Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
3628- Cro,  VitE,  CUR,    Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *lipid-P↓, *Aβ↓, *AChE↓, *cognitive↑, *Inflam↓,
3629- Cro,    Studying saffron nanopowder (Crocus Sativus L.) on the temporal memory of rats suffering Parkinson's disease
- in-vivo, Park, NA
*memory↑,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP↓, *Dose↝,
3631- Cro,    Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease
- in-vitro, AD, HT22 - in-vivo, AD, NA
*ROS↓, *Ca+2↓, *BAX↓, *BAD↓, *Casp3↓, *cognitive↑, *memory↑, *Aβ↓, *GPx↑, *SOD↑, *ChAT↑, *Ach↑, *AChE↓, *ROS↓, *p‑Akt↑, *p‑mTOR↑, *neuroP↑,
3634- Cro,    A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease
- Trial, AD, NA
*cognitive↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3637- Cro,    Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
- NA, AD, NA
*cognitive∅, *MAOA↓, *MDA↓, *GSH↑, *AChE↓,
3832- Cro,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *memory↑, *Apoptosis↓, *cognitive↑, *ER Stress↓,
4158- Cro,    Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus
- in-vivo, AD, NA
*CREB↑, *BDNF↑, *Mood↑,
945- Cro,    Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa
LDH↓,
4208- Cro,    Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus
- in-vivo, NA, NA
*BDNF↑, *CREB↑, *p‑CREB↑,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
6533- CRV,    Potential anticancer activity of carvone in N2a neuroblastoma cell line
- in-vitro, neuroblastoma, N9
*antiOx↑, tumCV↓,
6532- CRV,  doxoR,    R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro
- in-vivo, BC, MCF-7 - in-vivo, Nor, H9c2
tumCV↓, ChemoSen↑, cardioP↑, *Catalase↑,
6531- CRV,    D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats
- in-vivo, Nor, NA
*TRAF1↓, *IL1β↓, *TNF-α↓, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *Inflam↓, *NRF2↑, *Bcl-2↑, *IL8↓, *antiOx↑,
6530- CRV,    Monoterpenes as Anticancer Therapeutic Agents
- Review, Var, NA
selectivity↑, TumCP↓, Apoptosis↑, TumCCA↑, tumCV↓,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
6528- CRV,    D-carvone inhibits growth, migration, cell cycle at G0/G1 phase and induces apoptosis in A431 cells by disrupting mitochondrial membrane potential
- in-vitro, Melanoma, A431
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, TumCP↓,
6526- CRV,    Multi-targeted effects of D-carvone against Non-Small Cell Lung Cancer (NSCLC): A network pharmacology-based study
- Review, NSCLC, NA
TumCP↓, Wound Healing↓, Apoptosis↓,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
6524- CRV,    d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells
- in-vitro, GC, AGS
ROS↑, MMP↝, JAK↓, STAT3↓, TumCD↑,
6523- CRV,    Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion
- NA, Melanoma, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCI↓, p‑p38↓,
6522- CRV,    l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation
- in-vivo, Var, NA
*Inflam↓, TumCG↓, VEGF↓, ChemoSen↑, FAK↓, ITGB1↓,
6521- CRV,    L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, DNAdam↑, ROS↑, GSH↑, P53↑, BAD↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑,
6520- CRV,    Health Benefits and Pharmacological Properties of Carvone
- Review, Nor, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *Inflam↓, AntiCan↑, *AntiDiabetic↑, *Obesity↓, TumCCA↑, *AntiArt↑, Imm↑, *P450↓, *GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, TumCP↓, TumCMig↓, Apoptosis↑,
6176- Cu,    Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
- in-vitro, Liver, HepG2
ROS↑, P53↑, MMP↓, Bax:Bcl2↑, Apoptosis↑, *Bacteria↓, MDA↑, GSH↓, eff↓, Casp3↑,
6177- Cu,    Toxicity of copper oxide nanoparticles: a review study
- Review, Nor, NA
*ROS↑, *Inflam↑, *toxicity↑, lipid-P↑, GSH↓, MDA↑, *SOD↓, *Catalase↓,
6171- Cu,    Copper in the tumor microenvironment and tumor metastasis
- Review, Var, NA
*angioG↑, other↑, *ROS↑, CTR1↝, other↝, COX17↝, ATOX1↝,
6170- Cu,    Copper induces cell death by targeting lipoylated TCA cycle proteins
- in-vitro, Var, NA
TCA↓, toxicity↝, Cupro↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6183- Cu,    Copper(II) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response
- in-vitro, Liver, HepG2
ROS↑, MAPK↑, ERK↑, AP-1↑,
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,
1642- Cu,  HCAs,    Copper-assisted anticancer activity of hydroxycinnamic acid terpyridine conjugates on triple-negative breast cancer
- in-vitro, BC, 4T1 - in-vitro, Nor, L929
tumCV↓, selectivity↑,
1639- Cu,  HCAs,    Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
angioG↓, tumCV↓, Dose↓, ROS↑,
1604- Cu,    Targeting copper metabolism: a promising strategy for cancer treatment
- Review, NA, NA
eff↓, eff↓, ROS↑, eff↑,
1603- Cu,  BP,  SDT,    Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response
- in-vitro, BC, 4T1 - in-vivo, NA, NA
GSH↓, Fenton↑, ROS↑, NO↑, sonoS↑, eff↑, NO↑, *toxicity∅, eff?,
1602- Cu,    A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†
- in-vitro, BC, MCF-7 - in-vitro, BC, 4T1 - in-vitro, Lung, A549 - in-vitro, Liver, HepG2
eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,
1600- Cu,    Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis
- Review, NA, NA
ER Stress↑, ROS↑, AntiTum↑, GSH↓, Ferroptosis↑, selectivity↑, GSH/GSSG↓, *ROS∅, eff↑,
1599- Cu,    Copper in tumors and the use of copper-based compounds in cancer treatment
- Review, NA, NA
ROS↑, RadioS↑,
1569- Cu,    Copper Nanoparticles as Therapeutic Anticancer Agents
- Review, NA, NA
Dose∅, Dose∅, ROS↑,
1570- Cu,    Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector
- Review, NA, NA
selectivity↑, antiOx↑, ROS↑, eff↑, GSH↓, lipid-P↑, Catalase↓, SOD↓, other↑,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, NA, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
1595- Cu,    The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy
- Review, NA, NA
eff↑, ROS↑, eff↓,
1598- Cu,    Targeting copper in cancer therapy: 'Copper That Cancer'
- Review, NA, NA
eff↓, eff↑, Dose∅, eff↑, angioG↑, ROS↑,
1597- Cu,    Anticancer potency of copper(II) complexes of thiosemicarbazones
- Review, NA, NA
eff↑, ROS↑,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
1590- Cuc,    ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism
- Review, NA, NA
ACLY↓,
6187- Cuc,    Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments
- in-vitro, Lung, A549
STAT3↓,

Showing Research Papers: 2401 to 2450 of 6604
Prev Page 49 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6604

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   Fenton↑, 6,   Ferroptosis↑, 2,   GSH↓, 7,   GSH↑, 3,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 2,   H2O2↑, 2,   HNE↑, 1,   HO-1↑, 1,   ICD↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 2,   NQO1↑, 1,   ROS↑, 22,   mt-ROS↑, 1,   SOD↓, 2,   TBARS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   i-ATP↓, 1,   COX17↝, 1,   ETC↓, 1,   MMP↓, 5,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   ATG7↑, 1,   LDH↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Apoptosis↓, 2,   Apoptosis↑, 13,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cupro↑, 4,   Cyt‑c↑, 2,   Ferroptosis↑, 2,   JNK↑, 1,   MAPK↑, 2,   p‑p38↓, 1,   Paraptosis↑, 2,   Pyro↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 3,   other↝, 1,   sonoS↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   i-CRT↓, 1,   ER Stress↑, 3,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 2,   p53 Wildtype↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   STAT3↓, 2,   TumCG↓, 2,  

Migration ⓘ

AP-1↑, 2,   ATOX1↝, 1,   Ca+2↑, 1,   FAK↓, 1,   ITGB1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 3,   NO↑, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

CTR1↝, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   i-HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,   Imm↑, 1,   JAK↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 4,   DDS↑, 1,   Dose↓, 1,   Dose∅, 3,   eff?, 1,   eff↓, 6,   eff↑, 24,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   cardioP↑, 1,   chemoPv↑, 1,   toxicity↝, 1,   Wound Healing↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 113

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiArt↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Catalase↓, 1,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   lipid-P↓, 3,   MDA↓, 4,   NRF2↑, 2,   ROS↓, 7,   ROS↑, 2,   ROS∅, 1,   SOD↓, 1,   SOD↑, 4,   TAC↑, 1,   Thiols↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cAMP↑, 1,   CREB↑, 2,   p‑CREB↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   BAD↓, 1,   BAX↓, 2,   Bcl-2↑, 2,   Casp3↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   other↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↑, 1,  

Migration ⓘ

Ca+2↓, 1,   MMP9↑, 1,   SMAD3↓, 1,   TGF-β1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   IL1β↓, 1,   IL8↓, 1,   Inflam↓, 6,   Inflam↑, 1,   NF-kB↓, 2,   TNF-α↓, 2,   TRAF1↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 5,   BDNF↑, 2,   ChAT↑, 1,   MAOA↓, 1,   MAOA↝, 1,   monoA↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   Dose↝, 1,   eff↑, 1,   P450↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cognitive↑, 6,   cognitive∅, 1,   hepatoP↑, 1,   memory↑, 6,   Mood↑, 1,   neuroP↑, 5,   Obesity↓, 1,   toxicity?, 1,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,  
Total Targets: 77

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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