ER Stress Cancer Research Results

ER Stress, endoplasmic reticulum (ER) stress signaling pathway: Click to Expand ⟱
Source:
Type:
Protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.
The endoplasmic reticulum (ER) stress signaling pathway plays a crucial role in maintaining cellular homeostasis and responding to various stressors, including those encountered in cancer. When cells experience stress, such as the accumulation of misfolded proteins, they activate a series of signaling pathways collectively known as the unfolded protein response (UPR). The UPR aims to restore normal function by enhancing the protein-folding capacity of the ER, degrading misfolded proteins, and, if the stress is unresolved, triggering apoptosis.
The activation of ER stress pathways can contribute to resistance against chemotherapy and targeted therapies. Cancer cells may utilize the UPR to survive treatment-induced stress, making it challenging to achieve effective therapeutic outcomes.

-ER stress-associated proteins include: phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12
Scientific Papers found: Click to Expand⟱
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, neuroblastoma, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
4231- LT,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
4517- MAG,    Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironment
- vitro+vivo, Var, NA
eff↑, AntiCan↑, ROS↑, ER Stress↑, Apoptosis↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,
8754- MeSA,    Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity
- in-vitro, CRC, RKO
Synergy↑, ER Stress↑, UPR↑,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3459- MF,    EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON ENDOPLASMIC RETICULUM STRESS
- in-vitro, Cerv, HeLa
GRP78/BiP↑, GRP94↑, CHOP/DDIT3↑, ER Stress↓,
7384- MF,    Reactive oxygen species (ROS) production in HepG2 cancer cell line through the application of localized alternating magnetic field
- in-vitro, Liver, HepG2
ROS↑, tumCV↓, mtDam↑, Dose↝, ER Stress↑,
3499- MFrot,  MF,    Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans
- in-vitro, Nor, HUVECs
*AntiAge↑, *AMPK↑, *mPGES-1↓, *Ca+2↑, *ER Stress↑, *OS↑, *ROS↓,
773- Mg,    Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells
- in-vitro, BC, MCF7
TRPM7↓, ROS↑, ER Stress↑, MAPK↑, ATP↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
3458- MNPs,    Magnetic Control of Protein Expression via Magneto-mechanical Actuation of ND-PEGylated Iron Oxide Nanocubes for Cell Therapy
- in-vitro, GBM, NA
ER Stress↑, UPR↑, Ca+2↑, TRAIL↓, GRP78/BiP↑,
8808- MT/VAE,    A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, NA, B16-F10
p‑eIF2α↑, CRT↑, HSP70/HSPA5↑, HSP90↑, mt-ROS↑, Imm↑, ER Stress↑,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27/CDKN1B↑,
4973- Nimb,    Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells
- in-vitro, NSCLC, A549
tumCV↓, ROS↑, ER Stress↑, DNAdam↑, Apoptosis↑, eff↓,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,
4975- Nimb,    Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma
- in-vitro, Oral, NA
Apoptosis↑, ROS↑, Ca+2↑, ER Stress↑, Casp↑, MMP↓, tumCV↓,
150- NRF,  CUR,  docx,    Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
- in-vitro, Pca, C4-2B
p‑Akt↓, p‑eIF2α↑, ER Stress↑, ATF4↑, CHOP/DDIT3↑, TRIB3↑, ChemoSen↑, Casp3↑, cl‑PARP↑, BID↑, XBP-1↑,
1229- OA,    Review of the Clinical Effect of Orlistat
- Review, Var, NA
NPC1L1↓, FASN↓, ER Stress↑, angioG↓, TumCG↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
2052- PB,    Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications
- Review, Nor, NA
*HDAC↓, *Half-Life↑, *Half-Life↑, *lipoGen↓, *ER Stress↓, *FAO↑, *ROS↓, *BioAv↑,
2051- PB,    Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium
- in-vivo, Inf, NA
*Inf↓, *GutMicro↑, *IL17↑, *Inflam↓, *ER Stress↓, *ROS↓, *OS↑, *Bacteria↓, *Neut↑, *toxicity↓,
2053- PB,    4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress
- in-vitro, ostP, 3T3
*ER Stress↓, *mtDam↓, *Apoptosis↓, eff↑,
2056- PB,    Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease
- in-vitro, Nor, HCE-2
*ROS↓, *NLRP3↓, *IL1β↓, *TXNIP↑, *ER Stress↓,
2057- PB,    Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER–mitochondria crosstalk in SiHa cells
- in-vitro, Cerv, SiHa
ROS↓, tumCV∅, cl‑PARP↓, cl‑Casp3↓, MMP∅, ER Stress↓,
2058- PB,    Induction of Human-Lung-Cancer-A549-Cell Apoptosis by 4-Hydroperoxy-2-decenoic Acid Ethyl Ester through Intracellular ROS Accumulation and the Induction of Proapoptotic CHOP Expression
- in-vitro, Lung, A549
ER Stress↓,
2059- PB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumAuto↑, ROS↑, ER Stress↑, TumCG↓, toxicity↓,
2065- PB,  TMZ,    Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
- in-vitro, GBM, NA
eff↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,
2078- PB,    Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response
- in-vitro, CRC, HCT116
p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP/DDIT3↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1/ATG6↑, other↝, other↝,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, ChemoSen↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
2034- PB,    Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress
- in-vitro, Nor, SH-SY5Y
*ER Stress↓, *ChemChap↓, *cytoP↑, *cellD↓, *neuroP↑,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP/DDIT3↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4951- PEITC,    ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis
- in-vitro, Ovarian, PA1 - in-vitro, Ovarian, SKOV3
ROS↑, TumCP↓, GSH↓, selectivity↑, UPR↑, CHOP/DDIT3↑, ER Stress↑, GRP78/BiP↑, PERK↑, ATF6↑, eff↓, TumCG↓, Apoptosis↑, toxicity↓,
2649- PL,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
AntiCan↑, ROS↑, GSH↓, TrxR↓, Trx↓, Apoptosis↑, TumCCA↑, ER Stress↑, DNAdam↑, ChemoSen↑, BioAv↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,

Showing Research Papers: 201 to 250 of 316
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 316

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 4,   Catalase↑, 1,   Fenton↑, 3,   GPx↓, 2,   GPx4↓, 4,   GPx4↑, 1,   GSH↓, 21,   GSH∅, 1,   GSH/GSSG↓, 4,   GSR↓, 1,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 9,   HO-2↑, 1,   Iron↑, 5,   i-Iron↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 16,   MDA↑, 2,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↑, 3,   NRF2↓, 8,   NRF2↑, 15,   p‑NRF2↑, 1,   Prx↓, 2,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   PrxII↓, 1,   RNS↑, 1,   ROS↓, 12,   ROS↑, 191,   ROS⇅, 2,   i-ROS↓, 1,   mt-ROS↑, 6,   selenoP↓, 1,   SOD↓, 5,   SOD1↓, 1,   SOD2↓, 1,   Thiols↓, 1,   TKT↝, 1,   Trx↓, 1,   TrxR↓, 8,   TrxR1↓, 6,   TrxR1⇅, 1,   mt-TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 3,   CDC25↓, 5,   EGF↓, 1,   ETC↓, 1,   ETC↝, 1,   mitResp↓, 2,   mitResp↑, 1,   mtDam↓, 1,   mtDam↑, 27,   OCR↓, 5,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PDH↝, 1,   PGC-1α↑, 1,   SIRT3↓, 1,   SIRT3↑, 4,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 3,   ALAT↓, 2,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 13,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 14,   e-ATP↑, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   ECAR↓, 1,   FASN↓, 3,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlucoseCon↑, 1,   GlucoseCon∅, 1,   Glycolysis↓, 22,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 3,   H2S↑, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 6,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 1,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 3,   PFK1↓, 1,   PKM2↓, 5,   PKM2↑, 1,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 2,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 120,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↑, 5,   Bak↑, 7,   BAX↓, 4,   BAX↑, 50,   Bax:Bcl2↑, 7,   Bcl-2↓, 51,   Bcl-xL↓, 10,   BID↓, 1,   BID↑, 6,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 17,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 9,   Casp12↝, 1,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 70,   cl‑Casp3↓, 1,   cl‑Casp3↑, 21,   proCasp3↓, 1,   proCasp3↑, 1,   CASP4↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 10,   Casp8∅, 2,   cl‑Casp8↑, 6,   Casp9↓, 1,   Casp9↑, 46,   cl‑Casp9↑, 7,   cFLIP↓, 5,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 57,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 4,   DR5↓, 1,   DR5↑, 17,   FADD↑, 3,   Fas↑, 11,   FasL↑, 1,   Ferroptosis↑, 10,   GranB/GZMB↝, 1,   GRP58↓, 1,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   ICD↑, 3,   iNOS↓, 6,   iNOS↑, 1,   Mcl-1↓, 9,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 7,   MOMP↓, 1,   MOMP↑, 3,   NAIP↓, 1,   necrosis↑, 3,   NOXA↑, 2,   p38↓, 3,   p38↑, 13,   p‑p38↑, 2,   Paraptosis↑, 6,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP1↓, 1,   survivin↓, 16,   TRAIL↓, 1,   TRAIL↑, 1,   TumCD↓, 2,   TumCD↑, 14,   XIAP↓, 9,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 52,   Akt↑, 4,   p‑Akt↓, 11,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   p‑cMET↑, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 12,   ERK↓, 14,   ERK↑, 5,   p‑ERK↓, 3,   p‑ERK↑, 5,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   IGF-1R↑, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 3,   JAK2↓, 1,   JNK↓, 6,   JNK↑, 24,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 13,   MAPK↑, 11,   p‑MEK↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 30,   mTOR↑, 2,   mTOR∅, 1,   p‑mTOR↓, 6,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 3,   P70S6K↓, 3,   P70S6K↑, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 37,   PI3K↑, 1,   PKCδ↓, 8,   PP2A↑, 1,   PPP2R1A↑, 1,   PRAS40↑, 1,   PTEN↑, 7,   p‑PTEN↓, 1,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 3,   RAS↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 7,   STAT↓, 2,   STAT3↓, 25,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 40,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 15,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 4,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 10,   HDAC∅, 1,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-19b↓, 1,   miR-21↓, 1,   miR-218↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   Myc↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 1,   other↑, 2,   other↝, 9,   PAX2↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 1,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   tumCV↓, 31,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 12,   cl‑ATF6↑, 3,   c-ATF6↑, 1,   CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 86,   CHOP/DDIT3↝, 1,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 2,   e-CRT↑, 1,   i-CRT↓, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 19,   p‑eIF2α↓, 3,   p‑eIF2α↑, 20,   p‑eIF2α↝, 1,   ER Stress↓, 8,   ER Stress↑, 251,   ER Stress↝, 2,   GRP78/BiP?, 1,   GRP78/BiP↓, 5,   GRP78/BiP↑, 67,   GRP78/BiP↝, 1,   GRP94↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 8,   e-HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSP90↑, 5,   e-HSP90↑, 2,   HSPs↑, 2,   IRE1↓, 1,   IRE1↑, 17,   p‑IRE1↓, 1,   p‑IRE1↑, 1,   NQO2↑, 1,   PDI↑, 4,   PERK↓, 2,   PERK↑, 33,   p‑PERK↓, 2,   p‑PERK↑, 6,   p‑PERK↝, 1,   Proteasome↓, 3,   UPR↓, 2,   UPR↑, 46,   XBP-1↓, 1,   XBP-1↑, 12,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 7,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↑, 11,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3B↑, 3,   LC3B-II↑, 3,   LC3II↑, 9,   LC3s↓, 1,   LC3s↑, 1,   lysoMP↑, 1,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 2,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto↓, 1,   TumAuto↑, 48,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 37,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 7,   p16↑, 1,   P53↑, 30,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 12,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 38,   PARP1↑, 2,   PCNA↓, 12,   Telomerase↓, 4,   TOP1↓, 4,   TOP2↓, 3,   TP53↓, 2,   TRF2↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   p‑CDK1↓, 2,   CDK2↓, 17,   CDK2↑, 1,   CDK4↓, 18,   p‑CDK4↓, 1,   CDK6↓, 8,   CDK6↑, 2,   CDK7↓, 1,   CHK1↓, 1,   Chk2↓, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 31,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 12,   cycE/CCNE↑, 1,   E2Fs↓, 1,   GADD34↑, 1,   GADD45A↑, 1,   Ki-67↓, 7,   MAD↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 29,   p27/CDKN1B↑, 11,   p‑RB1↓, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 88,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CEBPA↑, 1,   CEBPB↓, 1,   cFos↓, 4,   cFos↑, 1,   CSCs↓, 17,   CSCsMark↓, 1,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   HH↓, 1,   IGFBP3↑, 1,   Ki-67↓, 7,   Let-7↑, 1,   mTORC1↓, 6,   Nanog↓, 3,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 3,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 3,   NOTCH3↓, 2,   p300↓, 1,   Shh↓, 2,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 39,   TumCP↓, 51,   TumCP↑, 3,   Wnt?, 1,   Wnt↓, 14,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Alix/AIP‑1↓, 3,   AntiAg↓, 1,   AP-1↓, 6,   ASAP2↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 3,   Ca+2↑, 56,   Ca+2↝, 3,   i-Ca+2↑, 3,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   cal2↑, 2,   Cdc42↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 14,   EMT↓, 32,   FAK↓, 3,   p‑FAK↓, 1,   p‑FAK↑, 1,   Fibronectin↓, 1,   GLI2↓, 1,   ITGB3↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 1,   MMP2↓, 24,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 31,   MMP9↑, 2,   MMPs↓, 9,   N-cadherin↓, 12,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 5,   Smad1↓, 1,   SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 7,   STAC2↓, 1,   talin↓, 1,   TET1↑, 5,   TGF-β↓, 9,   TGF-β↑, 3,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 2,   TIMP2↑, 4,   TRIB3↑, 3,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 30,   TumCMig↓, 26,   TumMeta↓, 25,   TumMeta↑, 1,   Twist↓, 7,   uPA↓, 10,   Vim↓, 12,   Zeb1↓, 2,   Zeb1↑, 1,   ZEB2↓, 1,   α-tubulin↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   angioG↑, 1,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 21,   Hif1a↑, 3,   NO↓, 1,   NO↑, 2,   NO↝, 1,   VEGF↓, 31,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   CellMemb↑, 2,   CLDN1↓, 1,   CLDN2↓, 2,   EPR↑, 3,   EPR↝, 1,   GLUT1↓, 7,   GLUT4↓, 1,   MMP↓, 71,   MMP↑, 2,   MMP∅, 1,   MPT↑, 2,   SLC12A5↓, 1,   sonoP↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGCC↓, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 3,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCR4↓, 7,   DCells↑, 1,   DR4↑, 3,   FOXP3↑, 1,   HMGB1↓, 2,   HMGB1↑, 1,   e-HMGB1↑, 1,   i-HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL1↑, 1,   IL10↓, 5,   IL10↑, 1,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 3,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL6↓, 9,   IL8↓, 3,   IL8↑, 1,   Imm↑, 11,   Imm↝, 3,   Inflam↓, 8,   LRIG1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 2,   NF-kB↓, 41,   NF-kB↑, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↑, 1,   p65↓, 4,   PD-1↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 7,   PSA↓, 2,   RAGE↓, 1,   T-Cell↑, 1,   TLR4↓, 5,   TNF-α↓, 10,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↑, 1,   AR↓, 9,   ER-α36↓, 3,   Estro↝, 1,   PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 15,   BioAv↑, 19,   BioAv↝, 1,   BioEnh↑, 4,   ChemoSen↓, 3,   ChemoSen↑, 67,   CYP1A1↓, 1,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 18,   Dose∅, 2,   eff↓, 44,   eff↑, 63,   eff↝, 4,   eff∅, 2,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 7,   MDR1↓, 3,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 10,   P450↓, 1,   RadioS↑, 25,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 49,   Synergy↑, 63,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 2,   ALAT∅, 1,   ALP↓, 2,   AR↓, 9,   AST↓, 1,   AST∅, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 7,   IL6↓, 9,   LDH↓, 6,   LDH↑, 3,   Myc↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TRIB3↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 8,   cachexia↓, 1,   cardioP↑, 2,   CardioT↑, 2,   chemoP↑, 7,   chemoPv↑, 9,   ChemoSideEff↓, 2,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 2,   Mucositis↓, 1,   MusCon↓, 1,   neuroP↑, 2,   NP/CIPN↓, 1,   NP/CIPN↝, 1,   OS↑, 3,   PARP16↓, 1,   PFS↑, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 5,   Sleep↑, 1,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 7,   TumW↓, 5,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   GutMicro↑, 1,   GutMicro↝, 2,  
Total Targets: 794

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 38,   ARE↑, 1,   Catalase↑, 17,   GPx↑, 13,   GPx1↑, 1,   GPx4↑, 3,   GSH↑, 11,   GSR↑, 1,   GSTs↓, 1,   H2O2↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 13,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 18,   MDA↑, 1,   MPO↓, 4,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↑, 34,   Prx↑, 1,   Prx4∅, 1,   ROS↓, 58,   ROS↑, 2,   ROS∅, 4,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↑, 28,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↑, 2,   mitResp↓, 1,   mtDam↓, 4,   mtDam↑, 1,   PGC-1α↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 9,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 1,   FAO↑, 1,   FASN↓, 1,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 3,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   NH3↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 15,   BAX↓, 6,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 2,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp12↓, 7,   Casp3?, 1,   Casp3↓, 10,   cl‑Casp3↓, 2,   Casp9↓, 4,   cellD↓, 1,   Cyt‑c↓, 3,   Cyt‑c↑, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   GRP58↓, 1,   iNOS↓, 11,   MLKL↓, 1,   p38↓, 2,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 2,   CaMKII ↓, 1,   p‑CREB↑, 1,   ERK↑, 1,   IKKα↑, 1,   JAK2↑, 2,   JNK↓, 2,   p‑JNK↓, 3,   MAPK↓, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 2,   PI3K↑, 2,   PROKR1↑, 1,   PROKR2↑, 1,   STAT3?, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 6,   p‑cMyc↑, 1,   HDAC↓, 2,   miR-34a↓, 1,   other↓, 1,   other↑, 3,   other↝, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 5,   ChemChap↓, 1,   CHOP/DDIT3↓, 15,   eIF2α↓, 3,   p‑eIF2α↓, 2,   ER Stress↓, 54,   ER Stress↑, 2,   GRP78/BiP↓, 19,   HSP70/HSPA5↑, 1,   HSP90↑, 1,   IRE1↓, 6,   PDI↓, 1,   PERK↓, 6,   p‑PERK↓, 2,   UPR↓, 4,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 1,   p‑PARP↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Jun↓, 1,   neuroG↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 5,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↑, 2,   Ca+2↝, 1,   cal2↓, 1,   E-cadherin↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   PROK2↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↑, 1,   TXNIP↓, 3,   TXNIP↑, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 3,   E-sel↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 6,   NO↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 2,   CLDN1↓, 1,   CLDN5↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 6,   MUC5AC↓, 1,   TJ↓, 1,   TJ↑, 1,   TRPV1↑, 1,   ZO-1↓, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 13,   ICAM-1↓, 1,   IFN-γ↓, 3,   IL10↓, 4,   IL10↑, 3,   IL12↑, 1,   IL17↓, 1,   IL17↑, 1,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL6↓, 18,   IL6↑, 1,   IL8↓, 2,   Imm↓, 1,   Imm↑, 3,   Inflam↓, 58,   Inflam↑, 1,   LPS↓, 1,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NeuroI↓, 3,   Neut↑, 1,   NF-kB↓, 14,   NLRP3↓, 7,   NLRP3↑, 1,   PGE2↓, 3,   PGE2↑, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 1,   TNF-α↓, 22,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 4,   BDNF↓, 1,   BDNF↑, 2,   ChAT↑, 2,   monoA↑, 1,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 3,   Aβ↓, 10,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   PSEN1/PS1↓, 1,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARα↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 11,   BioAv↝, 2,   Dose↝, 7,   eff↓, 2,   eff↑, 5,   GSTA1↑, 1,   Half-Life↑, 2,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 3,   AST↓, 10,   BG↓, 2,   BMD↑, 1,   BP↓, 2,   creat↓, 2,   CRP↓, 3,   IL6↓, 18,   IL6↑, 1,   LDH↑, 1,   RAGE↓, 2,   TMAO↑, 1,   TP53↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 6,   AntiDiabetic↑, 5,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↑, 22,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↓, 2,   cognitive↑, 15,   cytoP↑, 1,   hepatoP↑, 16,   Learn↑, 4,   memory↑, 13,   Mood↑, 1,   motorD↑, 1,   neuroP↓, 2,   neuroP↑, 32,   Obesity↓, 3,   OS↑, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 6,   Sleep↑, 1,   Stroke↓, 4,   toxicity?, 1,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↑, 2,   AntiViral↑, 3,   Bacteria↓, 5,   GutMicro↑, 12,   Inf↓, 1,   Sepsis↓, 3,  
Total Targets: 320

Scientific Paper Hit Count for: ER Stress, endoplasmic reticulum (ER) stress signaling pathway
14 Phenylbutyrate
13 Silver-NanoParticles
12 Quercetin
11 Curcumin
11 Berberine
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
9 Luteolin
8 Ashwagandha(Withaferin A)
8 Licochalcone A
7 Artemisinin
7 Chrysin
7 salinomycin
7 Gambogic Acid
7 Piperlongumine
6 Apigenin (mainly Parsley)
6 Honokiol
6 Kaempferol
5 Allicin (mainly Garlic)
5 Magnetic Fields
5 Resveratrol
5 Rosmarinic acid
5 Sulforaphane (mainly Broccoli)
5 Vitamin C (Ascorbic Acid)
4 Baicalein
4 Betulinic acid
4 Capsaicin
4 Celastrol
4 Propolis -bee glue
4 Emodin
4 Electrical Pulses
4 Shikonin
4 Selenite (Sodium)
3 Photodynamic Therapy
3 Melatonin
3 Boron
3 Crocetin
3 Copper and Cu NanoParticles
3 Hydrogen Gas
3 HydroxyTyrosol
3 Matrine
3 Nimbolide
3 Selenium NanoParticles
2 3-bromopyruvate
2 Andrographis
2 Cisplatin
2 Boswellia (frankincense)
2 Celecoxib
2 Isobavachalcone
2 Isovitexin
2 methylseleninic acid
2 Plumbagin
2 Pterostilbene
2 Thymoquinone
1 5-Aminolevulinic acid
1 Auranofin
1 Astragalus
1 Radiotherapy/Radiation
1 Alpha-Lipoic-Acid
1 immunotherapy
1 Sorafenib (brand name Nexavar)
1 Aloe anthraquinones
1 Berbamine
1 Chemotherapy
1 Bacopa monnieri
1 α-Bisabolol / Chamomile oil
1 doxorubicin
1 Bortezomib
1 Bullatacin
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 carboplatin
1 Cannabidiol
1 chitosan
1 Choline
1 Cinnamon
1 Coenzyme Q10
1 Cynaropicrin
1 Dichloroacetate
1 Diindolylmethane
1 Dipyridamole
1 Aspirin
1 Dandelion Root
1 Disulfiram
1 Ellagic acid
1 Ferulic acid
1 Fenbendazole
1 verapamil
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hyperthermia
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoquercitrin
1 Ivermectin
1 Vitexin
1 Lemongrass Extract/Citral
1 Lycopene
1 Magnolol
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Mistletoe/Viscum album Extracts
1 Naringin
1 nelfinavir/Viracept
1 Docetaxel
1 Oroxylin-A
1 Oleuropein
1 temozolomide
1 Phenethyl isothiocyanate
1 Parthenolide
1 Paclitaxel/Taxol
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Osimertinib
1 Adagrasib
1 Taurine
1 Urolithin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:103  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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