Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
6370- CPLE,    Delving into the Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
- Review, Var, NA
CIT↓, *Imm↑, *AntiDiabetic↑, *AntiCan↑, angioG↓, *Bacteria↓, *antiOx↑,
6371- CPLE,    Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions
- Review, Nor, NA
eff↓, toxicity↝,
6372- CPLE,    Anti-proliferation and Apoptosis Induction of Aqueous Leaf Extract of Carica papaya L. on Human Breast Cancer Cells MCF-7
- in-vitro, BC, MCF-7
TumCP↓, Apoptosis↑,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
6374- CPLE,    Antiviral & platelet-protective properties of Carica papaya in dengue
- Review, Nor, NA
*antiOx↑, *lipid-P↓, *AntiTum↑, Imm↑, CIT↓,
6375- CPLE,    Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review
- Review, Var, NA
*antiOx↑, *ROS↓, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Wound Healing↑, *GSH↑, *MDA↓, *DNAdam↓,
5810- CPT,  CPT-11,    Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index
- Review, NA, NA
AntiCan↑, BioAv↓, toxicity⇅, TOP1↓, Apoptosis↑, TumCP↓, other↝, BioAv↑, other↝, eff↑,
5809- CPT,    Cancer Therapies Utilizing the Camptothecins: A Review of in Vivo Literature
- Review, Var, NA
BioAv↓, TOP1↓, BioAv↑,
5808- CPT,    Repair of Topoisomerase I-Mediated DNA Damage
- Review, Var, NA
TOP1↓, AntiCan↑, Dose?, CHK1↑, Chk2↑,
5807- CPT,    The mechanism of topoisomerase I poisoning by a camptothecin analog
- Study, NA, NA
TOP1↓, AntiTum↑,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
5791- CRMs,  HCA,  NAD,  Sper,  RES  Caloric Restriction Mimetics in Nutrition and Clinical Trials
- Review, Nor, NA
*Dose↝, *Glycolysis↓,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6291- Cro,    Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
- vitro+vivo, PC, MIA PaCa-2 - vitro+vivo, PC, Bxpc-3 - vitro+vivo, PC, Capan1 - vitro+vivo, PC, AsPC-1
TumCG↓, EGFR↓, Apoptosis↑, Bax:Bcl2↑, TumCP↓, TumCCA↑, Dose↝,
6316- Cro,    Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCI↓, Apoptosis↑, TLR4↓, NF-kB↓, IKKα↓, NLRP3↓, TumCG↓,
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, NA, NA
*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,
6314- Cro,    Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway
- in-vitro, GC, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, antiOx↓, Ferroptosis↑, NRF2↑, P53↑, TumCCA↑, ChemoSen↑, EMT↓, Hif1a↓, ROS↑,
6313- Cro,    Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications
- Review, Covid, NA - Review, Var, NA - Review, Stroke, NA
RadioS↑, *other↑, *other↑, *OCR↑, *neuroP↑, ChemoSen↑, ROS↑,
6312- Cro,    Crocin from Crocus Sativus Possesses Significant Anti-Proliferation Effects on Human Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48 - in-vitro, CRC, HT29
tumCV↓, TumCG↓, selectivity↑,
6311- Cro,    Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model
- in-vivo, Nor, NA
*BioAv↝, *BioAv↑,
6310- Cro,    Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption
- in-vivo, Nor, NA
BioAv↓, BioAv↑, BioAv↑, eff↑,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6307- Cro,    Effects of Intestinal Microbiota on Pharmacokinetics of Crocin and Crocetin in Male Sprague-Dawley Rats
- in-vivo, Nor, NA
*BioAv↝,
6306- Cro,    Crocetin induces apoptosis of BGC-823 human gastric cancer cells
- in-vitro, GC, BGC-823
TumCP↓, MMP↓, Casp3↑, Cyt‑c↑,
6305- Cro,    Bridging Preclinical and Clinical Evidence on Crocin in Breast Cancer
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, TumCG↓, ChemoSen↑,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6334- Cro,  Eug,  Rad,    Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro
- in-vitro, OS, NA
tumCV↓, RadioS↑, TumCCA↑, BAX↑, Casp3↑, Bcl-2↓, cycA1/CCNA1↓, CycB/CCNB1↓,
6303- Cro,    Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation
- in-vitro, CRC, HCT116 - in-vitro, CRC, DU145
NF-kB↓, VEGF↓, MMP9↓, Inflam↓, HMGB1↓, IL6↓, IL8↓, TumCG↓, Apoptosis↑,
6302- Cro,    Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases
- Review, NA, NA
LDHA↓,
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6298- Cro,    Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2
- in-vitro, AMD, RPE-1
*ATP↑, *antiOx↑, *ROS↓,
6297- Cro,    Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
- in-vitro, Nor, RAW264.7
*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,
6296- Cro,    Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
- in-vivo, Nor, NA
*BioAv↓,
6295- Cro,    Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract
- Human, Nor, NA
*BioAv↑, *Dose↝, Half-Life↓, Dose↝,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
6292- Cro,    Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, P21↑, Apoptosis↑, eff↑,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6180- Cro,    New findings in the metabolism of the saffron apocarotenoids, crocins and crocetin, by the human gut microbiota
- Study, Nor, NA
*BioAv↑,
6179- Cro,    Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway
- NA, CRC, HCT116
TumCMig↓, VEGF↓, MMP9↓, p‑p38↑, TumCP↓,
6178- Cro,    Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, ChemoSen↑,
3636- Cro,    Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies
- in-vitro, AD, NA
*AChE↓,
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
3625- Cro,    Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial
- Trial, AD, NA
*Aβ↓, *cognitive↑,
3626- Cro,    Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial
- Trial, AD, NA
*cognitive↓,

Showing Research Papers: 2351 to 2400 of 6604
Prev Page 48 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

CIT↓, 2,   PRKCQ/PKCθ↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Catalase↓, 1,   Catalase↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 1,   ROS↑, 6,   SOD↓, 2,   SOD↑, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 3,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   CRM↑, 1,   LDHA↓, 2,  

Cell Death ⓘ

Apoptosis↓, 2,   Apoptosis↑, 13,   BAX↑, 2,   Bax:Bcl2↑, 3,   Bcl-2↓, 3,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   Chk2↑, 1,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↓, 1,   p27↑, 1,   p38↑, 1,   p‑p38↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

NQO2↑, 1,  

DNA Damage & Repair ⓘ

CHK1↑, 1,   DNAdam↑, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   EMT↓, 2,   ERK↓, 1,   HDAC2↓, 1,   PTEN↓, 1,   Shh↓, 1,   STAT3↓, 1,   TOP1↓, 4,   TOP2↓, 1,   TumCG↓, 8,  

Migration ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 14,   TumMeta↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↑, 1,   HMGB1↓, 1,   IKKα↓, 1,   IL1β↓, 3,   IL6↓, 3,   IL8↓, 3,   Imm↑, 1,   Inflam↓, 4,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 5,   TLR4↓, 1,   TNF-α↓, 4,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   ChemoSen↑, 6,   Dose?, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 3,   Half-Life↓, 1,   RadioS↑, 3,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   ERα/ESR1↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 6,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP↑, 2,   neuroP↑, 1,   radioP↑, 1,   toxicity⇅, 1,   toxicity↝, 1,  
Total Targets: 116

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 8,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 3,   lipid-P↓, 4,   MDA↓, 3,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 5,   ROS↓, 10,   SOD↑, 5,   Thiols↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   Insulin↓, 1,   MEK↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1,   ALAT↓, 1,   AMPK↑, 3,   CRM↓, 1,   Glycolysis↓, 1,   NADPH↑, 1,   SIRT1↑, 4,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   iNOS↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 3,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   GSK‐3β↓, 1,   miR-34a↓, 1,   mTOR↓, 2,   mTORC1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 2,   TLR1↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   ChAT↑, 1,   tau↓, 2,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 2,   Dose?, 1,   Dose↝, 3,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BloodF↑, 1,   BP↓, 2,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 3,   AntiCan↑, 2,   AntiDiabetic↑, 3,   AntiTum↑, 2,   cardioP↑, 4,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 3,   hepatoP↑, 4,   memory↑, 3,   neuroP↑, 8,   OS↑, 2,   RenoP↑, 1,   toxicity↓, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 85

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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