HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱

Source:

Type:

(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
Reducing oxidative stress and inflammation
Promoting angiogenesis (the formation of new blood vessels)
Inhibiting apoptosis (programmed cell death)
Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.

Scientific Papers found: Click to Expand⟱

7034-

GA,

RES,

The Growth Inhibitory Effect of Resveratrol and Gallic Acid on Prostate Cancer Cell Lines through the Alteration of Oxidative Stress Balance: The Interplay between Nrf2, HO-1, and BACH1 Genes

in-vitro,

Pca,

PC3

in-vitro,

Pca,

DU145

TumCG↓, ROS↓, SOD↑, GPx↑, Catalase↑, GSR↑, GSH↑, HO-1↑, NRF2↑,

7040-

GA,

Effects of gallic acid on acrylamide-induced endoplasmic reticulum stress, neuroinflammation and neuronal apoptosis in rats

Trial,

AD,

Fifty male Sprague-Dawley rats

*SOD↑, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TNF-α↓, *IL1β↓, *BAX↓, *Casp3↓, *BDNF↑, *NRF2↑, *HO-1↑,

7215-

GBE,

Cisplatin,

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

vitro+vivo,

NSCLC,

xenograft nude mouse

AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,

6562-

Ger,

Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings

Review,

Var,

Review,

AD,

*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,

6573-

Ger,

Systematic elucidation of the mechanism of geraniol via network pharmacology

Study,

Nor,

Study,

Var,

HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,

7140-

GI,

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes

Review,

Var,

*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,

1005-

GI,

Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells

vitro+vivo,

Nor,

HUVECs

30uM

*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,

7250-

Gink,

Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy

Review,

Var,

AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,

7296-

Gins,

Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1

vitro+vivo,

AD,

SH-SY5Y

transgenic mice and SH-SY5Y cells

*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,

4513-

GLA,

Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines

in-vitro,

Liver,

HUH7

TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,

834-

Gra,

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Review,

Var,

EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,

3787-

H2,

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Review,

AD,

*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,

3770-

H2,

Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Review,

AD,

Review,

Park,

*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,

3773-

H2,

Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases

Review,

Park,

*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,

7482-

H2,

Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application

Review,

Var,

Review,

IBD,

Review,

Stroke,

Review,

Sepsis,

Review,

AD,

Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,

7489-

H2,

Molecular Hydrogen in the Treatment of Respiratory Diseases

Review,

Asthma,

*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,

2521-

H2,

Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer

Review,

CRC,

Review,

Lung,

Review,

BC,

Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,

2516-

H2,

Hydrogen Gas in Cancer Treatment

Review,

Var,

*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,

2514-

H2,

Hydrogen: A Novel Option in Human Disease Treatment

Review,

Nor,

*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,

2508-

H2,

Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Review,

Var,

Review,

Sepsis,

*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑, *antiAll↑,

7500-

H2S,

Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2

in-vivo,

AD,

APP/PS1 transgenic mice were injected sodium hydrosulfide (NaHS, a H2S donor, 2.8mg/kg) once a day for three months.

*neuroP↑, *memory↑, *CBS↑, *3MST/MPST↑, *APP↓, *BACE/β-secretase↓, *NRF2↑, *HO-1↑, *GSTs↑, *Aβ↓, *ARE↑,

1633-

HCA,

Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway

in-vivo,

NA,

mice, Lung ischemia-reperfusion injury (LIRI)

in-vitro,

Nor,

HUVECs

*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,

2873-

HNK,

Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2

in-vitro,

Nor,

PC12

*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,

2871-

HNK,

Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling

in-vivo,

Nor,

honokiol 10 mg/kg i.p.

adult male BALB/c mic

*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,

2870-

HNK,

Honokiol attenuates oxidative stress and vascular calcification via the upregulation of heme oxygenase-1 in chronic kidney disease

in-vitro,

CKD,

*HO-1↑, *ROS↓,

2868-

HNK,

Honokiol: A review of its pharmacological potential and therapeutic insights

Review,

Var,

Review,

Sepsis,

*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,

2894-

HNK,

Pharmacological features, health benefits and clinical implications of honokiol

Review,

Var,

Review,

AD,

*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,

2080-

HNK,

Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells

in-vitro,

AML,

THP1

20 μM

in-vitro,

AML,

U937

35 μM

in-vitro,

AML,

SK-HEP-1

30 μM

tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,

7565-

HYP,

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Review,

AD,

*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,

7563-

HYP,

Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury

vitro+vivo,

Nor,

SCI mice were treated with HYP (10 mg/kg or 50 mg/kg) via intraperitoneal injection

*Inflam↓, *antiOx↑, *Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NOX4↓, *NOX2↓, *NOX1↓, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *neuroP↑,

7546-

HYP,

Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway

in-vitro,

Nor,

L02

*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,

7558-

HYP,

The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation

in-vivo,

AD,

*ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *GSK‐3β↑, *Keap1↓, *eff↑,

7561-

HYP,

Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway

in-vivo,

Park,

*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,

7804-

IBC,

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

Review,

Nor,

*BioAv↓, *BBB↑, *hepatoP↓, ROS↑, *NA↓, ERK↓, Wnt↓, Apoptosis↑, *NF-kB↓, *NRF2↑, *HO-1↑, *Inflam↓,

7758-

ISL,

Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications

Review,

Ovarian,

JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,

7766-

ISL,

Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice

in-vivo,

Stroke,

mice

*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,

7765-

ISL,

Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications

Review,

Var,

*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,

7784-

ISL,

Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity

in-vivo,

AD,

rat model of cognitive impairment by intracerebroventricular injection of lipopolysaccharide (LPS)

*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,

7780-

ISL,

Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response

in-vivo,

Nor,

*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,

7777-

ISL,

Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells

vitro+vivo,

Gall,

SGC996

210.1 μmol/L, 72.9 μmol/L, and 51.9 μmol/L at 24 h, 48 h, and 72 h

TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,

7865-

isoO,

Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis

in-vivo,

Diabetic,

A mouse model of TDACD was induced by high-fat diet and streptozotocin

*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,

7861-

isoO,

Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β

vitro+vivo,

Nor,

RAW264.7

Mice

*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *Synergy↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,

7852-

isoO,

Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways

in-vitro,

AD,

*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,

7878-

isoO,

Cisplatin,

Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway

in-vivo,

Nor,

mice

*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,

7876-

isoO,

Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway

in-vitro,

Nor,

*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,

7874-

isoO,

Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways

in-vivo,

Nor,

*ROS↓, *IL6↓, *NRF2↑, *HO-1↑, *Keap1↓, *NOD1↓, *NLRP3↓, *Casp1↓, *ASC↓, *IL1β↓, *Apoptosis↓,

7872-

isoO,

Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways

in-vivo,

Arthritis,

*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,

7813-

ISQ,

Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress

in-vivo,

Stroke,

Sprague Dawley rats.

*Apoptosis↓, *ROS↓, *SOD↑, *GSH↑, *Catalase↑, *NRF2↑, *HO-1↑, *MDA↓, *NGB↑, *neuroP↑,

7837-

ISQ,

Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation

in-vivo,

Nor,

*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,

7835-

ISQ,

QC,

Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves

in-vitro,

AD,

HT22

*Apoptosis↓, *ROS↓, *SOD2↑, *Ca+2↓, *mtDam↓, *NRF2↑, *HO-1↑, *other↑, *AIF↓, *LC3‑Ⅱ/LC3‑Ⅰ↓, *Synergy↑,

Showing Research Papers: 151 to 200 of 366
Prev Page 4 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,
Total Targets: 716

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

NA↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 119, ARE↓, 1, ARE↑, 8, Bil↑, 2, Catalase↑, 81, DUOX1↓, 1, Fenton↓, 3, GCLC↑, 5, GCLC↝, 1, GCLM↑, 4, GCLM↝, 1, GPx↓, 1, GPx↑, 54, GPx1↑, 1, GPx4↓, 2, GPx4↑, 6, GPx4∅, 1, GSH↓, 2, GSH↑, 90, GSH/GSSG↑, 1, GSR↓, 1, GSR↑, 9, GSS↑, 1, GSSG↓, 1, GSTs↓, 2, GSTs↑, 14, H2O2↓, 5, H2O2↑, 1, HDL↓, 1, HDL↑, 1, HNE↓, 2, HNE↑, 1, HO-1?, 2, HO-1↓, 9, HO-1↑, 237, HO-1⇅, 1, HO-1↝, 1, HO-1∅, 1, HO-2↓, 1, hyperG↝, 1, Iron↓, 3, Iron↝, 1, i-Iron↓, 1, Keap1↓, 12, Keap1↑, 1, Keap1↝, 2, lipid-P↓, 56, lipid-P↑, 3, mt-lipid-P↓, 1, MDA↓, 84, MDA↑, 1, MPO↓, 12, MPO↑, 1, NOX↓, 2, NOX1↓, 1, NOX2↓, 2, NOX4↓, 7, NQO1↑, 47, NQO1↝, 2, Nrf1↑, 3, NRF2↓, 7, NRF2↑, 216, NRF2∅, 1, p‑NRF2↑, 1, ONOO↓, 1, Prx↑, 4, RNS↓, 2, ROS?, 1, ROS↓, 201, ROS↑, 4, ROS⇅, 2, ROS∅, 1, mt-ROS?, 1, mt-ROS↓, 2, SOD↓, 2, SOD↑, 120, SOD1↑, 7, SOD2↑, 5, TAC↑, 13, TBARS↓, 4, Thiols↑, 1, TOS↓, 1, Trx↑, 3, Trx1↑, 6, TrxR↑, 2, TrxR1↑, 1, UCPs↑, 1, uricA↓, 1, VitC↑, 5, VitE↓, 1, VitE↑, 4, xCT/SLC7A11↓, 1, xCT/SLC7A11↑, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1, FTH1↓, 1, FTH1↑, 1, IronCh↑, 10, Mets↝, 1, NCOA4↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1, compII↑, 1, compIII↑, 1, DRP1/DNM1L↓, 1, Insulin↑, 1, MFN2↑, 1, mitResp↑, 1, mtDam↓, 9, mtDam↑, 1, NGB↑, 1, OCR↑, 1, PDH↑, 1, PGC-1α↓, 1, PGC-1α↑, 5, PGC-1α↝, 2, PINK1↓, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 3MST/MPST↑, 1, 5LO↓, 3, ACC↓, 1, ACSL4↓, 1, ACSL4∅, 1, ALAT↓, 18, AMPK↑, 17, p‑AMPK↑, 1, ATP↑, 10, Buty↑, 1, cAMP↑, 1, CBS↑, 1, CRM↑, 2, cytoP450↓, 1, FABP4↓, 1, FASN↓, 1, G6PD↑, 1, GAPDH↑, 1, glucose↓, 5, glucose↝, 1, GlucoseCon↑, 6, GlutMet↑, 1, Glycolysis↑, 3, GSK‐3β↓, 16, GSK‐3β↑, 3, p‑GSK‐3β↓, 1, p‑GSK‐3β↑, 4, H2S↑, 2, HK1↑, 1, HK2↑, 1, HMG-CoA↓, 1, LDHA↓, 1, LDL↓, 6, NAD↑, 1, NADH:NAD↑, 1, NADPH↓, 9, NADPH↑, 10, PDKs↓, 1, PFK↓, 1, PFK↑, 1, PKM2↓, 2, PKM2↑, 1, SCFAs↑, 1, SIRT1↓, 1, SIRT1↑, 25, SREBF2⇅, 1, SREBP1/SREBF1↓, 3,

Cell Death(tgid=5) ⓘ

AIF↓, 2, Apoptosis↓, 31, ASC?, 1, ASC↓, 1, ASK1↓, 1, BAX↓, 15, BAX↑, 2, Bax:Bcl2↓, 7, Bcl-2↓, 1, Bcl-2↑, 17, Bcl-xL↑, 1, BNIP3↓, 1, Casp↓, 2, Casp1↓, 4, proCasp1↓, 1, Casp12↓, 2, Casp3?, 1, Casp3↓, 27, Casp3↑, 1, Casp3∅, 1, cl‑Casp3↓, 5, cl‑Casp8↓, 1, cl‑Casp8↑, 1, Casp9↓, 7, Casp9↑, 1, Casp9∅, 1, Cyt‑c↓, 5, Cyt‑c∅, 3, Fas↓, 1, Ferroptosis↓, 12, Ferroptosis↑, 1, GranB/GZMB↓, 1, IAP1↓, 1, iNOS↓, 39, iNOS↑, 2, necrosis↓, 2, p38↓, 5, p‑p38↓, 3, Pyro?, 1, Pyro↓, 1, RIP1↓, 1, survivin↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6, Akt↑, 19, p‑Akt↓, 1, p‑Akt↑, 4, e-Akt↑, 1, AMPKα↑, 2, CREB↑, 4, p‑CREB↑, 2, ERK↓, 10, ERK↑, 9, p‑ERK↓, 2, p‑ERK↑, 3, e-ERK↑, 1, HGF/c-Met↑, 1, IKKα↓, 2, IKKα↑, 1, p‑IKKα↓, 1, IκB?, 1, IκB↓, 1, IκB↑, 2, JAK↓, 1, JAK2↓, 1, JAK2↑, 1, JNK↓, 8, p‑JNK↓, 5, p‑JNK↑, 1, LPAR1/EDG2↑, 1, MAPK?, 1, MAPK↓, 23, p‑MAPK?, 1, p‑MAPK↓, 2, MEK↓, 1, mTOR↓, 5, mTOR↑, 1, p‑mTOR↓, 2, PDGFR-BB↓, 1, PDGFRB↓, 1, PI3K↓, 3, PI3K↑, 14, p‑PI3K↑, 1, PKA↑, 2, PKCδ↓, 2, PKCδ↑, 1, PP2A↑, 2, PTEN↓, 1, STAT↓, 1, STAT3↓, 6, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF2↑, 1, ATF4↓, 3, ATF4↑, 1, cJun↓, 1, p‑cJun↓, 2, p‑cMyc↑, 1, DNMT1↓, 1, DNMT3A↓, 1, DNMTs↓, 1, FOXO↑, 1, FOXO3↑, 2, HDAC↓, 2, HDAC↑, 1, miR-34a↓, 1, other?, 1, other↓, 3, other↑, 6, other↝, 5, SOX2↑, 1, tumCV↓, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 8, CHOP/DDIT3↑, 1, p‑eIF2α↓, 1, ER Stress↓, 7, GRP78/BiP↓, 5, GRP78/BiP↑, 3, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 5, HSP70/HSPA5↝, 1, HSPs↑, 1, HSPs↝, 1, PERK↓, 1, UPR↑, 1, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1, autophagy↓, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3B↓, 1, LC3II↓, 1, LC3II↑, 1, MitoP↑, 1, p62↓, 1, p62↑, 2, PARK2↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10, PARP↓, 1, PARP∅, 1, PARP1↓, 1, SIRT6↑, 1, Telomerase↓, 1, TOP1↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2, Ki-67↓, 1, Ki-67↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1, cFos↓, 1, Choline↑, 1, Diff↑, 1, Diff↝, 1, FGF↑, 1, HH↓, 1, IGF-1↓, 1, IGF-1↑, 1, Ki-67↓, 1, Ki-67↑, 1, Nestin↑, 1, neuroG↑, 3, NOTCH1↑, 1, p300↓, 1, TumCP↓, 2, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↓, 2, AntiAg↑, 6, AP-1↓, 3, mt-ATPase↑, 1, Ca+2↓, 9, Ca+2↑, 1, i-Ca+2↓, 1, Cartilage↑, 1, COL1↓, 1, EMT↑, 1, Fibrosis↓, 1, heparanase↑, 1, LRP1↑, 1, MMP1↓, 1, MMP2↓, 2, MMP2↑, 2, MMP3↓, 1, MMP7↓, 1, MMP9↓, 8, MMP9↑, 1, MUC1↑, 1, Na+↑, 1, p‑Rac1↓, 1, Rho↓, 1, ROCK1↓, 1, TGF-β↓, 5, TGF-β↑, 2, TGF-β1↓, 2, TGF-β1↑, 1, TIMP1↓, 1, TumCI↓, 1, TumCMig↓, 1, TXNIP↓, 3, uPA↑, 1, α-SMA↓, 2, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2, angioG↑, 1, E-sel↓, 3, Endoglin↑, 1, eNOS↑, 1, p‑eNOS↑, 2, Hif1a↓, 2, Hif1a↑, 2, LOX1↓, 1, NO↓, 24, NO↑, 2, TXA2↓, 1, VCAM-1↓, 10, VEGF↓, 4, VEGF↑, 4,

Barriers & Transport(tgid=15) ⓘ

BBB?, 1, BBB↓, 1, BBB↑, 23, BBB↝, 1, GLUT2↑, 2, GLUT3↑, 4, GLUT4↑, 6, H+/K+-ATPase↓, 1, IBI↑, 4, memfluid↑, 1, MMP↓, 3, MMP↑, 15, Na+↑, 1, NHE3↑, 1, OCLN↑, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, TRPV1↑, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1, CB2 / CNR2↑, 2, CD25+↑, 1, CD4+↑, 2, COX1↓, 2, COX2/PTGS2↓, 54, COX2/PTGS2↑, 2, CXCc↓, 1, FOXP3↑, 2, HMGB1↓, 5, ICAM-1↓, 10, IFN-γ↓, 8, IFN-γ↑, 1, IL1↓, 2, IL10↓, 7, IL10↑, 13, IL12↓, 3, IL17↓, 7, IL18↓, 4, IL1β↓, 75, IL2↓, 5, IL22↓, 1, IL23↓, 3, IL33↓, 2, IL4↓, 3, IL4↑, 5, IL6↓, 73, IL6↑, 3, IL8↓, 9, Imm↑, 4, Imm↝, 1, Inflam?, 2, Inflam↓, 145, Inflam↑, 2, LPS↓, 1, M2 MC↑, 1, pol-M2 MC↑, 1, MCP1/CCL2↓, 8, MCP1/CCL2↑, 1, MIP‑1α/CCL3↓, 1, MIP2↓, 2, MyD88↓, 2, NeuroI↓, 3, NF-kB↓, 97, NF-kB↑, 3, NLRP3↓, 29, NLRP3↑, 1, NOD1↓, 1, p65↓, 5, PGE2↓, 16, RAGE↓, 3, RANTES↓, 1, TLR1↓, 1, TLR2↓, 2, TLR3↓, 1, TLR4↓, 19, TLR4↑, 1, TLR4∅, 1, TNF-α↓, 98, TNF-α↑, 1, TRAF6↓, 1, Treg lymp↝, 1, TRIF↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 6, Ach↑, 4, AChE↓, 34, AChE∅, 1, BChE↓, 7, BChE∅, 1, BDNF↑, 30, BrainVol↑, 1, ChAT↑, 6, ChE↓, 1, GABA↑, 2, GDNF↑, 1, MAOA↓, 4, MAOB↓, 2, NGF↑, 5, PSD95↑, 4, SYP↑, 1, TPH1↓, 1, TrkB↑, 5,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, APP↓, 5, Aβ↓, 41, BACE/β-secretase↓, 15, tau↓, 11, p‑tau↓, 11, XO↓, 1, β-Amyloid↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, AKR1C3/17β-HSD5/PGF Synthase↑, 1, END↑, 1, ER(estro)↑, 1, FGF21↑, 1, GLP-1R↑, 1, GR↑, 2, NR1H4↑, 1, PPARα↑, 4, PPARα↝, 1, PPARγ↓, 2, PPARγ↑, 14, p‑PPARγ↓, 1, RAAS↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1, AKR1B10↝, 1, BioAv↓, 28, BioAv↑, 36, BioAv↝, 21, ChemoSen↑, 3, CompStab↑, 1, CYP2D6↓, 1, Dose?, 1, Dose↓, 1, Dose↑, 3, Dose↝, 21, eff↓, 2, eff↑, 22, eff↝, 1, GSTA1↓, 1, GSTA1↑, 4, Half-Life↓, 5, Half-Life↑, 3, Half-Life↝, 9, MRP↓, 1, P-gp/ABCB1↓, 1, P450↑, 2, selectivity↑, 2, Synergy↑, 16,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 18, ALB↑, 1, ALP↓, 3, AST↓, 19, BG↓, 1, Bil↑, 2, BloodF↑, 2, BMD↑, 2, BP↓, 6, BUN?, 1, BUN↓, 4, creat↓, 8, CRP↓, 5, Ferritin↑, 1, IL6↓, 73, IL6↑, 3, IRes↝, 1, LDH↓, 6, LDH↑, 3, NOS2↓, 4, RAGE↓, 3, SpO2↑, 1, TMAO↓, 1, Urea↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 9, antiAll↑, 10, AntiArt↑, 3, AntiCan↑, 11, antiCG↑, 2, AntiDiabetic↑, 12, antiPs↑, 2, AntiTum↑, 5, ANXi↓, 1, cardioP?, 2, cardioP↑, 45, CardioT↓, 2, chemoP↑, 13, chemoPv↑, 2, cognitive↓, 1, cognitive↑, 47, diuretic↑, 2, fatigue↓, 1, GFR↑, 1, hepatoP↓, 2, hepatoP↑, 45, Learn↑, 6, memory↑, 51, Mood↑, 1, motorD↓, 1, motorD↑, 5, neuroP↑, 115, NP/CIPN↓, 2, Obesity↓, 9, OS↑, 5, Pain↓, 4, QoL↑, 1, radioP↑, 7, RenoP↑, 25, Risk↓, 1, Risk↑, 1, Sleep↑, 1, Strength↑, 3, Stress↓, 1, Stroke↓, 11, toxicity↓, 18, toxicity↑, 2, toxicity↝, 4, toxicity∅, 3, Weight↓, 1, Weight↑, 1, Weight∅, 1, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4, AntiFungal↑, 5, AntiViral↑, 7, Bacteria↓, 10, Diar↓, 3, GutMicro↑, 21, Sepsis↓, 7,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,
Total Targets: 619

Scientific Paper Hit Count for: HO-1, HMOX1

17 Curcumin
16 Luteolin
15 Resveratrol
15 Sulforaphane (mainly Broccoli)
15 Thymoquinone
11 Quercetin
9 Chemotherapy
9 Hydrogen Gas
9 Silymarin (Milk Thistle) silibinin
9 Shikonin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Ferulic acid
7 isoorientin
7 Lycopene
6 Cisplatin
6 Baicalein
6 Chlorogenic acid
6 Chrysin
6 Honokiol
6 Isoliquiritigenin
6 Morin
5 Alpha-Lipoic-Acid
5 diet FMD Fasting Mimicking Diet
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
5 Propolis -bee glue
4 doxorubicin
4 Berberine
4 Beta-Caryophyllene
4 Betulinic acid
4 Carnosic acid
4 Crocetin
4 Vitamin C (Ascorbic Acid)
4 Emodin
4 Piperlongumine
4 Pterostilbene
4 Rosmarinic acid
3 Artemisinin
3 Radiotherapy/Radiation
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Celastrol
3 isoquercitrin
3 Isovitexin
3 Kaempferol
3 Matrine
3 Vitexin
2 Silver-NanoParticles
2 Selenite (Sodium)
2 Allicin (mainly Garlic)
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Gallic acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Licochalcone A
2 SDG/lignans
2 Linalool
2 Melatonin
2 5-fluorouracil
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Vitamin K2
1 1,8-Cineole
1 5-Aminolevulinic acid
1 chemodynamic therapy
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 xanthohumol
1 Brucea javanica
1 brusatol
1 Bromelain
1 buckwheat sprouts
1 Caffeic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Cucurbitacin
1 Cynaropicrin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 Dipyridamole
1 Dandelion Root
1 Disulfiram
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginkgo biloba
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 Juglone
1 Lactobacillus
1 lambertianic acid
1 Licorice
1 Lutein
1 Metformin
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Propyl gallate
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Polyphenols
1 salinomycin
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Spermidine
1 erastin
1 Taurine
1 Urolithin
1 Vanillic Acid
1 Mung Bean Sprouts

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:597  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

HO-1 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

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