cycD1/CCND1 Cancer Research Results

cycD1/CCND1, cyclin D1 pathway: Click to Expand ⟱
Source:
Type:
Also called CCND1 Gatekeeper of Cell-Cycle Commitment
The main function of cyclin D1 is to maintain cell cycle and to promote cell proliferation. Cyclin D1 is a key regulatory protein involved in the cell cycle, particularly in the transition from the G1 phase to the S phase. It is part of the cyclin-dependent kinase (CDK) complex, where it binds to CDK4 or CDK6 to promote cell cycle progression.
Cyclin D1 is crucial for the regulation of the cell cycle. Overexpression or dysregulation of cyclin D1 can lead to uncontrolled cell proliferation, a hallmark of cancer.
Cyclin D1 is often found to be overexpressed in various cancers.
Cyclin D1 can interact with tumor suppressor proteins, such as retinoblastoma (Rb). When cyclin D1 is overexpressed, it can lead to the phosphorylation and inactivation of Rb, releasing E2F transcription factors that promote the expression of genes required for DNA synthesis and cell cycle progression.
Cyclin D1 is influenced by various signaling pathways, including the PI3K/Akt and MAPK pathways, which are often activated in cancer.
In some cancers, high levels of cyclin D1 expression have been associated with poor prognosis, making it a potential biomarker for cancer progression and treatment response.
Scientific Papers found: Click to Expand⟱
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6964- Form,    Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo
- vitro+vivo, BC, MCF7
IGF-1↓, IGFR↓, PI3K↓, Akt↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, TumCG↓, Dose↝,
6965- Form,    Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
- in-vitro, CRC, HCT116
TumCP↓, TumCI↓, cycD1/CCND1↓, TumCCA↑, MMP2↓, MMP9↓, miR-149↑, tumCV↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓,
8308- FS,  lign,    The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1
- in-vivo, BPH, NA
*eff↑, *other↝, *GPER↑, *TumCCA↑, *P53↑, *P21↑, *cycD1/CCND1↓,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7037- GA,  Chit,    Gallic acid-loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease-1 in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231
DNAdam↑, Apoptosis↑, FEN1↓, selectivity↑, ROS↑, DNAdam↑, PARP1↑, TumCP↓, p‑PI3K↓, Akt↓, cycD1/CCND1↓, BAX↑, Casp3↑,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
1065- GA,    Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
- vitro+vivo, Pca, NA
tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Inflam↓, HATs↓, p300↓, CBP↓, PCAF↓, cycD1/CCND1↓, STAT↓, PI3K↓, Akt↓, TumCP↓, TumCI↓, TumMeta↓, TumCCA↑, CDK2↓, CDK4↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
802- GAR,    Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway
- in-vitro, GC, HGC27
TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
7136- GI,    [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2
- vitro+vivo, NSCLC, H1650
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, EGFR↓, STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, TumCG↓, Ki-67↓, eff↑, Dose↝,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7246- Gink,    Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma
- in-vitro, GC, DAOY - in-vitro, MB, D283
Wnt↓, tumCV↓, TumCCA↑, Axin2↓, cycD1/CCND1↓, survivin↓, β-catenin/ZEB1↓,
7259- Gink,    Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, TumCCA↑, Casp3↑, Bcl-2↓, Bcl-xL↓, survivin↓, cycD1/CCND1↓, cl‑PARP↑,
7284- Gins,  5-FU,    Ginsenoside Rg3 enhances the anticancer effect of 5-FU in colon cancer cells via the PI3K/AKT pathway
- vitro+vivo, CRC, SW-620 - in-vitro, CRC, LoVo
ChemoSen↑, TumCP↓, TumCI↓, TumCMig↓, APAF1↑, Casp9↑, Casp3↑, TumCCA↑, cycD1/CCND1↑, CDK2↑, CDK4↑, PI3K↓, Akt↓,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, Var, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
30- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1
HH↓, Gli1↓, Shh↓, cycD1/CCND1↓, TumCP↓,
108- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1 - in-vitro, PC, C3H10T1/2
HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,
7169- HDN-1,  CHA,    Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
- in-vitro, Lung, H1975 - in-vitro, Lung, HCC827 - in-vitro, Lung, A549
HSP90↓, TumCP↓, EGFR↓, STAT3↓, Akt↓, ERK↓, Raf↓, cycD1/CCND1↓, SUV39H↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7364- HibSad,    Hibiscus sabdariffa calyx extract induces anti-proliferative and anti-migratory effects in ovarian cancer
- in-vitro, Ovarian, OVCAR-3
*Inflam↓, *AntiBio↑, *antiOx↑, TumCMig↓, AKT1↓, cycD1/CCND1↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,

Showing Research Papers: 151 to 200 of 381
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 381

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   ARE↑, 1,   Catalase↑, 3,   ENOX2↓, 1,   Fenton↑, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 3,   GSH↓, 14,   GSH↑, 6,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   HO-2↓, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 12,   NRF2↝, 2,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 20,   ROS↑, 148,   ROS⇅, 6,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TAC?, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR↓, 1,   Bfl-1↓, 1,   CDC16↓, 1,   CDC2↓, 6,   CDC25↓, 11,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 14,   OCR↓, 5,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   ACC↑, 4,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↑, 1,   AMPK↓, 3,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 12,   ATP↑, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 4,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlucoseCon∅, 1,   Glycolysis↓, 19,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 8,   H2S↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2↓, 15,   IDO1↓, 1,   lactateProd↓, 8,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PFK↓, 3,   PKM2↓, 11,   PPP↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 11,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 6,   Apoptosis↑, 173,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASC↑, 1,   aSmase↝, 1,   BAD↓, 3,   BAD↑, 7,   Bak↑, 5,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 3,   Bax:Bcl2↑, 30,   Bcl-2↓, 138,   Bcl-2↑, 3,   Bcl-2↝, 2,   Bcl-xL↓, 56,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 1,   Casp↑, 22,   Casp1↓, 1,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 133,   Casp3↝, 2,   cl‑Casp3↑, 18,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7?, 1,   Casp7↑, 19,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↑, 2,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 73,   cl‑Casp9↑, 9,   proCasp9↑, 1,   cFLIP↓, 6,   CSR1↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 66,   Cyt‑c↝, 2,   mt-Cyt‑c↓, 1,   Diablo↑, 15,   DR5↓, 1,   DR5↑, 18,   DR5∅, 1,   FADD↑, 2,   FADD∅, 1,   Fas↓, 1,   Fas↑, 11,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 4,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 13,   IAP2/BIRC3↓, 6,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 17,   iNOS↑, 1,   Mcl-1↓, 28,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 10,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 6,   p38↑, 14,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 6,   Pyro↑, 2,   RIP1↓, 1,   survivin↓, 81,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 29,   XIAP↝, 1,   YAP/TEAD↓, 4,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 100,   Akt↑, 4,   Akt↝, 2,   p‑Akt↓, 32,   AKT1↓, 3,   Akt2↓, 2,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 4,   CREB↓, 1,   p‑CREB↓, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   EphB4↓, 1,   ERK↓, 31,   ERK↑, 7,   p‑ERK↓, 15,   p‑ERK↑, 1,   FGFR1↓, 1,   FLT4↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 8,   IGFR↓, 1,   IKKα↓, 10,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 5,   JAK1?, 1,   JAK1↓, 7,   p‑JAK1↓, 1,   JAK2↓, 22,   p‑JAK2↓, 3,   JNK↓, 5,   JNK↑, 16,   JNK↝, 1,   p‑JNK↓, 2,   MAPK↓, 20,   MAPK↑, 6,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 2,   mTOR↓, 49,   mTOR↝, 2,   p‑mTOR↓, 8,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 4,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 75,   PI3K↝, 2,   p‑PI3K↓, 5,   PI3K/Akt↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 18,   PTEN↝, 1,   PTPN6↑, 1,   Raf↓, 5,   c-Raf↓, 1,   RAS↓, 8,   RSK2/RPS6KA3/p90RSK2↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 2,   c-Src↓, 1,   STAT↓, 4,   STAT3↓, 70,   STAT3↑, 2,   p‑STAT3↓, 21,   p‑STAT3↑, 2,   STAT4↓, 1,   STAT5↓, 6,   STAT6↓, 3,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 7,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   CBP↑, 1,   cJun↓, 6,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 63,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 17,   HDAC1↓, 6,   HDAC10↓, 1,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 2,   IRF1↑, 1,   miR-130a↓, 2,   miR-149↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-21↓, 4,   miR-27a-3p↓, 3,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-34a↑, 9,   miR-590-3p↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   OCT4↓, 11,   other↓, 3,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PCAF↓, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SPP1↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 47,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 1,   ER Stress↑, 32,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   GRP78/BiP↝, 1,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   IRE1↑, 4,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   MitoP↓, 1,   p62↓, 3,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 16,   TumAuto⇅, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 2,   p‑ATR↑, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 53,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   Ku70/XRCC6↓, 1,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 5,   P53↑, 83,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   ac‑P53↑, 1,   PARP↓, 2,   PARP↑, 10,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 67,   proPARP↓, 1,   PARP1↓, 2,   PARP1↑, 4,   PCNA↓, 42,   PCNA↑, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 3,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 2,   CDK1/2/5/9↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 75,   CDK2↑, 4,   p‑CDK2↓, 1,   CDK4↓, 106,   CDK4↑, 2,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK4/6↓, 4,   CDK6↓, 39,   CDK6↑, 3,   CDK6∅, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 2,   CHK1↑, 3,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 3,   CycB/CCNB1↓, 26,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 366,   cycD1/CCND1↑, 8,   cycD1/CCND1↝, 2,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 64,   cycE/CCNE↑, 5,   cycE1↓, 5,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   Ki-67↓, 25,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21?, 2,   P21↓, 8,   P21↑, 108,   P21↝, 2,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 56,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 220,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↑, 2,   Axin2↓, 1,   BMP2↓, 1,   BMPs↑, 1,   CD133↓, 9,   CD24↓, 1,   cFos↓, 7,   CSCs↓, 33,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP300↑, 1,   FBXW7↝, 1,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 10,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 6,   IGF-1↑, 1,   IGF-2↓, 1,   IGFBP3↑, 1,   Jun↓, 1,   p‑Jun↓, 1,   Ki-67↓, 25,   Let-7↑, 4,   LGR5↓, 1,   LRP6↓, 3,   p‑LRP6↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 11,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 12,   NOTCH⇅, 1,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 4,   SCF↓, 1,   SFRP5↑, 1,   Shh↓, 9,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 73,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 35,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 9,   AP-1↝, 1,   APC↑, 1,   ATPase↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 21,   Ca+2↝, 3,   i-Ca+2↑, 2,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 36,   EMT↓, 49,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 6,   p‑FAK↓, 3,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 2,   ITGB1↓, 1,   ITGB1↑, 1,   LAMs↓, 2,   LEF1↓, 2,   MALAT1↓, 1,   MET↓, 3,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 2,   MMP2↓, 70,   MMP2↝, 1,   MMP3↓, 5,   MMP7↓, 14,   MMP9↓, 88,   MMP9↑, 1,   MMPs↓, 18,   MUC4↓, 2,   N-cadherin↓, 21,   NCAM↑, 1,   NM23↑, 1,   p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 10,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   p‑SMAD4↓, 1,   Snail↓, 21,   TET1↑, 2,   TGF-β↓, 13,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 9,   TIMP2↑, 7,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCI↑, 2,   TumCMig↓, 58,   TumCMig↑, 1,   TumMeta↓, 45,   TumMeta↑, 4,   Twist↓, 19,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 28,   Zeb1↓, 13,   α-SMA↓, 3,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 56,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 7,   Endoglin↑, 1,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 42,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 84,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 13,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 2,   CLDN2↓, 2,   EPR↑, 2,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 3,   MMP↓, 79,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SLC12A5↝, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 9,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 72,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 6,   DR4∅, 1,   FOXP3↓, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   IL7↓, 1,   IL8↓, 8,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 26,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 2,   NF-kB↓, 125,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 9,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 15,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 4,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 14,   AR↝, 1,   ER-α36↓, 2,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 6,   PRL↓, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 4,   ChemoSen↓, 3,   ChemoSen↑, 104,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 3,   CYP1B1↓, 1,   CYP1B1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 26,   Dose∅, 10,   DrugR↓, 1,   eff↓, 26,   eff↑, 38,   eff↝, 7,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 12,   P450↓, 3,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 52,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 14,   AR↝, 1,   ascitic↓, 2,   AST↓, 1,   AST↝, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CRP↓, 2,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 5,   Ferritin↓, 1,   FOXM1↓, 7,   HEC1↓, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 14,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   LDH↓, 10,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 26,   AntiCan∅, 1,   antiNeop↑, 2,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 1,   chemoP↑, 15,   chemoPv↑, 15,   ChemoSideEff↓, 4,   FTO↑, 1,   hepatoP↑, 10,   IMPDH1↓, 1,   IMPDH2↓, 1,   K17↓, 1,   neuroP↑, 7,   NKG2D↑, 1,   NP/CIPN↓, 2,   OS↑, 9,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↑, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 2,   TumVol↓, 24,   TumVol↑, 1,   TumW↓, 9,   Weight↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 1007

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 46,   ARE↑, 1,   Catalase↑, 20,   GPx↑, 16,   GSH↑, 20,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 2,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 11,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 13,   MDA↓, 14,   MDA↑, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↑, 23,   RNS↓, 1,   ROS↓, 45,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 23,   Trx↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   Insulin↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   adiP↑, 1,   ALAT↓, 5,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 1,   CRM↑, 1,   ECAR∅, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   glyC↓, 1,   LDL↓, 1,   lipidLev↓, 2,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 4,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 9,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 2,   PI3K↓, 3,   PI3K↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↝, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 1,   P53↑, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AntiAg↑, 6,   Ca+2↓, 1,   Ca+2↝, 2,   COL1A1↓, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   Rho↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 3,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC5AC↓, 1,   TRPC1↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 1,   IL6↓, 16,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 50,   Inflam↑, 1,   IRF3↓, 1,   pol-M2 MC↑, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 23,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 3,   TNF-α↓, 14,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 8,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 15,   BioAv↑, 16,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↝, 1,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   AST↓, 7,   BMD↑, 2,   BP↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 16,   LDH↓, 4,   LDH↑, 1,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 10,   AntiArt↑, 6,   AntiCan↑, 8,   AntiDiabetic↑, 10,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 21,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 9,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 12,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 37,   Obesity↓, 5,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 4,   toxicity↓, 13,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↑, 4,   AntiViral↑, 3,   Bacteria↓, 9,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 263

Scientific Paper Hit Count for: cycD1/CCND1, cyclin D1 pathway
20 Quercetin
19 Thymoquinone
16 Curcumin
14 Fisetin
13 Lycopene
10 Resveratrol
9 Boswellia (frankincense)
8 Garcinol
7 Berberine
7 Chrysin
7 Sulforaphane (mainly Broccoli)
7 Ferulic acid
7 Honokiol
7 Magnolol
6 Silver-NanoParticles
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Artemisinin
5 Baicalein
5 D-limonene
5 Ellagic acid
5 Eugenol
5 Gallic acid
5 Licorice
5 Morin
5 salinomycin
5 Silymarin (Milk Thistle) silibinin
5 Shikonin
4 Cisplatin
4 Caffeic acid
4 Metformin
4 Indole-3-carbinol
4 Formononetin
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Luteolin
4 doxorubicin
4 Piperlongumine
3 Beta-Caryophyllene
3 Betulinic acid
3 Capsaicin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Ursolic acid
3 Diindolylmethane
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ginkgetin
3 phytic acid, Inositol hexakisphosphate
3 Ivermectin
3 lambertianic acid
3 Propolis -bee glue
3 Vitamin K2
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Astaxanthin
2 Berbamine
2 Bufalin/Huachansu
2 Chemotherapy
2 Carnosic acid
2 Celastrol
2 Cucurbitacin
2 Cyclopamine
2 tamoxifen
2 Flaxseed/Linseed
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Hibiscus sabdariffa
2 Melatonin
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Niclosamide (Niclocide)
2 Phenethyl isothiocyanate
2 VitK3,menadione
2 Rosmarinic acid
1 2-DeoxyGlucose
1 Alpha-Lipoic-Acid
1 Andrographis
1 Gemcitabine (Gemzar)
1 Fennel Oil/Foeniculum vulgare
1 Isovitexin
1 Ashwagandha(Withaferin A)
1 Radiotherapy/Radiation
1 borneol
1 Boron
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chlorophyllin
1 Crocetin
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Dandelion Root
1 Disulfiram
1 Copper and Cu NanoParticles
1 Emodin
1 Evodiamine
1 Fenbendazole
1 SDG/lignans
1 Fucoidan
1 chitosan
1 Geraniol
1 Ginseng
1 5-fluorouracil
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 chaetocin
1 Baicalin
1 isoorientin
1 itraconazole
1 Juglone
1 Kaempferol
1 Lapachol
1 Lemongrass Extract/Citral
1 Lutein
1 Matrine
1 Modified Citrus Pectin
1 Lemon Balm/Melissa officinalis
1 Mucuna pruriens/Velvet Bean
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Naringin
1 Nimbolide
1 Orlistat
1 Plumbagin
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:73  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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