Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1083- CGA,    In Silico Insight the Prediction of Chlorogenic Acid in Coffee through Cyclooxygenase-2 (COX2) Interaction
- Analysis, NA, NA
COX2↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF-7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
1244- CGA,  immuno,    Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody
- in-vivo, NA, NA
PD-L1↓, T-Cell↑, eff↑,
1298- CGA,    Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells
- in-vitro, Lung, A549
Bcl-2↓, BAX↑, Casp3↑, p38↑, JNK↑, Nanog↓, SOX2↓, OCT4↓,
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1↓, LDHA↓, GLUT1↓, ECAR↓,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
MDSCs↓, TregCell↓, IL10↓, NK cell↑,
6025- Chit,    Glycated chitosan as a new non-toxic immunological stimulant
- vitro+vivo, Var, HeLa
*Imm↑, *BioAv↑, eff↑, *toxicity↓, *TNF-α↑, *Obesity↓,
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, IFN-γ↑, IL12↑, IL15↑, STAT4↑, NF-kB↑, DCells↑,
6000- Chit,    Chitosan in Modern Pharmacotherapy: From Drug Encapsulation to Targeted Delivery Systems
- Review, Var, NA
DDS↑, toxicity↓, TJ↓, BioAv↑, *Bacteria↓, *Inflam↓, *antiOx↓, Wound Healing↑, other↝, eff↑, eff↑,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,
5980- Chit,    Chitosan-based nanosystems for cancer diagnosis and therapy: Stimuli-responsive, immune response, and clinical studies
- Review, Var, NA
other↑, Imm↑, DDS↑,
5981- Chit,    Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review
- Review, CRC, NA
DDS↑, eff↑, BioAv↑, BioEnh↑, eff↑,
5982- Chit,    Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges
- Review, Var, NA
DDS↑, antiOx↑, Bacteria↓, AntiTum↑, Half-Life↑, BioAv↑, toxicity↓,
5983- Chit,    Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
- Review, BC, NA
DDS↑, BioAv↑, EPR↑, TumCP↓, angioG↓, TumMeta↓, other↑,
5984- Chit,    Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
- Review, Var, NA
DDS↑, BioAv↑, TumCP↓, angioG↓, TumMeta↓, Apoptosis↑, eff↑,
5985- Chit,  immuno,    Immunomodulatory potential of chitosan-based materials for cancer therapy: a systematic review of in vitro, in vivo and clinical studies.
- Review, Var, NA
TumCP↓, TumW↓, OS↑, eff↑,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
5989- Chit,    Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms
- Review, Var, NA
Wound Healing↑, Imm↑, AntiTum↑,
5991- Chit,    Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies
- Review, BC, NA
*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,
5999- Chit,    How chitosan can help against breast cancer
- Review, BC, NA
eff↑, DDS↑, Half-Life↑, eff↑, eff↑,
5998- Chit,    Trial: Chitosan can help reduce AGE levels in patients with prostate cancer.
- Trial, Pca, NA
AGEs↓, Wound Healing↑, Obesity↓,
5997- Chit,    Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU
- in-vivo, Lung, NA
Imm↑, TumMeta↓, eff↑,
5996- Chit,    NEW CHITOSAN-BASED CHEMO PHARMACEUTICAL DELIVERY SYSTEMS FOR TUMOR CANCER TREATMENT: SHORT-REVIEW
- Review, Var, NA
BioAv↑, Wound Healing↑, DDS↑, toxicity↓, eff↑,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
5993- Chit,    In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy
- in-vitro, Var, NA
Imm↑,
5992- Chit,    Preparation of chitosan nanoparticles for simultaneous drug delivery of dacarbazine and enoxaparin in melanoma
- in-vitro, Melanoma, B16-F10
eff↑, DDS↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, NA, NA
*LDL↓,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, NA, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
4482- Chit,    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
EPR↑, mtDam↑, ROS↑, Apoptosis↑,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6066- CHL,    The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
- in-vitro, BC, MCF-7
ERK↓, Bcl-2↓, Apoptosis↑,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6074- CHL,    Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME)
- Study, GBM, NA
*Inflam↓,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
6071- CHL,    First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent
- Trial, Nor, NA
*Dose↑, *toxicity↓, *Imm↑,
6081- CHL,    Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review
- Review, Nor, NA
*antiOx↑, *toxicity↓, *BioAv↓, *BioAv↑, *neuroP↑, *Obesity↓, *AntiCan↑, *TumCP↓, *PhotoS↑, *neuroP↑,
6073- CHL,  GEM,    Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis
- in-vitro, PC, NA
ChemoSen↑, eff↑, AntiTum↑, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, GSH↓, ROS↑, HSP70/HSPA5↑,

Showing Research Papers: 2101 to 2150 of 6604
Prev Page 43 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 2,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   ROS↑, 10,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   MPT↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   homoC↓, 1,   LDHA↓, 1,   PDK1↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 10,   BAX↑, 2,   Bcl-2↓, 3,   Casp↑, 1,   Casp3↑, 3,   Casp8↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↑, 1,   p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   other↝, 7,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   LRP6↓, 1,   p‑LRP6↓, 1,   Nanog↓, 1,   OCT4↓, 1,   SOX2↓, 1,   STAT1↑, 1,   STAT4↑, 1,   TumCG↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 2,   MMP9↓, 3,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TJ↓, 1,   TregCell↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 5,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EPR↑, 8,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   DCells↑, 1,   IFN-γ↑, 2,   IL10↓, 1,   IL10↑, 1,   IL12↑, 1,   IL15↑, 1,   IL1β↓, 1,   IL2↑, 1,   Imm↑, 5,   Inflam↓, 1,   MDSCs↓, 1,   NF-kB↑, 1,   NK cell↑, 4,   PD-L1↓, 1,   T-Cell↑, 1,  

Cellular Microenvironment ⓘ

cGAS–STING↑, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 8,   BioEnh↑, 1,   ChemoSen↑, 7,   DDS↑, 13,   Dose↝, 1,   eff↓, 2,   eff↑, 32,   eff↝, 2,   Half-Life↑, 6,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 6,   chemoPv↑, 2,   Obesity↓, 1,   OS↑, 1,   toxicity↓, 7,   TumVol↓, 2,   TumW↓, 2,   Wound Healing↑, 4,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 108

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 4,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 5,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 2,  

Transcription & Epigenetics ⓘ

other↝, 3,   PhotoS↑, 1,  

Migration ⓘ

Cartilage↑, 1,   TGF-β1↓, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   IL10↓, 1,   Imm↑, 5,   Inflam↓, 4,   TNF-α↓, 1,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 8,   BioAv↝, 1,   Dose↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 3,   toxicity↓, 7,   Weight↝, 2,   Wound Healing↑, 3,  

Infection & Microbiome ⓘ

Bacteria↓, 4,  
Total Targets: 38

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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