DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
474- CUR,    Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
6682- DCA,  QC,    Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
- in-vivo, HNSCC, MEER
PDK1↓, lactateProd↓, GlucoseCon↓, tumCV↓, mTOR↓, Apoptosis↑, ROS↑, TumCG↓, pH↑, cl‑PARP↑, Casp3↑, DNAdam↑, p‑γH2AX↑, eff↓, OS↑,
1444- Deg,    Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
- in-vitro, GC, MKN-28
Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6668- DFE,  AgNPs,    Saponin-Derived Silver Nanoparticles from Phoenix dactylifera (Ajwa Dates) Exhibit Broad-Spectrum Bioactivities Combating Bacterial Infections
- in-vitro, Lung, A549
*AntiBio↑, antiOx↑, TumCD↑, ROS↑, DNAdam↑, *Catalase↑, *GPx↑, *SOD↑, *ROS↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1851- dietFMD,  Chemo,    Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
- in-vitro, GBM, LN229 - in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, selectivity↑, ROS↑, DNAdam↑, BG↓,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, eff↑, HO-1↓, DNAdam↑, eff↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1↑, ATG7↑, Bcl-2↓, NO↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *Albumin↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6740- DSF,    Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway
NPL4↓, other↝, DNAdam↑,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
6611- Ech,    Proliferative activity of a blend of Echinacea angustifolia and Echinacea purpurea root extracts in human vein epithelial, HeLa, and QBC-939 cell lines, but not in Beas-2b cell lines
- in-vitro, Cerv, HeLa - in-vitro, Nor, BEAS-2B - in-vitro, Nor, HUVECs
Imm↑, TumCP↑, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓,
6606- Ech,  Cic,    Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓, eff↑,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2↓, 5LO↓,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
6410- EGCG,    Evaluation of the neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage
- in-vitro, Nor, NA
*FIS1↓, *neuroP↑, *Ca+2↓, *VGCC↝, *ROS↓, *DNAdam↓, *Apoptosis↓,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
1331- EMD,    Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
- in-vitro, NPC, NA
TumCCA↑, CycB/CCNB1↑, DNAdam↑, Casp3↑, cl‑PARP↑, MMP↓, Ca+2↑, ROS↑,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, eff↑, MMP2↓, MMP9↓, eff↑, ChemoSen↑, P-gp↓, SREBP2↓, eff↑, *other↝, *COX2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?,
6834- EMD,    Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9
- in-vitro, Cerv, HeLa
AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, TumCD↑, DNAdam↑,
5527- EP,    Nanosecond pulsed electric field (nsPEF) application effects on human cells: intracellular membrane disruption and apoptosis induction
- in-vivo, Var, NA
*Dose↓, Apoptosis↑, DNAdam↑, mtDam↑,
5492- EP,    Nano-Pulse Stimulation Therapy in Oncology
- in-vivo, PC, Panc02 - in-vivo, BC, 4T1
CellMemb↑, Ca+2↑, DNAdam↑, eff↝, Imm↑,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, eff↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, Apoptosis↑, Diff↑, TumCP↓, Wound Healing↑, CellMemb↑, VGCC↑, VGSC↑, DNAdam↑, selectivity↑,
6576- EU,    Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
- in-vitro, HCC, HepG2
TumCD↑, selectivity↑, Apoptosis↓, ChrMod↑, DNAdam↑, P53↑, BAX↑, Bcl-2↓, Cyt‑c↑, eff↑, TumCCA↑,
6585- EU,    Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
- vitro+vivo, AML, K562
Dose↝, TumCG↓, Apoptosis↑, TumCCA↑, DNAdam↑, Akt↓, Bcl-2↓, PCNA↓,
6586- EU,    Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
TumCD↑, DNAdam↑, TumCCA↑, Cyt‑c↑, Casp3↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27↑, NF-kB↓, COX2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,

Showing Research Papers: 151 to 200 of 360
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 360

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NPL4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   CYP1A1↑, 1,   Fenton↑, 1,   GSH↓, 2,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   H2O2↑, 1,   HO-1↓, 4,   HO-1↑, 1,   HO-2↓, 1,   lipid-P↑, 1,   i-MDA↑, 1,   NQO1↑, 1,   NRF2↓, 1,   OXPHOS↑, 2,   ROS↑, 28,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,   SOD1↓, 1,   Trx2↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 2,   ATP↑, 1,   ETC↝, 1,   Insulin↓, 2,   MMP↓, 9,   mtDam↑, 4,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 4,   ATG7↑, 1,   cMyc↓, 1,   CRM↑, 1,   ECAR↝, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   GLUT2↓, 1,   Glycolysis↓, 4,   lactateProd↓, 3,   LDHA↓, 1,   PDK1?, 2,   PDK1↓, 2,   p‑S6K↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   Akt↑, 2,   p‑Akt↓, 5,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 23,   mt-Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 4,   Bcl-2↓, 8,   Bcl-xL↓, 3,   Casp↑, 1,   Casp3↑, 18,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 4,   Casp9↑, 14,   Cyt‑c↓, 1,   Cyt‑c↑, 5,   Diablo↑, 1,   Fas↑, 1,   iNOS↓, 1,   JNK↑, 1,   JWA↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p27↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 3,   TumCD↑, 9,  

Kinase & Signal Transduction(tgid=6) ⓘ

FOXD3↑, 1,   HER2/EBBR2↓, 3,   SOX9?, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   EZH2↓, 1,   ac‑H3↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↑, 2,   other↝, 2,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   ER Stress↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1↑, 2,   LAMP2↑, 1,   LC3II↓, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   DNAdam↓, 1,   DNAdam↑, 44,   mt-DNAdam↑, 1,   DNMT1↓, 2,   GADD45A↑, 1,   p16↑, 1,   P53↑, 9,   p‑P53↑, 1,   cl‑PARP↑, 7,   PCNA↓, 1,   SIRT6↑, 1,   TP53↑, 1,   γH2AX↑, 2,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↑, 7,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD133↓, 1,   CD44↓, 1,   CDK8↓, 1,   CSCs↓, 6,   Diff↑, 1,   EMT↓, 6,   ERK↓, 1,   p‑ERK↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGF-1↓, 4,   IGFBP7↑, 1,   mTOR↓, 7,   mTOR⇅, 1,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   OCT4↓, 1,   PI3K↓, 6,   PI3K↑, 1,   PTEN↑, 3,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 4,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT5↓, 1,   TumCG↓, 8,   VGCC↑, 1,   VGSC↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg?, 1,   Ca+2↑, 4,   Ca+2↝, 1,   CXCL12↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   p‑FAK↓, 1,   LAMs↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMPs↓, 2,   NEDD9↓, 1,   PKCδ↓, 2,   Slug↓, 1,   SMAD3↓, 3,   p‑SMAD4↓, 1,   Snail↓, 2,   STAC2↓, 1,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↑, 1,   Treg lymp↓, 1,   TSC1↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 14,   TumCP↑, 1,   TumMeta↓, 4,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   EGFR↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 5,   Hypoxia↓, 1,   miR-210↓, 1,   NO↓, 1,   VEGF↓, 8,   VEGFR2↓, 1,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 2,   CTR1↑, 1,   GLUT1↓, 2,   NHE1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2↓, 4,   CXCR4↓, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL6↓, 1,   Imm↑, 7,   Inflam↓, 3,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 1,   M2 MC↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 2,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 16,   DDS↑, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   Dose∅, 4,   DrugR↓, 1,   eff↓, 3,   eff↑, 30,   eff↝, 3,   Half-Life↓, 1,   RadioS↑, 7,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   EZH2↓, 1,   GutMicro↑, 3,   HER2/EBBR2↓, 3,   IL6↓, 1,   Myc↓, 1,   PD-L1↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   ChemoSideEff↓, 2,   OS↑, 2,   QoL↑, 1,   Risk↓, 2,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 282

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   lipid-P↓, 1,   MDA↓, 1,   RNS↓, 1,   ROS↓, 8,   SOD↓, 1,   SOD↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

FIS1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↓, 1,   LDL↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   VGCC↝, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   PKCδ↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a↑, 1,   NO↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CRP↓, 1,   Imm↑, 1,   Inflam↓, 7,   NF-kB↓, 1,   NK cell↑, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   MAOA↓, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioEnh↑, 1,   Dose↓, 1,   Dose↝, 3,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Albumin↝, 1,   creat↓, 1,   CRP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   RenoP↑, 1,   toxicity?, 1,   toxicity↓, 3,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 67

Scientific Paper Hit Count for: DNAdam, DNA damage
31 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
12 Curcumin
9 Fisetin
7 Cisplatin
7 Ashwagandha(Withaferin A)
7 Chrysin
7 Quercetin
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Chemotherapy
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 doxorubicin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 Anethole/trans-Anethole
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Magnolol
3 Magnetic Field Rotating
3 Nimbolide
3 Phenethyl isothiocyanate
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 chitosan
2 Moringa oleifera
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Gallic acid
2 Garcinol
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Hydroxycinnamic-acid
2 Juglone
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Zinc
1 carboplatin
1 Catechins
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Ferulic acid
1 Galloflavin
1 Gambogic Acid
1 Honokiol
1 HydroxyTyrosol
1 Licorice
1 Luteolin
1 Methyl salicylate / Sweet Birch oil
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 Urolithin
1 Iron
1 Magnesium
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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