HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱
Source:
Type:
(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
  Reducing oxidative stress and inflammation
  Promoting angiogenesis (the formation of new blood vessels)
  Inhibiting apoptosis (programmed cell death)
  Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin   Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol  Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin   Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG     Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin    Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin   Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.
Scientific Papers found: Click to Expand⟱
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
834- Gra,    Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
- Review, NA, NA
EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3787- H2,    Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis
- Review, AD, NA
*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,
7500- H2S,    Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2
- in-vivo, AD, NA
*neuroP↑, *memory↑, *CBS↑, *3MST/MPST↑, *APP↓, *BACE/β-secretase↓, *NRF2↑, *HO-1↑, *GSTs↑, *Aβ↓, *ARE↑,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
2870- HNK,    Honokiol attenuates oxidative stress and vascular calcification via the upregulation of heme oxygenase-1 in chronic kidney disease
- in-vitro, CKD, NA
*HO-1↑, *ROS↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
2080- HNK,    Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
- in-vitro, AML, THP1 - in-vitro, AML, U937 - in-vitro, AML, SK-HEP-1
tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7563- HYP,    Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury
- vitro+vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NOX4↓, *NOX2↓, *NOX1↓, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *neuroP↑,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7558- HYP,    The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *GSK‐3β↑, *Keap1↓, *eff↑,
7561- HYP,    Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway
- in-vivo, Park, NA
*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,
7804- IBC,    Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms
- Review, Nor, NA
*BioAv↓, *BBB↑, *hepatoP↓, ROS↑, *NA↓, ERK↓, Wnt↓, Apoptosis↑, *NF-kB↓, *NRF2↑, *HO-1↑, *Inflam↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,
7777- ISL,    Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
- vitro+vivo, Gall, SGC996
TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,
7865- isoO,    Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis
- in-vivo, Diabetic, NA
*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7852- isoO,    Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
- in-vitro, AD, NA
*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7874- isoO,    Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways
- in-vivo, Nor, NA
*ROS↓, *IL6↓, *NRF2↑, *HO-1↑, *Keap1↓, *NOD1↓, *NLRP3↓, *Casp1↓, *ASC↓, *IL1β↓, *Apoptosis↓,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
7813- ISQ,    Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress
- in-vivo, Stroke, NA
*Apoptosis↓, *ROS↓, *SOD↑, *GSH↑, *Catalase↑, *NRF2↑, *HO-1↑, *MDA↓, *NGB↑, *neuroP↑,
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
7835- ISQ,  QC,    Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves
- in-vitro, AD, HT22
*Apoptosis↓, *ROS↓, *SOD2↑, *Ca+2↓, *mtDam↓, *NRF2↑, *HO-1↑, *other↑, *AIF↓, *LC3‑Ⅱ/LC3‑Ⅰ↓, *eff↑,
7890- IVT,    Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses
- in-vivo, Nor, NA
RenoP↑, *BUN↓, *creat↓, *TNF-α↓, *IL1β↓, *IL6↓, *MDA↓, *ROS↓, *NF-kB↓, *NRF2↑, *HO-1↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,

Showing Research Papers: 151 to 200 of 331
Prev Page 4 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 331

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 1,   CD47↓, 1,   miR-124-3p↓, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase↑, 1,   Ferroptosis↑, 4,   GPx4↓, 3,   GPx4∅, 1,   GSH/GSSG↓, 2,   H2O2↑, 1,   HO-1↓, 4,   HO-1↑, 5,   HO-1↝, 1,   Iron↑, 1,   i-Iron↑, 1,   lipid-P↑, 4,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 10,   SOD?, 1,   SOD↑, 1,   Trx↑, 1,   xCT/SLC7A11↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,   mtDam↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CYP3A4↓, 1,   ECAR↓, 1,   Glycolysis↓, 1,   PI3K/Akt↓, 1,   SCD1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↑, 9,   BAX↑, 3,   Bcl-2↓, 3,   Casp↑, 1,   Casp↝, 1,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 3,   cFLIP↓, 2,   Cyt‑c↑, 1,   Ferroptosis↑, 4,   GSDMD↑, 1,   IAP2/BIRC3↓, 1,   MAPK↑, 2,   MOMP↑, 1,   p27/CDKN1B↑, 1,   p38↓, 1,   p38↑, 1,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   other?, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   P53↝, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   p‑cMET↑, 1,   ERK↓, 2,   FOXM1↓, 1,   FOXO1↑, 1,   HDAC↓, 1,   HDAC1↓, 1,   HRAS↓, 1,   mTOR↓, 4,   Nestin↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   RAS↓, 1,   RAS↑, 1,   Shh↓, 1,   STAT↓, 2,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 3,   TumCG↑, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MALAT1↓, 1,   MMP2↓, 1,   MMPs↓, 1,   Rho↑, 1,   ROCK1↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 4,   TumMeta↓, 1,   Twist↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 2,   Hif1a↓, 4,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT4↓, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1,   Imm↑, 1,   Inflam↑, 1,   JAK↓, 2,   NF-kB↓, 5,   NK cell↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   NLRP3↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↓, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 6,   eff↝, 2,   RadioS↑, 1,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 2,   EGFR↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   Appetite↑, 1,   chemoP↑, 7,   cognitive↑, 1,   NP/CIPN↓, 1,   Pain↓, 1,   QoL↑, 3,   radioP↑, 4,   RenoP↑, 1,   Sleep↑, 1,   toxicity↓, 3,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 165

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   AIF1/Iba-1↓, 1,   AntiBio↑, 1,   antiCG↑, 1,   autophagy↓, 1,   CBS↑, 1,   compII↑, 1,   CYP2D6↓, 1,   DUOX1↓, 1,   Learn↑, 1,   LPAR1/EDG2↑, 1,   NA↓, 1,   NGB↑, 1,   NOD1↓, 1,   NOX1↓, 1,   NOX2↓, 2,   SpO2↑, 1,   Stroke↓, 4,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   ARE↑, 3,   Catalase↑, 13,   Fenton↓, 1,   Ferroptosis↓, 1,   GCLC↑, 1,   GCLC↝, 1,   GCLM↑, 1,   GCLM↝, 1,   GPx↑, 7,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 9,   GSTs↑, 2,   HNE↑, 1,   HO-1↓, 2,   HO-1↑, 39,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 3,   MDA↓, 14,   MPO↓, 6,   MPO↑, 1,   NOX4↓, 4,   NQO1↑, 6,   NQO1↝, 2,   NRF2↑, 38,   RNS↓, 1,   ROS↓, 34,   mt-ROS↓, 1,   SIRT3↑, 2,   SOD↓, 1,   SOD↑, 16,   SOD1↑, 1,   SOD2↑, 3,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 2,   TrxR1↑, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,   compIII↑, 1,   MMP↓, 1,   MMP↑, 3,   mtDam↓, 3,   PGC-1α↑, 1,   PGC-1α↝, 1,   PINK1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   ALAT↓, 2,   AMPK↑, 2,   p‑AMPK↑, 1,   ATG7↓, 1,   BUN↓, 1,   H2S↑, 1,   LDH↑, 2,   LDL↓, 2,   NADPH↓, 5,   NADPH↑, 2,   PPARγ↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 5,   p‑Akt↑, 1,   Apoptosis↓, 9,   ASK1↓, 1,   BAX↓, 2,   Bax:Bcl2↓, 4,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 4,   cl‑Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 4,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK?, 1,   MAPK↓, 3,   p‑MAPK↓, 1,   p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   SIRT6↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   p‑ERK↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 4,   mTOR↓, 2,   p‑mTOR↓, 1,   PDGFRB↓, 1,   PI3K↑, 4,   p‑PI3K↑, 1,   PTEN↓, 1,   STAT3↓, 2,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   APP↓, 2,   Ca+2↓, 1,   E-sel↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   TGF-β↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   VCAM-1↓, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   Hif1a↓, 1,   NO↓, 4,   PDGFR-BB↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB↝, 1,   IBI↑, 1,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 7,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IKKα↑, 1,   IL10↓, 2,   IL10↑, 2,   IL1β↓, 16,   IL2↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 3,   Imm↑, 1,   Inflam↓, 24,   IκB↑, 1,   JAK↓, 1,   JAK2↑, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   NF-kB↓, 16,   p65↓, 1,   PGE2↓, 3,   RANTES↓, 1,   TLR4↓, 1,   TLR4∅, 1,   TNF-α↓, 19,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↑, 5,   BrainVol↑, 1,   NGF↑, 1,   PSD95↑, 2,   p‑tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 2,   NLRP3↓, 7,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↑, 5,   Half-Life↓, 2,   Half-Life↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   creat↓, 2,   GutMicro↑, 1,   IL6↓, 19,   LDH↑, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 7,   chemoP↑, 3,   cognitive↑, 5,   hepatoP↓, 1,   hepatoP↑, 7,   memory↑, 4,   motorD↑, 1,   neuroP↑, 15,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 5,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Diar↓, 1,   Sepsis↓, 5,  
Total Targets: 252

Scientific Paper Hit Count for: HO-1, HMOX1
17 Curcumin
15 Resveratrol
15 Sulforaphane (mainly Broccoli)
15 Thymoquinone
11 Luteolin
11 Quercetin
9 Chemotherapy
9 Hydrogen Gas
9 Silymarin (Milk Thistle) silibinin
9 Shikonin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Ferulic acid
7 isoorientin
6 Baicalein
6 Chlorogenic acid
6 Chrysin
6 Honokiol
6 Isoliquiritigenin
6 Lycopene
5 Alpha-Lipoic-Acid
5 Cisplatin
5 diet FMD Fasting Mimicking Diet
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
5 Propolis -bee glue
4 doxorubicin
4 Berberine
4 Beta-Caryophyllene
4 Betulinic acid
4 Carnosic acid
4 Crocetin
4 Vitamin C (Ascorbic Acid)
4 Emodin
4 Piperlongumine
4 Pterostilbene
4 Rosmarinic acid
3 Artemisinin
3 Radiotherapy/Radiation
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Celastrol
3 isoquercitrin
3 Isovitexin
3 Vitexin
2 Silver-NanoParticles
2 Selenite (Sodium)
2 Allicin (mainly Garlic)
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Gallic acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Vitamin K2
1 1,8-Cineole
1 5-Aminolevulinic acid
1 chemodynamic therapy
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 xanthohumol
1 Brucea javanica
1 brusatol
1 Bromelain
1 Caffeic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Cucurbitacin
1 Cynaropicrin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Dipyridamole
1 Dandelion Root
1 Disulfiram
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginkgo biloba
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 Juglone
1 Melatonin
1 Metformin
1 Magnetic Fields
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Oleuropein
1 Propyl gallate
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Polyphenols
1 salinomycin
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Spermidine
1 erastin
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vanillic Acid
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:597  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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