AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
8149- lamb,    Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, TumCCA↑, AMPK↑, Akt↓, FOXM1↓, Bcl-2↓, CycB/CCNB1↓, APOE4↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, Var, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
3265- Lyco,    Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- in-vitro, Nor, NA
*AMPK↑, *mTOR↓, *NLRP3↓, *Pyro↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
8492- MAG,    Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway
- in-vivo, AD, NA
*Apoptosis↑, *cl‑Casp9↓, *BAX↓, *Bcl-2↓, *p62↓, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ULK1/ATG1↑,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
4531- MAG,    Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway
- in-vitro, CRC, HCT116
Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, p‑AMPK↑, Bcl-2↓, P53↑, BAX↑, Cyt‑c↑, TumCMig↓, TumCI↓,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
6538- MeSal,  ASA,    Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- in-vitro, CRC, NA
chemoPv↑, AMPK↑, NRF2↑, miR-34a↑, cMyc↓, tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, MET↑,
6537- MeSal,    The ancient drug salicylate directly activates AMP-activated protein kinase
- Review, Nor, NA
*BioAv↝, *AMPK↑, *Half-Life↝,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
2492- MET,    The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
- Review, Nor, NA
*glucose↓, *glucoNG↓, *AMPK↑,
2456- MET,    Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
GlucoseCon↓, TumCG↓, HK2↓, p‑AMPK↑, TXNIP↓, *toxicity↓,
2383- MET,    Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2
- in-vitro, RCC, A498
AMPK↑, TumCP↓, eff↓, eff↑,
2379- MET,    Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, BC, UMUC3
PKM2↓, p‑STAT3↓, TumCG↓, Synergy↑, chemoP↑, AMPK↑,
2377- MET,    Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
EMT↓, P70S6K↓, mTOR↓, PKM2↓, Warburg↓, AMPK↑,
2386- MET,    Mechanisms of metformin inhibiting cancer invasion and migration
- Review, Var, NA
OS↑, AMPK↑, EMT↓, TGF-β↓, mTOR↓, P70S6K↓, PKM2↓, Hif1a↓, ChemoSen↑,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
5796- MET,    Tumor, whole blood, plasma, and tissue concentrations of metformin in lung cancer patients
- Human, Lung, NA
selectivity↑, AMPK↑, Risk↓, Half-Life↝, ChemoSen↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
994- MET,    Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy
- in-vitro, Var, NA
Glycolysis↓, HK2↓, ATP↓, AMPK↑, P53↑, Warburg↓, Apoptosis↑,
970- MET,    Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer
- in-vitro, BC, NA
CAFs/TAFs↝, p‑AMPK↑, PHDs↑, Hif1a↓, TumCI↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
3499- MFrot,  MF,    Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans
- in-vitro, Nor, HUVECs
*AntiAge↑, *AMPK↑, *mPGES-1↓, *Ca+2↑, *ER Stress↑, *OS↑, *ROS↓,
8478- MFrot,    Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity
- vitro+vivo, Lung, NA
Dose↝, Dose↝, AMPK↑, NF-kB↑, pol-M1↝, OS?, Dose↝, Dose↝, eff↝, eff↑,
8898- MOR,    Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells
- in-vitro, Cerv, HeLa
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, WEE1↑, CDK1↓, CDC25↓, survivin↓, CycB/CCNB1↓, Chk2↓, BAX↑, BAD↑, Cyt‑c↑, APAF1↑, Casp9↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, Casp10↑, PARP↑, PI3K↑, Akt↑, mTOR↑, p70S6↑, Diablo↑, Bcl-2↓, Bcl-xL↓, AMPK↓, IAP1↓, NF-kB↓, ROS↑,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
8878- MOR,    Investigating the Effects of Morin and Aminoimidazole Carboxamide Ribonucleotide on the AMPK/mTOR/ULK1 Signaling Pathway in Breast Cancer Cell Line (MCF-7)
- in-vitro, BC, MCF7
tumCV↓, p‑AMPK↑, p‑ULK1/ATG1↑, LC3B↑, p‑mTOR↓, mt-ROS↑, MMP↓, tumCV↓, TumCP↓, Apoptosis↑,
8936- MushCha,    Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis
- vitro+vivo, Lung, LLC1
AMPK↑, tumCV↓, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, MMP↓, OXPHOS↓, Glycolysis↓, Dose?, MPT↑, ATP↓,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
1237- PTS,    Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade
- in-vitro, Ovarian, SKOV3
TumCMig↓, TumCI↓, MDA↑, ROS↑, BAX↑, Casp3↑, Bcl-2↓, SREBP1/SREBF1↓, FASN↓, AMPK↓, p‑AMPK↑, p‑P53↑, p‑TSC2↑, p‑Akt↓, p‑mTOR↓, p‑S6K↓, p‑4E-BP1↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3381- QC,    Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
- in-vitro, Cerv, HeLa
SREBP1/SREBF1↓, TumCP↓, TumCD↑, AMPK↑, SREBP1/SREBF1↓, FASN↓, ACC↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
*AMPK↑, *IRE1↓, *p‑PERK↓, *p‑tau↓, *cognitive↑, *antiOx↑, *ER Stress↓, *Inflam↓, *neuroP↑, *TXNIP↓, *NLRP3↓,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2/PTGS2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE/β-secretase↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,

Showing Research Papers: 151 to 200 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 4,   GSH↓, 5,   GSH↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 5,   i-Iron↓, 1,   lipid-P↑, 8,   MDA↑, 5,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 9,   Prx↓, 1,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 8,   ROS↑, 74,   ROS⇅, 3,   mt-ROS↑, 8,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   TKT↝, 1,   Trx↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 5,   compI↓, 3,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam↑, 8,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 3,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↓, 5,   ACC↑, 5,   p‑ACC↑, 2,   p‑ACC-α↑, 1,   ACLY↓, 5,   adiP↑, 1,   AMP↑, 2,   AMPK?, 1,   AMPK↓, 6,   AMPK↑, 128,   AMPK↝, 2,   p‑AMPK↑, 20,   ATP↓, 17,   mt-ATP↓, 1,   CRM↑, 2,   ECAR↓, 3,   FAO↑, 1,   FASN↓, 9,   FDG↓, 1,   G6PD↓, 3,   GLS↓, 3,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 7,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 23,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 15,   HK2↑, 1,   lactateProd↓, 8,   lactateProd↑, 3,   LDHA↓, 6,   LDHA↑, 1,   LDL↓, 1,   lipidLev↓, 2,   lipoGen↓, 2,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PFK1↓, 1,   PKM2↓, 11,   PKM2↑, 1,   PPP↓, 2,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 5,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↑, 58,   ASC↑, 1,   BAD↓, 1,   BAD↑, 4,   Bak↑, 4,   BAX↓, 2,   BAX↑, 28,   Bax:Bcl2↑, 7,   Bcl-2↓, 37,   Bcl-xL↓, 11,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp10↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 10,   Casp7↑, 4,   Casp8↑, 11,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 23,   cl‑Casp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 26,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   FADD↑, 6,   Fas↓, 1,   Fas↑, 9,   FasL↑, 7,   Ferroptosis↑, 9,   IAP1↓, 2,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 7,   Mcl-1↑, 1,   MDM2↓, 3,   MOMP↑, 1,   NAIP↓, 1,   p38↓, 1,   p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 12,   TRAIL↑, 2,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 46,   Akt↑, 5,   p‑Akt↓, 11,   p‑Akt↑, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   cMET↓, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 12,   ERK↓, 12,   ERK↑, 3,   p‑ERK↓, 3,   IGF-1R↓, 1,   IKKα↓, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 10,   MAPK?, 1,   MAPK↓, 9,   MAPK↑, 4,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 1,   mTOR↓, 58,   mTOR↑, 11,   mTOR↝, 1,   mTOR∅, 1,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   P70S6K↑, 1,   P90RSK↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 30,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PP2A↑, 1,   PTEN↑, 5,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   p‑S6K↓, 4,   Sp1/3/4↓, 3,   Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   STAT3↑, 1,   p‑STAT3↓, 6,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 4,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 12,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   H3↑, 1,   p‑H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 4,   HDAC∅, 1,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 3,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   miR-326-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-592↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↓, 3,   other↑, 1,   other↝, 3,   SOX2↓, 3,   SOX4↓, 2,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 17,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 4,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 10,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 6,   PARK2↑, 2,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 27,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↑, 22,   DNArepair↓, 1,   NBR2↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 30,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 20,   cl‑PARP1↑, 1,   PCNA↓, 6,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 16,   CDK4↑, 2,   CDK6↓, 5,   CDK6↑, 2,   CDK7↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 24,   cycE/CCNE↓, 7,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 8,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 15,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 52,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMI1↓, 2,   BMP7/OP1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 2,   cFos↓, 5,   CSCs?, 1,   CSCs↓, 16,   Diff↓, 1,   Diff↑, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGFBP1↑, 2,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH1↓, 3,   NOTCH3↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 3,   Smo↓, 1,   Sufu↓, 1,   TumCG↓, 34,   TumCG↑, 1,   TumCP↓, 49,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 17,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 4,   ASAP2↓, 1,   Ca+2↑, 7,   CAFs/TAFs↝, 1,   cal2↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 18,   EMT↓, 27,   EMT↑, 1,   EMT↝, 1,   F-actin↑, 1,   FAK↓, 3,   Fibronectin↓, 1,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 24,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 27,   MMPs↓, 7,   N-cadherin↓, 10,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   Snail↓, 7,   talin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP2↓, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 31,   TumCMig↓, 24,   TumMeta↓, 22,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↓, 1,   uPA↓, 6,   Vim↓, 14,   Zeb1↓, 5,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   angioG↑, 1,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   Hypoxia↓, 1,   LOX1↓, 1,   NO↑, 4,   PHDs↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 27,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 7,   GLUT1↑, 2,   GLUT2↓, 1,   GLUT3↓, 1,   MMP↓, 40,   MPT↑, 2,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 28,   CXCL1↓, 1,   CXCR4↓, 4,   DCells↑, 1,   DR4↑, 2,   DR4∅, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 4,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 11,   IL6↑, 1,   IL8↓, 3,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 7,   LRIG1↑, 1,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 40,   NF-kB↑, 3,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PGE2↓, 9,   PSA↓, 2,   TCF↓, 2,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 10,   BioAv↑, 5,   BioAv↝, 4,   ChemoSen↑, 45,   ChemoSen⇅, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 3,   Dose↝, 14,   Dose∅, 4,   eff↓, 21,   eff↑, 24,   eff↝, 6,   Half-Life↓, 3,   Half-Life↝, 5,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P450↓, 1,   RadioS↑, 20,   selectivity↑, 17,   Synergy↑, 28,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BMD↑, 1,   EGFR↓, 12,   Ferritin↓, 1,   FOXM1↓, 4,   IL6↓, 11,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 5,   p‑LDH↓, 1,   Myc↓, 3,   PD-L1↓, 6,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 7,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 6,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 7,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   PFS∅, 1,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 7,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 3,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 1,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 658

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 45,   mt-antiOx↑, 1,   Catalase↑, 15,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 9,   GPx4↑, 2,   GSH↑, 25,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 2,   H2O2∅, 1,   HO-1↑, 20,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 19,   mt-lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 16,   MPO↓, 3,   NQO1↑, 5,   NRF2↓, 1,   NRF2↑, 36,   RNS↓, 1,   ROS↓, 68,   ROS↑, 1,   SOD↑, 22,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TOS↓, 1,   Trx1↑, 1,   TrxR1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 4,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 2,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 7,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACC↑, 1,   p‑ACC↑, 1,   Acetyl-CoA↓, 2,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 13,   AMPK↓, 4,   AMPK↑, 77,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 8,   ATP↓, 1,   ATP↑, 8,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 4,   ECAR↓, 1,   ECAR↑, 1,   FAO↑, 4,   FASN↓, 1,   G6PD↑, 1,   glucoNG↓, 1,   glucose↓, 9,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 7,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PDKs↓, 1,   PGM1?, 1,   PKM2↓, 2,   PKM2↑, 1,   SIRT1↑, 27,   SIRT1↝, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 10,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 10,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 4,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 4,   iNOS↓, 9,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 5,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 2,   ERK↑, 4,   p‑ERK↓, 1,   p‑ERK↑, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 6,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 11,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 12,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   p‑mTOR↑, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 2,   PP2A↑, 3,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 2,   p‑cMyc↑, 1,   FOXO↑, 2,   FOXO1↝, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 4,   ER Stress↓, 4,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 2,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 2,   p62↓, 4,   p62↑, 1,   PARK2↑, 4,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 3,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   P21↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   MMP3↓, 2,   MMP9↓, 6,   PDGF↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TXNIP↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 4,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 3,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 10,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 11,   TRPC1↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 14,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL10↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 17,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam↓, 61,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 33,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 7,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 23,   TNF-α↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 1,   AChE↓, 8,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 10,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 15,   BioAv↝, 12,   BioEnh↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   eff↓, 1,   eff↑, 8,   eff↝, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 2,   AST↓, 11,   BG↓, 1,   BloodF↑, 1,   BMD↑, 4,   BP↓, 5,   BP↝, 1,   BP∅, 1,   CRP↓, 3,   IL6↓, 21,   IRes↑, 1,   IRes↝, 1,   LDH↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 12,   antiAll↑, 6,   AntiCan↑, 4,   antiCG↑, 1,   AntiDiabetic↑, 9,   AntiTum↑, 2,   cardioP↑, 18,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 21,   diuretic↑, 1,   hepatoP↑, 23,   Learn↑, 1,   memory↑, 22,   motorD↑, 5,   neuroP↑, 47,   NP/CIPN↓, 1,   Obesity↓, 8,   OS↑, 4,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 3,   toxicity↓, 15,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 11,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 407

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
17 Resveratrol
14 Metformin
12 Berberine
10 Capsaicin
9 Alpha-Lipoic-Acid
8 Fisetin
7 Curcumin
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Hydrogen Gas
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Betulinic acid
4 Caffeic acid
4 diet Short Term Fasting
4 lambertianic acid
4 Morin
4 Quercetin
4 Urolithin
3 HydroxyCitric Acid
3 Aspirin
3 Ashwagandha(Withaferin A)
3 Chrysin
3 Calorie Restriction Mimetics
3 diet FMD Fasting Mimicking Diet
3 Emodin
3 Honokiol
3 Inositol
3 isoorientin
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnolol
3 Magnetic Field Rotating
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Baicalin
2 bempedoic acid
2 Boron
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Gambogic Acid
2 Juglone
2 Luteolin
2 Methylene blue
2 Methyl salicylate / Sweet Birch oil
2 Magnetic Fields
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Shikonin
2 Thymoquinone
2 Vitamin K2
2 Vitexin
1 Astragalus
1 Andrographis
1 Radiotherapy/Radiation
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Chemotherapy
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Spermidine
1 Garcinol
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dandelion Root
1 Ellagic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Hibiscus sabdariffa
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 L-Theanine
1 Licochalcone A
1 Licorice
1 Lycopene
1 Matrine
1 MCT oil
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Piperine
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Selenium NanoParticles
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Gallic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:9  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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