EMT Cancer Research Results

EMT, Epithelial-Mesenchymal Transition: Click to Expand ⟱
Source:
Type:
Biological process in which epithelial cells lose their cell polarity and cell-cell adhesion properties and gain mesenchymal traits, such as increased motility and invasiveness. This process is pivotal during embryogenesis and wound healing. Hh signaling pathway is able to regulate the EMT. Snail, E-cadherin and N-cadherin, key components of EMT; EMT-related factors, E-cadherin, N-cadherin, vimentin; The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin.
EMT is regulated by various signaling pathways, including TGF-β, Wnt, Notch, and Hedgehog pathways. Transcription factors such as Snail, Slug, Twist, and ZEB play critical roles in repressing epithelial markers (like E-cadherin) and promoting mesenchymal markers (like N-cadherin and vimentin).
EMT is associated with increased tumor aggressiveness, enhanced migratory and invasive capabilities, and resistance to apoptosis.
Scientific Papers found: Click to Expand⟱
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
1113- FIS,    Fisetin suppresses migration, invasion and stem-cell-like phenotype of human non-small cell lung carcinoma cells via attenuation of epithelial to mesenchymal transition
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, MMP2↓, CD44↓, CD133↓, β-catenin/ZEB1↓, NF-kB↓, EGFR↓, STAT3↓, CSCs↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
1114- Fuc,    The Potential Effect of Fucoidan on Inhibiting Epithelial-to-Mesenchymal Transition, Proliferation, and Increase in Apoptosis for Endometriosis Treatment: In Vivo and In Vitro Study
- vitro+vivo, Var, NA
tumCV↓, TumCMig↓, VEGF↓, EMT↓, Apoptosis↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
1115- GA,    Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway
- in-vivo, GC, GES-1
TumCP↓, TumCCA↑, Wnt/(β-catenin)↓, EMT↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
814- GAR,  PacT,    Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model
- in-vivo, BC, NA
Apoptosis↑, TumCCA↑, EMT↓, TumCI↓,
29- GEN,    Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
- in-vivo, Pca, 22Rv1 - in-vivo, Pca, DU145
HH↓, Gli1↓, CSCs↓, TumCI↓, EMT↓, TumCG↓, CD44↓,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
7252- Gink,    STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells
- in-vitro, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, SV-HUC-1
tumCV↓, selectivity↑, TumCMig↓, EMT↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, STEAP3↓, Bax:Bcl2↑, cl‑Casp3↑,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
1118- GSE,    Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF- β Signaling Pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 5637
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Vim↓, Slug↓, E-cadherin↑, ZO-1↑, p‑SMAD2↓, p‑SMAD3↓, p‑Akt↓, p‑ERK↓, p‑p38↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
1119- HNK,    Honokiol inhibits epithelial—mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E‐cadherin axis
- vitro+vivo, BC, NA
EMT↓, MSCmark↓, EM↑, STAT3↓, Zeb1↓, E-cadherin↑,
1120- HNK,    Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling
- vitro+vivo, RCC, NA
EMT↓, CSCs↓, TumCG↓, miR-141↑,
2877- HNK,    Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer
- in-vitro, GC, AGS
HDAC3↓, NF-kB↓, CEBPB↓, ER Stress↑, EMT↓, Wnt↓, β-catenin/ZEB1↓,
2881- HNK,    Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis
- in-vitro, PC, PANC1
tumCV↓, Casp3↑, Apoptosis↑, TumCCA↑, TumCI↓, Mcl-1↓, EMT↓,
2882- HNK,    Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling
- in-vitro, PC, PANC1
TumCI↓, TumCMig↓, p‑SMAD2↓, p‑SMAD3↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, Snail↓, Slug↓, Rho↓, ROCK1↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2884- HNK,    Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP
- in-vitro, Lung, A549 - in-vitro, Lung, H460
EMT↓, cFLIP↓, N-cadherin↓, Snail↓, p‑SMAD2↓, p‑SMAD3↓, IKKα↑, TumCMig↓,
2866- HNK,    Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship
- Review, Var, NA
EMT↓, TumMeta↓, BioAv↑, BBB↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
4688- HNK,    Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
- vitro+vivo, RCC, A498
CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
7549- HYP,  Rad,    Study on the mechanism of hyperoside in affecting the biological progression and radiosensitivity of esophageal carcinoma by modulating the STAT3/AKT/ERK pathway
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE150
TumCP↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, RadioS↑, p‑STAT3↓, p‑Akt↓, p‑ERK↓,
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, Synergy↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,
7639- Ins,    Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells
- in-vitro, Nor, MCF10
EMT↓, E-cadherin↑, AntiCan↑, MMP9↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7696- IP6,  Ins,    The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7
- vitro+vivo, Colon, SW48 - in-vitro, Colon, SW-620
AntiCan↑, CLDN7↑, EMT↓, E-cadherin↑, N-cadherin↓, Synergy↑, TumCG↓,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7783- ISL,    Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
EMT↓, E-cadherin↑, TumCMig↓, TumCI↓, OS↑, Zeb1↓, Vim↓, N-cadherin↓,
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, HOTAIR↓, VEGF↓, CXCL12↓, CXCR4↓, ER-α36↝, Shh↓, miR-155↝, miR-34a↝, miR-10a-5p↝, CSCs↓, EMT↓,
7859- isoO,    Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells
- in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, EMT↓, MMPs↓, VEGF↓, AMPK↑, TumCP↓, Dose↝, TumCMig↓, TumCI↓,
7858- isoO,    Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
- in-vitro, Oral, SCC25
CSCs↓, EMT↓, JAK↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, TCF7/TCF1↓, LEF1↓, ChemoSen↑,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,
7845- ISQ,    Isoquercitrin, ingredients in Tetrastigma hemsleyanum Diels et Gilg, inhibits hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion
- vitro+vivo, Bladder, NBT-II
p‑MET↓, TumCMig↓, TumCI↓, EMT↓, *Inflam?, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑,
1168- IVM,  SRF,    Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
- in-vitro, HCC, NA
TumMeta↓, mTOR↓, EMT↓, CSCsMark↓, STAT3↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,

Showing Research Papers: 151 to 200 of 366
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   Catalase↓, 7,   ENOX2↓, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↓, 3,   GPx1↓, 1,   GPx4↓, 8,   GPx4↝, 1,   GSH↓, 21,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 8,   HO-1↑, 13,   Iron↑, 3,   c-Iron↑, 1,   Keap1↑, 1,   lipid-P↓, 2,   lipid-P↑, 8,   MDA↓, 1,   MDA↑, 4,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 4,   NRF2↓, 20,   NRF2↑, 14,   NRF2↝, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 20,   ROS↑, 140,   ROS⇅, 4,   ROS↝, 2,   i-ROS↓, 1,   mt-ROS↑, 2,   selenoP↑, 1,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 3,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 2,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 6,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 4,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 13,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   AApath↓, 1,   ACADS/SCAD↓, 1,   ACC↑, 1,   ACLY↓, 1,   p‑ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 22,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 15,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FABP4↑, 1,   FASN↓, 2,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 9,   GlutMet↓, 1,   Glycolysis↓, 27,   GSK‐3β↓, 9,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 8,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 4,   IDH1↑, 1,   lactateProd↓, 9,   LDHA↓, 4,   LDL↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NADPH↓, 4,   NADPH↑, 1,   O-Glc↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PIP3↑, 1,   PKM2↓, 15,   PKM2↑, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   SIRT1↓, 10,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   TCA↓, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis↓, 6,   Apoptosis↑, 124,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 7,   BAX↓, 1,   BAX↑, 59,   BAX↝, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 69,   Bcl-2↑, 1,   Bcl-xL↓, 18,   Bcl-xL↑, 1,   BID↑, 4,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 17,   Casp1↓, 3,   Casp10↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp3↓, 3,   Casp3↑, 71,   cl‑Casp3↑, 16,   Casp6↑, 1,   Casp7↑, 15,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 45,   cl‑Casp9↑, 5,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 42,   mt-Cyt‑c↓, 1,   Diablo↑, 4,   DR5↑, 19,   Endon↑, 1,   FADD↑, 4,   Fas↓, 1,   Fas↑, 15,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 13,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   IAP2/BIRC3↑, 1,   iNOS↓, 5,   Mcl-1?, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 7,   MDM2↑, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 1,   TumCD↑, 5,   TUNEL↑, 1,   XIAP↓, 19,   YAP/TEAD↓, 4,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 109,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 30,   AKT1↓, 2,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 3,   cSrc↓, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 28,   ERK↑, 7,   ERK↝, 1,   p‑ERK↓, 10,   ERK5↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↑, 1,   Hippo↝, 1,   IGF-1R↓, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 3,   p‑JAK↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 6,   p‑JAK2↓, 3,   p‑JAK3↓, 1,   JNK↓, 5,   JNK↑, 12,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 28,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 63,   mTOR↝, 1,   p‑mTOR↓, 6,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 2,   P90RSK↓, 2,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 94,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PKCδ↓, 5,   PTEN↓, 2,   PTEN↑, 19,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 4,   RET↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 12,   Src↓, 3,   p‑Src↓, 1,   STAT↓, 2,   p‑STAT2↓, 1,   STAT3↓, 54,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 12,   p‑STAT3↑, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 10,   p‑ATF4↝, 1,   CBP↓, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 29,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 5,   DNMTs↓, 2,   EZH2↓, 6,   FOXM1↓, 3,   FOXO1↓, 3,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   H3↓, 2,   H3↑, 2,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 3,   HDAC↓, 14,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 2,   HES1↓, 3,   HOTAIR↓, 1,   miR-107↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-141↑, 1,   miR-145↑, 1,   miR-155↓, 1,   miR-155↝, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 3,   miR-34a↑, 4,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   MTA2↓, 1,   Myc↓, 2,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 18,   other↓, 3,   other↑, 4,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 9,   SOX4↓, 4,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 31,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 16,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 32,   GRP78/BiP↓, 2,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 6,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 11,   IRE1↑, 5,   PDI↑, 1,   PERK↑, 7,   p‑PERK↝, 1,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 2,   LC3II↓, 2,   LC3II↑, 10,   LC3s↓, 1,   lysoMP↑, 1,   p62↓, 3,   p62↑, 2,   SESN2↑, 1,   TumAuto↑, 28,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↑, 33,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 55,   P53↝, 1,   p‑P53↑, 1,   ac‑P53↑, 1,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↑, 25,   PARP1↑, 2,   PCNA↓, 21,   PCNA↑, 1,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 9,   TOP1?, 1,   TOP1↓, 6,   TOP2↓, 4,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 7,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 25,   CDK2↑, 2,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 1,   Ki-67↓, 22,   MAD↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 33,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   TumCCA↓, 4,   TumCCA↑, 105,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 6,   AXIN1↓, 1,   AXIN1↑, 1,   BMI1↓, 1,   BMP2↓, 1,   BMPs↑, 1,   CD133↓, 15,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 69,   CSCsMark↓, 2,   Diff↓, 2,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 13,   GREM1↓, 1,   HH↓, 15,   HH↝, 1,   IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↓, 1,   Let-7↑, 2,   LRP6↓, 3,   p‑LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 18,   NOTCH↑, 1,   NOTCH1↓, 18,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH3↓, 3,   p300↓, 2,   Pirin↓, 1,   PTCH1↓, 4,   PTCH2↓, 1,   SFRP5↑, 1,   Shh↓, 13,   Smo↓, 6,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG?, 2,   TumCG↓, 62,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 112,   TumCP↑, 3,   tyrosinase↓, 1,   WDR72↓, 1,   Wnt↓, 44,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AEG1↓, 2,   AEG1↑, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 7,   AP-1↝, 1,   AXL↓, 2,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 21,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 1,   Cdc42↓, 1,   Chl↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 19,   E-cadherin↑, 123,   EM↑, 2,   EMT?, 1,   EMT↓, 349,   EMT↑, 7,   EMT↝, 2,   EpCAM↓, 1,   F-actin↓, 2,   F-actin↑, 1,   FAK↓, 16,   FAK↑, 1,   p‑FAK↓, 3,   fascin↓, 1,   Fibronectin↓, 11,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 3,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGA5↑, 1,   ITGB1↓, 7,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LAMA5↑, 1,   LAMs↓, 2,   LEF1↓, 4,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 2,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 97,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 7,   MMP9↓, 99,   MMP9↑, 2,   MMP9↝, 1,   MMPs↓, 28,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 87,   PAK1↓, 1,   p‑pax↓, 1,   PDGF↓, 5,   PIR↓, 1,   Rac1↓, 3,   RHBDD1↓, 1,   Rho↓, 6,   ROCK1↓, 9,   Slug?, 1,   Slug↓, 41,   Smad1↓, 4,   Smad1↝, 1,   SMAD2↓, 5,   p‑SMAD2↓, 10,   SMAD3↓, 7,   p‑SMAD3↓, 8,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 75,   Snail↑, 2,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 31,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 3,   TIMP1↑, 6,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSP-1↑, 4,   TumCA↓, 2,   TumCI↓, 128,   TumCI↑, 3,   TumCMig↓, 129,   TumCMig↑, 3,   TumMeta↓, 77,   TumMeta↑, 5,   Twist↓, 30,   Twist↑, 2,   Tyro3↓, 1,   uPA↓, 22,   uPAR↓, 2,   Vim?, 1,   Vim↓, 103,   Vim↑, 3,   Zeb1↓, 32,   Zeb1↑, 2,   ZEB2↓, 2,   ZEB2↑, 2,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 65,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 64,   angioG↑, 2,   CD31/PECAM-1↓, 3,   eNOS↓, 3,   HIF-1↓, 5,   Hif1a↓, 49,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   TXA2↓, 1,   VEGF↓, 76,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 14,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 4,   CLDN1↓, 6,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN7↑, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT2↓, 1,   MMP↓, 62,   MMP↑, 1,   MPT↑, 4,   NHE1↓, 1,   TRPV2↑, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   CD44↓, 18,   CD8+↑, 4,   COX1↓, 2,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR4↓, 10,   DR4↑, 3,   FOXP3↑, 1,   FoxP3+↓, 1,   HMGB1↓, 6,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 4,   IL12↓, 1,   IL12↑, 1,   IL18↓, 2,   IL1β↓, 13,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL6↓, 32,   IL6↑, 1,   IL8↓, 7,   Imm↑, 9,   Imm↝, 3,   Inflam↓, 22,   IRAK1↓, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   NF-kB↓, 101,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 3,   p50↓, 1,   p65↓, 6,   p65↑, 1,   p‑p65↓, 5,   PD-1↓, 4,   PD-L1↓, 9,   PD-L2↓, 1,   PGE2↓, 19,   PSA↓, 4,   RAGE↓, 1,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↓, 5,   TCF7/TCF1↓, 2,   Th1 response↑, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR4↓, 3,   TNF-α↓, 23,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   IM↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 2,   AR↓, 12,   ER-α36↓, 1,   ER-α36↝, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 26,   BioAv↑, 26,   BioAv↝, 7,   ChemoSen↓, 1,   ChemoSen↑, 111,   ChemoSen⇅, 1,   CompStab↓, 2,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 4,   Dose↝, 19,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 38,   eff↝, 6,   eff∅, 2,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 8,   Half-Life↑, 1,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 7,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS↑, 37,   selectivity?, 1,   selectivity↑, 38,   Synergy↑, 83,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 4,   ALB↑, 1,   ALP↓, 3,   AR↓, 12,   AST?, 1,   AST↓, 2,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 2,   DBIL↓, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 6,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IBIL↓, 1,   IL6↓, 32,   IL6↑, 1,   IRes↓, 1,   LDH↓, 5,   LDH↑, 3,   Maspin↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 4,   RAGE↓, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 15,   cachexia↓, 2,   cardioP↑, 6,   chemoP?, 1,   chemoP↑, 11,   chemoPv↑, 10,   ChemoSideEff↓, 4,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 12,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 6,   Symptoms∅, 1,   toxicity?, 1,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 7,   toxicity∅, 2,   TumVol↓, 15,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 958

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 43,   Catalase↑, 18,   DPPH↓, 1,   GPx↓, 1,   GPx↑, 13,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 16,   GSR↑, 2,   GSTs↑, 7,   HDL↓, 1,   HDL↑, 1,   HO-1?, 1,   HO-1↑, 8,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 13,   MDA↑, 1,   MPO↓, 2,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 20,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 56,   SOD↓, 1,   SOD↑, 18,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 1,   TrxR↑, 1,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   PKM2↓, 1,   PLA2↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp↓, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 4,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↓, 1,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 4,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 1,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↝, 2,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Ki-67↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 4,   EMT↓, 7,   EMT↑, 2,   Fibronectin↓, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   Smad7↑, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   Twist↑, 1,   Vim↓, 4,   Vim↑, 1,   α-SMA↓, 6,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↓, 2,   NO↓, 4,   NO↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↑, 3,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL10↓, 3,   IL10↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 1,   IL2↑, 1,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 2,   IL6↓, 14,   IL8↓, 3,   Imm↓, 1,   Imm↑, 3,   Inflam?, 2,   Inflam↓, 43,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 17,   NLRP3↓, 2,   PGE2↓, 8,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 17,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   PPARα↝, 1,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 8,   BioAv↝, 3,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 3,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   AST↓, 7,   BMD↑, 1,   BP↓, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 14,   LDH↓, 2,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 5,   AntiArt↑, 2,   AntiCan↑, 5,   AntiDiabetic↑, 10,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 19,   chemoP↑, 2,   chemoPv↑, 5,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↑, 19,   Learn↑, 1,   memory↑, 6,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 34,   Obesity↓, 2,   PDE4↓, 1,   radioP↑, 2,   RenoP↑, 5,   Stroke↓, 2,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   GutMicro↑, 5,   GutMicro↝, 1,   Sepsis↓, 2,  
Total Targets: 244

Scientific Paper Hit Count for: EMT, Epithelial-Mesenchymal Transition
19 Curcumin
17 Resveratrol
16 Quercetin
13 Honokiol
13 Luteolin
10 Sulforaphane (mainly Broccoli)
9 Ashwagandha(Withaferin A)
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
9 Thymoquinone
7 Kaempferol
6 Astragalus
6 Berberine
6 Matrine
6 Metformin
6 Piperine
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Betulinic acid
5 Chrysin
5 Emodin
5 Eugenol
5 Silymarin (Milk Thistle) silibinin
4 Alpha-Lipoic-Acid
4 Baicalein
4 Propolis -bee glue
4 Chlorogenic acid
4 Diindolylmethane
4 Inositol
4 Morin
4 Pterostilbene
4 Shikonin
3 Artemisinin
3 Atorvastatin
3 5-fluorouracil
3 Cyclopamine
3 salinomycin
3 Genistein (soy isoflavone)
3 Ferulic acid
3 Fucoidan
3 Garcinol
3 HydroxyTyrosol
3 Lycopene
3 Magnolol
3 Melatonin
3 Nimbolide
3 Piperlongumine
3 Urolithin
2 Anethole/trans-Anethole
2 Cisplatin
2 Astaxanthin
2 Beta-Caryophyllene
2 brusatol
2 Capsaicin
2 Cannabidiol
2 Celecoxib
2 Centella asiatica / Gotu kola → asiaticoside
2 Crocetin
2 Radiotherapy/Radiation
2 Deguelin
2 Dandelion Root
2 Disulfiram
2 Ellagic acid
2 Sorafenib (brand name Nexavar)
2 Paclitaxel/Taxol
2 Ginkgetin
2 Grapeseed extract
2 phytic acid, Inositol hexakisphosphate
2 Isoliquiritigenin
2 isoflavones
2 isoorientin
2 isoquercitrin
2 Ivermectin
2 Juglone
2 Licorice
2 Lactoferrin/Talactoferrin
2 Naringin
2 Phenethyl isothiocyanate
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 Anthocyanins
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Brucea javanica
1 Boron
1 Carnosic acid
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cucurbitacin
1 Oxaliplatin
1 Dichloroacetate
1 Docosahexaenoic Acid
1 immunotherapy
1 Copper and Cu NanoParticles
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Cinnamon
1 Evodiamine
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgolide B
1 Proanthocyanidins
1 Hydrogen Gas
1 Chemotherapy
1 Hydroxycinnamic-acid
1 Hyperoside
1 Isovitexin
1 methotrexate
1 Lutein
1 mebendazole
1 MCT, metronomic chemo
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Plumbagin
1 Psoralidin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Selenium
1 Selenate
1 Gemcitabine (Gemzar)
1 Selenite (Sodium)
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin K2
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:96  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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