro, CRC, HCT116
Fas↑, Casp8↑, Casp9↑, Casp3↑, BID↑, MMP↓, BAX↑, Cyt‑c↑, ROS↑, Bcl-2↓, IAP1↓, Apoptosis↑, Akt↓,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8766- MSM,    Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
TumCG↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, TumVol↓, AST↓, ALAT↓,
8804- MT/VAE,    Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells
- in-vitro, lymphoma, U937
DNAdam↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, cl‑PKCδ↑, Apoptosis↑,
8951- mushLions,    Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL
- vitro+vivo, GC, NA
Apoptosis↑, ROS↑, selectivity↑, TumCG↓, FasL↑, TRAIL↑, PCNA↓, cycD1/CCND1↓, Casp3↑, Casp9↑, Casp8↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, tumCV↓, TumVol↓, TumW↓,
8954- mushLions,    Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis
- in-vitro, GC, SGC-7901
TumCP↓, Tumccf↓, Apoptosis↑, TumCCA↑, Bcl-2↓, PI3K↓, Akt↓, Casp8↑, Casp3↑, P53↑, CDK4↑, BAX↑, BAD↑, ROS↑,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
8424- OM,    Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells
- in-vitro, CRC, HT-29
tumCV?, mTOR↓, P70S6K↓, Casp8↑, Casp9↑, p38↑, MAPK↑,
8427- OM,    Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
- in-vitro, BC, MDA-MB-231
tumCV↓, Dose↝, mitA↑, Apoptosis↑, TNF-α↑, Casp3↑, Casp8↑, cl‑PARP↑, survivin↓, p53 Wildtype↓, P21↑, ac‑H3↑, ac‑H4↑, γH2AX↑, DNAdam↑, TumCCA↑,
9049- PatchO,    Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling
- vitro+vivo, HCC, HepG2 - in-vivo, Liver, HUH7
ROS?, MMP↓, DNAdam↑, TumCCA↑, Apoptosis↑, P53↑, P21↑, Fas↑, FasL↑, Casp8↑, BAX↑, Casp9↑, ChemoSen↑, AR↓, TumCP↓, selectivity↑, eff↓, Snail↓, Twist↓, ICAM-1↓, VCAM-1↓, MMP9↓, EMT↓, toxicity↓, chemoP↑,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4945- PEITC,    Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells
- in-vitro, Pca, DU145
AntiCan↑, TumCG↓, Apoptosis↑, tumCV↓, TumCCA↑, DNAdam↑, P53↑, CDC25↓, Casp9↑, Casp8↑, mtDam↑, Cyt‑c↑,
4923- PEITC,    Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis
- Study, Var, NA
cl‑BID↑, Apoptosis↑, Bcl-xL↓, Casp8↑, Cyt‑c↑,
5184- PEITC,    Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
- vitro+vivo, AML, U937
Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,
5217- PG,    Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells
- in-vitro, AML, THP1 - in-vitro, AML, Jurkat - in-vitro, AML, HL-60
tumCV↓, Casp3↑, Casp8↑, Casp9↑, P53↑, BAX↑, Fas↑, FasL↑, MAPK↑, NRF2↓, GSH↓,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
TumCG↓, TumCCA↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, Casp8↑, cl‑PARP↑,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↑, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,

Showing Research Papers: 151 to 200 of 235
Prev Page 4 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 235

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 7,   Catalase↑, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 1,   GSH↓, 20,   GSH↑, 3,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   i-H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 6,   HO-1↝, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↑, 5,   MPO↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 4,   NRF2↑, 7,   p‑NRF2↑, 1,   RNS↑, 1,   ROS?, 3,   ROS↓, 8,   ROS↑, 106,   ROS⇅, 3,   ROS∅, 1,   i-ROS?, 1,   i-ROS↑, 2,   mt-ROS↑, 3,   SOD↓, 5,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   ox-Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 6,   CDC25↓, 13,   CDC25↑, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 1,   HSP60/HSPD1↑, 1,   mtDam↑, 9,   OCR↓, 1,   OXPHOS↓, 1,   PDH↓, 1,   PINK1↑, 1,   SDH↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 4,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 9,   AMPK↝, 1,   ATP↓, 4,   ATP↝, 1,   CAIX/CA9↓, 1,   citrate↓, 1,   CPT1A↓, 1,   ENO1↓, 1,   FABP4↓, 1,   FASN↓, 2,   FASN↑, 2,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 4,   Glycolysis↓, 6,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 3,   H2S↑, 1,   HK2↓, 5,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 2,   PFK1↓, 1,   PFK2?, 1,   PFK2↓, 1,   PKM2↓, 3,   PKM2∅, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   TCA↑, 1,   Warburg↓, 2,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 6,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 11,   Bak↓, 1,   Bak↑, 4,   BAX↑, 86,   BAX⇅, 1,   BAX∅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 80,   Bcl-2↑, 4,   Bcl-2∅, 2,   Bcl-xL↓, 19,   Bcl-xL↑, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 9,   cl‑BID↑, 6,   BIM↑, 4,   BOK↑, 1,   Casp↑, 5,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 2,   Casp2↑, 4,   Casp3↓, 3,   Casp3↑, 146,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↑, 29,   proCasp3↓, 2,   proCasp3↑, 2,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 4,   Casp8↓, 5,   Casp8↑, 181,   Casp8↝, 1,   Casp8∅, 4,   cl‑Casp8↑, 30,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 2,   Casp9↑, 129,   Casp9↝, 1,   cl‑Casp9↑, 18,   proCasp9↓, 2,   proCasp9↑, 2,   cFLIP↓, 8,   Cyt‑c↑, 70,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 26,   DR5∅, 1,   FADD↑, 9,   FADD∅, 1,   Fas↓, 1,   Fas↑, 34,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 1,   IAP1↓, 7,   IAP2/BIRC3↓, 4,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 5,   Mcl-1↓, 18,   cl‑Mcl-1↑, 1,   MDM2↓, 5,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 2,   p38↓, 2,   p38↑, 15,   p‑p38↓, 1,   p‑p38↑, 6,   PUMA↑, 3,   PUMA↝, 1,   Pyro↑, 2,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 31,   TNFR 1↑, 2,   TRAIL↑, 9,   TRAILR↑, 3,   TumCD↓, 1,   TumCD↑, 7,   XIAP↓, 23,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 56,   Akt↑, 3,   p‑Akt↓, 15,   AKT1↓, 2,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 2,   cMET↓, 3,   cSrc↓, 2,   EGFR↓, 16,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 23,   ERK↑, 6,   p‑ERK↓, 7,   p‑ERK↑, 1,   p‑ERK⇅, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGF-1R↑, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JAK1↓, 5,   p‑JAK1↓, 1,   JAK2↓, 7,   p‑JAK2↓, 4,   JNK↓, 2,   JNK↑, 14,   p‑JNK↓, 2,   p‑JNK↑, 2,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 8,   MEK↓, 2,   p‑MEK↓, 2,   mTOR↓, 28,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 6,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 40,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 5,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PTEN↓, 2,   PTEN↑, 10,   Raf↓, 3,   RAS↓, 6,   RIP1↑, 1,   SHP1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 2,   STAT↓, 1,   STAT3↓, 21,   STAT3↑, 1,   p‑STAT3↓, 5,   STAT6↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 5,   ATFs↑, 1,   cJun↓, 2,   cJun↑, 3,   p‑cJun↑, 2,   cMyc↓, 11,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↓, 2,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC1↓, 2,   HDAC3↓, 1,   HES1↓, 1,   miR-130a↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-21↓, 2,   Myc↓, 3,   MYCN↓, 1,   OCT4↓, 2,   other↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   SOX2↓, 1,   SOX9↓, 1,   SUV39H↓, 1,   tumCV?, 1,   tumCV↓, 36,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 15,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 3,   UPR↑, 4,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG5↝, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 7,   Beclin-1/ATG6↝, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3B↑, 2,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 2,   p62↑, 2,   PARK2↑, 1,   TumAuto↑, 17,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↑, 35,   DNArepair↓, 1,   hTERT/TERT↓, 5,   p16↑, 2,   P53↓, 1,   P53↑, 48,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 16,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 73,   cl‑PARP1↑, 2,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 2,   TOP2↓, 4,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1↓, 9,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK2↓, 18,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 23,   CDK4↑, 2,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 8,   CDK6↑, 3,   CDK6∅, 1,   CDK8↓, 1,   CHK1↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 33,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 1,   cycE/CCNE↓, 15,   cycE1↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 6,   mitA↑, 1,   p19↑, 1,   P21↑, 37,   p27/CDKN1B↑, 15,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↑, 91,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 9,   Diff↑, 2,   FGF↓, 1,   Gli1↓, 2,   HH↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 6,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 4,   NOTCH1↓, 6,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 2,   Smo↓, 2,   STAT1↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 43,   TumCG↑, 1,   TumCP↓, 60,   tyrosinase↓, 1,   Wnt↓, 12,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 14,   Ca+2↝, 4,   i-Ca+2↑, 3,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 9,   EM↑, 1,   EMT↓, 18,   EMT↑, 1,   FAK↓, 7,   p‑FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 35,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 41,   MMPs↓, 11,   MTA1↓, 1,   N-cadherin↓, 10,   PAK1↓, 1,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 8,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 15,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 7,   TIMP3↑, 1,   TSP-1↑, 1,   TumCI↓, 31,   TumCI↑, 1,   TumCMig↓, 25,   TumMeta↓, 16,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 11,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 16,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 12,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 38,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CLDN1↓, 1,   CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 4,   GLUT2↓, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 75,   MMP↑, 1,   MPT↑, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD8+↑, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   DR4↑, 7,   DR4∅, 2,   DR6↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL12↓, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 12,   IL8↓, 5,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 12,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 55,   NF-kB↑, 6,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 2,   RAGE↓, 2,   T-Cell↝, 1,   TCF↑, 1,   TLR4↓, 2,   TNF-α↓, 14,   TNF-α↑, 5,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 7,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 13,   BioAv↑, 25,   BioAv↝, 2,   ChemoSen↓, 2,   ChemoSen↑, 41,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 13,   Dose∅, 3,   eff↓, 24,   eff↑, 30,   eff↝, 8,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 2,   P450↝, 1,   RadioS↑, 15,   selectivity↓, 1,   selectivity↑, 51,   Synergy↑, 20,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALP↓, 2,   AR↓, 7,   ascitic↓, 1,   AST↓, 4,   CEA↓, 2,   EGFR↓, 16,   EGFR↑, 2,   p‑EGFR↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 12,   LDH↑, 1,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↑, 4,   cachexia↓, 2,   cardioP↑, 2,   chemoP↑, 8,   chemoPv↑, 8,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 4,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 7,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 3,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 750

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 34,   Catalase↑, 17,   GPx↑, 13,   GSH↑, 15,   GSR↑, 2,   GSTs↑, 10,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 5,   hyperG↝, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 13,   MPO↓, 3,   NADH↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 11,   RNS↓, 3,   ROS↓, 32,   ROS↑, 3,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 20,   SOD1↑, 1,   TBARS↓, 2,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ALAT↓, 8,   AMPK↑, 2,   ATP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   lipidLev↓, 1,   SIRT1↑, 4,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC↓, 1,   BAD↓, 1,   BAX↓, 8,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↑, 3,   Casp1↓, 3,   Casp3↓, 10,   Casp3↑, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 3,   Casp9↓, 4,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Fas↑, 2,   iNOS↓, 8,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 2,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   RIP1↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   cJun↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 1,   other↑, 2,   other↝, 1,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 1,   GRP78/BiP↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 3,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Ki-67↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   MMP13↓, 1,   MMP3↓, 1,   PAI-1/SERPINE1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   NO↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 4,   IBI↑, 1,   MMP↓, 2,   MMP↑, 3,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 12,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 2,   IL13↑, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL6↓, 12,   IL6↑, 1,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 33,   IP-10/CXCL-10↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 3,   TNF-α↓, 16,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   NGF↑, 2,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARα↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 9,   BioAv↝, 5,   BioEnh↑, 1,   CYP2E1↓, 2,   Dose↝, 6,   eff↓, 1,   eff↑, 8,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 5,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 2,   AST↓, 9,   BP↓, 3,   BUN↓, 1,   CEA↓, 1,   creat↓, 3,   CRP↓, 1,   IL6↓, 12,   IL6↑, 1,   LDH↓, 4,   NOS2↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 6,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 7,   antiNeop↑, 1,   AntiTum↑, 3,   cardioP↑, 16,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 16,   memory↑, 2,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 4,   Stroke↓, 3,   toxicity↓, 16,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 4,   Sepsis↓, 1,  
Total Targets: 257

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
11 Apigenin (mainly Parsley)
10 Fisetin
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
5 Silver-NanoParticles
5 Magnolol
4 Phenethyl isothiocyanate
4 Curcumin
4 Emodin
4 Gambogic Acid
4 Morin
4 Luteolin
3 Allyl isothiocyanate
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Benzyl isothiocyanate
3 Photodynamic Therapy
3 Citric Acid
3 Ferulic acid
3 Gallic acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Kaempferol
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Boron
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Fucoidan
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 isoquercitrin
2 Juglone
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Patchouli Oil (Pogostemon cablin)
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Metformin
1 Cisplatin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Chlorophyllin
1 Crocetin
1 Carvone
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Isorhamnetin
1 L-Theanine
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Lutein
1 Matrine
1 Methyl Jasmonate
1 Chemotherapy
1 Mangiferin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:44  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page