Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
4092- MF,    Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology
- Review, Var, NA
Apoptosis↑, selectivity↑, ROS↑, Catalase↓, TumVol↓, angioG↓,
4116- MF,    Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, NA, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *ROS↓, *Catalase↑, *SOD↑, HSP70/HSPA5↑,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
209- MFrot,  MF,    The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study
- Human, NA, NA
*SOD↑, *Catalase↑, *ROMO1↑, *MDA↓, *TAC↑, *ROS↓,
3838- Moringa,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
3839- Moringa,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
3840- Moringa,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1767- PG,    Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
- in-vitro, Nor, NA
*ROS↑, *GSH↓, *SOD↓, *Catalase↓, eff↓,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF-7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
2969- PL,    Piperlongumine induces autophagy by targeting p38 signaling
- in-vitro, OS, U2OS - in-vitro, Cerv, HeLa
p38↑, ROS↑, GPx1∅, SOD∅, Catalase∅,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
4703- PTS,  RES,    Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review
- NA, Nor, NA
*AntiAge↑, *eff↑, *Inflam↓, *AntiCan↑, *ROS↓, *Catalase↑, *GSR↑, *HO-1↑, *NAD↑, *NQO1↑, *SOD↑, *NRF2↑,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, eff↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
3349- QC,    Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression
- in-vivo, Sepsis, NA
*Sepsis↓, *ROS↓, *SOD↑, *Catalase↑, *HMGB1↓, *Inflam↓, *TAC↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
p65↓, SOD2↓, Prx↓, Catalase↓, Trx↓, TNF-α↓, IL8↓, MCP1↓, SIRT1↑,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
3024- RosA,    rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice
- in-vivo, Sepsis, NA
*Ferroptosis↓, *GRP78/BiP↓, *PERK↓, *ATF4↓, *Sepsis↓, *GSH↑, *SOD↑, *Catalase↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,

Showing Research Papers: 151 to 200 of 254
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 254

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 6,   Catalase↑, 5,   Catalase∅, 1,   GPx↓, 1,   GPx↑, 3,   GPx1∅, 1,   GSH↓, 1,   GSH↑, 3,   GSR↑, 1,   H2O2↓, 1,   H2O2↑, 1,   lipid-P↓, 3,   MDA↑, 1,   NOX4↑, 1,   NRF2↑, 2,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 4,   ROS↑, 14,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 4,   SOD∅, 1,   SOD1↑, 1,   SOD2↓, 4,   Trx↓, 2,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   ATP↑, 1,   p‑MEK↓, 1,   MMP↓, 3,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

CAIX↓, 1,   cMyc↓, 1,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   lactateProd↓, 2,   LDHA↓, 2,   NADPH↑, 2,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 8,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 5,   Bcl-2↓, 4,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↑, 2,   MCT1↓, 1,   MDM2↓, 1,   p27↑, 1,   p38↑, 2,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSPs↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   GADD45A↑, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 3,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑FOXO3↓, 1,   Gli1↓, 2,   HDAC1↓, 1,   HDAC2↓, 3,   HDAC3↓, 1,   IGF-1R↓, 2,   mTOR↓, 2,   NOTCH1↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   PI3K↑, 1,   p‑PI3K↑, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 2,  

Migration ⓘ

ATPase↓, 1,   Ca+2↑, 2,   E-cadherin↑, 2,   KRAS↓, 1,   MARK4↓, 1,   miR-155↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCP↓, 5,   TumMeta↓, 3,   uPAR↓, 1,   Vim↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 3,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT3↓, 1,   NHE1↓, 1,   P-gp↓, 2,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CXCR4↓, 1,   IFN-γ↓, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 1,   MCP1↓, 1,   NF-kB↓, 2,   p65↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 5,   Dose↝, 2,   eff↓, 2,   eff↑, 14,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

AR↓, 2,   BloodF↑, 1,   BP↓, 1,   IL6↓, 3,   KRAS↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 3,   neuroP↑, 1,   radioP↑, 1,   RenoP↑, 1,   TumVol↓, 1,  
Total Targets: 184

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 15,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 40,   Copper↓, 1,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 14,   GPx1↑, 2,   GPx3↑, 1,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 21,   GSH/GSSG↑, 1,   GSR↑, 6,   GSTs↑, 5,   H2O2↓, 2,   HO-1↑, 12,   HO-1⇅, 1,   Iron↓, 2,   Keap1↓, 2,   lipid-P↓, 10,   MDA↓, 16,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↓, 2,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 1,   ROMO1↑, 1,   ROS↓, 37,   ROS↑, 1,   ROS⇅, 1,   ROS∅, 1,   SOD↓, 1,   SOD↑, 34,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 3,   TBARS↑, 1,   Thiols↑, 1,   Trx↑, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   MMP↑, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   AMP↓, 1,   AMPK↑, 2,   BUN↓, 1,   cAMP↑, 1,   p‑CREB↑, 1,   CYP3A2↓, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH∅, 1,   PPARα↑, 1,   SIRT1↑, 3,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 5,   p‑JNK↓, 1,   MAPK↑, 1,   MAPK↝, 1,   p38↓, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 6,  

Protein Folding & ER Stress ⓘ

GRP78/BiP↓, 1,   PERK↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   p‑ERK↓, 1,   FOXO1↝, 1,   GSK‐3β↓, 1,   PI3K↑, 3,   PTEN↑, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 2,   Ca+2↓, 3,   Ca+2↑, 1,   Cartilage↑, 1,   E-sel↓, 1,   MMP9↓, 4,   MMPs↓, 3,   TGF-β↓, 2,   TGF-β↑, 1,   TXNIP↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↓, 1,   eNOS↑, 1,   LOX1↓, 1,   NO↓, 3,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 9,   HMGB1↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 4,   IL8↓, 3,   Inflam↓, 19,   MCP1↓, 2,   NF-kB↓, 8,   p65↓, 1,   PGE2↓, 3,   PGE2↑, 1,   TLR4↓, 3,   TNF-α↓, 9,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 5,   BChE↓, 1,   BDNF↑, 2,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 5,  

Hormonal & Nuclear Receptors ⓘ

cortisol↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 1,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 6,   Half-Life↑, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   ALP↓, 2,   AST↓, 3,   BG↓, 1,   Bil↓, 1,   BP↓, 2,   creat↓, 1,   GutMicro↑, 2,   IL6↓, 4,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 2,   cognitive↑, 5,   hepatoP↑, 6,   memory↑, 5,   motorD↓, 1,   neuroP↑, 14,   Pain↓, 2,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 2,   toxicity?, 1,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 3,  
Total Targets: 180

Scientific Paper Hit Count for: Catalase, Catalase
18 Thymoquinone
13 Magnetic Fields
12 Curcumin
9 Silver-NanoParticles
9 Quercetin
8 Carvacrol
8 Hydrogen Gas
8 Lycopene
7 Resveratrol
7 Boron
7 Chrysin
7 Luteolin
7 Silymarin (Milk Thistle) silibinin
6 Selenium NanoParticles
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Propolis -bee glue
5 Crocetin
5 Ferulic acid
4 Alpha-Lipoic-Acid
4 Radiotherapy/Radiation
4 Betulinic acid
4 Chlorogenic acid
4 EGCG (Epigallocatechin Gallate)
4 Eugenol
4 Moringa oleifera
4 Sulforaphane (mainly Broccoli)
4 Urolithin
4 Vitamin C (Ascorbic Acid)
3 Ascorbyl Palmitate
3 Melatonin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Fisetin
3 Pterostilbene
3 Shikonin
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Selenium
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 Celastrol
2 Copper and Cu NanoParticles
2 Shilajit/Fulvic Acid
2 HydroxyCitric Acid
2 Honokiol
2 Magnetic Field Rotating
2 Piperine
2 Piperlongumine
2 salinomycin
2 Selenite (Sodium)
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Allicin (mainly Garlic)
1 Andrographis
1 Astaxanthin
1 Aloe anthraquinones
1 Bacopa monnieri
1 Bromelain
1 Caffeic acid
1 Exercise
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Zinc
1 Graviola
1 Orlistat
1 Hydroxycinnamic-acid
1 Juglone
1 doxorubicin
1 Magnolol
1 Metformin
1 Methylsulfonylmethane
1 Nimbolide
1 Oleuropein
1 HydroxyTyrosol
1 Propyl gallate
1 Parthenolide
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Taurine
1 5-fluorouracil
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:46  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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