TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

8178-

Las,

Lasiokaurin suppresses breast cancer growth by blocking autophagic flux and regulating cellular energy homeostasis

-

in-vitro,

BC,

NA

Akt↓, mTOR↓, PDK1 / PDPK1↓, ATP↓, TumCD↑,

8260-

LCA,

Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway

-

vitro+vivo,

Liver,

HepG2

-

in-vitro,

Liver,

HUH7

tumCV↑, xCT/SLC7A11↓, Ferroptosis↑, GPx4↑, ROS↑, TumCP↓, TumCD↑, Iron↑,

8222-

LCA,

Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways

-

in-vitro,

CCA,

KKU-100

-

in-vitro,

CCA,

KKU-213

-

in-vitro,

CCA,

KKU-214

-

in-vitro,

CCA,

KKU-156

-

in-vitro,

0-Reserved,

KKU-452

TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,

8195-

LGE,

In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity

-

vitro+vivo,

BC,

4T1

TumCD↑, Dose↝, TumVol↓, cl‑Casp3↑, β-catenin/ZEB1↑, ALDH↓, Wnt↓,

8192-

LGE,

Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

H1975

Dose↝, TumCD↑, Apoptosis↑, TumCCA↑, Apoptosis↑,

6480-

LIN,

Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs

-

in-vitro,

lymphoma,

U937

2.59 and 11.02 μM

-

in-vitro,

Var,

HeLa

TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,

2923-

LT,

Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells

-

in-vitro,

neuroblastoma,

NA

Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,

8735-

M-Blu,

PDT,

Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

Nor,

MCF10

*Dose↝, *TumCD↑, *selectivity↑,

2546-

M-Blu,

SDT,

The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro

-

in-vitro,

sarcoma,

S180

1,10,100uM  0.24 W/cm(2) for 30 seconds

TumCD↑,

8516-

MAG,

Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma

-

in-vitro,

Melanoma,

NA

TumCCA↑, Apoptosis↑, TumCD↑, PI3K↓, Akt↓, H3K4↓, ChemoSen↑,

8573-

Matr,

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

BT20

-

in-vitro,

BC,

MDA-MB-231

TumCD↑, IKKα↓,

8541-

Matr,

Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway

-

in-vivo,

CRC,

NA

TumCP↓, necrosis↑, Ferroptosis↑, TumCD↑, lipid-P↑, MDA↑, GSH↓, xCT/SLC7A11↓, P53↑, p‑STAT3↓,

8627-

MBZ,

Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death

-

in-vitro,

CRC,

HT-29

1 µM at 48 h

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

TumCD↑, selectivity↑, Apoptosis↑, Casp3↑, DNAdam↑, MOMP↑, ROS↑, TumCCA↑, eff↓, RadioS↑,

8634-

MBZ,

Rad,

Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer

-

vitro+vivo,

BC,

MCF7

mice

-

in-vitro,

BC,

T47D

-

in-vitro,

BC,

MDA-MB-231

RadioS↑, TumCCA↑, DNAdam↑, Apoptosis↑, TumCD↑, *toxicity↓,

8786-

mCHEMO,

Metronomic chemotherapy in cancer treatment: new wine in an old bottle

-

Review,

Var,

NA

eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,

8721-

MeJa,

Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

LN229

HK2↓, Glycolysis↓, TumCD↑, TumAuto↑, Necroptosis↑, Apoptosis↑,

2235-

MF,

Increase of intracellular Ca2+ concentration in Listeria monocytogenes under pulsed magnetic field

-

in-vitro,

Inf,

NA

~7mT, us duration, repeat every second

Ca+2↑, TumCD↑,

528-

MF,

Caff,

Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells

-

in-vitro,

GBM,

U373MG

3mT, 50Hz

Ca+2↑, TumCP∅, TumCD∅, eff↑,

533-

MF,

Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization

-

in-vitro,

BC,

MDA-MB-231

1mT, 50Hz for 4 h

-

in-vitro,

Nor,

MCF10

TumCD↑, necrosis↑, mt-ROS↑, other↑, *STAT3↓, STAT3↑,

523-

MF,

MTX,

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

-

in-vitro,

AML,

THP1

10uM(MTX), 0.1 and 0.6 μT

-

in-vitro,

NA,

PC12

pheocrmomocytoma (PC12) Pheochromocytoma is a type of tumor

-

in-vivo,

Cerv,

HeLa

H2O2↑, TumCD↑, CellMemb↑, Synergy↑,

8477-

MFrot,

Urchin-like magnetic nanoparticles loaded with type X collagen siRNA and Stattic to treat triple negative breast cancer under rotating magnetic field like an "enchanted micro-scalpel"

-

Study,

BC,

NA

TumCD↑, Dose↝, CellMemb↑,

2258-

MFrot,

MF,

EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE

-

in-vitro,

GBM,

GBM

-

in-vitro,

Nor,

SVGp12

TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,

3493-

MFrot,

MF,

Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes

-

in-vivo,

GBM,

NA

20 ± 2 mT and a rotating frequency of 20 Hz

TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,

3492-

MFrot,

Chemo,

MF,

Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells

-

in-vitro,

Var,

NA

eff↑, TumCD↑,

3494-

MFrot,

MF,

Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance

-

in-vitro,

Var,

NA

eff↑, TumCD↑,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

-

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

-

in-vitro,

CRC,

SW-620

23% reduction

-

in-vitro,

NA,

HT1080

37% reduction

-

in-vitro,

Pca,

PC3

40% reduction

-

in-vitro,

OS,

U2OS

46% reduction

-

in-vitro,

BC,

MCF7

33% reduction

-

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, Synergy↑, *TumCG∅,

186-

MFrot,

MF,

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields

-

in-vitro,

GBM,

GBM

 new device that generates oscillating magnetic fields (OMF) by rapid rotation of strong permanent magnets in specially designed patterns of frequency and timing

-

in-vitro,

Lung,

NA

mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,

184-

MFrot,

MF,

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

-

in-vitro,

GBM,

GBM

 80mT pulsed

ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,

198-

MFrot,

MF,

Biological effects of rotating magnetic field: A review from 1969 to 2021

-

Review,

Var,

NA

AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,

8460-

Mg,

Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy

-

vitro+vivo,

Var,

NA

TRPM7↑, TumAuto↓, TumCD↑, TumMeta↓, TumCG?, Apoptosis↑, TumCCA↑, ROS↑, other?,

8737-

MGO,

Induction of mitochondrial apoptotic pathway in triple negative breast carcinoma cells by methylglyoxal via generation of reactive oxygen species

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

4T1

TumCP↓, TumCD↑, Apoptosis↑, ROS↑, eff↓, Cyt‑c↑, BAX↑, Bcl-2↓, p‑Akt↓, NF-kB↓,

8738-

MGO,

Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy

-

in-vitro,

Var,

NA

TumCD↑,

1785-

MLT,

Antitumoral melatonin-loaded nanostructured lipid carriers

-

in-vitro,

Var,

NA

selectivity↑, TumCD↑,

995-

MLT,

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

-

vitro+vivo,

GBM,

NA

1.5 and 3.0 mM

five glioma tumor initiating cell lines (GBM1A [15], QNS120, GBM612, GBM965, and QNS108

LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,

8865-

MOR,

Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells

-

in-vitro,

Liver,

HepG2

Mst1↑, cl‑Casp3↑, YAP/TEAD↓, Apoptosis↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, TumCD↑,

8920-

MP,

Therapeutic peptides of Mucuna pruriens L.: Anti‐genotoxic molecules against human hepatocellular carcinoma and hepatitis C virus

-

in-vitro,

Liver,

HepG2

-

in-vitro,

HCC,

SMMC-7721 cell

-

in-vitro,

HCC,

QGY-7703

TumCD↑, Dose↝, *DNAdam↓,

8803-

MT/VAE,

Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis

-

in-vitro,

Var,

NA

Imm↝, Casp9↑, Casp9↑, Casp3↑, TumCD↑, Cyt‑c↑, ChemoSen↑,

8960-

mushLions,

Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway

-

Review,

AD,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,

9307-

MushMait,

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer

-

in-vitro,

BC,

NA

TumCP↓, TumCD↑, TumCMig↓, TumCI↓, TumMeta↓, tumCV↓, TumCA↓,

4970-

Nimb,

Insights into Nimbolide molecular crosstalk and its anticancer properties

-

Review,

Var,

NA

chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,

2078-

PB,

Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response

-

in-vitro,

CRC,

HCT116

0-20mM

p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,

2039-

PB,

TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment

-

in-vitro,

Lung,

A549

-

in-vitro,

Nor,

HEK293

TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,

4948-

PEITC,

Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

-

vitro+vivo,

Oral,

CAL27

-

vitro+vivo,

Oral,

FaDu

-

vitro+vivo,

Oral,

SCC4

-

vitro+vivo,

Oral,

SCC9

TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4953-

PEITC,

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

-

in-vitro,

CLL,

NA

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

-

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, Synergy↑,

4955-

PEITC,

Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

H1299

TumCG↓, α-tubulin↓, TumCD↑, TumCCA↑, Apoptosis↑,

4943-

PEITC,

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation

-

in-vitro,

Ovarian,

OVCAR-3

23.2 microM

TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,

1765-

PG,

Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion

-

in-vitro,

Lung,

A549

800 uM at 24 h

-

in-vitro,

Lung,

Calu-6

TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,

9023-

Phyco,

PDT,

In Vitro Photodynamic Effect of Phycocyanin against Breast Cancer Cells

-

in-vitro,

BC,

MDA-MB-231

Synergy↑, ROS↑, TumCD↑, *toxicity↓, hepatoP↑, Dose↝, MMP↓, BAX↑, Bak↑, Cyt‑c↑,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Lung,

A549

-

in-vitro,

BC,

MCF7

TrxR1?, TumCD↑, ROS↑, GSH↓, Synergy↑,

Showing Research Papers: 151 to 200 of 232
Prev Page 4 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 232

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, Catalase↓, 3, Catalase↑, 2, Fenton↑, 2, GPx↓, 1, GPx↑, 1, GPx4↓, 2, GPx4↑, 1, GSH↓, 16, GSH↑, 1, GSH⇅, 1, GSH/GSSG↓, 2, GSR↓, 1, GSR↑, 1, H2O2↑, 11, i-H2O2↑, 1, mt-H2O2↑, 1, HO-1↓, 3, HO-1↑, 1, Iron↑, 4, Keap1↓, 1, lipid-P↓, 1, lipid-P↑, 9, MDA↑, 4, NOX2↑, 1, NQO1↑, 1, NRF2↓, 5, NRF2↑, 2, ROS↓, 8, ROS↑, 102, ROS⇅, 3, ROS↝, 1, ROS∅, 1, i-ROS↑, 2, mt-ROS↑, 7, SOD↓, 1, SOD↑, 1, SOD1↓, 1, SOD2↓, 1, SOD2↑, 1, Thiols↓, 1, Trx↓, 3, TrxR↓, 1, TrxR1?, 1, TrxR1↓, 2, xCT/SLC7A11↓, 4,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, compI↓, 3, compIII↓, 1, ETC↓, 4, ETC↝, 1, Insulin↓, 1, mitResp↓, 4, mtDam↓, 1, mtDam↑, 12, OCR↓, 4, OXPHOS↓, 1, OXPHOS↑, 1, PDH↓, 2, PINK1↑, 1, SDH↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ACC↓, 1, ACC↑, 1, ACLY↓, 1, ALAT↓, 1, AMPK↑, 4, p‑AMPK↑, 1, ATP↓, 9, ATP↑, 1, FASN↓, 2, GLS↓, 1, GlucoseCon↓, 4, Glycolysis↓, 7, Glycolysis↑, 1, GSK‐3β↑, 1, HK2?, 1, HK2↓, 4, lactateProd↓, 3, LDHA↓, 3, MCT4↓, 1, NAD↓, 2, NADPH↓, 2, NADPH↑, 1, PDK1 / PDPK1↓, 2, PFK↓, 1, PKM2↓, 2, p‑PKM2↓, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 2, Warburg↓, 2,

Cell Death(tgid=5) ⓘ

AIF↑, 3, APAF1↑, 1, Apoptosis↓, 5, Apoptosis↑, 78, mt-Apoptosis↑, 1, autoS↑, 1, BAD↑, 2, Bak↑, 1, BAX?, 1, BAX↓, 1, BAX↑, 26, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↓, 31, Bcl-xL↓, 5, BID↑, 2, BIM↑, 1, BNIP3?, 1, Casp↑, 8, Casp1↑, 1, Casp12↑, 1, Casp3↑, 40, cl‑Casp3↑, 12, proCasp3↓, 1, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 6, cl‑Casp7↑, 1, Casp8↑, 7, Casp9↓, 1, Casp9↑, 19, cl‑Casp9↑, 6, pro‑Casp9↑, 1, cFLIP↓, 2, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 27, Endon↑, 1, Fas↑, 3, FasL↑, 1, Ferroptosis↑, 6, HEY1↓, 1, IAP1↓, 1, ICD↑, 1, iNOS↓, 1, Mcl-1↓, 6, MDM2↓, 1, MOMP↓, 1, MOMP↑, 5, Necroptosis↑, 2, necrosis↑, 5, p38↓, 1, p38↑, 7, p‑p38↑, 2, Paraptosis↑, 2, survivin↓, 1, TumCD?, 1, TumCD↓, 11, TumCD↑, 215, TumCD∅, 4, XIAP↓, 1, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 23, Akt↑, 1, p‑Akt↓, 6, p‑Akt↑, 2, AKT1↓, 1, CK2↓, 1, EGFR↓, 2, p‑EGFR↓, 1, ERK↓, 7, ERK↑, 1, p‑ERK↑, 2, HER2/EBBR2↓, 1, Hippo↓, 1, IKKα↓, 1, p‑IKKα↓, 1, p‑IκB↓, 1, JAK↓, 1, JAK1↓, 1, JAK2↓, 1, JNK↓, 4, JNK↑, 5, p‑JNK↑, 2, MAPK↓, 3, MAPK↑, 2, p‑MAPK↓, 1, Mst1↑, 1, mTOR↓, 9, mTOR↑, 1, p‑mTOR↓, 3, mTORC2↓, 1, p‑p70S6↑, 1, P70S6K↓, 2, PDGFR-BB↓, 1, PI3K↓, 14, PI3K↑, 2, PKCδ↓, 1, PTEN↑, 1, STAT↓, 1, STAT3↓, 9, STAT3↑, 1, p‑STAT3↓, 3, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 3, ChrMod↑, 2, cMyc↓, 3, FOXM1↓, 1, FOXO1↓, 1, FOXO3↑, 1, FOXO4↑, 1, H3↑, 1, H3K4↓, 1, H3K9↓, 1, HDAC↓, 2, OCT4↓, 2, other?, 1, other↓, 2, other↑, 4, other↝, 10, PhotoS↑, 3, sonoS↑, 1, SOX2↓, 1, SOX4↓, 1, SUV39H↓, 1, TFE3↑, 1, tumCV↓, 19, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 5, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 16, GRP78/BiP↓, 1, GRP78/BiP↑, 4, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↑, 2, HSP90↓, 5, IRE1↑, 1, p‑IRE1↑, 1, PERK↑, 1, p‑PERK↑, 1, Proteasome?, 1, UPR↑, 2, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2, ATG5↑, 3, Beclin-1/ATG6↑, 3, CTSB↓, 1, CTSD↓, 1, LAMP2↑, 1, LC3B-II↑, 2, LC3II↑, 1, MitoP↑, 2, p62↑, 1, p‑p62↑, 1, PARK2↑, 1, TumAuto↓, 1, TumAuto↑, 18,

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 2, DNAdam↑, 31, hTERT/TERT↓, 1, p16↑, 2, P53↓, 1, P53↑, 23, PARP↓, 3, PARP↑, 4, cl‑PARP↑, 17, PCNA↓, 3, γH2AX↑, 5, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK2↓, 8, CDK4↓, 7, CDK6↓, 2, CDKN2C/p18↑, 1, cellSen↑, 1, CHK1↓, 1, Chk2↓, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 9, cycD1/CCND1↓, 11, cycE/CCNE↓, 3, E2Fs↓, 2, Ki-67↓, 2, mitA↓, 1, mitA↑, 1, P21↓, 2, P21↑, 10, p27/CDKN1B↓, 1, p27/CDKN1B↑, 3, p‑RB1↓, 1, TumCCA↓, 2, TumCCA↑, 69,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4, CD133↓, 2, cFos↑, 1, CSCs↓, 13, CSCs↑, 1, CSCs↝, 1, Diff↓, 1, Diff↑, 2, IGF-1↓, 2, IGF-2↑, 1, Ki-67↓, 2, mTORC1↓, 1, NOTCH↓, 1, NOTCH↑, 1, NOTCH1↓, 2, TumCG?, 1, TumCG↓, 29, TumCP?, 1, TumCP↓, 37, TumCP↑, 2, TumCP∅, 1, Wnt↓, 4,

Migration(tgid=13) ⓘ

AP-1↓, 1, ATPase↓, 1, BACH1↓, 1, Ca+2↓, 1, Ca+2↑, 13, i-Ca+2↑, 1, CD11b↑, 1, i-Chl↑, 1, Cofilin↓, 1, DLC1↑, 1, E-cadherin↓, 1, E-cadherin↑, 4, EMT↓, 7, EpCAM↓, 2, FAK↓, 1, Fibronectin↓, 1, hnRNPA1↓, 1, LAMs↓, 1, LIMK2↓, 1, MMP1↓, 1, MMP15↓, 1, MMP2↓, 9, MMP9↓, 8, MMPs↓, 5, N-cadherin↓, 4, PAK1↑, 1, ROCK1↓, 1, Slug?, 1, Slug↓, 4, Snail?, 1, Snail↓, 6, TGF-β↓, 1, TIMP1↑, 1, TIMP2↓, 1, TIMP2↑, 1, TumCA↓, 1, TumCI↓, 12, TumCMig↓, 16, TumMeta↓, 18, Twist↓, 1, TXNIP↑, 1, uPA↓, 1, Vim↓, 3, Zeb1↓, 2, α-SMA↓, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 5, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16, angioG↑, 1, HIF-1↓, 1, Hif1a↓, 4, NO↑, 2, VEGF↓, 7,

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1, CellMemb↑, 4, CLDN1↓, 1, EPR↑, 2, GLUT1↓, 3, GLUT3↓, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 44, MMP↝, 1, MPT↑, 2, SVCT-2↝, 1, TRPM7↑, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, CD44↓, 3, CD8+↑, 2, COX2/PTGS2↓, 7, COX2/PTGS2↑, 1, DCells↑, 1, DR4↑, 1, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 1, IL1β↓, 1, IL2↓, 1, IL6↓, 6, IL8↓, 3, Imm↑, 10, Imm↝, 1, Inflam↓, 6, M2 MC↓, 1, NF-kB↓, 21, NF-kB↑, 3, p‑NF-kB↓, 1, p65↓, 2, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 1, TCF↝, 1, TNF-α↓, 3, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1, Temp↓, 1, Temp∅, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1, ER-α36↓, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 7, BioAv↝, 5, ChemoSen↑, 35, CompStab↑, 2, CYP3A4↓, 1, Dose?, 3, Dose↓, 2, Dose↑, 1, Dose↝, 30, Dose∅, 1, eff↓, 39, eff↑, 42, eff↝, 4, eff∅, 1, GSTP1/GSTπ↓, 1, Half-Life↓, 1, Half-Life↑, 1, Half-Life↝, 1, P-gp/ABCB1↓, 1, P-gp/ABCB1∅, 1, RadioS↑, 14, selectivity↓, 1, selectivity↑, 53, Synergy↑, 27,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↑, 1, BG↓, 1, BloodF↑, 1, E6↓, 2, E7↓, 1, EGFR↓, 2, p‑EGFR↓, 1, Ferritin↓, 1, FOXM1↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↓, 6, LDH?, 1, LDH↓, 3, LDH↑, 2, PD-L1↓, 1, Polyps↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13, AntiCan⇅, 1, antiNeop↑, 1, AntiTum↑, 8, Appetite↑, 1, BowelM↑, 1, breath↑, 1, cardioP↑, 2, chemoP↑, 8, chemoPv↑, 4, ChemoSideEff↓, 2, hepatoP↑, 4, MusCon↓, 2, NP/CIPN↓, 1, OS↑, 8, OS⇅, 1, Pain↓, 2, PFS↑, 1, QoL↑, 2, radioP↑, 1, Remission↑, 1, RenoP↑, 1, Risk↓, 3, Sleep↑, 1, Strength↑, 2, toxicity↓, 7, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 2, Weight↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1, Bacteria↓, 2, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 498

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 13, Catalase↑, 5, GPx↑, 3, GPx1↑, 1, GSH↑, 1, GSTs↑, 3, HDL↑, 1, HO-1↓, 1, HO-1↑, 1, hyperG↝, 1, Keap1↝, 1, lipid-P↓, 2, MDA↓, 2, NRF2↑, 3, Prx↑, 1, RNS↓, 2, ROS↓, 12, ROS↑, 1, ROS∅, 2, mt-ROS?, 1, SOD↓, 1, SOD↑, 2, SOD1↑, 2, SOD2↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1, Insulin↑, 1, mitResp↑, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, ATP↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, LDL↓, 1, lipidLev↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 1, BAX↓, 1, Casp1↓, 1, Casp3?, 1, Casp3↓, 2, cl‑Casp3↓, 1, cl‑Casp8↓, 1, Cyt‑c↓, 1, iNOS↓, 1, TumCD↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1, mTOR↓, 1, PI3K↓, 1, RIP1↓, 1, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, P53↓, 1, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1, BMP2↑, 1, neuroG↑, 1, TumCG∅, 1,

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1, VCAM-1↓, 2,

Barriers & Transport(tgid=15) ⓘ

MMP↑, 2, MMP∅, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2, COX2/PTGS2↑, 1, IL18↓, 1, IL1β↓, 2, IL6↓, 4, Inflam↓, 10, pol-M2 MC↑, 1, NF-kB↓, 3, PGE2↓, 1, PSA∅, 1, TNF-α↓, 4,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 1, BDNF↑, 2, MAOA↓, 1, NGF↑, 2, β-Endo↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 1, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3, BioAv↑, 10, BioAv↝, 2, CompStab↝, 1, CYP2E1↓, 1, Dose↝, 1, Half-Life∅, 1, selectivity↑, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BMD↑, 1, BP↓, 2, HOMA↓, 1, hs-CRP↓, 1, IL6↓, 4, PSA∅, 1, TC↓, 1, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5, antiAll↑, 2, AntiCan↑, 4, antiCG↑, 1, AntiDiabetic↑, 5, antiPs↑, 1, AntiTum↓, 1, AntiTum↑, 2, cardioP↑, 1, chemoP↑, 1, cognitive↑, 3, hepatoP↑, 2, memory↑, 1, neuroP↑, 5, Obesity↓, 2, OS↑, 1, radioP↑, 1, RenoP↑, 1, Stroke↓, 2, toxicity↓, 15, toxicity↑, 2, toxicity↝, 5, toxicity∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiP↑, 2, AntiViral↑, 2, Bacteria↓, 4, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 2,
Total Targets: 143

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

23 Silver-NanoParticles
12 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
9 Magnetic Field Rotating
6 Electrical Pulses
6 Phenethyl isothiocyanate
6 Selenite (Sodium)
5 Curcumin
5 Copper and Cu NanoParticles
5 Dandelion Root
5 Disulfiram
5 Ivermectin
4 Radiotherapy/Radiation
4 Chemotherapy
4 Photodynamic Therapy
4 Metformin
4 Eugenol
4 Quercetin
4 VitK3,menadione
3 Rosmarinic acid
3 Hyperthermia
3 Astaxanthin
3 Melatonin
3 Chrysin
3 Date Fruit Extract
3 Eurycomanone
3 Fisetin
3 salinomycin
2 3-bromopyruvate
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 chaetocin
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fenbendazole
2 Ginkgetin
2 Gossypol/AT-101
2 Honokiol
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoorientin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 lambertianic acid
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Methylene blue
2 Matrine
2 mebendazole
2 Magnesium
2 Methylglyoxal
2 Phenylbutyrate
2 Selenium
1 1,8-Cineole
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Allyl isothiocyanate
1 Anethole/trans-Anethole
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Bullatacin
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Chlorophyllin
1 Docetaxel
1 Zinc
1 Cranberry
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Deguelin
1 Diclofenac
1 Echinacea
1 Cannabichromene
1 Bortezomib
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Galloflavin
1 Ginkgo biloba
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Indole-3-carbinol
1 Inositol
1 iodine
1 Paclitaxel/Taxol
1 Isothiocyanates
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Linalool
1 Luteolin
1 SonoDynamic Therapy UltraSound
1 Magnolol
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 Caffeine
1 methotrexate
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Nimbolide
1 Propyl gallate
1 Phycocyanin
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Vitexin
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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