E-cadherin Cancer Research Results

E-cadherin, E-cadherin: Click to Expand ⟱
Source: HalifaxProj(restore)
Type:
Also known as Cadherin1 (CDH1)
E-cadherin, is a type of cell adhesion molecule that plays a crucial role in maintaining tissue structure and cell-cell interactions. In the context of cancer, E-cadherin has been found to be a tumor suppressor gene.

E-cadherin is a transmembrane protein that mediates cell-cell adhesion through its extracellular domain, which interacts with other E-cadherin molecules on adjacent cells. This interaction helps to maintain tissue integrity and prevent cancer cells from invading surrounding tissues.

In many types of cancer, including breast, colon, and prostate cancer, E-cadherin expression is often reduced or lost.
cell adhesion molecules spanning four families of 1) Integrins (α2β1, α5/β1, αL/β2); 2) Cadherins (E-cad, P-cad, N-cad); 3) Ig-CAMs (VCAM, NCAM, ICAM, Nectins, Necl); and 4) Selectins (E-selectin, P-selectin, L-selectin).


Scientific Papers found: Click to Expand⟱
1131- PI,    Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
1163- PI,    E-cadherin_Expression_in_Breast_Cancer_MCF-7_Cell_Line">The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line
- in-vitro, BC, MC38
tumCV↓, VEGF↓, MMP9↓, E-cadherin↓,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
2973- PL,    The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1
MMP2↓, MMP9↓, IL6↓, E-cadherin↑, ROS↑, EMT↓, Zeb1↓, Slug↓, TumMeta↓, selectivity↑, MMP2↓, GSH↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
4693- PTS,    Pterostilbene in the treatment of inflammatory and oncological diseases
BioAv↑, *Inflam↓, *antiOx↑, AntiTum↑, BBB↑, Half-Life↝, *ROS↓, *NRF2↑, *NQO1↑, *HO-1↑, PTEN↑, miR-19b↓, TumCCA↑, ER Stress↑, PERK↑, ATF4↑, CHOP/DDIT3↑, Ca+2↝, EMT↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, ChemoSen↑, toxicity∅, toxicity↝,
4701- PTS,  RES,    Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene
- Review, Var, NA
CSCs↓, E-cadherin↑, NF-kB↓, EMT↓, GRP78/BiP↓, CD133↓, COX2/PTGS2↓, β-catenin/ZEB1↓, NOTCH↓,
4700- PTS,    Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
CSCs↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑,
4699- PTS,    Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vivo, BC, MDA-MB-231
TumCMig↓, TumCI↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, Zeb1↑, miR-205↑, Src↓, TumCG↓, FAK↓, EMT↓,
4698- PTS,    Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF ‐κ B /microRNA 448 circuit
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
CSCs↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, miR-448↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
65- QC,    Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
- in-vitro, BC, NA
HSP27↓, EMT↓, NF-kB↓, Snail↓, Vim↓, E-cadherin↑, CSCs↓,
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF7
EMT↓, E-cadherin↑, Vim↓, MMP2↓, NOTCH1↓, PI3K/Akt↓, PI3k/Akt/mTOR↓, p‑Akt↓, EZH2↓, H3K27ac↓, TumCCA↑, CSCs↓, CDK1↓, CycB/CCNB1↓, Bcl-xL↓, Bcl-2↓, Nanog↓, H3↓,
53- QC,    Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer
- in-vitro, BC, MDA-MB-231 - NA, NA, MDA-MB-468
E-cadherin↑, Vim↓, cycD1/CCND1↓, cMyc↓, EMT↓, TumCG↓, TumCMig↓, β-catenin/ZEB1↓, ChemoSen↑,
96- QC,  docx,    Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
PI3K/Akt↓, Ki-67↓, BAX↑, Bcl-2↓, EpCAM↓, Twist↓, E-cadherin↑, P-gp/ABCB1↓, TumCP↓, TumCMig↓, TumCI↓,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
EMT↓, E-cadherin↑, N-cadherin↓, Ki-67↓, PI3K/Akt↓, MALAT1↓, TumCG↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
101- RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑, TumCI↓, TumMeta↓,
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
PD-L1↑, Snail↑, E-cadherin↓, N-cadherin↑, Fibronectin↑, Vim↑, Axin2↓,
878- RES,    Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression
- vitro+vivo, CRC, LoVo
TumMeta↓, E-cadherin↑, Vim↓, TGF-β↓, SMAD2↓, EMT↓, SMAD3↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
*ROS↓, ROS↑, DNAdam↑, Apoptosis↑, Hif1a↑, Casp3↑, Casp9↑, Cyt‑c↑, Dose↝, MMPs↓, MMP2↓, MMP9↓, EMT↓, E-cadherin↑, N-cadherin↓, AR↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3025- RosA,    Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
- in-vivo, IBD, NA
*GutMicro↑, *ROCK1↓, *Rho↓, *CaMKII ↓, *Zeb1↓, *ZO-1↓, *E-cadherin↓, *IL1β↓, *IL6↓, *TNF-α↓, *GRP78/BiP↓, *PERK↓, *IRE1↓, *ATF6↓, *CHOP/DDIT3↓, *Casp12↓, *Casp9↓, *BAX↓, *Casp3↓, *Cyt‑c↓, *RIP1↓, *MLKL↓, *IL10↑, *Bcl-2↑, *ER Stress↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
1132- RT,    Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2/KDR/Flk1↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, eff↑,
1136- SFN,    Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells
- in-vitro, Lung, NA - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Snail↓, ERK5↑, EMT↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,
1462- SFN,    Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2/PTGS2↝, MMP2↝, MMP9↝,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3322- SIL,    Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, HATs↑, Zeb1↓, E-cadherin↑, TumCMig↓,
2357- SK,    GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism
- Study, HCC, NA - in-vivo, NA, NA
AntiTum↑, GTPBP4↓, PKM2↓, lactateProd↓, GlucoseCon↓, Glycolysis↓, E-cadherin↑, TumCG↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,
1575- statins,  Citrate,    Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kinase (PI3K)/AKT Pathways
- in-vitro, NSCLC, A549
eff↑, HMG-CoA↓, eff↑, AntiTum↑, EGFR↓, eff↑, ROS↑, EMT↓, E-cadherin↑, MUC1↑, p‑ACLY↓, p‑Akt↓, eff↑,

Showing Research Papers: 151 to 200 of 218
Prev Page 4 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 218

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 1,   GSH↓, 3,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 4,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS?, 1,   ROS↓, 4,   ROS↑, 14,   SOD↓, 1,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC?, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

ATP↓, 2,   MMP↓, 7,   mtDam↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4)

p‑ACLY↓, 1,   AMPK↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   cMyc↓, 9,   FGF21↓, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   HMG-CoA↓, 1,   lactateProd↓, 2,   PFK↓, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,   POLD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5)

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 6,   BAD↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 14,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 1,   Casp1↓, 1,   Casp10↑, 1,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 9,   cl‑Casp3↑, 3,   Casp7↑, 2,   Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 6,   cFLIP↓, 1,   CK2↓, 1,   Cyt‑c↑, 4,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 2,   Fas↑, 2,   hTERT/TERT↓, 1,   IAP1↓, 1,   iNOS↓, 2,   p‑JNK↓, 1,   Mcl-1↓, 1,   MDM2↓, 2,   p27/CDKN1B↑, 2,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 5,   Telomerase↓, 2,   TNFR 1↑, 1,   TRAILR↑, 1,  

Kinase & Signal Transduction(tgid=6)

HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7)

EZH2↓, 1,   H3↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↑, 2,   miR-205↑, 1,   other↓, 1,   tumCV↓, 6,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9)

Beclin-1↓, 1,   BNIP3↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10)

DFF45↑, 1,   DNAdam↑, 3,   DNMTs↓, 3,   P53↑, 8,   cl‑PARP↑, 4,   PARP1↑, 1,   PCNA↓, 3,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11)

CDK1↓, 3,   CDK2↓, 1,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 1,   P21↑, 4,   RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12)

ALDH↓, 1,   ALDH1A1↓, 1,   Axin2↓, 1,   CD133↓, 1,   CD44↓, 5,   cFos↓, 1,   cMET↓, 1,   cMYB↓, 1,   CSCs↓, 12,   Diff↓, 1,   EMT↓, 32,   EMT↑, 1,   EpCAM↓, 1,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 2,   ERK5↑, 1,   FOXM1↓, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli1↓, 4,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   GTPBP4↓, 1,   H3K27ac↓, 1,   HDAC↓, 4,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 1,   HDAC8↓, 1,   HH↓, 2,   HOXB-AS1↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   miR-448↑, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   Nanog↓, 5,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH⇅, 1,   NOTCH1↓, 3,   NOTCH2↓, 1,   OCT4↓, 2,   PDGFRA↓, 1,   PI3K↓, 6,   p‑PI3K↑, 1,   PTCH1↓, 1,   PTEN↑, 5,   Shh↓, 2,   Smo↓, 2,   SOX2↓, 2,   Src↓, 1,   STAT3↓, 9,   STAT5↓, 1,   TCF↓, 1,   TOP2↓, 2,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 7,  

Migration(tgid=13)

AntiAg↓, 1,   CA↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   E-cadherin↓, 8,   E-cadherin↑, 40,   FAK↓, 2,   Fibronectin↓, 1,   Fibronectin↑, 1,   GIT1↓, 1,   GLI2↓, 1,   Ki-67↓, 6,   LEF1↓, 1,   MALAT1↓, 2,   MARK4↓, 2,   miR-155↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 18,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 17,   MMP9↝, 1,   MMPs↓, 6,   MUC1↑, 1,   N-cadherin↓, 16,   N-cadherin↑, 2,   PDGF↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   Slug↓, 7,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail↓, 13,   Snail↑, 1,   TGF-β↓, 6,   TSP-1↑, 2,   TumCI↓, 12,   TumCMig↓, 13,   TumCMig↑, 1,   TumCP↓, 7,   TumCP↑, 1,   TumMeta↓, 10,   Twist↓, 6,   Twist↑, 1,   uPA↓, 2,   VCAM-1↓, 1,   Vim?, 1,   Vim↓, 22,   Vim↑, 3,   Zeb1↓, 9,   Zeb1↑, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 12,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 8,   ATF4↑, 2,   EGFR↓, 6,   HIF-1↓, 1,   Hif1a↓, 9,   Hif1a↑, 1,   NO↓, 1,   VEGF↓, 17,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15)

BBB↑, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16)

ASC↑, 1,   COX2/PTGS2↓, 9,   COX2/PTGS2↝, 1,   CRP↓, 1,   CXCR4↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 2,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL6↓, 9,   IL6↑, 1,   IL8↓, 2,   Inflam↓, 2,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 15,   p50↓, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Protein Aggregation(tgid=19)

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20)

AR↓, 2,   CDK6↓, 3,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 4,   BioAv↑, 2,   ChemoSen↑, 5,   ChemoSen⇅, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 15,   eff↝, 2,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   MDR1↓, 1,   P450↓, 2,   RadioS↑, 5,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22)

AR↓, 2,   BMPs↑, 1,   CRP↓, 1,   EGFR↓, 6,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 9,   IL6↑, 1,   Ki-67↓, 6,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↓, 1,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   AntiTum↑, 5,   cardioP↑, 3,   chemoP↑, 2,   ChemoSideEff↓, 2,   hepatoP↑, 1,   MKI67↑, 1,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 1,   radioP↑, 1,   toxicity?, 1,   toxicity↓, 1,   toxicity↝, 2,   toxicity∅, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24)

CD8+↑, 1,  
Total Targets: 354

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 7,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   HO-1↑, 2,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 3,   NQO1↑, 1,   NRF2↑, 5,   ROS↓, 10,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2)

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3)

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

ALAT↓, 1,   AMPK↑, 1,   PPARγ↑, 1,   SIRT1↑, 4,  

Cell Death(tgid=5)

BAX↓, 1,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 2,   JNK↑, 1,   MLKL↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6)

CaMKII ↓, 1,  

Protein Folding & ER Stress(tgid=8)

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   IRE1↓, 1,   PERK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12)

EMT↓, 1,   GSK‐3β↓, 1,  

Migration(tgid=13)

COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP2↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad7↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14)

angioG↑, 2,  

Immune & Inflammatory Signaling(tgid=16)

COX2/PTGS2↓, 1,   HMGB1↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 6,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18)

5HT↑, 1,   AChE↓, 1,  

Protein Aggregation(tgid=19)

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   eff↑, 2,   P450↓, 1,  

Clinical Biomarkers(tgid=22)

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23)

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 4,   CardioT↓, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 3,   motorD↑, 1,   neuroP↑, 5,  
Total Targets: 84

Scientific Paper Hit Count for: E-cadherin, E-cadherin
16 Curcumin
11 Resveratrol
7 Fisetin
7 Luteolin
7 Quercetin
6 Pterostilbene
6 Sulforaphane (mainly Broccoli)
6 Thymoquinone
5 Honokiol
4 Astragalus
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Berberine
4 Chrysin
4 Inositol
4 Piperine
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Propolis -bee glue
3 Cinnamon
3 5-fluorouracil
3 Cyclopamine
3 Eugenol
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Magnolol
3 Urolithin
2 Allicin (mainly Garlic)
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Boron
2 Capsaicin
2 Carvacrol
2 Chlorogenic acid
2 Hydroxycinnamic-acid
2 Citric Acid
2 Ellagic acid
2 Emodin
2 Fucoidan
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Isoliquiritigenin
2 Juglone
2 Kaempferol
2 Laetrile B17 Amygdalin
2 Lycopene
2 Piperlongumine
2 Shikonin
2 Selenite (Sodium)
2 Ursolic acid
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 brusatol
1 Butyrate
1 Caffeic acid
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Crocetin
1 Oxaliplatin
1 diet FMD Fasting Mimicking Diet
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Sorafenib (brand name Nexavar)
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgolide B
1 Proanthocyanidins
1 Chemotherapy
1 HydroxyTyrosol
1 capecitabine
1 Melatonin
1 Metformin
1 Naringin
1 Oroxylin A
1 Oleuropein
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Docetaxel
1 Rutin
1 salinomycin
1 Selenate
1 statins
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:89  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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