AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
*antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *AMPK↑, *SIRT1↑, *miR-155↓, *NLRP3↓,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4735- SeNPs,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
3186- SFN,    A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- in-vivo, Nor, NA
*NLRP3↓, *ASC↓, *Casp1↓, *IL1β↓, *ALAT↓, *AST↓, *AMPK↑, *mTOR↓, *P70S6K↓,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1723- SFN,    Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review
- Review, Var, NA
*NRF2↑, ROS↑, MMP↓, Cyt‑c↑, cl‑PARP↑, Apoptosis↑, AMPK↑, GSH↓,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
4203- SIL,    Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders
- Review, NA, NA
*MAPK↝, *AMPK↝, *NF-kB↓, *mTOR↝, *PI3K↝, *Akt↝, *BioAv↝, *memory↑, *BDNF↑, *TNF-α↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,
1193- SM,    Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- in-vivo, Alcohol, NA - in-vitro, Liver, HepG2
*p‑AMPK↑, *SIRT1↑, *NRF2↑, *CYP2E1↓, *lipoGen↓, *ROS↓, *Inflam↓,
3401- TQ,    Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review
- Review, Var, NA
TumCP↓, *antiOx↑, *ROS↓, NRF2↑, NF-kB↓, TumCCA↑, *GABA↑, P53↑, P21↑, AMPK↑, neuroP↑, cardioP↑, hepatoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, p‑STAT3↓, Src↓, AMPK↑, GlutMet↑, TCA↑, glut↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1↑, *ROS↓, *GutMicro↑, *Risk↓,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,
4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE↑, *neuroG↑, *Inflam↓, *memory↑,
3141- VitC,    High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer
- in-vitro, CRC, HCT116
Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF-7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 151 to 183 of 183
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 183

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Ferroptosis↑, 1,   GSH↓, 1,   GSH↑, 1,   Iron↑, 1,   MDA↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 7,   ROS⇅, 2,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   CDC2↓, 1,   CDC25↓, 1,   MMP↓, 6,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↓, 1,   AMPK↑, 14,   p‑AMPK↑, 2,   ATG7↑, 1,   cMyc↓, 1,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 3,   Glycolysis↑, 1,   HK2↓, 4,   HK2↑, 1,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 1,   LDHA↑, 1,   PDH↓, 1,   PKM2↓, 4,   PPARγ↑, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↑, 5,   BAX↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 2,   BID↓, 1,   Casp↑, 1,   Casp1↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↑, 4,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   p27↑, 2,   p38↑, 2,   survivin↓, 1,   TRAIL↑, 1,  

Transcription & Epigenetics ⓘ

p‑H3↑, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   ER Stress↑, 1,   HSP27↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   BNIP3↑, 1,   LC3I↑, 1,   LC3II↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CYP1B1↑, 1,   DNAdam↑, 2,   DNMT1↓, 2,   DNMTs↓, 1,   p16↑, 1,   P53↑, 3,   cl‑PARP↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 3,   E2Fs↓, 1,   P21↓, 1,   P21↑, 4,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   mTOR↓, 3,   mTOR↑, 2,   mTORC1↓, 1,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   PI3K↑, 1,   Shh↓, 1,   Src↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   CD31↓, 1,   DLC1↑, 1,   E-cadherin↑, 3,   F-actin↑, 1,   GIT1↓, 1,   ITGA5↓, 1,   Ki-67↓, 1,   MARK4↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 3,   N-cadherin↓, 2,   Rho↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 3,   Zeb1↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↑, 1,   NO↑, 3,   VEGF↓, 2,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↑, 1,   CD4+↑, 1,   COX2↓, 3,   CXCL1↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 1,   IL6↑, 1,   Inflam↓, 1,   p‑IκB↓, 1,   JAK2↓, 1,   NF-kB↓, 5,   p50↓, 1,   p65↓, 2,   p‑p65↓, 1,   PD-L1↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 4,   Dose↝, 1,   eff↓, 9,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   EGFR↓, 1,   FOXM1↓, 1,   IL6↓, 1,   IL6↑, 1,   Ki-67↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 3,   OS↑, 2,   Risk↓, 1,   toxicity∅, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 209

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 4,   CYP2E1↓, 1,   Ferroptosis↓, 1,   GPx↑, 2,   GSH↑, 6,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 5,   lipid-P↓, 4,   MDA↓, 3,   NRF2↓, 1,   NRF2↑, 6,   PARK2↑, 3,   ROS↓, 12,   SIRT3↑, 1,   SOD↑, 6,   VDAC1↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 3,   PGC-1α↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 13,   AMPK↝, 1,   p‑AMPK↑, 1,   p‑CREB↑, 1,   FAO↑, 1,   G6PD↑, 1,   lipoGen↓, 1,   PPARγ↑, 1,   SIRT1↑, 6,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 1,   Apoptosis↓, 5,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↝, 1,   necrosis↓, 1,   p‑p38↓, 1,  

Autophagy & Lysosomes ⓘ

ATG3↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 2,   p62↓, 2,   p62↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   GSK‐3β↓, 1,   mTOR↓, 3,   mTOR↝, 1,   neuroG↑, 1,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

AntiAg↑, 1,   Cartilage↑, 1,   E-sel↓, 1,   miR-155↓, 1,   MMP9↓, 1,   PKA↑, 1,   VCAM-1↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 3,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↓, 2,   CRP↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1β↓, 6,   IL4↓, 1,   IL6↓, 4,   Inflam↓, 10,   NF-kB↓, 7,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   ADAM10↑, 1,   BChE↓, 1,   BDNF↑, 2,   GABA↑, 1,   tau↓, 1,   p‑tau↓, 4,  

Protein Aggregation ⓘ

Aβ↓, 9,   BACE↓, 3,   BACE↑, 1,   NLRP3↓, 4,   PP2A↑, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   Dose↓, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 4,  

Functional Outcomes ⓘ

chemoPv↑, 1,   cognitive↑, 4,   memory↑, 7,   motorD↑, 1,   neuroP↑, 10,   radioP↑, 1,   Risk↓, 2,   Strength↑, 3,   toxicity↓, 1,  
Total Targets: 127

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
17 Resveratrol
13 Metformin
12 Berberine
10 Capsaicin
9 Alpha-Lipoic-Acid
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Curcumin
5 Fisetin
5 Hydrogen Gas
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Betulinic acid
4 Caffeic acid
4 diet Short Term Fasting
4 Quercetin
4 Urolithin
3 HydroxyCitric Acid
3 Ashwagandha(Withaferin A)
3 Chrysin
3 Calorie Restriction Mimetics
3 diet FMD Fasting Mimicking Diet
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Aspirin -acetylsalicylic acid
2 Baicalin
2 bempedoic acid
2 Boron
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Honokiol
2 Juglone
2 Luteolin
2 Methylene blue
2 Magnetic Field Rotating
2 Magnetic Fields
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Shikonin
2 Thymoquinone
2 Vitamin K2
1 Astragalus
1 Andrographis
1 Radiotherapy/Radiation
1 Berbamine
1 Chemotherapy
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Hydroxycinnamic-acid
1 Spermidine
1 Garcinol
1 Deguelin
1 Docosahexaenoic Acid
1 Ellagic acid
1 Gambogic Acid
1 Ginkgo biloba
1 Lycopene
1 Magnolol
1 MCToil
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Piperine
1 Pterostilbene
1 salinomycin
1 Selenium NanoParticles
1 Salvia miltiorrhiza
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:9  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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