Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

6133-

CHr,

Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells.

Review,

Var,

TumCP↓, Apoptosis↑, angioG↓, eff↑, CYP19↓, Hif1a↓, VEGF↓, NF-kB↓, PI3K↓, Akt↓,

6132-

CHr,

MET,

Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression

in-vitro,

BC,

T47D

Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, TumCP↓, Apoptosis↑, TumCI↓, TumMeta↓, angioG↓, selectivity↑,

6130-

CHr,

Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4

vitro+vivo,

Colon,

CT26

80 μg.mL-1

tumCV↓, Apoptosis↑, TumVol↓, BAX↑, SALL4↓, Casp3↑, Casp9↑, ChemoSen↑, GSH↓,

6131-

CHr,

Bor,

Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells

in-vitro,

Lung,

A549

*BioAv↑, ROS↑, TumCD↑, TumCCA↑, MMP2↓, TumMeta↓, TumCI↓, GSH↓, eff↑,

6139-

CHr,

Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials

Review,

Var,

RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, Synergy↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,

6134-

CHr,

QC,

RT,

Comparative Pharmacokinetics and Safety of a Micellar Chrysin–Quercetin–Rutin Formulation: A Randomized Crossover Trial

Trial,

Nor,

 novel micellar chrysin formulation co-encapsulated with quercetin and rutin (LMC) compared with a non-micellar chrysin formulation (NMC) and unformulated chrysin (UFC).

Dose↝, BioAv↑, MPT↑, Synergy↑, Half-Life↑,

6135-

CHr,

Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review

Review,

Var,

Review,

AD,

Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, Synergy↑, Synergy↑, *Synergy↑, RadioS↑, Synergy↑, ChemoSen↑, eff↑,

6136-

CHr,

Tras,

Synergistic anticancer effects of Chrysin and trastuzumab in HER2-Positive breast cancer cells

in-vitro,

BC,

SkBr3

in-vitro,

BC,

BT474

in-vitro,

Nor,

MCF10

eff↑, HER2/EBBR2↓, p‑STAT3↓, PD-L1↓, ChemoSen↑,

6137-

CHr,

Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters

in-vitro,

NA,

CYP2C9↓, OATPs↓, ABCG2↓, BioEnh↝,

6138-

CHr,

Cisplatin,

Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53

in-vivo,

Nor,

Wistar rats once daily for 14 consecutive days at the doses of 25 and 50 mg/kg body weight orally in corn oil.

*toxicity↝, eff↑, chemoP↑, *ROS↓, *MAPK↑, *P53↑, GSH↓,

6129-

CHr,

A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases

vitro+vivo,

Melanoma,

 Xenograft Mouse Model

ATP↓, TumCCA↑, CDK2↓, CDK4↓, TumW↓,

6128-

CHr,

Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential

Review,

Nor,

Review,

Var,

Review,

AD,

*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,

6127-

CHr,

Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric Cancer Cells

in-vitro,

GC,

AGS

AP-1↓, p‑cJun↓, p‑cFos↓, JNK↓, ERK↓, MMP9↓, TumCI↓,

6126-

CHr,

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

in-vitro,

Melanoma,

tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,

6125-

CHr,

Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells

in-vitro,

SCC,

CLDN1↓, p‑Akt↓, ChemoSen↑,

6124-

CHr,

EGCG,

The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells

in-vitro,

HCC,

HepG2

TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, Synergy↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,

6123-

CHr,

Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms

Review,

Nor,

*eff↓, *BioAv↓, *eff↑, *BioAv↓, OATPs↓, MRP↓,

6122-

CHr,

Disposition and metabolism of the flavonoid chrysin in normal volunteers

Human,

Nor,

Oral 400 mg doses of chrysin were administered to seven subjects.

*Dose↝, *BioAv↓,

2590-

CHr,

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

in-vitro,

GBM,

T98G

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,

2591-

CHr,

doxoR,

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

in-vitro,

HCC,

Bel-7402

NRF2↓, ChemoSen↑, HO-1↓,

2796-

CHr,

Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice

in-vivo,

Lung,

(250mg/kg

Swiss albino mice

PCNA↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2/PTGS2↓, *NF-kB↓, *ROS↓,

2797-

CHr,

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells

in-vivo,

BC,

40-100 uM

metastasis mouse model of breast cancer

in-vitro,

BC,

4T1

100 and 250 mg/kg daily

tumCV↓, p‑STAT3↓, VEGF↓, Weight∅, angioG↓,

2798-

CHr,

Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

90 mg/kg/day

xenograft animal model

HDAC↓, HDAC8↓, TumCG↓, Diff↑,

2799-

CHr,

Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB

in-vivo,

RCC,

20 and 40 mg/kg body weight

Rat

*chemoPv↑, *ROS↓, *Inflam↓,

2800-

CHr,

Chrysin Activates Notch1 Signaling and Suppresses Tumor Growth of Anaplastic Thyroid Carcinoma In vitro and In vivo

in-vitro,

Thyroid,

TumCG↓, NOTCH↑, cl‑PARP↑, Apoptosis↑,

2801-

CHr,

AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells

in-vitro,

Lung,

A549

AMPK↑, Akt↓, ChemoSen↑, ROS↑,

2802-

CHr,

Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis

in-vitro,

Pca,

DU145

in-vivo,

Pca,

nude mice

Hif1a↓, VEGF↓, angioG↓,

2803-

CHr,

5-FU,

Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells

in-vitro,

GC,

AGS

chrysin doses of 40, 50, 60 and 80 µM, and 5-FU doses of 20, 25, 30 and 40 µM,

ChemoSen↑, TumCCA↑, Synergy↑, MDR1↓,

2804-

CHr,

Rad,

Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway

in-vitro,

CRC,

HT29

RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,

2805-

CHr,

Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

in-vitro,

ESCC,

KYSE150

in-vivo,

ESCC,

FAK↓, GlucoseCon↓, Casp3↑, Casp7↑, p‑Akt↓, TumCG↓, Weight∅,

2806-

CHr,

Se,

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy

in-vitro,

Var,

ChemoSen↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,

2807-

CHr,

Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats

in-vivo,

Nor,

Wistar rats

*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,

2795-

CHr,

Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

in-vitro,

Liver,

HepG2

ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,

2780-

CHr,

Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Review,

Var,

*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,

2781-

CHr,

PBG,

Chrysin a promising anticancer agent: recent perspectives

Review,

Var,

PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,

2782-

CHr,

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Review,

Var,

Review,

Stroke,

Review,

Park,

*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,

2783-

CHr,

Apoptotic Effects of Chrysin in Human Cancer Cell Lines

Review,

Var,

TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,

2784-

CHr,

Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)

Review,

Var,

Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,

2785-

CHr,

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Review,

Var,

*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,

2786-

CHr,

Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives

Review,

Var,

Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,

2787-

CHr,

Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics

Analysis,

Var,

MCF7

22.55 µM

TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,

2788-

CHr,

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Review,

Var,

*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2/PTGS2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,

2789-

CHr,

Anticancer Activity of Ether Derivatives of Chrysin

Review,

Var,

eff↑, COX2/PTGS2↓, PGE2↓, Synergy↑,

2790-

CHr,

Chrysin: Pharmacological and therapeutic properties

Review,

Var,

*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,

2791-

CHr,

Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

in-vitro,

Ovarian,

OV90

TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,

2792-

CHr,

Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

in-vitro,

Pca,

DU145

0, 5, 10, 20, 50 and 100 Î¼M

in-vitro,

Pca,

PC3

DNAdam↑, TumCCA↑, MMP↓, ROS↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, PI3K↓, Akt↓, p70S6↓, MAPK↑,

2793-

CHr,

Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer

in-vitro,

Lung,

A549

17.59 μM, 7.29 μM, and 4.11 μM at 24 h, 48 h, and 72 h,

in-vitro,

Lung,

H157

20.65 μM, 7.83 μM, and 3.70 μM

in-vivo,

NA,

mice

TumCG↓, M2 MC↑, CDK1↓,

2794-

CHr,

An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

Review,

Park,

Review,

Stroke,

*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,

1144-

CHr,

8-bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK

in-vitro,

HCC,

HepG2

10 μmol/L

in-vitro,

HCC,

Bel-7402

in-vitro,

Nor,

HL7702

BrMC had little effect on human embryo liver L-02 cells  ****

Casp3↑, *ROS∅, ROS↑, JNK↑, *toxicity↓,

1145-

CHr,

Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways

in-vitro,

Cerv,

HeLa

tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,

Showing Research Papers: 2351 to 2400 of 8542
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8542

Pathway results for Effect on Cancer / Diseased Cells:

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,
Total Targets: 2882

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1, 15-LOX/ALOX15↓, 1, 2/16-OHE1↑, 1, 3-NT↓, 1, 3MST/MPST↑, 1, 5-HETE↓, 1, ACADS/SCAD↑, 1, ACE/ACE1↓, 6, ACE2↓, 1, AcOH↑, 2, e-ADO↑, 1, AIF1/Iba-1↓, 3, Airway↓, 3, AirwayM↓, 4, AKR1B1/ALR2↑, 1, AKR1B10↝, 1, AKR1C3/17β-HSD5/PGF Synthase↑, 1, ALDOC↑, 1, Analgesic↑, 2, anemia↓, 1, AntiBio↓, 1, AntiBio↑, 61, antiM↑, 1, antiPy↑, 1, APOE4↓, 1, Astr↓, 2, autophagy↓, 2, autophagy↑, 1, autophagy↝, 1, Aβ42↓, 11, BALF-Infl↓, 3, BALF-Lym↓, 1, BDI↓, 1, Buty↑, 4, CBS↑, 1, CCL11↓, 1, CCr / CrCl↓, 1, CCr / CrCl∅, 1, CD19↑, 1, CES2↓, 1, CHRM1↑, 1, Cit/L-Cit↝, 1, colonLen↑, 1, compII↑, 1, CompStab↓, 2, CompStab↑, 1, compV↑, 1, cough?, 1, CryoP↑, 2, CXCL15↓, 1, CYP2C19↓, 1, CYP2C8↓, 1, CYP2D6↓, 2, DA↑, 1, DCR∅, 1, DHODH↓, 1, diuretic↑, 10, DUOX1↓, 1, Dysb↓, 2, Eic↓, 1, END↑, 2, ENL↑, 1, Eos↓, 7, FAM↑, 1, p‑FcεRI↓, 1, FEV1↑, 2, FFA/NEFA↓, 2, FFA/NEFA↝, 1, FNDC5↑, 1, FPN↑, 1, GAD1/GAD67↑, 1, GDNF↑, 1, GFAP↓, 6, GLP-1R↑, 1, GlyFlow↑, 3, GPER↑, 1, H+/K+-ATPase↓, 1, H3K9↓, 1, HRV↑, 1, IgE↓, 7, IgG1↓, 1, IL13↓, 7, IL1RL1/ST2↓, 1, ILC2↓, 1, Ingr?, 2, Ingr↑, 1, Ingr↝, 16, IPSS↓, 1, IRes↓, 3, IRes↑, 2, IRes↝, 1, Learn?, 2, Learn↑, 25, p‑LIMK1↑, 1, LPAR1/EDG2↑, 1, LTB4↓, 1, LTC4↓, 2, MEF2D↑, 1, MGlio↓, 1, miR-107↑, 1, miR-23a-3p↓, 1, p‑MLC2/MYL9↑, 1, MUC5AC↓, 1, Mucositis↓, 2, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1, NA↓, 1, NA↑, 1, NA↝, 2, Nausea↓, 1, NeuroI↓, 15, NGB↑, 1, NLR↓, 2, NMDAR↑, 1, p‑NMDAR↑, 1, NMSS↓, 1, NOD1↓, 1, NOX1↓, 1, NOX2↓, 3, ODC1↝, 1, ONOO↓, 1, ORR∅, 1, P-sel↓, 1, PA↑, 2, PAF↓, 2, PAF↑, 2, PCO↓, 1, PEF↑, 1, PFS∅, 1, PLA2↓, 2, PSEN1/PS1↓, 2, PSEN1/PS1↑, 1, PSEN2/PS-2↓, 1, PV↓, 4, QPCT/QC↓, 1, RBC↑, 2, RELN↑, 1, rHR↓, 1, RT↓, 2, SCFAs↑, 4, SCFAs∅, 1, SLIT2↑, 1, SNAP25↑, 2, SoreThr?, 1, SpO2↑, 1, Stress↓, 9, Stroke↓, 43, Stroke↑, 1, Stroke↝, 1, SUV39H↓, 1, SYN1↑, 1, SYN3↓, 1, SYP↑, 2, SYT1↑, 1, Tinn↓, 4, TMAO↓, 4, TMAO↑, 7, TMAO⇅, 1, TMAO∅, 2, TPH1↓, 1, TREM2↓, 1, TRPA1↑, 2, UFR↑, 3, UGT1A↓, 1, ULK1/ATG1↑, 1, UPDRS↓, 1, UPDRSIII∅, 1, UR↓, 2, Vomit↓, 1, β-HEX↓, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 6, antiOx?, 3, antiOx↓, 44, antiOx↑, 782, i-antiOx↑, 1, mt-antiOx↑, 1, ARE↑, 13, ARE↝, 1, Bil↓, 5, Bil↑, 2, Catalase↓, 9, Catalase↑, 252, Catalase↝, 2, compI↓, 2, compI↑, 2, Copper↓, 4, CoQ10↑, 1, CYP1A1↓, 3, CYP1A1↑, 1, CYP2E1↓, 8, DPPH↓, 2, Fenton↓, 8, Ferroptosis↓, 27, Ferroptosis↑, 3, GCLC↑, 7, GCLC↝, 1, GCLM↑, 5, GCLM↝, 1, GPx↓, 6, GPx↑, 183, GPx↝, 1, GPx∅, 1, GPx1↑, 11, GPx3↑, 1, GPx4↓, 1, GPx4↑, 21, GPx4∅, 1, GSH↓, 16, GSH↑, 314, GSH⇅, 1, GSH∅, 2, GSH/GSSG↓, 1, GSH/GSSG↑, 3, GSR↓, 3, GSR↑, 38, GSS↑, 2, GSSG↓, 7, GSSG∅, 1, GSTA1↓, 2, GSTA1↑, 13, GSTP1/GSTπ↓, 1, GSTs↓, 5, GSTs↑, 51, H2O2↓, 26, H2O2↑, 2, H2O2∅, 2, HDL↓, 3, HDL↑, 19, HDL∅, 2, HK1↑, 1, HNE↓, 3, HNE↑, 1, HO-1?, 1, HO-1↓, 8, HO-1↑, 227, HO-1⇅, 1, HO-1↝, 1, HO-1∅, 1, HO-2↓, 1, hyperG↓, 2, Iron↓, 13, Iron↑, 2, Iron↝, 1, Iron∅, 1, i-Iron↓, 3, i-Iron↑, 1, Keap1↓, 22, Keap1↑, 2, Keap1↝, 2, ox-Keap1↑, 1, lipid-P?, 3, lipid-P↓, 246, lipid-P↑, 6, mt-lipid-P↓, 1, lipidDe↓, 1, MDA↓, 250, MDA↑, 11, MDA∅, 1, Mets↝, 1, MFN1↓, 1, MFN1↑, 3, MFN1↝, 1, MFN2↓, 2, MFN2↑, 8, MFN2↝, 1, MPO↓, 29, MPO↑, 2, MPOD↑, 3, NADH↓, 1, NADPH/NADP+↑, 1, NFE2L2↓, 1, NOX4↓, 13, NQO1↑, 57, NQO1↝, 2, NQO1∅, 1, Nrf1?, 1, Nrf1↓, 1, Nrf1↑, 9, NRF2?, 1, NRF2↓, 17, NRF2↑, 406, NRF2⇅, 1, NRF2↝, 2, NRF2∅, 2, p‑NRF2↑, 2, OPA1↓, 2, OPA1↑, 4, OXPHOS↓, 3, OXPHOS↑, 8, PARK2↑, 7, Prx↓, 1, Prx↑, 7, Prx4∅, 1, PrxII↑, 1, RNS↓, 11, ROMO1↑, 1, ROS?, 8, ROS↓, 1071, ROS↑, 56, ROS⇅, 13, ROS↝, 3, ROS∅, 26, i-ROS↑, 1, mt-ROS?, 1, mt-ROS↓, 10, mt-ROS↑, 4, RPM↑, 1, RPM↝, 1, SAM-e↓, 3, SAM-e↑, 1, selenoP↑, 20, SIRT3↑, 16, SOD?, 2, SOD↓, 15, SOD↑, 365, SOD↝, 2, mt-SOD↑, 1, SOD1↓, 2, SOD1↑, 18, SOD2↓, 2, SOD2↑, 22, TAC↑, 48, TAC∅, 1, TBARS↓, 11, TBARS↑, 1, Thiols↓, 1, Thiols↑, 5, TOS↓, 3, TOS↑, 2, Trx↓, 2, Trx↑, 10, Trx1↑, 6, TrxR↓, 2, TrxR↑, 4, TrxR1↑, 4, UCPs↑, 2, UCPs↝, 1, uricA↓, 8, VDAC1↓, 1, VitC↑, 16, VitE↓, 1, VitE↑, 8, xCT/SLC7A11↓, 1, xCT/SLC7A11↑, 5,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, Ferritin↑, 2, FTH1↑, 2, FTL↓, 1, IronCh↓, 1, IronCh↑, 55, IronCh↝, 1, NCOA4↝, 1, TfR1/CD71↓, 5, TfR1/CD71↑, 1, Zn2+↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1, AIF↓, 4, AIF↑, 1, ATP↓, 5, ATP↑, 55, ATP↝, 1, ATP∅, 1, mt-ATP↑, 1, compIII↓, 1, compIII↑, 2, DRP1/DNM1L↓, 11, DRP1/DNM1L↑, 3, p‑DRP1/DNM1L↝, 1, EGF↑, 1, ETC↓, 4, ETC↑, 3, ETC↝, 2, FIS1↓, 12, FIS1↑, 3, Insulin↓, 9, Insulin↑, 9, Insulin↝, 1, MEK↓, 1, p‑MEK↓, 1, p‑MEK↑, 1, mitResp↓, 3, mitResp↑, 10, p‑MKK4↑, 1, MMP↓, 15, MMP↑, 77, MMP⇅, 1, MMP↝, 1, MMP∅, 4, MPT↑, 1, mtDam↓, 35, mtDam↑, 1, OCR↓, 4, OCR↑, 7, mt-OCR↑, 1, PGC-1α↓, 3, PGC-1α↑, 32, PGC-1α↝, 2, PINK1↓, 1, PINK1↑, 4, Raf↓, 1, UCP1↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 10, 12LOX↑, 1, Ac-histone H3↑, 1, ACC↓, 3, ACC↑, 3, p‑ACC↑, 1, mt-ACC⇅, 1, Acetyl-CoA↓, 2, Acetyl-CoA↑, 5, ACLY↓, 2, ACLY∅, 1, ACSL4↓, 3, ACSL4∅, 1, adiP↓, 2, adiP↑, 8, ALAT?, 1, ALAT↓, 96, ALAT↑, 2, ALAT∅, 4, ALDOA↑, 1, AMP↓, 1, AMPK↓, 4, AMPK↑, 75, AMPK⇅, 1, AMPK↝, 1, p‑AMPK↑, 8, ATG7↓, 1, BMAL1↑, 1, BUN?, 1, BUN↓, 13, BUN↑, 1, cAMP↑, 9, cMyc↓, 2, cMyc↑, 1, p‑cMyc↑, 1, cPLA2↓, 1, CPT1A↑, 1, CREB↓, 3, CREB↑, 30, CREB∅, 1, p‑CREB↑, 13, CRM↓, 1, CRM↑, 11, CYP2C6↓, 2, CYP2C6↑, 1, CYP3A2↓, 2, CYP3A2↑, 1, CYP3A4↓, 6, CYP3A4↑, 1, cytoP450↓, 2, DGAT1↓, 1, DHA↑, 3, ECAR↓, 5, ECAR↑, 2, ECAR∅, 1, FABP4↓, 2, FAO↓, 2, FAO↑, 7, mt-FAO↑, 1, FASN↓, 9, FGF21↑, 4, G6PD↑, 3, GAPDH↑, 1, GDH↓, 1, glucoNG↓, 3, glucose↓, 31, glucose↑, 2, glucose↝, 6, glucose∅, 1, GlucoseCon↓, 4, GlucoseCon↑, 22, GLUT2↑, 2, GlutMet↑, 1, glyC↓, 1, Glycolysis↓, 8, Glycolysis↑, 10, Glycolysis↝, 4, GPI↑, 1, H2S↑, 4, ac‑Histones↑, 1, HK2↓, 7, HK2↑, 6, HMG-CoA↓, 3, KeyT↑, 5, KeyT↝, 2, lactateProd↓, 6, LAT↑, 1, LDH↓, 42, LDH↑, 3, LDH∅, 1, LDHA↓, 4, LDHA↑, 5, LDHB↑, 1, LDL↓, 67, lipidLev↓, 5, lipoGen↓, 2, MATs↓, 1, MCU↓, 1, NAD↓, 1, NAD↑, 8, NAD↝, 1, NADH:NAD↑, 1, NADPH↓, 20, NADPH↑, 17, NADPH∅, 1, NH3↓, 3, NH3↑, 1, PDH↑, 1, PDK1 / PDPK1↓, 2, p‑PDK1 / PDPK1↓, 1, PDKs↓, 2, PDKs↑, 1, PFK↓, 2, PFK↑, 1, PFK1↓, 1, PFK2↓, 1, PFKFB2↓, 1, PFKL↑, 3, PFKM↑, 2, PFKP↓, 1, PFKP↑, 1, PGC1A↑, 2, PGM1?, 1, PIP3↑, 1, PKM1↑, 2, PKM2↓, 18, PKM2↑, 8, polyA↝, 1, PONs↓, 1, PONs↑, 1, PPARα↑, 14, PPARα↝, 1, PPARγ↓, 8, PPARγ↑, 30, p‑PPARγ↓, 1, PPP↓, 2, SCD1↓, 1, SIRT1↓, 4, SIRT1↑, 79, SIRT1↝, 1, SIRT1∅, 1, SIRT2↑, 3, SREBF2↓, 1, SREBP1/SREBF1↓, 8, SREBP1/SREBF1↑, 1, SREBP2↓, 1, SREBP2↑, 1, STK11/LKB1↑, 1, TCA↑, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AhR↑, 4, APAF1↓, 2, Apoptosis↓, 152, Apoptosis↑, 5, Apoptosis∅, 2, mt-Apoptosis↓, 1, ASK1↓, 2, ATF2↑, 1, BAD↓, 3, BAX↓, 59, BAX↑, 8, Bax:Bcl2↓, 13, Bax:Bcl2↑, 3, Bax:Bcl2↝, 1, Bcl-2↓, 10, Bcl-2↑, 50, Bcl-2↝, 1, Bcl-2∅, 1, Bcl-xL↓, 1, Bcl-xL↑, 2, BMP2↑, 3, Casp↓, 4, Casp1?, 1, Casp1↓, 14, cl‑Casp1↓, 2, proCasp1↓, 2, Casp12↓, 6, Casp3?, 1, Casp3↓, 93, Casp3↑, 9, Casp3∅, 2, cl‑Casp3↓, 17, cl‑Casp3↑, 1, proCasp3↓, 2, Casp6↓, 1, Casp7↓, 1, Casp8↓, 3, Casp8↑, 1, cl‑Casp8↑, 3, Casp9↓, 28, Casp9↑, 3, Casp9∅, 1, cl‑Casp9↓, 4, cl‑Casp9↑, 1, cellD↓, 1, CK2↓, 1, CK2↑, 1, Cyt‑c↓, 22, Cyt‑c↑, 5, Cyt‑c∅, 4, DR4↓, 1, Fas↓, 6, Fas↑, 2, FasL↓, 1, Ferroptosis↓, 27, Ferroptosis↑, 3, GADD34↓, 1, GranB/GZMB↓, 1, GRP58↓, 1, GSDMD?, 1, GSDMD↓, 3, HEY1↑, 1, HGF/c-Met↑, 2, Hippo↑, 1, IAP1↓, 1, iNOS↓, 130, iNOS↑, 6, JNK↓, 29, JNK↑, 4, p‑JNK↓, 13, p‑JNK↑, 4, MAPK?, 1, MAPK↓, 66, MAPK↑, 13, MAPK↝, 4, p‑MAPK?, 1, p‑MAPK↓, 3, MCT1↓, 1, MLKL↓, 1, necrosis↓, 4, p38↓, 20, p38↑, 6, p‑p38↓, 12, Pyro?, 1, Pyro↓, 5, RIP1↓, 1, RKIP↑, 1, survivin↓, 1, Telomerase↓, 1, TRPV1↑, 8, TUNEL↓, 1, YAP/TEAD↑, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 28, Akt↑, 65, Akt↝, 3, p‑Akt↓, 10, p‑Akt↑, 17, e-Akt↑, 1, AKT1↓, 2, AKT1↑, 1, p‑AKT1↑, 1, AMPKα↑, 2, CaMKII ↓, 2, HCAR2↑, 1, HER2/EBBR2↓, 1, OCN↑, 1, OCN∅, 1, p‑p70S6↓, 1, SOX9↑, 2, Sp1/3/4↓, 6, Sp1/3/4↑, 1, TRPV3↑, 2,

Transcription & Epigenetics(tgid=7) ⓘ

Ach?, 1, Ach↑, 48, AntiThr↑, 22, BowelM↑, 1, cJun↓, 5, p‑cJun↓, 5, H3↑, 1, ac‑H3↑, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 4, other?, 24, other↓, 69, other↑, 131, other⇅, 2, other↝, 171, other∅, 6, PhotoS↑, 1, TFAM↑, 2, TREM-1↓, 1, tumCV↓, 5, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 4, ChemChap↓, 1, ChemChap↑, 2, CHOP/DDIT3↓, 20, CHOP/DDIT3↑, 2, eIF2α↓, 3, p‑eIF2α↓, 3, cl‑eIF2α↑, 1, ER Stress↓, 52, ER Stress↑, 2, GRP78/BiP↓, 27, GRP78/BiP↑, 4, GRP94↑, 1, HSF1↑, 2, HSP27↓, 1, HSP27↑, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 18, HSP70/HSPA5↝, 1, HSP90↓, 2, HSP90↑, 3, HSPs↓, 1, HSPs↑, 6, HSPs↝, 1, IRE1↓, 7, NQO2↑, 1, PERK↓, 8, p‑PERK↓, 2, p‑PERK↑, 1, UPR↓, 5, UPR↑, 3, XBP-1↓, 4,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1, ATG5↓, 1, ATG5↑, 2, Beclin-1/ATG6↓, 5, Beclin-1/ATG6↑, 10, BNIP3↓, 1, DYRK1A↓, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 3, LC3A↑, 1, LC3B↓, 1, LC3B↑, 3, LC3II↓, 2, LC3II↑, 5, LC3s↓, 1, lysosome↑, 1, MitoP↓, 1, MitoP↑, 7, p62↓, 9, p62↑, 7, TFEB↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, ATR↑, 1, CYP1B1↓, 1, DNAdam↓, 61, DNAdam↑, 3, DNAdam∅, 1, DNArepair↑, 6, DNMT1↓, 6, DNMT3A↓, 3, DNMT3A↑, 1, DNMTs↓, 3, GADD45A↑, 1, importin α/β↓, 1, p16↓, 2, P53↓, 12, P53↑, 7, P53↝, 1, PARP↓, 3, PARP↑, 1, PARP∅, 1, p‑PARP↓, 1, cl‑PARP↓, 2, cl‑PARP↑, 2, PARP1↓, 1, cl‑PARP1↓, 1, PCNA↓, 4, PCNA↑, 1, RAD51↓, 1, SIRT6↑, 3, TP53↑, 1, γH2AX↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CDK2↓, 2, CDK4↓, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 4, cycE/CCNE↓, 1, cycE/CCNE↑, 1, E2Fs↑, 2, P21↓, 6, P21↑, 6, RB1↓, 1, TumCCA↑, 8,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↑, 1, CD133↑, 1, CD34↑, 1, CEBPA↓, 2, cFos↓, 1, cFos↑, 1, CHIP↑, 1, Choline↑, 3, CLOCK↝, 2, Diff↓, 2, Diff↑, 14, Diff↝, 2, EMT↓, 7, EMT↑, 2, EP2↓, 1, EP2↑, 1, EP300↓, 2, ERK↓, 26, ERK↑, 30, p‑ERK↓, 11, p‑ERK↑, 11, e-ERK↑, 1, FGF↑, 7, FOXO↑, 3, FOXO1↑, 2, FOXO1↝, 1, FOXO3?, 1, FOXO3↑, 7, GH↑, 3, Gli1↑, 1, GSK‐3β↓, 48, GSK‐3β↑, 9, GSK‐3β↝, 1, p‑GSK‐3β↓, 2, p‑GSK‐3β↑, 8, HDAC↓, 15, HDAC↑, 2, HDAC1↓, 2, HDAC2↓, 5, HDAC3↓, 4, HH↓, 2, HMGCR↓, 2, IGF-1↓, 9, IGF-1↑, 16, IGF-1R↓, 1, IGFBP1↑, 1, IGFBP3↓, 1, IGFBP3↑, 1, IGFR↓, 1, Jun↓, 1, Jun↑, 1, KLF4↑, 1, miR-34a↓, 1, MSCs↑, 1, Mst1↓, 2, mTOR↓, 25, mTOR↑, 14, mTOR↝, 2, p‑mTOR↓, 8, p‑mTOR↑, 3, mTORC1↓, 3, n-MYC↑, 1, Nestin↑, 1, neuroG↑, 17, NOTCH↓, 1, NOTCH↑, 1, NOTCH1↑, 2, OCT4↓, 1, p300↓, 1, P70S6K↓, 3, p‑P70S6K↓, 1, p‑P70S6K↑, 1, PDGFRB↓, 1, PI3K↓, 25, PI3K↑, 50, PI3K↝, 2, p‑PI3K↓, 3, p‑PI3K↑, 1, PR↝, 1, PTEN↓, 8, PTEN↑, 6, p‑PTEN↓, 1, p‑PTEN↑, 1, RAS↓, 2, RUNX2↑, 2, RUNX2∅, 1, Shh↓, 1, Shh↑, 1, SOX2↑, 2, Src↓, 1, STAT↓, 5, STAT1↓, 1, p‑STAT1↓, 1, STAT3?, 1, STAT3↓, 18, STAT3↑, 5, STAT3↝, 1, p‑STAT3↓, 4, STAT4↓, 1, STAT5↓, 1, TCF-4↓, 1, TOP2↑, 1, TRPM7↓, 4, TRPM7⇅, 1, TRPM7↝, 1, TumCG↓, 4, TumCG↑, 1, TumCG∅, 1, tyrosinase↓, 2, VDR↑, 1, VGCC↓, 1, VGCC↑, 2, VGCC⇅, 1, VGCC↝, 1, VGSC↓, 1, VGSC↑, 1, Wnt↓, 3, Wnt↑, 4, Wnt/(β-catenin)↓, 1, Zn2+↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 29, 5LO↝, 1, ACTA2↓, 1, AntiAg↓, 3, AntiAg↑, 97, AntiAg∅, 3, AP-1↓, 18, AP-1↑, 1, APP↓, 27, APP∅, 2, cl‑APP↓, 1, cl‑APP↑, 1, ARG1/2↑, 2, mt-ATPase↑, 1, BACH1↓, 1, Ca+2?, 3, Ca+2↓, 47, Ca+2↑, 20, Ca+2↝, 14, Ca+2∅, 1, p‑Ca+2↓, 1, i-Ca+2↓, 2, mt-Ca+2↓, 1, cal2↓, 5, Cartilage↑, 11, CD31/PECAM-1↓, 1, CD31/PECAM-1↑, 3, CDK5↓, 9, CEA↓, 2, CLDN1↓, 2, CLDN1↑, 2, CLDN1↝, 1, p‑Cofilin↓, 1, p‑Cofilin↑, 1, COL1↓, 6, COL1↑, 2, COL1∅, 1, COL1A1↓, 1, COL2A1↑, 2, COL3A1↓, 3, CXCL12↑, 1, CYP2D1↑, 1, E-cadherin↓, 1, E-cadherin↑, 7, E-sel↓, 5, F-actin↓, 1, F-actin↑, 1, FAK↑, 2, Fibronectin↓, 2, Fibrosis↓, 1, FLRT2↑, 1, GIT1↑, 1, heparanase↑, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB1↑, 1, Ki-67↓, 4, Ki-67↑, 2, LAMs↑, 1, LRP1↑, 3, miR-155↓, 1, miR-22↑, 1, miR-29b↑, 1, MMP-10↓, 1, MMP-10↝, 1, MMP1↓, 5, MMP11↑, 1, MMP13↓, 8, MMP2↓, 14, MMP2↑, 6, MMP3↓, 5, MMP3↑, 2, MMP7↓, 1, MMP9↓, 32, MMP9↑, 6, MMPs↓, 9, MMPs↑, 3, MUC1↑, 3, N-cadherin↓, 1, N-cadherin↑, 2, Na+↑, 2, Na+↝, 1, Netrins↑, 1, NFAM1↑, 1, NFAT↓, 1, NFAT↑, 2, OPN↑, 1, PAI-1/SERPINE1↓, 1, PDGF↓, 1, PDGF↑, 1, PKA↑, 7, PKCδ?, 1, PKCδ↓, 4, PKCδ↑, 8, p‑PKCδ↑, 1, proline↝, 1, PTP1B↓, 2, Rac1↑, 1, p‑Rac1↓, 1, RAGE↓, 6, Rho↓, 7, ROCK1↓, 7, ROCK1↑, 1, Sema3A/PlexinA1↑, 1, serineP↓, 1, Smad1↑, 1, p‑Smad1↑, 1, SMAD2↓, 1, p‑SMAD2↓, 3, SMAD3↓, 3, p‑SMAD3↓, 1, p‑SMAD3↑, 1, SMAD4↑, 1, SMAD5↑, 1, p‑SMAD5↑, 1, Smad7↑, 2, Snail↓, 1, Snail↑, 1, SPARC↓, 1, STAC2↑, 1, p‑T-cadherin↓, 2, TG2/TGase↓, 4, TGF-β↓, 21, TGF-β↑, 12, TGF-β1↓, 6, TGF-β1↑, 4, TIMP1↓, 5, TIMP1↑, 3, TIMP2↑, 3, TJ↓, 1, TJ↑, 4, TJ↝, 1, Treg lymp↓, 1, Treg lymp↑, 1, Treg lymp↝, 1, TRPC1↓, 1, TRPC1↑, 1, TumCI↓, 2, TumCI∅, 1, TumCMig↓, 3, TumCMig↑, 1, TumCMig∅, 1, TumCP↓, 9, TumCP↑, 1, TumMeta↓, 2, Twist↑, 1, TXNIP↓, 8, TXNIP↑, 2, Tyro3↓, 1, uPA↓, 1, VCAM-1↓, 19, Vim↓, 9, Vim↑, 1, Zeb1↓, 1, ZO-1↓, 5, ZO-1↑, 11, ZO-1↝, 1, α-SMA↓, 18, α-SMA↑, 1, α-SMA↝, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 4, β-catenin/ZEB1↑, 8, β-catenin/ZEB1↝, 1, β-Endo↑, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG?, 1, angioG↓, 14, angioG↑, 26, angioG↝, 1, ATF4↓, 8, ATF4↑, 1, CLDN5↓, 1, CLDN5↑, 1, ECM/TCF↑, 1, EGFR↓, 3, EGR4↑, 1, Endoglin↑, 1, eNOS↓, 2, eNOS↑, 7, p‑eNOS↑, 2, EPR↑, 3, HIF-1↓, 1, Hif1a↓, 18, Hif1a↑, 14, Hif1a↝, 1, Hif1a∅, 2, HIF2a↑, 1, Hypoxia↓, 1, LOX1↓, 2, miR-34b-5p↓, 1, NO?, 1, NO↓, 110, NO↑, 17, NPY↑, 1, PDGFR-BB↓, 2, PDGFR-BB↑, 1, PDI↓, 1, REL↑, 1, SOX18↑, 1, TXA2↓, 8, VEGF↓, 22, VEGF↑, 31, VEGFR2/KDR/Flk1↓, 1, VEGFR2/KDR/Flk1↑, 1, p‑VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 3, AQPs↑, 3, pol-AQPs↑, 1, BBB?, 3, BBB↓, 9, BBB↑, 160, BBB↝, 13, BBB∅, 4, CellMemb↑, 6, CLDN3↑, 1, GastroP↑, 15, GLUT1↓, 2, GLUT1↑, 5, GLUT3↑, 5, GLUT4↓, 1, GLUT4↑, 10, IBI↑, 11, MRP↓, 1, Na+↑, 2, Na+↝, 1, NHE3↑, 1, OATPs↓, 3, OCLN↓, 3, OCLN↑, 5, P-gp/ABCB1↓, 12, P-gp/ABCB1↑, 2, SVCT-2↑, 1, Vm/CMP↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIM2↓, 2, ASC?, 1, ASC↓, 5, CB2 / CNR2↑, 5, CD14↑, 1, CD25+↓, 1, CD25+↑, 1, CD4+↑, 8, CD69↓, 1, cellSen↓, 1, cellSen↑, 1, COX1↓, 24, COX1↑, 1, COX2/PTGS2?, 1, COX2/PTGS2↓, 206, COX2/PTGS2↑, 2, COX2/PTGS2∅, 1, CRP↓, 29, CTLA-4↓, 1, CTSZ↓, 1, CTSZ↝, 1, CXCc↓, 2, CXCc↑, 1, CXCL1↓, 1, CXCR2↑, 1, CXCR4↓, 2, DCells↑, 1, Dectin1↑, 1, FOXP3↑, 2, GM-CSF↓, 1, GM-CSF↑, 1, HCAR2↑, 1, HMGB1↓, 9, ICAM-1↓, 22, IFN-γ↓, 26, IFN-γ↑, 10, IFN-γ∅, 1, IKKα↓, 4, IKKα↑, 1, p‑IKKα↓, 4, IL1?, 1, IL1↓, 18, IL1↑, 1, IL10?, 1, IL10↓, 21, IL10↑, 44, IL10∅, 1, IL12↓, 10, IL12↑, 1, IL17↓, 19, IL17↑, 2, IL17∅, 1, IL18↓, 11, IL18↑, 1, IL1α↓, 2, IL1α∅, 1, IL1β↓, 232, IL1β↑, 2, IL1β∅, 1, IL2↓, 17, IL2↑, 6, IL22↓, 3, IL23↓, 3, IL33↓, 3, IL4↓, 23, IL4↑, 10, IL4∅, 1, IL5↓, 11, IL5↑, 1, IL6?, 2, IL6↓, 257, IL6↑, 11, IL8↓, 45, IL8↑, 1, IL8∅, 1, Imm↓, 2, Imm↑, 72, Imm⇅, 2, Imm↝, 2, INF-γ↓, 3, Inflam?, 6, Inflam↓, 994, Inflam↑, 15, Inflam∅, 2, IP-10/CXCL-10↓, 1, IP-10/CXCL-10↑, 1, IκB?, 1, IκB↓, 2, IκB↑, 3, p‑IκB↓, 1, JAK↓, 4, p‑JAK1↓, 1, JAK2↓, 4, JAK2↑, 4, p‑JAK2↓, 2, LIF↑, 1, LPS↓, 3, LTA/TNF-β↓, 1, LTA/TNF-β↑, 1, M1↓, 1, M2 MC↑, 2, pol-M2 MC↑, 2, Macrophages↓, 1, MCP1/CCL2↓, 26, MCP1/CCL2↑, 2, MCP1/CCL2↝, 1, MCP1/CCL2∅, 1, MIP‑1α/CCL3↓, 4, MIP2↓, 3, mPGES-1↓, 1, MUC2↓, 1, MyD88↓, 9, Neut↓, 3, Neut↑, 2, NF-kB?, 1, NF-kB↓, 353, NF-kB↑, 9, p‑NF-kB↓, 9, NK cell↑, 10, NTF3/NT-3↑, 1, OSM↑, 1, p‑p50↓, 1, p65↓, 9, p‑p65↓, 3, PAR-2↓, 1, PGD2↓, 1, PGE1↓, 1, PGE2↓, 76, PGE2↑, 3, PSA↓, 2, PSA∅, 1, RANTES↓, 5, T-Cell↑, 1, Th1 response↓, 2, Th1 response↑, 1, Th17↓, 1, Th2↓, 3, Th2↑, 2, TLR1↓, 3, TLR2↓, 10, TLR3↓, 1, TLR4↓, 42, TLR4↑, 1, TLR4∅, 1, TNF-α↓, 368, TNF-α↑, 12, TRAF1↓, 1, TRIF↓, 3, VitD↑, 6,

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 2, cGAS–STING↓, 2, NOX↓, 6, NOX↑, 1, pH↓, 1, pH↑, 1, pH↝, 2, Temp↝, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 4, 5HT↑, 34, AChE↓, 198, AChE↑, 3, AChE↝, 2, AChE∅, 5, ADAM10↑, 16, ADAM10↝, 2, BChE?, 1, BChE↓, 34, BChE∅, 1, BDNF↓, 4, BDNF↑, 215, BDNF⇅, 1, BDNF↝, 1, BDNF∅, 8, BrainVol↑, 3, BrainVol↝, 1, BrainVol∅, 3, ChAT↑, 22, ChE↓, 1, EndoR↑, 1, GABA↓, 4, GABA↑, 15, GABA↝, 1, MAOA↓, 17, MAOA↑, 1, MAOA↝, 1, monoA↓, 1, monoA↑, 3, NGF↑, 15, PSD95?, 1, PSD95↑, 16, tau?, 1, tau↓, 63, p‑tau↓, 94, TrkB↓, 2, TrkB↑, 25, TrkB↝, 1,

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1, AGEs↓, 15, Aβ?, 1, Aβ↓, 332, Aβ↑, 3, Aβ∅, 6, BACE/β-secretase↓, 76, BACE/β-secretase↑, 3, BACE/β-secretase↝, 1, IDE↑, 3, MAOB↓, 8, NEP↑, 1, NLRP3↓, 91, NLRP3↑, 3, PP2A↑, 9, XO↓, 6, XO↝, 1, β-Amyloid↓, 5,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ARNT↑, 1, BNP↓, 1, cortisol↓, 2, cortisol↑, 1, CYP19↓, 2, DHT↓, 1, DHT↑, 1, ER(estro)↓, 1, ER(estro)↑, 2, ERβ/ESR2↑, 1, GR↓, 1, GR↑, 5, GR↝, 1, Leptin↓, 1, RAAS↓, 1, SHBG↓, 1, testos↓, 1, testos↑, 5, testos?, 1, TSHR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1, BioAv?, 4, BioAv↓, 204, BioAv↑, 343, BioAv⇅, 4, BioAv↝, 153, BioAv∅, 2, BioEnh↑, 36, BioEnh↝, 1, ChemoSen↑, 4, CYP1A2↑, 1, CYP2A3/CYP2A6↝, 1, CYP2C9↓, 1, DDS↑, 5, Dose?, 18, Dose↓, 15, Dose↑, 38, Dose⇅, 4, Dose↝, 453, Dose∅, 10, eff?, 2, eff↓, 36, eff↑, 273, eff↝, 35, eff∅, 2, Half-Life?, 2, Half-Life↓, 36, Half-Life↑, 27, Half-Life⇅, 1, Half-Life↝, 82, Half-Life∅, 6, MRP1/ABCC1↓, 1, P450↓, 7, P450↑, 2, P450↝, 1, RadioS↑, 1, selectivity↑, 10, selectivity⇅, 1, Synergy↑, 61, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1, ALAT↓, 96, ALAT↑, 2, ALAT∅, 4, Albumin↑, 4, Albumin↝, 1, ALP↓, 22, ALP↑, 2, ALP∅, 1, ascitic↓, 1, AST↓, 95, AST↑, 2, AST∅, 4, BG↓, 9, Bil↓, 5, Bil↑, 2, BloodF↓, 1, BloodF↑, 21, BMD↑, 31, BMPs↓, 1, BMPs↑, 2, BP?, 1, BP↓, 69, BP↝, 1, BP∅, 3, Calcium↑, 2, Calcium↝, 2, CEA↓, 2, creat↓, 27, creat↑, 2, CRP↓, 29, EGFR↓, 3, Ferritin↓, 1, Ferritin↑, 2, GutMicro↓, 1, GutMicro↑, 122, GutMicro↝, 9, GutMicro∅, 2, HbA1c↓, 1, Hcy/homoC↓, 24, Hcy/homoC↝, 2, HemoG↑, 2, HER2/EBBR2↓, 1, hs-CRP↓, 3, IL6?, 2, IL6↓, 257, IL6↑, 11, Ki-67↓, 4, Ki-67↑, 2, LDH↓, 42, LDH↑, 3, LDH∅, 1, Mag↑, 2, MUC19↓, 1, NOS2↓, 8, NSE↑, 1, PSA↓, 2, PSA∅, 1, RAGE↓, 6, TG/TAG↓, 6, TP53↑, 1, Urea↓, 5, VitD↑, 6,

Functional Outcomes(tgid=23) ⓘ

Anger↓, 1, AntiAge↑, 50, AntiAge⇅, 1, antiAll↑, 12, AntiArt↑, 21, AntiCan?, 1, AntiCan↓, 4, AntiCan↑, 87, antiCG↑, 1, antiCG↝, 1, antiD↓, 1, AntiDiabetic↓, 4, AntiDiabetic↑, 109, AntiMyl↑, 1, antiNeop↑, 1, AntiP↓, 1, AntiP↑, 15, antiPs↑, 5, AntiTum↓, 2, AntiTum↑, 27, ANXi↓, 4, Appetite↓, 1, BOLD↑, 2, Bone Healing↑, 1, cachexia↓, 1, cachexia↑, 1, cardioP?, 2, cardioP↓, 4, cardioP↑, 258, cardioP⇅, 1, cardioP∅, 1, CardioT↓, 4, chemoP↑, 41, chemoPv↑, 32, ChemoSideEff↓, 1, cognitive?, 3, cognitive↓, 16, cognitive↑, 590, cognitive↝, 9, cognitive?, 1, cognitive∅, 27, cytoP↑, 2, fatigue↓, 6, GFR↓, 1, GFR↑, 1, GFR∅, 1, Hear↑, 1, hepatoP↓, 8, hepatoP↑, 244, memory?, 4, memory↓, 4, memory↑, 408, memory∅, 6, Mood↑, 49, Mood⇅, 1, Mood↝, 1, motorD↓, 3, motorD↑, 67, MusCon↓, 2, neuroP?, 4, neuroP↓, 5, neuroP↑, 704, neuroP↝, 1, NP/CIPN↓, 3, Obesity↓, 51, OS↓, 1, OS↑, 44, Pain↓, 42, PDE4↓, 2, QoL?, 1, QoL↑, 24, QoL∅, 1, radioP↑, 48, RenoP↓, 2, RenoP↑, 93, RenoP↝, 1, Risk↓, 75, Risk↑, 14, Risk↝, 2, Risk∅, 3, Sleep↑, 25, Sleep∅, 1, STEP↓, 1, Strength↑, 15, toxicity?, 6, toxicity↓, 320, toxicity↑, 34, toxicity⇅, 2, toxicity↝, 73, toxicity∅, 70, Weight↓, 17, Weight↑, 4, Weight↝, 3, Weight∅, 4, Wound Healing↓, 2, Wound Healing↑, 40,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 2, AntiFungal↑, 32, AntiViral↑, 42, Bacteria?, 1, Bacteria↓, 136, Bacteria↑, 1, CD8+↑, 4, Dectin1↑, 1, Diar↓, 9, Inf↓, 3, IRF3↓, 4, Sepsis↓, 28,

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1, CA↑, 1, Catechins↑, 1, FA↑, 1, Fibre↑, 1, Flav↑, 1, GA↑, 1, LT↑, 1, Myr↑, 1, Phen↑, 2, Poly↑, 1, QC↑, 2,
Total Targets: 1595

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

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