ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid
Scientific Papers found: Click to Expand⟱
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
4775- CoQ10,  Chemo,    Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines
- in-vitro, Var, NA
ChemoSen↓, *antiOx↑, *lipid-P?,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
1411- CUR,  Cisplatin,    Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects
- Review, Var, NA
ChemoSen↑, *ROS↓, *NF-kB↓, TumCCA↑,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1488- CUR,    Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma
RadioS↑, ChemoSen↑,
1487- CUR,    Relationship and interactions of curcumin with radiation therapy
- Review, Var, NA
RadioS↑, ChemoSen↑,
1486- CUR,    Curcumin and lung cancer--a review
- Review, Lung, NA
RadioS↑, ChemoSen↑,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, ChemoSen↑,
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
miR-143↑, PDK1↓, FOXD3↑, TumCP↓, TumCMig↓, *Inflam↓, *antiOx↑, *chemoPv↑, RadioS↑, ChemoSen↑,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,
4831- CUR,    The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity
- in-vitro, NA, NA
*NRF2↑, *P53↓, *NF-kB↓, ROS↑, Inflam↓, ChemoSen↑,
4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
CSCs↓, TumCG↓, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, Shh↓, NOTCH↓, DNMT1↓, STAT3↓, NF-kB↓, EGFR↓, IGFR↓, TumCCA↓, cl‑PARP↑, BAX↑, ECM/TCF↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
4675- CUR,    Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines
- in-vitro, NSCLC, A549
ChemoSen↑, CSCs↓, EpCAM↓, TumCCA↓, VEGF↓, MMP9↓, toxicity↓,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
5197- DCA,  5-FU,    Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
- in-vitro, GC, NA
Glycolysis↓, ChemoSen↑, PDK1↓,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
1845- dietFMD,    Fasting and fasting mimicking diets in cancer prevention and therapy
- Review, Var, NA
eff↑, selectivity↑, ChemoSen↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
1848- dietFMD,  Chemo,    Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial
- Trial, BC, NA
ChemoSideEff↓, ChemoSen↑, eff↑,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, eff↑, HO-1↓, DNAdam↑, eff↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1857- dietFMD,    Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
- in-vitro, BC, 4T1 - in-vivo, NA, NA
TumCG↓, ChemoSen↑, OS↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
1897- dietMet,    Methionine metabolism in health and cancer: a nexus of diet and precision medicine
- Review, Var, NA
OS↑, TumCG↓, TumCCA↑, ChemoSen↑, RadioS↑,
1895- dietMet,    Altering Diet Enhances Response to Cancer Treatments in Mice
- Review, Var, NA
ChemoSen↑,
1893- dietMet,    Clinical Studies of Methionine-Restricted Diets for Cancer Patients
- Review, Var, NA
TumCG↓, ChemoSen↑, MATs↓,
2268- dietMet,    Methionine dependency and cancer treatment
- Review, Var, NA
ChemoSen↑, *eff↑, selectivity↑, eff↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
2264- dietMet,    Methionine restriction for cancer therapy: From preclinical studies to clinical trials
- Review, Var, NA
TumCP↓, *ROS?, ChemoSen↑, RadioS↑, eff↑, ROS↑, selectivity↑, TS↓, eff↑,
5188- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, Var, NA
AntiAge↑, MethCyc↓, TumCG↓, ChemoSen↑, RadioS↑, OS↑, GSH↓,
5191- dietMet,    Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
- in-vitro, Colon, HT29
ChemoSen↑, RadioS↑, Ferroptosis↑, eff↑, eff↑, GSH↓, eff↓,

Showing Research Papers: 201 to 250 of 530
Prev Page 5 of 11 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 530

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 4,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 4,   GSH↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 1,   Iron↑, 2,   lipid-P↑, 2,   MDA↑, 1,   NADPH/NADP+↓, 1,   NQO1↑, 1,   NRF2↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,   ROS↑, 23,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 2,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   ATP↑, 1,   Insulin↓, 3,   MMP↓, 4,   mtDam↑, 2,   OCR↑, 1,   Raf↓, 1,   SDH↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 2,   adiP↑, 1,   AminoA↓, 1,   AMPK↑, 2,   ATP:AMP↓, 1,   cMyc↓, 2,   ECAR↓, 1,   FASN↓, 1,   FASN↑, 1,   FBPase↑, 2,   GAPDH↓, 1,   glucoNG↑, 2,   GlucoseCon↓, 4,   GLUT2↓, 1,   glyC↓, 1,   Glycolysis↓, 8,   HK2↓, 5,   KeyT↑, 1,   lactateProd↓, 4,   LDHA↓, 1,   MATs↓, 1,   MCT4↓, 1,   MethCyc↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDK1↓, 2,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 4,   PFK2↓, 2,   PFKP↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   polyA↓, 1,   Pyruv↓, 1,   SIRT1↑, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 2,   Warburg↓, 2,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 7,   Akt↑, 2,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 14,   Apoptosis∅, 1,   Bak↑, 2,   BAX↑, 5,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BID↑, 1,   Casp2↑, 2,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 6,   Cupro↑, 2,   Cyt‑c↑, 4,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 4,   MCT1↓, 1,   p27↑, 1,   p38↑, 1,   Paraptosis↑, 2,   Pyro↑, 1,   survivin↓, 2,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   RTK-RAS↓, 1,   SOX9?, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   miR-143↑, 1,   miR-192-5p↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↓, 1,   other↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   Beclin-1↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3s↓, 1,   p62↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   DNMT1↓, 2,   p16↑, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycD1/CCND1↓, 5,   P21↑, 3,   TumCCA↓, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 4,   EMT↓, 3,   EpCAM↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   Gli1↓, 1,   HDAC↓, 2,   HDAC8↓, 2,   HH↓, 1,   IGF-1↓, 5,   IGF-1R↓, 2,   IGFBP1↑, 1,   IGFR↓, 1,   miR-99↑, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   n-MYC↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 3,   PI3K↑, 1,   PTCH1↓, 1,   PTEN↑, 4,   SCF↓, 1,   Shh↓, 2,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,   p‑STAT3↑, 1,   STAT5↓, 1,   TumCG↓, 16,   TumCG∅, 2,   Wnt↓, 4,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   CDKN1C↑, 1,   CLDN1↓, 1,   CXCL12↓, 1,   E-cadherin↑, 3,   FAK↓, 1,   LAMs↓, 1,   miR-130a↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 2,   PDGF↓, 1,   PKA↓, 1,   Snail↓, 1,   TGF-β↓, 1,   Treg lymp↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 2,   TumMeta↑, 1,   Twist↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   ECM/TCF↓, 1,   EGFR↓, 2,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 5,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   HCAR1↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   JAK2↓, 1,   M2 MC↓, 2,   NF-kB↓, 8,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 47,   ChemoSen∅, 3,   Dose?, 1,   Dose↑, 1,   Dose↝, 4,   Dose∅, 1,   eff↓, 6,   eff↑, 40,   RadioS↑, 15,   selectivity↑, 16,  

Clinical Biomarkers ⓘ

BG↓, 4,   EGFR↓, 2,   EZH2↓, 1,   Ferritin↓, 2,   GutMicro↑, 2,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   antiNeop∅, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   ChemoSideEff↓, 4,   neuroP↑, 1,   OS↑, 6,   QoL↑, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 2,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 261

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   GSTs↑, 2,   HDL↑, 1,   HO-1↑, 1,   lipid-P?, 1,   MDA↓, 1,   NRF2↑, 2,   ROS?, 1,   ROS↓, 12,   SOD↑, 2,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,   lipidLev↓, 1,   NADPH↑, 2,   PPARα↑, 1,  

Cell Death ⓘ

Akt↓, 2,   MAPK↓, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p300↓, 1,   PI3K↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   Inflam↓, 3,   NF-kB↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   eff↑, 1,   P450↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   cardioP↑, 1,   cardioP⇅, 1,   chemoPv↑, 2,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 2,  
Total Targets: 47

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
34 Chemotherapy
26 Cisplatin
19 Curcumin
17 doxorubicin
16 Resveratrol
15 Thymoquinone
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Quercetin
13 Sulforaphane (mainly Broccoli)
12 Magnetic Fields
11 Apigenin (mainly Parsley)
11 Capsaicin
10 Propolis -bee glue
10 diet FMD Fasting Mimicking Diet
10 Fisetin
10 Lycopene
9 Vitamin C (Ascorbic Acid)
8 Docetaxel
8 Luteolin
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 Chrysin
8 salinomycin
8 diet Methionine-Restricted Diet
8 Shikonin
7 Astragalus
7 Copper and Cu NanoParticles
7 5-fluorouracil
7 Ashwagandha(Withaferin A)
7 Berberine
7 Gambogic Acid
7 Pterostilbene
7 Selenite (Sodium)
7 Vitamin K2
6 Sorafenib (brand name Nexavar)
6 Radiotherapy/Radiation
6 Allicin (mainly Garlic)
6 Gemcitabine (Gemzar)
6 borneol
6 chitosan
6 Disulfiram
6 Honokiol
6 Metformin
6 Phenethyl isothiocyanate
6 Rosmarinic acid
5 2-DeoxyGlucose
5 Silver-NanoParticles
5 Anti-oxidants
5 Selenium
5 Astaxanthin
5 Atorvastatin
5 Coenzyme Q10
5 diet Short Term Fasting
5 EGCG (Epigallocatechin Gallate)
5 Melatonin
5 Piperlongumine
5 VitK3,menadione
5 Urolithin
4 Alpha-Lipoic-Acid
4 Caffeic acid
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Citric Acid
4 Oxygen, Hyperbaric
4 Ellagic acid
4 Paclitaxel
4 Magnolol
3 Auranofin
3 Andrographis
3 beta-glucans
3 Baicalin
3 Berbamine
3 Brucea javanica
3 Piperine
3 Carvacrol
3 Celastrol
3 Emodin
3 Electrical Pulses
3 Bicarbonate(Sodium)
3 Phenylbutyrate
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 immunotherapy
2 Biochanin A
2 Bromelain
2 Boron
2 erastin
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Dichloroacetate
2 Exercise
2 Shilajit/Fulvic Acid
2 Hydrogen Gas
2 Spermidine
2 Hydroxycinnamic-acid
2 Naringin
2 Niclosamide (Niclocide)
2 Hyperthermia
2 Plumbagin
2 Psoralidin
2 Oxaliplatin
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 temozolomide
1 Aspirin -acetylsalicylic acid
1 Dipyridamole
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 Trastuzumab
1 urea
1 Vitamin E
1 diet Ketogenic
1 Zinc
1 Ferulic acid
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 HydroxyTyrosol
1 Bortezomib
1 carboplatin
1 Moringa oleifera
1 Mushroom Reishi
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rutin
1 Sulfasalazine
1 irinotecan
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page