Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
6067- CHL,    Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
- in-vitro, BC, MCF-7
TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CycB/CCNB1↑,
6065- CHL,    Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin
- Review, HCC, NA
*eff↑, *chemoPv↑, *other↝,
6075- CHL,  docx,    The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro
- vitro+vivo, BC, 4T1
TumCMig↓, eff↑, TumMeta↓, TumCCA↑, Trx↓, ROS↓, TumCD↑, GSTP1/GSTπ↓,
6077- CHL,    Cancer chemoprevention by dietary chlorophylls: A 12,000-animal dose-dose matrix biomarker and tumor study
- in-vivo, Var, NA
eff↑, chemoP↑,
6079- CHL,    Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
- in-vivo, Nor, NA
*eff↑, *GutMicro↑, *NF-kB↓, *MMPs↑, *TIMP1↓, *Inflam↓, *Dysb↓,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
6076- CHL,    Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers
- Human, Nor, NA
eff↑,
6093- CHOC,    The relevance of theobromine for the beneficial effects of cocoa consumption
- Review, Nor, NA - NA, asthmatic, NA
*toxicity↓, *eff↑, *Half-Life↑, *eff↑, *Inflam↓, *HDL↑, *Obesity↓,
6094- CHOC,    Impact of Cocoa Products Intake on Plasma and Urine Metabolites: A Review of Targeted and Non-Targeted Studies in Humans
- Human, Nor, NA
*GutMicro↑, *BP↓, *AntiAg↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2↓, iNOS↓, NF-kB↓, chemoP↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
6087- CHOC,    Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
- Trial, Nor, NA
*cardioP↑, *Dose↝, *BP↓, *Inflam↓, *AntiAg↑, *Risk↓,
6088- CHOC,    Effect of chocolate on older patients with cancer in palliative care: a randomised controlled study
- Trial, Var, NA
eff↑, *ROS↓, *MDA↓, *GSH↑,
6089- CHOC,    Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
- Trial, Nor, NA
*Dose↝, *BP↓, *cognitive↑,
6090- CHOC,    Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, Nor, NA
*Dose↝, *cardioP↑,
6091- CHOC,    Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women's Health Initiative
- Study, Nor, NA
*Risk↓, *cardioP↑, *OS↑,
6092- CHOC,    Long-term effect of cocoa extract supplementation on incident hypertension
- Review, Nor, NA
BP↝,
6107- Chol,    Choline supplements: An update
- Review, AD, NA
*memory↑, *cognitive↑, *Dose↝, *BBB↑, *cardioP↑, *ROS↓, *TMAO↑, *memory∅, *eff↑,
6111- Chol,    The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
- Human, AD, NA
*Risk↑, *TMAO↑, *Dose↝, *eff↑,
6113- Chol,    Association between choline supplementation and Alzheimer’s disease risk: a systematic review protocol
- Review, AD, NA
*cognitive↑, *eff↑, *Dose↝, *Dose↓,
6112- Chol,    Trimethylamine N-oxide induced cognitive impairment through disruption of blood-brain barrier by inhibiting TGF-β pathway
- in-vivo, AD, NA
*TMAO↑, *cognitive↓, *BBB↝, *TJ↝,
6151- Chol,    Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study
- Study, GBM, NA
OS↑,
6150- Chol,    Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
- Trial, AD, NA
*cognitive↑,
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
6121- Chol,    Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial
- Human, AD, NA
*TMAO⇅, *eff↑,
6114- Chol,    Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults
- Study, AD, NA
*Risk↓, *Dose↝,
6115- Chol,    Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study
- Study, AD, NA
*Risk↓, *cognitive↑, *Dose↝, *TMAO↑,
6116- Chol,    Is dietary choline intake related to dementia and Alzheimer’s disease risks? Results from the Framingham Heart Study
- Study, AD, NA
*Risk↓, *TMAO↑,
6117- Chol,    Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- Trial, AD, NA
*memory↑, *TMAO∅, *Dose↝,
6118- Chol,    Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis
- Review, NA, NA
*eff↑, *cognitive↑, *BBB↑, *Ach↑,
6119- Chol,    Is Citicoline Effective in Preventing and Slowing Down Dementia?—A Systematic Review and a Meta-Analysis
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, *Ach↑, *Apoptosis↓, *neuroP↑, *memory↑,
6120- Chol,    Citicoline: A Cholinergic Precursor with a Pivotal Role in Dementia and Alzheimer’s Disease
- Trial, AD, NA
*Dose↝, *cognitive↑, *QoL?,
6106- Chol,    Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study
- Study, HCC, NA
OS↑,
6105- Chol,    Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet
- in-vivo, Nor, NA
*hepatoP↑,
6104- Chol,    Dietary choline intake and colorectal cancer: a cross-sectional study of 2005–2018 NHANES cycles
- Study, HCC, NA
Risk∅, Risk⇅,
6103- Chol,    Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice
- in-vivo, HCC, NA
AntiTum↑, eff↑,
6102- Chol,    Higher dietary choline intake is associated with increased risk of all-cause and cause-specific mortality: A systematic review and dose-response meta-analysis of cohort studies
- Analysis, CardioV, NA
*Risk↑,
6101- Chol,    Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men
- Human, Nor, NA
*TMAO↑, *Dose↝, *GutMicro↝, *TMAO∅,
6100- Chol,    Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells
- Review, Var, NA
other↑, other↝, other↝, other↝, other↝,
6099- Chol,    Choline metabolism-based molecular diagnosis of cancer: an update
- Review, Var, NA
other↝, other↝,
6098- Chol,    Choline
- Review, Nor, NA - Review, AD, NA
*BioAv↝, *Dose↝, *cardioP↑, *BP↓, *cognitive↑, *memory↑, eff∅,
6097- Chol,    Choline intake and risk of lethal prostate cancer: incidence and survival
- Study, Pca, NA
Risk↑, other↝,
6096- Chol,    Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Study, CRC, NA
Risk↓, other↑,
6095- Chol,    Choline metabolism and its implications in cancer
- Review, Var, NA
BioAv↑, other↑, other↑, other↝,
6149- Chol,    Prostate cancer progression and mortality: a review of diet and lifestyle factors
- Review, Var, NA
Risk↑,
3699- Chol,    Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study
- Study, AD, NA
*other∅, *cognitive↑,

Showing Research Papers: 2151 to 2200 of 6604
Prev Page 44 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

CYP1A1↓, 1,   CYP1A1↑, 1,   GSH↑, 1,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   ROS↓, 2,   ROS↑, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis

AKT1↓, 1,  

Cell Death

p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp↑, 1,   Casp8↓, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics

other↑, 4,   other↝, 8,  

DNA Damage & Repair

cl‑PARP↑, 1,  

Cell Cycle & Senescence

CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State

TumCG↓, 1,  

Migration

TumCMig↓, 1,   TumCP↓, 4,   TumMeta↓, 2,  

Angiogenesis & Vasculature

angioG↓, 1,  

Immune & Inflammatory Signaling

COX1↑, 1,   COX2↓, 2,   IKKα↓, 1,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 3,   PGE2↓, 2,  

Drug Metabolism & Resistance

BioAv↑, 1,   eff↑, 6,   eff∅, 1,   selectivity↑, 1,  

Clinical Biomarkers

BP↝, 1,  

Functional Outcomes

AntiTum↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   OS↑, 2,   Risk↓, 1,   Risk↑, 2,   Risk⇅, 1,   Risk∅, 1,  
Total Targets: 54

Pathway results for Effect on Normal Cells:


NA, unassigned

Dysb↓, 1,   TMAO↑, 7,   TMAO⇅, 1,   TMAO∅, 2,  

Redox & Oxidative Stress

antiOx↑, 2,   GSH↑, 1,   HDL↑, 2,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 5,   ROS↑, 1,  

Mitochondria & Bioenergetics

MMP∅, 1,  

Core Metabolism/Glycolysis

LDL↓, 1,   NADPH↑, 1,  

Cell Death

Apoptosis↓, 1,  

Transcription & Epigenetics

Ach↑, 2,   other↓, 1,   other↝, 4,   other∅, 1,  

Protein Folding & ER Stress

ER Stress↑, 1,  

Migration

5LO↓, 1,   AntiAg↓, 1,   AntiAg↑, 5,   Ca+2↓, 1,   Ca+2↑, 1,   CLDN1↓, 1,   MMPs↑, 1,   TIMP1↓, 1,   TJ↓, 1,   TJ↝, 1,   ZO-1↓, 1,  

Barriers & Transport

BBB↑, 2,   BBB↝, 1,  

Immune & Inflammatory Signaling

Imm↑, 1,   Inflam↓, 4,   Inflam↑, 1,   NF-kB↓, 2,  

Protein Aggregation

NLRP3↑, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 2,   BioAv⇅, 1,   BioAv↝, 1,   Dose↓, 1,   Dose↝, 14,   eff↓, 1,   eff↑, 10,   Half-Life↑, 1,  

Clinical Biomarkers

BP↓, 6,   GutMicro↑, 2,   GutMicro↝, 1,  

Functional Outcomes

AntiDiabetic↑, 1,   cardioP↑, 6,   chemoPv↑, 3,   cognitive↓, 3,   cognitive↑, 12,   hepatoP↑, 1,   memory↑, 4,   memory∅, 1,   neuroP↑, 1,   Obesity↓, 2,   OS↑, 1,   QoL?, 1,   Risk↓, 6,   Risk↑, 2,   toxicity↓, 1,  
Total Targets: 65

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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