Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
6506- BCP,    Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
- vitro+vivo, Nor, HMC3
*neuroP↑, *NF-kB↓, *SIRT1↑, *PGC-1α↓, *BDNF↓, *TNF-α↓, *IL6↓, *IL10↑, *Inflam↓,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2724- BetA,    Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
- in-vivo, Nor, NA - in-vivo, Stroke, NA
AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2/PTGS2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
4273- BetA,    Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats
- in-vivo, AD, NA
*neuroP↑, *BDNF↑, *ROS↓, *Inflam↓, *cognitive↑,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *Hcy/homoC↓, *TNF-α↓, *other↝, *memory↑,
5626- Bif,    Bifidobacterium in anticancer immunochemotherapy: friend or foe?
- Review, Var, NA
*Inflam↓, *Treg lymp↑, *IL10?, Imm↑, eff↑,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5482- BM,    Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways
- in-vitro, Nor, NA
*neuroP↑, *ERK↑, *Akt↑, *MAPK↑, *PI3K↑, *Inflam↓, antiOx↑,
5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
- Review, Var, NA
*memory↑, *neuroP↑, *cognitive↑, *hepatoP↑, *antiOx↑, *AntiDiabetic↑, *fatigue↓, *GSK‐3β↓, *PI3K↑, *Akt↑, *tau↓, *ROS↓, *Inflam↓,
3692- BM,    Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Aβ↓, *cognitive↑,
3693- BM,    Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE/β-secretase↓, *Inflam↓, *ROS↓, *antiOx↑,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5677- BML,    Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
- in-vitro, Melanoma, A431 - in-vitro, Melanoma, A375
TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2/PTGS2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5681- BML,    Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review
- Review, Var, NA
Inflam↓, chemoP↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *Synergy↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, Synergy↑, other↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp/ABCB1↓, *CYP3A4↓, *ROS↓, *neuroP↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
758- Bor,    Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
- Human, Nor, NA
*hs-CRP↓, *TNF-α↓, *SHBG↓, *DHT↑, *cortisol↑, *VitD↑, *BioAv↑, *Inflam↓,
760- Bor,    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
- in-vivo, AD, NA
*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,
730- Bor,  Cisplatin,    The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication
- in-vivo, Var, NA
*ROS↓, *Inflam↓, RenoP↑,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3511- Bor,    Boron
- Review, Var, NA
*memory↑, *motorD↑, *neuroP↑, Ca+2↓, ATF4↑, NRF2↑, *Inflam↓, *ROS↓,
3524- Bor,    Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice
- in-vivo, Nor, NA
*Inflam↓, *SOD↑, *MDA↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NRF2↑, *HO-1↑,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
- in-vivo, AD, NA
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
3868- Bos,    Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract
- in-vivo, Nor, NA
*Inflam↓, *BioAv↓, *BioAv↑, *eff↑,
3866- Bos,    Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Ach↑, *NRF2↑, *NF-kB↓, *Aβ↓,
2777- Bos,    Inflammatory_Damage">Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
- in-vitro, IBD, NA
*p‑NF-kB↓, *ROS↓, Inflam↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, Synergy↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, Synergy↑, MMP1↓, MMP2↓, Synergy↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑, *antiAll↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
8981- BRice,    The Science of Colour in Rice: A Review on Health Benefits, Genetic Regulation, and Anthocyanin Stability
- Review, Nor, NA
*Ingr↑, *antiOx↑, *Inflam↓, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *GutMicro↑, *eff↝, *Ingr↝,
8973- BRice,    Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
- in-vitro, Nor, RAW264.7
*Ingr↝, *Inflam↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *NF-kB↓, *AP-1↓, *p‑ERK↓, *p‑p38↓, *p‑JNK↓, *MAPK↓,
8974- BRice,    Impact of anthocyanin-rich black rice consumption on cognitive function, inflammation and microvascular function in older adults: a crossover intervention trial
- Trial, AD, NA
*Dose↝, *Dose↝, *memory↑, *IL6↓, *cognitive↑, *Inflam↓,
5704- BRU,    Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis
- in-vivo, PSA, HaCaT
*Inflam↓, *IL17↓, *TNF-α↓, *IL22↓, *STAT3↓, *other↝, *eff↑, *Dose?,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
6549- BSB,    (-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *Dose↝, *neuroP↑, *motorD↑, *memory↑, *MPO↓, *TNF-α↓, *iNOS↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6544- BSB,    Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis
- in-vitro, GBM, NA
*Inflam↓, *AntiBio↑, selectivity↑, Apoptosis↑, Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, MPT↑, ROS↑, eff↓, OCR↓, eff↑,

Showing Research Papers: 151 to 200 of 1306
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1306

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 37,   antiOx⇅, 2,   ARE↓, 1,   Catalase↓, 6,   Catalase↑, 6,   Fenton↑, 1,   frataxin↑, 1,   GCLC↑, 1,   GPx↑, 3,   GPx4↓, 5,   GSH↓, 28,   GSH↑, 7,   GSR↑, 1,   GSTs↑, 4,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 4,   HO-1↑, 18,   HO-2↓, 1,   Iron↑, 4,   Iron↝, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 12,   MDA↓, 5,   MDA↑, 10,   MPO↓, 5,   NADH↓, 2,   NOX↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 16,   NRF2↑, 22,   Prx↓, 2,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 36,   ROS↑, 218,   ROS⇅, 7,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 3,   mt-ROS↑, 5,   SOD?, 1,   SOD↓, 7,   SOD↑, 7,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   ac‑SOD2↓, 1,   Thiols↓, 2,   Trx↓, 2,   TrxR↓, 2,   TrxR1↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 4,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 23,   OCR↓, 2,   OXPHOS↓, 5,   OXPHOS↝, 1,   PDH↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5-HETE↓, 1,   5LO↓, 6,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 2,   ACSL4↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 20,   ATP↑, 1,   mt-ATP↓, 1,   BHB↑, 1,   Buty↑, 1,   CAIX/CA9↓, 3,   CRM↑, 2,   DHODH↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 8,   FFA/NEFA↓, 1,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 9,   glut↓, 1,   GlutMet↓, 2,   Glycolysis↓, 32,   Glycolysis↝, 1,   GSK‐3β↓, 11,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 5,   HK2↓, 14,   HMG-CoA↓, 1,   HMGCS2↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 3,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   PDK3↑, 1,   PFK↓, 2,   PKM2↓, 13,   PLA2↓, 1,   Pyruv↓, 1,   SCD1↓, 2,   SCFAs↑, 1,   SIRT1↓, 8,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 9,   Apoptosis?, 4,   Apoptosis↓, 10,   Apoptosis↑, 233,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 8,   BAX↓, 4,   BAX↑, 96,   Bax:Bcl2↑, 19,   Bcl-2↓, 116,   Bcl-2↑, 3,   Bcl-xL↓, 24,   Bcl-xL↑, 1,   BID↑, 2,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 39,   Casp↝, 1,   Casp1↓, 2,   Casp1↑, 2,   cl‑Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 3,   Casp3↓, 7,   Casp3↑, 131,   cl‑Casp3↑, 19,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 18,   cl‑Casp7↑, 5,   Casp8↓, 2,   Casp8↑, 37,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 88,   cl‑Casp9↑, 9,   CellShr↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 3,   Cyt‑c↑, 82,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 15,   DR5↝, 1,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 14,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GranB/GZMB↓, 1,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 23,   iNOS↑, 1,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↓, 4,   p‑p38↑, 4,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 3,   survivin↓, 41,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 14,   XIAP↓, 26,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 8,   p‑Akt↓, 31,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ?, 1,   CIP2A↓, 1,   CK2↓, 6,   cMET↓, 1,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 47,   ERK↑, 5,   p‑ERK↓, 17,   p‑ERK↑, 1,   FGFR1↓, 1,   FOXD3↑, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 5,   IκB↓, 2,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 2,   JAK2↓, 18,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 9,   JNK↑, 18,   p‑JNK↓, 3,   p‑JNK↑, 7,   LIMK1↓, 1,   MAPK↓, 36,   MAPK↑, 14,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 75,   mTOR↝, 2,   p‑mTOR↓, 9,   mTORC2↓, 2,   OR13G1?, 1,   p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 1,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 114,   PI3K↑, 2,   p‑PI3K↓, 5,   PIK3CA↓, 1,   PKA↓, 2,   p‑PKA↓, 1,   PKCδ↓, 10,   PRKCQ/PKCθ↓, 1,   PTEN↓, 5,   PTEN↑, 28,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 12,   STAT↓, 7,   STAT3↓, 78,   STAT3↑, 4,   p‑STAT3↓, 8,   STAT4↓, 1,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 5,   cJun↑, 1,   p‑cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 35,   cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 3,   DNMTs↓, 7,   EZH2↓, 4,   FOXM1↓, 3,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 22,   HDAC1↓, 7,   HDAC2↓, 5,   HDAC3↓, 5,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 3,   HES1↓, 2,   Matr↓, 1,   miR-106b↓, 2,   miR-124-3p↓, 1,   miR-143↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-218↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-34a↓, 2,   miR-34a↑, 6,   miR-590-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 5,   other↑, 10,   other⇅, 1,   other↝, 16,   PCAF↓, 2,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SUMO↓, 1,   TCF-4↓, 1,   tumCV?, 2,   tumCV↓, 59,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 20,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↑, 6,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 37,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 7,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 5,   HSP72↓, 1,   HSP90↓, 8,   HSPs↓, 1,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 2,   p‑IRE1↓, 1,   NQO2↑, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 7,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 7,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 13,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 14,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 8,   p62↑, 3,   PARK2↑, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 47,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM↑, 4,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↑, 1,   DNAdam↓, 6,   DNAdam↑, 55,   DNArepair↓, 3,   hTERT/TERT↓, 8,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 78,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↑, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 14,   cl‑PARP↓, 2,   cl‑PARP↑, 51,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 32,   POLD1↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 7,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 2,   TP53↑, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 3,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 36,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 19,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 75,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 19,   E2Fs↓, 4,   GADD45A↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   mitA↑, 2,   P21?, 1,   P21↓, 7,   P21↑, 46,   p‑P21↑, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 19,   pRB↓, 3,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 186,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 3,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 1,   CD34↓, 1,   cFos↓, 4,   CSCs?, 1,   CSCs↓, 32,   Diff↓, 2,   Diff↑, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 4,   IGF-1?, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   Let-7↑, 2,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 5,   Nestin↓, 3,   NOTCH↓, 14,   NOTCH↑, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 2,   TumCG↓, 83,   TumCG↑, 4,   TumCP↓, 163,   TumCP↑, 3,   Wnt↓, 37,   Wnt↑, 2,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 29,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 1,   cal2↑, 1,   Cal9↑, 1,   CCN2/CTGF↓, 3,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   COL1↓, 2,   COL3A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 32,   EMT↓, 65,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 2,   FAK↓, 17,   FAK↑, 1,   p‑FAK↓, 5,   fascin↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↑, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   p‑MET↓, 1,   MMP1↓, 6,   MMP13↓, 3,   MMP2↓, 74,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 93,   MMP9↑, 4,   MMPs↓, 36,   MUC4↓, 2,   N-cadherin↓, 19,   pax↓, 1,   PDGF↓, 6,   PGF↓, 1,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 5,   ROCK1↓, 3,   Slug↓, 8,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 2,   Snail↓, 13,   TET1↑, 3,   TGF-β↓, 18,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 8,   TIMP2↓, 1,   TIMP2↑, 7,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 3,   TSP-1↑, 2,   TumCA↓, 3,   TumCI↓, 98,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 86,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 14,   TXNIP↑, 1,   uPA↓, 19,   uPAR↓, 1,   Vim?, 1,   Vim↓, 16,   Zeb1↓, 9,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 50,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 7,   Hif1a↓, 44,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 3,   NO↓, 7,   NO↑, 3,   PGI2↓, 1,   PHDs↓, 1,   VCAM-1↓, 2,   VEGF↓, 100,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN2↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 11,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 111,   MMP↑, 2,   MPT↑, 6,   NHE1↓, 2,   OATPs↓, 1,   TJ↓, 1,   TRPM7↓, 3,   TRPV1↓, 1,   TRPV1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CCR7↓, 1,   CD25+↓, 1,   CD25+↑, 1,   CD4+↓, 2,   CD4+↑, 2,   CD44↓, 8,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX1↓, 7,   COX1↑, 1,   COX2/PTGS2↓, 113,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR4↓, 14,   DR4↑, 4,   Eos↑, 1,   FOXP3↑, 2,   FoxP3+↓, 1,   HCAR2↑, 4,   HLA-I/II↑, 1,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 8,   IFN-γ↑, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 9,   IL10↑, 2,   IL12↑, 2,   IL17↓, 3,   IL17↑, 1,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 38,   IL1β↑, 3,   IL2↓, 5,   IL2↑, 3,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 1,   IL6↓, 61,   IL6↑, 2,   IL8↓, 11,   IL8↑, 1,   Imm↑, 29,   Imm↝, 6,   INF-γ↓, 1,   INF-γ↝, 1,   Inflam↓, 214,   Inflam↑, 3,   Inflam↝, 2,   LPS↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 9,   MCT1↓, 2,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 1,   MyD88↑, 1,   Neut↑, 2,   NF-kB?, 1,   NF-kB↓, 170,   NF-kB↑, 6,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 8,   NLRP3↑, 3,   NOD1↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 31,   PGE2↑, 1,   PSA↓, 12,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 56,   TNF-α↑, 5,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↓, 1,   pH↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   ADAM10?, 1,   ADAM10↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 10,   AR-V7?, 1,   CYP19?, 1,   ER(estro)↓, 1,   EstroRS/ERS↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 4,   PPARγ↑, 8,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 55,   BioAv↑, 59,   BioAv⇅, 1,   BioAv↝, 15,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 181,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab?, 1,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 5,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 1,   Dose↝, 64,   Dose∅, 9,   DrugR↓, 1,   eff↓, 15,   eff↑, 87,   eff⇅, 1,   eff↝, 18,   eff∅, 4,   GSTM1↑, 1,   Half-Life↓, 15,   Half-Life↑, 2,   Half-Life↝, 16,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 16,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 2,   P450↝, 1,   RadioS↑, 53,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 90,   selectivity∅, 1,   Synergy↓, 1,   Synergy↑, 117,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 10,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 7,   BloodF⇅, 1,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 9,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 4,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 8,   IBIL↓, 1,   IL6↓, 61,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 7,   LDH↑, 2,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 5,   NLR↓, 1,   NOS2↓, 1,   NOS2↑, 1,   PC↑, 1,   PD-L1↓, 9,   Polyps↓, 1,   PSA↓, 12,   RAGE↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 1,   TRIB3↑, 3,   Tumccf↓, 2,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiArt↑, 1,   AntiCan?, 1,   AntiCan↓, 5,   AntiCan↑, 121,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 3,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 53,   AntiTum∅, 1,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 19,   CardioT↑, 2,   chemoP↑, 65,   chemoPv↑, 29,   ChemoSideEff↓, 4,   cognitive?, 1,   cognitive↑, 6,   DCR↑, 1,   fatigue↓, 2,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 19,   hepatoP∅, 1,   memory↑, 4,   Mood↑, 1,   Mucositis↓, 1,   neuroP↑, 21,   NP/CIPN↓, 3,   Obesity↓, 2,   OS↓, 1,   OS↑, 19,   OS↝, 1,   OS∅, 2,   Pain↓, 6,   PFS↑, 1,   PFS∅, 1,   QoL↑, 8,   QoL∅, 1,   radioP↑, 23,   Remission↑, 1,   RenoP↑, 15,   Risk↓, 41,   Risk↑, 2,   Sleep↑, 2,   toxicity↓, 20,   toxicity↑, 5,   toxicity↝, 13,   toxicity∅, 3,   TumNum↓, 1,   TumVol↓, 16,   TumW↓, 7,   Weight↓, 1,   Weight↑, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 18,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 9,  
Total Targets: 1058

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 4,   antiOx?, 2,   antiOx↓, 37,   antiOx↑, 535,   ARE↑, 7,   ARE↝, 1,   Bil↑, 2,   Catalase↓, 4,   Catalase↑, 152,   Copper↓, 1,   DPPH↓, 2,   DUOX1↓, 1,   Fenton↓, 5,   GCLC↑, 4,   GCLC↝, 1,   GCLM↑, 3,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 112,   GPx1↑, 4,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GSH↓, 4,   GSH↑, 162,   GSR↓, 2,   GSR↑, 24,   GSS↑, 1,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 27,   H2O2↓, 8,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 13,   HDL∅, 1,   HNE↓, 3,   HO-1?, 1,   HO-1↓, 4,   HO-1↑, 139,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 3,   hyperG↝, 1,   Iron↓, 4,   Iron↑, 1,   Iron↝, 1,   Iron∅, 1,   Keap1↓, 8,   Keap1↑, 1,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 143,   lipid-P↑, 3,   mt-lipid-P↓, 1,   MDA↓, 139,   MDA↑, 4,   MPO↓, 28,   MPO↑, 1,   NADH↓, 1,   NFE2L2↓, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 9,   NQO1↑, 35,   NQO1↝, 2,   Nrf1↑, 2,   NRF2?, 1,   NRF2↓, 7,   NRF2↑, 236,   NRF2↝, 1,   NRF2∅, 1,   Prx↓, 1,   Prx↑, 2,   RNS↓, 8,   ROS?, 5,   ROS↓, 567,   ROS↑, 11,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 10,   SOD↓, 6,   SOD↑, 210,   mt-SOD↑, 1,   SOD1↑, 9,   SOD2↓, 1,   SOD2↑, 9,   TAC↑, 24,   TBARS↓, 9,   Thiols↑, 2,   TOS↓, 2,   Trx↓, 1,   Trx↑, 6,   Trx1↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   UCPs↑, 2,   uricA↓, 5,   VitC↑, 9,   VitE↓, 1,   VitE↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 22,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compII↑, 2,   compIII↑, 2,   compIV↑, 3,   DRP1/DNM1L↓, 1,   EGF↓, 1,   EGF↑, 1,   ETC↑, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 3,   mtDam↓, 10,   mtDam↑, 1,   OCR↓, 1,   OCR↑, 4,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 10,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 8,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 2,   12LOX↑, 1,   5-HETE↓, 1,   5LO↓, 19,   5LO↝, 1,   ACC↓, 1,   ACC↑, 2,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   adiP↓, 1,   adiP↑, 4,   ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   AMPK↓, 2,   AMPK↑, 47,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 28,   ATP↝, 1,   BHB↑, 1,   Buty↑, 1,   cAMP↑, 6,   CPT1A↑, 1,   CRM↑, 3,   cytoP450↓, 1,   ECAR↓, 1,   Eic↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 3,   FASN↓, 3,   FFA/NEFA↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 18,   glucose↑, 2,   glucose↝, 4,   GlucoseCon↓, 1,   GlucoseCon↑, 11,   Glycolysis↓, 3,   Glycolysis↑, 1,   GSK‐3β↓, 25,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 2,   HK2↓, 2,   HMG-CoA↓, 3,   KeyT↝, 1,   lactateProd↓, 1,   LDHA↓, 2,   LDL↓, 43,   lipidLev↓, 7,   lipoGen↓, 1,   LTB4↓, 1,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 3,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 15,   NADPH↑, 10,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGC1A↑, 1,   PGM1?, 1,   PKM2↓, 8,   PLA2↓, 2,   PONs↓, 1,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 48,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 75,   Apoptosis↑, 2,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 27,   BAX↑, 1,   Bax:Bcl2↓, 5,   Bcl-2↓, 5,   Bcl-2↑, 22,   Bcl-2↝, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 4,   Casp1↓, 3,   Casp12↓, 2,   Casp3↓, 49,   Casp3↑, 3,   Casp3∅, 1,   cl‑Casp3↓, 6,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 19,   Casp9↑, 2,   Cyt‑c↓, 8,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 14,   GranB/GZMB↓, 1,   GRP58↓, 1,   GSDMD?, 1,   GSDMD↓, 1,   iNOS↓, 88,   iNOS↑, 3,   necrosis↓, 3,   p38↓, 9,   p38↑, 1,   p‑p38↓, 7,   Pyro↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 36,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 4,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 2,   CREB↓, 1,   CREB↑, 9,   p‑CREB↑, 3,   DYRK1A↓, 2,   EGFR↓, 1,   ERK↓, 14,   ERK↑, 14,   p‑ERK↓, 4,   p‑ERK↑, 3,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↑, 2,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   JAK↓, 3,   JAK2↓, 3,   JAK2↑, 3,   JNK↓, 20,   JNK↑, 1,   p‑JNK↓, 7,   MAPK?, 1,   MAPK↓, 46,   MAPK↑, 5,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 14,   mTOR↑, 8,   mTOR↝, 1,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 12,   PI3K↑, 25,   PI3K↝, 1,   PKA↑, 3,   PKCδ↓, 4,   PKCδ↑, 6,   PP2A↑, 4,   PTEN↓, 5,   PTEN↑, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3?, 1,   STAT3↓, 11,   STAT3↑, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,   STEP↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 14,   ATF2↑, 1,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXO↑, 3,   FOXO3↑, 6,   HATs↓, 2,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 2,   HDAC2↓, 2,   HOTAIR↑, 1,   KLF4↑, 1,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 19,   other↑, 32,   other↝, 51,   other∅, 1,   SOX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 13,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 28,   ER Stress↑, 1,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSF1↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 12,   HSP70/HSPA5↝, 1,   HSP90↓, 1,   HSP90↑, 2,   HSPs↓, 1,   HSPs↑, 2,   HSPs↝, 1,   IRE1↓, 3,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3II↓, 2,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 3,   p62↑, 4,   PARK2↑, 4,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATR↑, 1,   DNAdam↓, 30,   p16↓, 2,   P53↓, 6,   PARP↓, 2,   PARP1↓, 2,   cl‑PARP1↓, 1,   PCNA↓, 4,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 2,   cellSen↓, 1,   cellSen↝, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   P21↓, 3,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Choline↑, 2,   Diff↑, 4,   Diff↝, 2,   EP2↓, 1,   FGF↑, 3,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 4,   IGFBP1↑, 1,   Jun↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   MSCs↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 12,   NOTCH1↑, 1,   STAT1↓, 1,   TumCG↑, 1,   TumCP↓, 5,   tyrosinase↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 5,   AntiAg↑, 43,   AntiAg∅, 1,   AP-1↓, 11,   AP-1↑, 1,   ARG1/2↑, 1,   Ca+2?, 2,   Ca+2↓, 18,   Ca+2↑, 7,   Ca+2↝, 4,   cal2↓, 1,   Cartilage↑, 9,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   EMT↑, 1,   F-actin↑, 1,   FAK↑, 1,   Fibronectin↓, 1,   Fibronectin↑, 1,   Fibrosis↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LRP1↑, 3,   MLC2/MYL9↝, 1,   MMP-10↓, 2,   MMP-10↝, 1,   MMP1↓, 1,   MMP13↓, 6,   MMP2↓, 7,   MMP2↑, 2,   MMP3↓, 3,   MMP3↑, 1,   MMP9↓, 21,   MMP9↑, 2,   MMPs↓, 3,   MMPs↑, 3,   MUC1↑, 4,   N-cadherin↑, 1,   Na+↑, 1,   NFAT↓, 1,   PDGF↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 4,   serineP↓, 1,   SLIT2↑, 1,   SMAD3↓, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 10,   TGF-β↑, 10,   TGF-β1↓, 4,   TGF-β1↑, 3,   TIMP1↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 6,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 2,   Vim↑, 1,   α-SMA↓, 6,   α-SMA↑, 1,   α-SMA↝, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   angioG↑, 8,   angioG↝, 1,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 5,   ECM/TCF↑, 1,   eNOS↓, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 8,   Hif1a↑, 3,   Hif1a↝, 1,   Hif1a∅, 1,   HIF2a↑, 1,   LOX1↓, 1,   NO?, 1,   NO↓, 67,   NO↑, 7,   P-sel↓, 1,   TXA2↓, 3,   VCAM-1↓, 19,   VEGF↓, 13,   VEGF↑, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 8,   BBB↑, 80,   BBB↝, 6,   BBB∅, 3,   CLDN1↓, 2,   CLDN1↑, 3,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 2,   GastroP↑, 14,   GLUT1↑, 2,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 12,   ketosis↑, 1,   memfluid↑, 2,   MMP↓, 2,   MMP↑, 30,   MMP∅, 2,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 6,   OCLN↝, 1,   TJ↓, 1,   TJ↑, 6,   TRPA1↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 5,   TRPV3↑, 2,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 5,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 5,   CD40↓, 1,   CD8+↑, 1,   cGAS–STING↓, 2,   COX1↓, 14,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 144,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL1↓, 1,   CXCL15↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 1,   Eos↓, 5,   FOXP3↑, 1,   GM-CSF↓, 1,   HCAR2↑, 1,   HMGB1↓, 9,   ICAM-1↓, 17,   IFN-γ↓, 21,   IFN-γ↑, 4,   IFN-γ∅, 1,   IgE↓, 4,   IgG1↓, 1,   IL1?, 1,   IL1↓, 11,   IL1↑, 1,   IL10?, 1,   IL10↓, 16,   IL10↑, 32,   IL12↓, 8,   IL13↓, 6,   IL17↓, 16,   IL17↑, 1,   IL18↓, 4,   IL1RL1/ST2↓, 1,   IL1α↓, 1,   IL1β↓, 164,   IL1β↑, 1,   IL2↓, 15,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 3,   IL4↓, 20,   IL4↑, 7,   IL5↓, 8,   IL5↑, 1,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IL8?, 1,   IL8↓, 35,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 48,   Imm↝, 4,   INF-γ↓, 3,   Inflam?, 6,   Inflam↓, 1076,   Inflam↑, 16,   Inflam∅, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 21,   MCP1/CCL2↑, 2,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 3,   MyD88↓, 8,   NeuroI↓, 4,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 249,   NF-kB↑, 2,   p‑NF-kB↓, 4,   NK cell↑, 6,   NLRP3↓, 67,   NLRP3↑, 4,   p65↓, 6,   PAF↓, 2,   PAF↑, 1,   PGE1↓, 1,   PGE2↓, 52,   PGE2↑, 2,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 5,   RANTES↓, 4,   Th1 response↓, 1,   Th17↓, 1,   Th2↓, 2,   TLR1↓, 3,   TLR2↓, 8,   TLR3↓, 1,   TLR4↓, 36,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 269,   TNF-α↑, 4,   TRAF1↓, 1,   Treg lymp↑, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   GGT/CD224↓, 1,   TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↓, 1,   5HT↑, 16,   Ach↑, 25,   AChE↓, 98,   AChE↑, 1,   AChE∅, 2,   ADAM10↑, 6,   ADAM10↝, 1,   BChE↓, 24,   BChE∅, 1,   BDNF↓, 3,   BDNF↑, 71,   BDNF∅, 2,   proBDNF↑, 1,   BrainVol↑, 2,   ChAT↑, 13,   ChE↓, 1,   GABA↓, 3,   GABA↑, 9,   GABA↝, 1,   MAOA↓, 13,   MAOB↓, 4,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 6,   SNAP25↑, 2,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 12,   APOE4↓, 1,   APP↓, 15,   APP∅, 1,   cl‑APP↑, 1,   Aβ↓, 164,   Aβ↑, 2,   Aβ∅, 2,   Aβ42↓, 10,   BACE/β-secretase↓, 37,   BACE/β-secretase↑, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↑, 1,   tau↓, 37,   p‑tau↓, 49,   XO↓, 2,   XO↝, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 2,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   CYP19↓, 1,   DHT↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   Estro↓, 1,   GLP-1R↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 10,   PPARα↝, 1,   PPARγ↓, 5,   PPARγ↑, 24,   RAAS↓, 1,   SHBG↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 84,   BioAv↑, 127,   BioAv⇅, 3,   BioAv↝, 74,   BioEnh↑, 12,   ChemoSen↑, 3,   CompStab↓, 2,   CompStab↑, 7,   CompStab↝, 3,   CYP2C19↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 10,   Dose↓, 3,   Dose↑, 9,   Dose↝, 148,   eff?, 1,   eff↓, 9,   eff↑, 88,   eff↝, 11,   GSTA1↑, 7,   Half-Life?, 1,   Half-Life↓, 18,   Half-Life↑, 9,   Half-Life↝, 31,   P-gp/ABCB1↓, 3,   P450↓, 3,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 5,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   ALB↑, 2,   ALB↝, 1,   ALP↓, 10,   anemia↓, 1,   AR↓, 1,   AST↓, 56,   AST∅, 1,   BG↓, 4,   Bil↑, 2,   BloodF↑, 13,   BMD↑, 8,   BP↓, 30,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   Calcium↑, 1,   Calcium↝, 2,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 2,   creat↓, 16,   CRP↓, 22,   EGFR↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HbA1c↓, 1,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 2,   HER2/EBBR2↓, 1,   HOMA↓, 1,   hs-CRP↓, 5,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 19,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 5,   PSA↓, 1,   PSA∅, 1,   PV↓, 3,   RAGE↓, 5,   RBC↑, 1,   SpO2↑, 1,   TC↓, 5,   TG/TAG↓, 6,   TMAO↓, 1,   TMAO↑, 1,   TP53↑, 1,   UFR?, 1,   UFR↑, 2,   UR↓, 1,   Urea↓, 5,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 2,   AirwayM↓, 4,   Analgesic↑, 6,   AntiAge↑, 35,   antiAll?, 1,   antiAll↑, 47,   AntiArt↑, 18,   AntiCan?, 1,   AntiCan↓, 2,   AntiCan↑, 82,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 93,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↓, 2,   AntiTum↑, 26,   ANXi↓, 1,   BOLD↑, 1,   Bone Healing↑, 1,   cachexia↓, 1,   cardioP?, 1,   cardioP↓, 3,   cardioP↑, 180,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 28,   chemoPv↑, 21,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 221,   cognitive↝, 1,   cognitive∅, 1,   cough?, 1,   diuretic↑, 6,   fatigue↓, 3,   Hear↑, 1,   hepatoP↓, 5,   hepatoP↑, 164,   IPSS↝, 1,   Learn?, 1,   Learn↑, 16,   memory?, 1,   memory↑, 186,   memory∅, 1,   Mood↑, 13,   motorD↓, 1,   motorD↑, 24,   Mucositis↓, 2,   neuroP?, 3,   neuroP↓, 3,   neuroP↑, 405,   neuroP↝, 1,   NP/CIPN↓, 3,   Obesity↓, 39,   OS↑, 15,   Pain↓, 27,   PDE4↓, 1,   QoL↓, 1,   QoL↑, 9,   radioP↑, 16,   RenoP↑, 50,   Risk↓, 19,   Risk↑, 1,   Sleep↑, 8,   SoreThr?, 1,   Strength↓, 1,   Strength↑, 8,   Stress↓, 3,   Stroke↓, 31,   Tinn↓, 1,   toxicity?, 1,   toxicity↓, 93,   toxicity↑, 12,   toxicity⇅, 1,   toxicity↝, 22,   toxicity∅, 11,   Weight↓, 6,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 21,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 54,   AntiFungal↓, 2,   AntiFungal↑, 24,   AntiP↓, 1,   AntiP↑, 7,   AntiViral↑, 38,   Bacteria↓, 89,   Bacteria↑, 1,   Diar↓, 6,   Dysb↓, 1,   GutMicro↑, 93,   GutMicro↝, 2,   Inf↓, 3,   Sepsis↓, 20,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   Flav↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 6,   Ingr↝, 35,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 1030

Scientific Paper Hit Count for: Inflam, inflammation
43 Hydrogen Gas
41 Curcumin
34 Magnetic Fields
33 Thymoquinone
32 Quercetin
30 Silymarin (Milk Thistle) silibinin
24 Resveratrol
20 Lycopene
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
18 Fisetin
18 Rosmarinic acid
16 Ashwagandha(Withaferin A)
16 Ferulic acid
16 Sulforaphane (mainly Broccoli)
15 Capsaicin
15 Carvacrol
15 Honokiol
15 Kaempferol
15 Luteolin
15 Urolithin
14 Propolis -bee glue
14 Emodin
14 Eugenol
14 Licochalcone A
13 Silver-NanoParticles
13 Apigenin (mainly Parsley)
13 Beta-Caryophyllene
12 Radiotherapy/Radiation
12 Baicalein
12 Chlorogenic acid
12 Chrysin
11 Cinnamon
11 Isoliquiritigenin
10 Crocetin
10 Chemotherapy
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Matrine
10 Pterostilbene
9 Selenite (Sodium)
9 Isovitexin
9 Boron
9 Ginger/6-Shogaol/Gingerol
9 Magnolol
9 Morin
8 Astaxanthin
8 Boswellia (frankincense)
8 α-Bisabolol / Chamomile oil
8 Rutin
8 Diclofenac
8 Fucoidan
8 Licorice
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Allicin (mainly Garlic)
7 Betulinic acid
7 Vitamin B3,Niacin
7 Cisplatin
7 Butyrate
7 Centella asiatica / Gotu kola → asiaticoside
7 D-limonene
7 Gallic acid
7 Hyperoside
7 Moringa oleifera
7 Mushroom Lion’s Mane, Hericium erinaceus
7 Piperine
6 1,8-Cineole
6 Artemisinin
6 Aspirin
6 Caffeic acid
6 Thymol-Thymus vulgaris
6 Hydroxycinnamic-acid
6 Flaxseed/Linseed
6 Garcinol
6 HydroxyTyrosol
6 isoorientin
6 Vitexin
6 L-Theanine
6 Methylsulfonylmethane
5 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
5 Melatonin
5 Folic Acid, Vit B9
5 Phenethyl isothiocyanate
5 doxorubicin
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Celastrol
5 chitosan
5 Chocolate
5 Coenzyme Q10
5 Ellagic acid
5 Shilajit/Fulvic Acid
5 isoquercitrin
5 Mung Bean Sprouts
5 Lactoferrin/Talactoferrin
5 Magnetic Field Rotating
5 Phycocyanin
5 Ursolic acid
4 Isothiocyanates
4 Bacopa monnieri
4 Cichoric acid / Chicoric acid
4 Carvone
4 Ginkgo biloba-EGb 761
4 Formononetin
4 SDG/lignans
4 Ginkgo biloba
4 Geraniol
4 Ginkgetin
4 Isobavachalcone
4 Isorhamnetin
4 Lemongrass Extract/Citral
4 Methylene blue
4 nicotinamide adenine dinucleotide
4 Nimbolide
4 Patchouli Oil (Pogostemon cablin)
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Anethole/trans-Anethole
3 Baicalin
3 Biochanin A
3 Vitamin B12
3 Benzyl isothiocyanate
3 Bromelain
3 Black Rice, Oryza sativa
3 Lecithin
3 Carnosine
3 Camu camu
3 Chyawanprash
3 methotrexate
3 Spermidine
3 Cucurbitacin
3 Date Fruit Extract
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 diet Fermented Foods
3 Exercise
3 Gamma-aminobutyric acid
3 Genistein (soy isoflavone)
3 HydroxyCitric Acid
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 Linalool
3 5-fluorouracil
3 Mangiferin
3 Marjoram (Origanum majorana)
3 Purple Corn / Purple Maize
3 α-Santalol/Sandalwood oil
3 Sulfasalazine
3 Sesamin
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Allyl isothiocyanate
2 brusatol
2 borneol
2 buckwheat sprouts
2 Paclitaxel/Taxol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Indole-3-carbinol
2 Dipyridamole
2 Echinacea
2 Eurycomanone
2 flavonoids
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Ginkgolide B
2 Ginseng
2 Grapeseed extract
2 hydrogen sulfide
2 Orlistat
2 Hibiscus sabdariffa
2 Oleuropein
2 iodine
2 Inulin Prebiotic
2 isoflavones
2 Ivermectin
2 Juglone
2 Potassium
2 probiotics
2 Lutein
2 MBE, Maqui berry
2 Methyl salicylate / Sweet Birch oil
2 Metformin
2 Magnesium
2 Lemon Balm/Melissa officinalis
2 Naringin
2 Oleocanthal
2 Phenylbutyrate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Terpinen-4-ol / Tea Tree Oil
2 Aflavin-3,3′-digallate
2 Turmerones
2 Zyflamend
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Açaí, Euterpe oleracea
1 Astragalus
1 Acetyl-l-carnitine
1 Aloe anthraquinones
1 beta-glucans
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 Carnosic acid
1 Castalagin
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Prebiotic
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Copper and Cu NanoParticles
1 Rivastigmine
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 diet Ketogenic
1 Diindolylmethane
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Evodiamine
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Galloflavin
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Butein
1 Scopoletin
1 Lactobacillus
1 Zeaxanthin
1 Modified Citrus Pectin
1 irinotecan
1 MCT oil
1 Moringin
1 Mucuna pruriens/Velvet Bean
1 Mushroom Chaga, Inonotus obliquus
1 Nasturtium, Indian Cress
1 Neem
1 Oregano
1 Peppermint
1 Propyl gallate
1 Phenolic Acids
1 Propranolol
1 Psoralidin
1 Parthenolide
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 Spirulina(Arthrospira/Limnospira)
1 cetuximab
1 Terminalia bellirica
1 Terpenoids
1 Thyme
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 Walnut
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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