TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
Source:
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Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
1112- FA,    Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA
tumCV↓, Apoptosis↑, AntiTum↑, TumMeta↓, EMT↓, TumVol↓, TumW↓,
6890- Fer,    Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
- vitro+vivo, Var, NA
TumMeta↓, TumCD∅, Casp3↑, ROS↑, H2O2↑, TumCG↓, Dose↝, other↑,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
6912- FIS,    Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers
- Review, Var, NA
TumMeta↓, chemoPv↑, VEGF↓, VEGFR1↓, EGFR↓, Necroptosis↑, Hippo↝,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6980- Form,    The potential role of formononetin in cancer treatment: An updated review
- Review, Var, NA
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, TumCCA↑, p‑Akt↑, p38↑, P21↑, P53↑, NF-kB↓, ERK↓, LAMs↓, JAK↓, STAT↓, Akt↓,
6973- Form,    Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways
- Human, BC, NA
TumMeta↓, OS↑, TumCP↓, mtDam↑, Apoptosis↑, BACH1↑, eff↓, ChemoSen↑,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8580- FS,    Anti-Cancer Properties of Flaxseed Proteome
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↑, *Inflam?, *ROS?, *TNF-α?, *IL6?, TumCCA↑, Imm↑, ChemoSen↑, Synergy↑,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
8590- FS,    The Effect of Flaxseed in Breast Cancer: A Literature Review
- Review, BC, NA
*BioAv↑, *antiOx↑, *TC↓, *cardioP↑, *Ingr↑, *Ingr↑, chemoP↑, ChemoSen↑, TumVol↓, TumCG↓, Risk↓, Risk↓, Ki-67↓, OS↑, TumMeta↓,
8609- FSO,    Flax seed oil inhibits metastatic melanoma and reduces lung tumor formation in mice
- in-vivo, Melanoma, NA
TumMeta↓,
7010- Fuc,    Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells
- in-vitro, Lung, NA
ChemoSen↑, MMP9↓, Apoptosis↑, LC3s↓, Beclin-1/ATG6↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, TumMeta↓,
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, p42↑, p44↑, MAPK↑, TumMeta↓, hepatoP↑, *antiOx↑, *TumCP↓, Vim↓, E-cadherin↓, Fibronectin↓, NDRG1↑, VMP-1↑, TumMeta↓,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
1773- GA,    Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action
- Review, Var, NA
antiOx↑, AntiCan↑, Inflam↓, GutMicro↑, CompStab↝, BioAv↓, BioAv↑, TumMeta↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
1969- GamB,    Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
AntiTum↑, TumCI↓, Apoptosis↑, ROS↑, Cyt‑c↑, Akt↓, mTOR↓, TumCG↓, TumMeta↓,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Inflam↓, HATs↓, p300↓, CBP↓, PCAF↓, cycD1/CCND1↓, STAT↓, PI3K↓, Akt↓, TumCP↓, TumCI↓, TumMeta↓, TumCCA↑, CDK2↓, CDK4↓,
7223- GBE,    Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3K/Akt/NF- κ B/MMP-9 Signaling Pathway
- vitro+vivo, Melanoma, B16-F10
TumCP↓, TumCMig↓, p‑PI3K↓, p‑Akt↓, NF-kB↓, MMP9↓, TumMeta↓, Dose↝,
1190- GBE,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
7130- Ge-132,    Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer
- Trial, BC, NA
IL6↓, TumMeta↓, Dose↝, MCP1/CCL2↓,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7243- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathwa
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, *toxicity↓,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
7265- Gink,    Ginkgetin targets GRP78 to induce dual pathways of ER stress and immune activation in osteosarcoma
- vitro+vivo, OS, NA
GRP78/BiP↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumAuto↑, PERK↑, eIF2α↑, ATF4↑, TumCG↓, TumMeta↓, Synergy↑,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
2880- HNK,    Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vivo, NA, NA
tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2866- HNK,    Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship
- Review, Var, NA
EMT↓, TumMeta↓, BioAv↑, BBB↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,

Showing Research Papers: 151 to 200 of 371
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 371

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   antiOx⇅, 1,   Catalase↑, 3,   Fenton↑, 2,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 5,   GSH↓, 20,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 9,   Iron↑, 2,   lipid-P↓, 2,   lipid-P↑, 9,   MDA↓, 2,   MDA↑, 5,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 10,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 1,   RNS↑, 1,   ROS↓, 17,   ROS↑, 140,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 6,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 6,   TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC25↓, 4,   compI↓, 1,   EGF↓, 1,   ETC↓, 5,   mitResp↓, 3,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 9,   OCR↓, 5,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   ALAT↓, 3,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 14,   p‑AMPK↑, 1,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   Buty↑, 1,   CAIX/CA9↑, 1,   ECAR↓, 3,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 5,   G6PD↓, 3,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 12,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PA↑, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 10,   PPP↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 7,   Apoptosis↑, 154,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 2,   Bak↑, 4,   BAX↓, 1,   BAX↑, 57,   Bax:Bcl2↑, 11,   Bcl-2↓, 65,   Bcl-2↑, 4,   Bcl-xL↓, 18,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 76,   cl‑Casp3↑, 7,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 46,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   Endon↑, 1,   FADD↑, 5,   Fas↓, 1,   Fas↑, 10,   FasL↑, 4,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 8,   Mcl-1↓, 14,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 4,   p38↑, 11,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 37,   TRAIL↑, 1,   TumCD↑, 14,   TumCD∅, 1,   XIAP↓, 13,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 111,   Akt↑, 1,   p‑Akt↓, 16,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   CREB↓, 1,   CREB↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERK↓, 30,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   IKKα↓, 5,   IP6K1↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 4,   JAK1↓, 3,   JAK2↓, 8,   JNK↓, 4,   JNK↑, 13,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 34,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 3,   mTOR↓, 50,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   PI3K↓, 78,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 17,   p‑PTEN↓, 1,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 6,   SHP1↑, 2,   Sp1/3/4↓, 10,   Src↓, 2,   STAT↓, 4,   STAT3↓, 51,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 7,   STAT5↓, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↓, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 3,   ChrMod↑, 1,   circNAV3↓, 1,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 23,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 2,   DNMTs↓, 5,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA2↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 16,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC4↓, 3,   HDAC8↓, 1,   HES1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-125b↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-218↑, 1,   miR-224↓, 1,   miR-29b↑, 2,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   NDRG1↑, 2,   OCT4↓, 9,   other?, 3,   other↓, 1,   other↑, 8,   other↝, 12,   PCAF↓, 1,   SD↝, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 26,   tumCV∅, 1,   YMcells↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 23,   GRP78/BiP↓, 2,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 3,   e-HSP70/HSPA5↓, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 4,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 34,   TumAuto↝, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   P53?, 1,   P53↓, 2,   P53↑, 59,   P53↝, 2,   p‑P53↑, 3,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 38,   PARP1↑, 3,   PCNA↓, 20,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 21,   CDK2↑, 1,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 47,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 132,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 8,   ALDH1A1↓, 1,   AXIN1↑, 1,   Axin2↑, 1,   BMI1↓, 1,   BMPs↑, 2,   CD133↓, 5,   CD133↑, 1,   CD24↓, 3,   CD34↓, 2,   cFos↓, 5,   cMYB↓, 1,   CSCs↓, 35,   CSCsMark↓, 1,   Diff↑, 4,   Gli1↓, 7,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 7,   Nestin↓, 1,   NOTCH↓, 9,   NOTCH1↓, 9,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH3↓, 2,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 86,   TumCG↑, 4,   TumCG⇅, 1,   TumCG↝, 1,   TumCG∅, 2,   TumCP↓, 133,   TumCP↑, 4,   WDR72↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 14,   CAFs/TAFs↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   COL11A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 45,   EMT↓, 80,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 2,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 4,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 76,   MMP3↓, 6,   MMP7↓, 4,   MMP9↓, 95,   MMP9↑, 3,   MMPs↓, 40,   MUC4↓, 2,   N-cadherin↓, 29,   Na+↑, 1,   NEDD9↓, 1,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 7,   ROCK1↓, 4,   Slug↓, 14,   SMAD2↓, 3,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 27,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 2,   TIMP1↑, 8,   TIMP2↑, 9,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 2,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 116,   TumCI↑, 3,   TumCMig↓, 64,   TumCMig↑, 2,   TumMeta?, 1,   TumMeta↓, 354,   TumMeta↑, 20,   TumMeta∅, 1,   TumPF↓, 1,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 12,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 5,   Hif1a↓, 41,   Hif1a↝, 1,   NO↓, 4,   TXA2↓, 2,   VCAM-1↓, 1,   VEGF↓, 76,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 9,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 59,   MPT↑, 2,   Na+↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 11,   CD8+↑, 6,   COX1↓, 5,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 5,   FOXP3↓, 1,   Gal-3↓, 2,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 33,   IL6↑, 1,   IL8↓, 9,   IL8↑, 1,   Imm↑, 23,   Imm↝, 3,   Inflam↓, 30,   Inflam↝, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 100,   NF-kB↑, 2,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 7,   NLRP3↓, 5,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 3,   PGE2↓, 14,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 2,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 20,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 5,   TAMS↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 7,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 38,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 119,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 2,   Dose↓, 2,   Dose↑, 3,   Dose↝, 37,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 73,   eff↝, 4,   eff∅, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 12,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS?, 1,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 45,   Synergy↑, 63,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   ascitic↓, 1,   AST↓, 2,   BP↓, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 33,   IL6↑, 1,   LDH↓, 2,   LDH↑, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 3,   PSA↓, 6,   PSADT↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 39,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 2,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 21,   chemoPv↑, 20,   ChemoSideEff↓, 3,   fatigue↓, 1,   FTO↓, 1,   hepatoP↓, 1,   hepatoP↑, 6,   kidSt↓, 1,   neuroP↑, 7,   OS↑, 20,   OS⇅, 1,   Pain↓, 3,   Pin1↓, 1,   QoL↑, 8,   radioP↑, 11,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 21,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 14,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 7,   TumW∅, 1,   Weight↓, 1,   Weight↑, 2,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   GutMicro↑, 6,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 2,   Ingr↝, 3,  
Total Targets: 883

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 50,   Catalase↑, 19,   GPx↑, 16,   GPx1↑, 2,   GSH↑, 12,   GSR↑, 4,   GSTs↑, 10,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 10,   Iron∅, 1,   Keap1↓, 1,   lipid-P↓, 18,   MDA↓, 6,   NRF2↑, 19,   RNS↓, 1,   ROS?, 2,   ROS↓, 50,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 19,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   cytoP450↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDL↓, 2,   lipidLev↓, 2,   NAD↓, 1,   NADPH↑, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 7,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 2,   STAT↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 2,   Ca+2↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 13,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 8,   IL2↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 10,   Imm↓, 1,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 53,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB?, 1,   NF-kB↓, 15,   NLRP3↓, 3,   PGE2↓, 6,   TLR4↓, 1,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 6,   AChE↝, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 17,   BioAv↑, 23,   BioAv↝, 6,   BioEnh↑, 1,   CompStab↑, 2,   Dose?, 1,   Dose↝, 4,   eff↑, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AST↓, 4,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 10,   IRes↑, 1,   LDH↓, 2,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 4,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↑, 11,   AntiDiabetic↑, 12,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 23,   chemoP↑, 4,   cognitive↓, 1,   cognitive↑, 7,   cough?, 1,   hepatoP↑, 18,   memory↑, 8,   Mood↑, 1,   motorD↓, 1,   neuroP↑, 32,   Obesity↓, 4,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 1,   toxicity↓, 19,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 8,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 3,   Ingr↝, 8,   Phen↑, 1,   QC↑, 1,  
Total Targets: 224

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Resveratrol
8 Eugenol
8 Quercetin
7 Melatonin
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Fisetin
5 Fucoidan
5 Gambogic Acid
5 Honokiol
5 phytic acid, Inositol hexakisphosphate
5 Kaempferol
5 Luteolin
5 Phenethyl isothiocyanate
4 Silver-NanoParticles
4 brusatol
4 Capsaicin
4 Celastrol
4 Flaxseed/Linseed
4 Inositol
4 Ivermectin
4 Magnetic Field Rotating
4 Marjoram (Origanum majorana)
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Ginkgetin
3 Licorice
3 Matrine
3 mebendazole
3 Modified Citrus Pectin
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Isovitexin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Emodin
2 Sorafenib (brand name Nexavar)
2 Formononetin
2 Gallic acid
2 Ginkgo biloba
2 Isoliquiritigenin
2 isoorientin
2 Juglone
2 Licochalcone A
2 Lycopene
2 Magnolol
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Carnosic acid
1 Caffeic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Ferulic acid
1 ferumoxytol
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inulin Prebiotic
1 capecitabine
1 Gemcitabine (Gemzar)
1 isoflavones
1 isoquercitrin
1 itraconazole
1 Vitexin
1 Lapachol
1 VitK3,menadione
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Lutein
1 MCT oil
1 Magnesium
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Aromatherapy
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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