Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

AgNPs,

Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism

in-vitro,

Nor,

RAW264.7

68.9 nm, concentrations; 0.2, 0.4, 0.8, and 1.6 ppm, exposure time; 24, 48, 72, and 96 h

*GSH↓, *NO↑, *TNF-α↑, *MMP3↑, *MMP11↑,

4413-

AgNPs,

Anzaroot,

Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells

in-vitro,

BC,

MCF-7

12.35 μg/mL

The IC50 value for root extract-mediated SNPs was found to be 21.73 μg/mL

chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,

4412-

AgNPs,

Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A2780S

Bacteria↓, antiOx↑, AntiCan↑, eff↑,

4411-

AgNPs,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

in-vitro,

Lung,

A549

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4409-

AgNPs,

Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities

in-vitro,

BC,

MCF-7

12.75 nm

54.981 µg/mL

tumCV↓, TumCCA↑, cycD1/CCND1↓, COX2↓, HER2/EBBR2↓,

4408-

AgNPs,

Chitosan-coated silver nanoparticles synthesized using Moringa oleifera flower extract: A potential therapeutic approach against triple-negative breast cancer

in-vitro,

BC,

MDA-MB-231

 27 ± 0.5 μg/mL

tumCV↓,

4407-

AgNPs,

Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231)

in-vitro,

BC,

MDA-MB-231

 40-60 nm

antiOx↑, TumCG↓,

4406-

AgNPs,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

in-vitro,

BC,

MCF-7

63.1 ± 8.3 nm

tissues from 64 patients

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,

4405-

AgNPs,

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis

in-vitro,

OS,

Apoptosis↑, other↑, ROS↑, eff↑, P53↝, Apoptosis↑, cl‑Casp3↑, survivin↓, MMP↓, Cyt‑c↑,

4431-

AgNPs,

doxoR,

Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy

in-vitro,

BC,

4T1

PA-AgNPs have an average hydrodynamic diameter of 130 nm

in-vivo,

BC,

4T1

in-vitro,

Nor,

3T3

AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,

4362-

AgNPs,

Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers

in-vitro,

CRC,

HCT116

18–45 nm.

in-vitro,

CRC,

HT29

in-vivo,

NA,

Male Swiss nu/nu mice aged 5–8 weeks

eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,

4361-

AgNPs,

GoldNP,

Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives

in-vivo,

Liver,

HepG2

IC50 values of the AgNPs, AuNPs and Ag/AuNPs on HepG2 cells were determined as 38.42 μg ml-1, 43.25 μg ml-1 and 39.20 μg ml-1

Sprague Dawley (SD) rat model

TumCD↑, TumVol↓, *toxicity↝, hepatoP↑,

4360-

AgNPs,

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Study,

Nor,

*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,

4359-

AgNPs,

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

NA,

Wounds,

*Bacteria↓, *eff↑, *other↝, *toxicity↓,

4358-

AgNPs,

HPT,

Rad,

Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells

in-vitro,

GBM,

U251

10 nm silver nanoparticles (AgNPs) on human glioma U251 c

RadioS↑, eff↑, TumCD↑,

4426-

AgNPs,

Antiangiogenic properties of silver nanoparticles

Study,

NA,

angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,

4427-

AgNPs,

Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells

in-vitro,

Lung,

A549

tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,

4428-

AgNPs,

p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells

in-vitro,

AML,

Jurkat

toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,

4429-

AgNPs,

Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles

in-vitro,

Liver,

HepG2

*toxicity↝, selectivity↑, mt-ROS↑,

4430-

AgNPs,

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

in-vitro,

Colon,

HCT116

20 nm

in-vitro,

Nor,

NCM460

*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,

4363-

AgNPs,

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

in-vivo,

fibroS,

particles was approximately 10 nm

LACA mice

TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,

4432-

AgNPs,

Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions

Review,

NA,

ROS↑, TumCP↓, Apoptosis↑,

4433-

AgNPs,

Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

L02

selectivity↑, selectivity↓, mt-ROS↑,

4434-

AgNPs,

SSE,

Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway

vitro+vivo,

Nor,

*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

4436-

AgNPs,

Silver Nanoparticles (AgNPs) as Enhancers of Everolimus and Radiotherapy Sensitivity on Clear Cell Renal Cell Carcinoma

in-vitro,

Kidney,

786-O

61 ± 10 nm

AgNP doses ranging from 500 to 3000 µg/mL for 24 h

ROS↑, MMP↑, TumCCA↑, TumCP↓, Apoptosis↑, RadioS↑,

4437-

AgNPs,

Green Fabrication of silver nanoparticles by leaf extract of Byttneria Herbacea Roxb and their promising therapeutic applications and its interesting insightful observations in oral cancer

in-vitro,

Oral,

BH-AgNPs are almost spherical in nature with an average size range from of 2 nm to 12 nm.

TumCP↓,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

4439-

AgNPs,

Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)

in-vitro,

Cerv,

HeLa

33 nm

ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,

4447-

AgNPs,

Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis

Review,

Nor,

*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

in-vitro,

BC,

MCF-7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4381-

AgNPs,

Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells

in-vitro,

Liver,

HepG2

 human hepatoma cells.

eff↓, ROS↑, other↑,

4380-

AgNPs,

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

in-vitro,

Lung,

A549

ROS↑, tumCV↓, MMP↓, TumCCA↑, PCNA↓, eff↓,

4379-

AgNPs,

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

in-vitro,

CRC,

LoVo

eff↑, TumCD↑, ROS↑, Bacteria↓,

4378-

AgNPs,

Exploring silver nanoparticles for cancer therapy and diagnosis

Review,

Var,

AntiTum↑, ROS↑, eff↑, RadioS↑,

4377-

AgNPs,

Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates

in-vitro,

NA,

human neutrophils (white blood cell) ie transportation

eff↑, Apoptosis↑,

4376-

AgNPs,

Interaction of multi-functional silver nanoparticles with living cells

in-vitro,

Nor,

L929

in-vitro,

Lung,

A549

eff↑, selectivity↑,

4375-

AgNPs,

The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells

in-vitro,

AML,

K562

eff↑, ROS↑, Apoptosis↑, eff↓,

4374-

AgNPs,

Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides

in-vitro,

BC,

MCF-7

eff↑, TumCD↑,

4373-

AgNPs,

In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells

in-vitro,

Liver,

HepG2

TumCD↑,

4372-

AgNPs,

Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

TumCD↑,

4371-

AgNPs,

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

in-vitro,

Liver,

HUH7

20−50 nm

eco-friendly approach silver nanoparticles (AgNPs) using root extracts of Beta vulgaris L.

ROS↑, selectivity↑, DNAdam↑, Apoptosis↑, GSH↓, lipid-P↑, MMP↓, DNAdam↑,

4370-

AgNPs,

Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line

in-vitro,

Liver,

HepG2

 30.71 nm

75 μg/mL

tumCV↓, ROS↑, Apoptosis↑,

4369-

AgNPs,

Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells

in-vitro,

Nor,

BEAS-2B

*ROS↑,

4368-

AgNPs,

Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro

NA,

Nor,

*BBB↑,

4367-

AgNPs,

Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals

in-vivo,

Nor,

Eighty C57Вl/6 eight-week-old male mice

*other↝,

4366-

AgNPs,

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

in-vivo,

Nor,

 Sprague-Dawley male rats for two weeks

*GutMicro↝,

4365-

AgNPs,

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Review,

Var,

ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,

Showing Research Papers: 201 to 250 of 6589
Prev Page 5 of 132 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6589

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 3,
Total Targets: 77

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, GSH↓, 1, GSH↑, 1, HO-1↑, 1, MDA↓, 1, NRF2↑, 1, ROS↓, 2, ROS↑, 1,

Transcription & Epigenetics ⓘ

other↝, 3,

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,

Migration ⓘ

MMP11↑, 1, MMP3↑, 1, MMP9↓, 1, TGF-β↑, 1,

Angiogenesis & Vasculature ⓘ

NO↑, 1,

Barriers & Transport ⓘ

BBB↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL1↓, 1, IL10↑, 1, IL4↑, 1, IL5↑, 1, IL6↓, 2, Inflam↓, 4, NF-kB↓, 2, TNF-α↓, 1, TNF-α↑, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 1, eff↑, 6,

Clinical Biomarkers ⓘ

GutMicro↝, 1, IL6↓, 2,

Functional Outcomes ⓘ

toxicity↓, 5, toxicity↝, 3,

Infection & Microbiome ⓘ

Bacteria↓, 3, Inf↓, 1,
Total Targets: 35

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Transcription & Epigenetics ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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