Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
7593- I3C,    Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
- Review, Pca, NA
Risk↓, TumCG↓, TumCCA↑, P21↑, p27/CDKN1B↑, CDK6↓, cl‑RB1↓, cl‑PARP↑, BAX↑, Bcl-2↓,
7648- Ins,    Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol
- in-vivo, Liver, NA
AntiCan↑, Dose↝, Risk↓, chemoPv↑,
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
7685- iod,    Could iodine be the missing micronutrient in breast cancer development?
- Review, BC, NA
Risk↓, other↝, other↝, BioAv↝,
2172- iod,    A prospective study of iodine status, thyroid function, and prostate cancer risk: follow-up of the First National Health and Nutrition Examination Survey
- Study, Pca, NA
Risk↓,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7659- IP,    Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
- in-vivo, Colon, NA
GutMicro↑, SCFAs↑, eff↑, Buty↑, Risk↓,
7712- IP6,    Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
- in-vivo, Pca, NA
toxicity↓, PCNA↓, TumCG↓, TumCP↓, Apoptosis↑, Risk↓,
7727- IP6,    Suppression of colonic cancer by dietary phytic acid
- Review, Nor, NA
*IronCh↑, *ROS↓, Risk↓,
7740- isoFl,    Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial
- Trial, Pca, NA
Dose↝, Risk∅,
7739- isoFl,    Soy, red clover, and isoflavones and breast cancer: a systematic review
- Review, BC, NA
Dose↝, Risk↓, toxicity↓,
7737- isoFl,    An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health
- Review, Nor, NA
*cardioP↑, Risk↓, *BMD↑, *eff↑, *antiOx↑, *lipid-P↓, *LDL↓, AntiThr↑, AntiAg↑, PSA↓, TumCCA↑, cognitive↑, memory↑,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7841- ISQ,    Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease
- Human, CardioV, NA
*Risk↓, *BioAv↑, *Dose↝, *eff↑,
4005- K+,    Potassium
- Review, Nor, NA - Review, Stroke, NA
*Risk↓, *Dose↝, *Risk↓, *BMD↑, *glucose↓,
4010- K+,    Potassium-sparing diuretics might reduce risk of Alzheimer's disease
- Review, AD, NA
*Risk↓, *ROS↓, *Inflam↓, *AntiAg↑,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8062- KAE,    A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
- Study, Ovarian, NA
Risk↓, other↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8116- LA,    Associations of Cervicovaginal Lactobacilli With High-Risk Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia, and Cancer: A Systematic Review and Meta-Analysis
- Review, Cerv, NA
Risk↓,
1789- LEC,    Risk.33.aspx">Lecithin Supplements and Breast Cancer Risk
- Analysis, BC, NA
AntiCan↑, Risk↓,
8124- LF,    Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine
- Trial, CRC, NA
Risk↓, Dose↝, NK cell↑, Neut↑, CD4+↑, Imm↑, APG↓,
8298- lign,    Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer
- in-vitro, BC, MDA-MB-231
Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,
8345- Lut,    Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, SOD2↓, HO-1↓, NRF2↓, p‑Akt↓, p‑ERK↓, NF-kB↓, Apoptosis↑, Casp3↑, Bcl-2↓, PARP↓, ROS↓, XBP-1↓, Dose↝, Risk↓, MMP↓, selectivity↑, p‑Akt↓,
8354- Lut,  Zeax,    The Associations of Plasma/Serum Carotenoids with Alzheimer's Disease: A Systematic Review and Meta-Analysis
- Study, AD, NA
*Risk↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
4195- Lut,  Zeax,    Low Xanthophylls, Retinol, Lycopene, and Tocopherols in Grey and White Matter of Brains with Alzheimer’s Disease
- Human, AD, NA
*Risk↓, *cognitive↑, *other↓,
3816- Lyco,  Lut,  Zeax,    Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults
- Review, AD, NA
*Risk↓,
7742- Lyco,  isoFl,    Lycopene and soy isoflavones in the treatment of prostate cancer
- Trial, Pca, NA
Risk↓, PSA↓, Dose↝, eff↝,
8420- Lyco,    Anticancer activity of lycopene in HT-29 colon cancer cell line
- in-vitro, CRC, HT-29
Risk↓, Dose↝, TumCP↓, Casp3↑, BAX↑, cl‑PARP↑, 8-oxo-dG↑, γH2AX↑, Cyt‑c↑,
8410- Lyco,    Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose-response meta-analysis of prospective cohort studies
- Review, Var, NA
Risk↓, Dose↝, Risk↓, OS↑,
8409- Lyco,    Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy
- Trial, Pca, NA
Risk↓, PSA↓, TumCG↓,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4799- Lyco,    Anticancer Properties of Lycopene
- Review, Var, NA
Risk↓, TumCG↓, *antiOx↑, *Inflam↓, TumCP↓, TumCCA↑,
4802- Lyco,    Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose–response meta-analysis of prospective cohort studies
- Review, Var, NA
Risk↓,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4796- Lyco,    The Anti-proliferation Effects of Lycopene on Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,
4793- Lyco,    Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
- in-vitro, GC, AGS
antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
8709- MET,    Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer
- Trial, BC, NA
Risk∅, Dose↝, OS∅,
8710- MET,    Does metformin reduce the risk of cancer in obesity and diabetes? A systematic review and meta-analysis
- Review, Var, NA
Risk∅,
8712- MET,    Metformin Active Surveillance Trial in Low-Risk Prostate Cancer
- Trial, Pca, NA
Dose↝, Risk∅, eff∅,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
5796- MET,    Tumor, whole blood, plasma, and tissue concentrations of metformin in lung cancer patients
- Human, Lung, NA
selectivity↑, AMPK↑, Risk↓, Half-Life↝, ChemoSen↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,

Showing Research Papers: 151 to 200 of 303
Prev Page 4 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 303

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↓, 3,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   lipid-P↑, 1,   NRF2↓, 5,   NRF2↑, 2,   NRF2↝, 1,   PrxI↓, 1,   ROS↓, 9,   ROS↑, 31,   selenoP↑, 1,   SOD↑, 3,   SOD2↓, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   EGF↓, 1,   Insulin↓, 1,   mitResp↑, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 5,   ATP↓, 3,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 2,   glucose↓, 2,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HMG-CoA↓, 3,   lactateProd↑, 1,   LDL↓, 2,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 33,   BAX↑, 12,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 10,   cl‑Casp3↑, 4,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 14,   DR5↑, 2,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 2,   iNOS↓, 3,   MDM2↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 1,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ADCY4↑, 1,   Akt↓, 16,   Akt↑, 1,   p‑Akt↓, 4,   Akt2↓, 1,   cMET↓, 1,   EGFR↓, 4,   ERK↓, 3,   ERK↑, 3,   p‑ERK↓, 2,   HER2/EBBR2↓, 2,   IGFR↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 9,   mTOR↑, 2,   PI3K↓, 9,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 3,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   H3↓, 1,   HATs↑, 1,   HDAC↓, 7,   miR-194↑, 1,   miR-21↓, 1,   miR-590-3p↑, 1,   Myc↓, 1,   MYCN↓, 1,   other↓, 5,   other↑, 8,   other↝, 14,   other∅, 1,   SUZ12↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   IRE1∅, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   NEU1↑, 1,   TumAuto↓, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 8,   DNArepair↑, 1,   hTERT/TERT↓, 1,   P53↑, 12,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 4,   Telomerase↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 4,   CDK6↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   GADD34↑, 2,   GADD45A↓, 1,   Ki-67↓, 6,   P21↓, 2,   P21↑, 7,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑RB1↓, 1,   cl‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMP2↓, 1,   CSCs↓, 3,   EP300↓, 1,   GH↓, 1,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 7,   IGFBP1↑, 1,   JAG1↑, 1,   Ki-67↓, 6,   mTORC1↓, 2,   NOTCH↓, 1,   NOTCH3↑, 1,   TumCG↓, 26,   TumCG↑, 1,   TumCP↓, 35,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 7,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 1,   EMT↓, 4,   EMT↝, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 5,   pax↓, 2,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   serineP↓, 1,   Snail↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 11,   TumCI↑, 1,   TumCMig↓, 12,   TumCMig↑, 1,   TumMeta↓, 21,   UroPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   ECM/TCF↓, 1,   HIF-1↓, 3,   Hif1a↓, 7,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↑, 1,   GLUT1↓, 2,   GLUT2↓, 1,   MMP↓, 16,   MPT↑, 1,   TRPM7↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   DR4↑, 3,   FOXP3↑, 1,   IL10↓, 1,   IL1β↓, 5,   IL2↑, 1,   IL6↓, 2,   Imm↑, 9,   INF-γ↑, 1,   Inflam↓, 11,   MCT1↓, 1,   Neut↑, 1,   NF-kB↓, 14,   NF-kB⇅, 1,   p‑NF-kB↓, 1,   NK cell↑, 4,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 7,   SOCS-3↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AR↝, 1,   DHT↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARγ↑, 2,   SXR↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 7,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 40,   ChemoSen∅, 1,   CYP1A1↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 2,   Dose↓, 4,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 44,   Dose∅, 3,   eff↓, 4,   eff↑, 20,   eff↝, 11,   eff∅, 5,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 11,   selectivity↑, 16,   Synergy↑, 24,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BloodF↓, 1,   BMD↑, 2,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   Hcy/homoC↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 7,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiCan∅, 2,   antiNeop↑, 1,   AntiTum↑, 7,   APG↓, 1,   cardioP↑, 3,   chemoP↑, 17,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↓, 2,   OS↑, 16,   OS∅, 3,   Pain↓, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 213,   Risk↑, 16,   Risk⇅, 3,   Risk↝, 7,   Risk∅, 18,   Sleep↑, 1,   toxicity↓, 9,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 7,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 387

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 26,   Catalase↑, 6,   GPx↓, 1,   GPx↑, 10,   GPx1↑, 1,   GSH↑, 3,   GSR↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 7,   MDA↓, 4,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 6,   ROS↓, 36,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 10,   SOD↑, 9,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   Acetyl-CoA↑, 1,   adiP↓, 1,   ALAT↓, 1,   AMPK↑, 5,   ATP↑, 2,   ATP↝, 1,   CRM↑, 2,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   LDL↓, 9,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   JNK↓, 1,   MAPK↓, 2,   mTOR↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other?, 3,   other↓, 8,   other↑, 12,   other↝, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 9,   Ca+2↝, 1,   Cartilage↑, 2,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP-10↝, 1,   MMP9↓, 1,   MUC1↑, 1,   serineP↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   TXA2↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB∅, 1,   CLDN1↑, 1,   CLDN3↑, 1,   IBI↑, 1,   MMP↑, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 7,   COX2/PTGS2↓, 5,   IFN-γ↓, 2,   IL1↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 5,   Imm↑, 5,   Inflam↓, 38,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 12,   VitD↑, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 3,   AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 1,   BrainVol↑, 1,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 11,   Aβ↑, 1,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 2,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 24,   BioAv⇅, 1,   BioAv↝, 4,   Dose?, 1,   Dose↓, 2,   Dose↑, 5,   Dose↝, 28,   eff↓, 5,   eff↑, 6,   eff↝, 3,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 5,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BG↓, 1,   BMD↑, 4,   BP↓, 7,   Calcium↑, 2,   Calcium↝, 1,   CRP↓, 8,   Hcy/homoC↓, 3,   hs-CRP↓, 2,   IL6↓, 5,   Mag↑, 2,   TC↓, 1,   TG/TAG↓, 1,   TMAO↑, 3,   VitD↑, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 9,   AntiTum↓, 1,   BOLD↑, 1,   cardioP↑, 19,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 41,   cognitive↝, 2,   cognitive∅, 1,   hepatoP↑, 5,   memory↑, 11,   Mood↑, 2,   motorD↓, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 3,   Risk↓, 75,   Risk↑, 14,   Risk↝, 1,   Risk∅, 3,   Strength↑, 3,   Stroke↓, 5,   Stroke↑, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 3,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 18,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 5,  
Total Targets: 236

Scientific Paper Hit Count for: Risk, Risk
23 Selenium
18 Folic Acid, Vit B9
16 Boron
15 Selenite (Sodium)
14 Lycopene
13 Aspirin
10 Vitamin D3
10 Magnesium
9 Choline
8 Vitamin B6,pyridoxine
7 Vitamin K2
7 Metformin
6 Allicin (mainly Garlic)
6 Lutein
6 Vitamin C (Ascorbic Acid)
6 diet Plant based
6 Exercise
6 Vitamin B12
6 Flaxseed/Linseed
6 Kaempferol
6 Phenethyl isothiocyanate
5 Chemotherapy
5 Hormone replacement therapy
5 Calcium
5 diet Fermented Foods
5 isoflavones
5 Selenium NanoParticles
4 beta-carotene(VitA)
4 Zeaxanthin
4 Capsaicin
4 Coenzyme Q10
4 Vitamin E
4 Sulforaphane (mainly Broccoli)
4 Melatonin
4 Vitamin B5,Pantothenic Acid
3 Aluminum
3 Radiotherapy/Radiation
3 Celecoxib
3 Chlorogenic acid
3 Chocolate
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Silicic Acid
3 iodine
3 Urolithin
2 5-Hydroxytryptophan
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Bruteridin(bergamot juice)
2 Butyrate
2 EGCG (Epigallocatechin Gallate)
2 flavonoids
2 Indole-3-carbinol
2 Inulin Prebiotic
2 phytic acid, Inositol hexakisphosphate
2 Potassium
2 Quercetin
2 chitosan
2 Taurine
2 Vitamin B1/Thiamine
1 Anthocyanins
1 alpha Linolenic acid
1 Astaxanthin
1 beta-glucans
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Bullatacin
1 Carvacrol
1 Catechins
1 Chyawanprash
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Vitamin A, Retinoic Acid
1 Fisetin
1 Fucoidan
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Graviola
1 Grapeseed extract
1 Inositol
1 isoquercitrin
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 Oleuropein
1 Broccoli
1 Rutin
1 buckwheat sprouts
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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