RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
Source:
Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8066- KAE,  Rad,    Radiosensitization of non-small cell lung cancer by kaempferol
- in-vivo, Lung, A549
TumCG↓, selectivity↑, TumCCA↑, RadioS↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8404- LDN,  Rad,    Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells
- in-vitro, Oral, NA
TumCP?, ALDH1A1↓, CD44↓, selectivity↑, RadioS↑,
8405- LT,  Rad,    Luteolin's role as a radiosensitizer by promoting cell death and ROS modulation
- Review, NSCLC, NA
RadioS↑, ROS↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2917- LT,  Rad,    Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- in-vitro, Lung, NA
Bcl-2↓, Casp3↑, Casp8↑, Casp9↑, p‑p38↑, ROS↑, RadioS↑,
3273- Lyco,    Lycopene
- Review, Var, NA
antiOx↑, ChemoSen↓, RadioS↓,
8509- MAG,  Rad,    The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma
- in-vivo, HCC, NA
TumVol↓, TumW↓, *ERK↓, *NF-kB↓, Casp3↑, Casp9↑, RadioS↑, *toxicity↓, Ki-67↓, IL1β↓, TNF-α↓,
8933- MBS,  Rad,    The evaluation of radio-sensitivity of mung bean proteins aqueous extract on MCF-7, hela and fibroblast cell line
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa
TumCP↓, selectivity?, RadioS↑, radioP↑,
8627- MBZ,    Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death
- in-vitro, CRC, HT-29 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, selectivity↑, Apoptosis↑, Casp3↑, DNAdam↑, MOMP↑, ROS↑, TumCCA↑, eff↓, RadioS↑,
8630- MBZ,  Rad,    Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism
- in-vitro, GBM, GL261 - in-vitro, GBM, GBM14
RadioS↑, γH2AX↑, eff↑, mitA↑,
8634- MBZ,  Rad,    Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer
- vitro+vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
RadioS↑, TumCCA↑, DNAdam↑, Apoptosis↑, TumCD↑, *toxicity↓,
8651- MBZ,  Rad,    Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma
- in-vitro, Var, NA
Dose↝, RadioS↑, cl‑Casp3↑, Apoptosis↑, TumCP↓, angioG↓,
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
8787- mCHEMO,    Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy
- Review, Var, NA
*toxicity↓, angioG↓, Imm↑, DCells↑, T-Cell↑, CSCs?, chemoR↓, QoL↑, RadioS↑, Synergy↑,
8821- MCP,  Rad,    Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
Gal-3↓, TumCP↓, angioG↓, Apoptosis↑, RadioS?, BAX↓, DNArepair↓, PCNA↓, TumCI↓, TumCCA↑, ROS↑,
8724- MeJa,  Rad,    Methyl jasmonate enhances the radiation sensitivity of esophageal carcinoma cells by inhibiting the 11-ketoprostaglandin reductase activity of AKR1C3
- in-vitro, ESCC, KYSE170
AKR1C3/17β-HSD5/PGF Synthase↓, ROS↑, RadioS↑,
8719- MeJa,  Cisplatin,  Rad,    Enhanced killing of cervical cancer cells by combinations of methyl jasmonate with cisplatin, X or alpha radiation
- in-vitro, Cerv, SiHa - in-vitro, Cerv, CaSki - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
RadioS↑, ChemoSen↑,
8752- MeSA,  Rad,    Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells
- in-vitro, HNSCC, CAL27 - in-vitro, SCC, SCC25
selectivity↑, RadioS↑, GSH↓, lipid-P↑, OCR↑,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
8711- MET,    https://pubmed.ncbi.nlm.nih.gov/42725610/
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, OCR↑, Hypoxia↓, RadioS↑, ChemoSen↑,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
2244- MF,    Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer
- Review, Var, NA
RPM↑, Glycolysis∅, ROS↑, ChemoSen↑, RadioS↑, selectivity↑,
2251- MF,  Rad,    BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
- in-vitro, Lung, A549 - in-vitro, HNSCC, UTSCC15 - in-vitro, CRC, DLD1 - in-vitro, PC, MIA PaCa-2
RadioS↑, DNAdam↑, ROS↑, ChemoSen∅, Pyruv↓, ADP:ATP↓, ROS↑,
8483- MF,    Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies
- Review, Var, NA
Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
512- MF,    Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, FF95
TumCP↓, *toxicity↓, ChemoSen↑, RadioS↑, selectivity↑, Ca+2↑,
8739- MGO,    Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation
- vitro+vivo, CRC, NA
RadioS↑, ROS↑, Hypoxia↓, GutMicro↝,
8669- MLT,    Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities
- Review, Lung, NA
Apoptosis↑, ROS↑, Cyt‑c↑, Bcl-2↓, Casp↑, TumCP↓, TumCI↓, angioG↓, Inflam↓, ChemoSen↑, RadioS↑,
8672- MLT,    Glioblastoma and Melatonin’s Effects: A Narrative Review
- Review, GBM, NA
selectivity↑, *ROS↓, *DNAdam↓, *SOD↑, *Catalase↑, *GPx↑, *Inflam↓, *EGF↓, *HIF-1↓, Pyruv↓, Glycolysis↓, ROS↑, TumCG↓, IL1β↓, ICAM-1↓, VCAM-1↓, NRF2↓, RadioS↑, OS↑, NAD↓, LDHA↓, MCT4↓, pH↝, ChemoSen↑, Synergy↑, TRPV1↓, Pain↓, Synergy↑, Dose↑,
8692- MLT,    Melatonin as a Radio-Sensitizer in Cancer
- Review, Var, NA
RadioS↑, radioP↑, ROS↑, DNArepair↓, angioG↓, Inflam↓, Apoptosis↑, Telomerase↓, HSP70/HSPA5↑, P53↑, Glycolysis↓, Dose?, OS∅,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
4627- OLE,    Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity
- in-vitro, Oral, NA
tumCV↓, Mcl-1↓, TumCG↓, toxicity∅, RadioS↑, AntiTum↑,
1811- Oxy,    Hyperbaric oxygen therapy and cancer—a review
- Review, Var, NA
toxicity∅, AntiTum↑, MAPK↑, ERK↓, ChemoSen↑, ChemoSen↑, RadioS↑,
1813- Oxy,    Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironment
- Review, Var, NA
ChemoSen↑, RadioS↑, PD-L1↓, Hif1a↓, ROS↑,
1814- Oxy,    Hyperbaric oxygen therapy for malignancy: a review
- Review, Var, NA
ROS↑, SOD↑, OS↑, ChemoSen↑, RadioS↑, BioAv↑,
2063- PB,  Rad,    Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation
- in-vitro, GBM, U87MG - NA, NA, U251
RadioS↑, eff↝, P53↝,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
2066- PB,  Rad,    Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas
- in-vitro, GBM, U251
RadioS↑,

Showing Research Papers: 201 to 250 of 314
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 314

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 6,   Catalase↑, 1,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 4,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 4,   GSH↓, 25,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 2,   GSTs↝, 1,   GSTs∅, 1,   H2O2↓, 2,   H2O2↑, 4,   HO-1↓, 9,   HO-1↑, 4,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 2,   i-Iron↑, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 1,   MDA↑, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 14,   NRF2↑, 11,   NRF2∅, 1,   Prx↓, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 163,   ROS⇅, 5,   ROS↝, 1,   mt-ROS↑, 3,   RPM↑, 1,   SOD↓, 7,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 3,   TrxR↓, 12,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   CDC2↓, 2,   CDC25↓, 1,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   Insulin↓, 4,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 3,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 6,   p‑PDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↑, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK↑, 16,   ATP↓, 10,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 2,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycolysis↓, 26,   Glycolysis↝, 1,   Glycolysis∅, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK2↓, 11,   HMG-CoA↓, 2,   lactateProd↓, 9,   LDHA↓, 4,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   MethCyc↓, 1,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PDKs↑, 1,   PFK↓, 4,   PKM2↓, 9,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 2,   SIRT1↓, 4,   SIRT1↑, 5,   SIRT2↓, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 2,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 102,   ASC↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 34,   Bax:Bcl2↑, 11,   Bcl-2↓, 41,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 2,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 17,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 45,   cl‑Casp3↑, 10,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 5,   Casp8↑, 11,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 29,   cl‑Casp9↑, 5,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   Diablo↑, 3,   DR5↑, 7,   Fas↑, 7,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GSDME↑, 1,   IAP1↓, 3,   IAP2/BIRC3↑, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 8,   MDM2↓, 5,   p‑MDM2↓, 1,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 4,   Pyro↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 15,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 12,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 2,   p‑Akt↓, 13,   AMPKα↑, 1,   BRAF↓, 1,   p‑CaMKII ↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 2,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   EGFR↑, 2,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 4,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 2,   IκB↓, 2,   IκB↑, 1,   JAK↓, 1,   JAK↝, 1,   JAK1↓, 4,   JAK2↓, 8,   JNK↓, 2,   JNK↑, 12,   p‑JNK↑, 2,   MAPK↓, 16,   MAPK↑, 6,   MEK↓, 3,   mTOR↓, 36,   mTOR↑, 1,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 1,   P90RSK↓, 2,   PAK↓, 1,   PI3K↓, 38,   PI3K↑, 2,   p‑PI3K↓, 2,   PI3K/mTOR/ETS2↓, 1,   PIK3CA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 3,   RAS↓, 6,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 27,   STAT3↑, 1,   p‑STAT3↓, 9,   STAT6↓, 2,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 6,   ATF4↝, 1,   cJun↓, 5,   cMyc↓, 15,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 2,   H4↓, 1,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC8↓, 1,   miR-143↑, 1,   miR-21↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 4,   Myc↑, 1,   n-MYC↓, 2,   OCT4↓, 2,   other↓, 1,   other↑, 5,   other↝, 8,   PhotoS↑, 5,   Prot↓, 1,   sonoS↑, 2,   SOX2↓, 4,   SOX4↑, 1,   TCF-4↓, 2,   tumCV↓, 17,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 25,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP72↑, 1,   HSP90↓, 8,   HSPs↑, 2,   IRE1↑, 3,   PERK↑, 4,   Proteasome?, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   LC3s↓, 1,   lysoMP↑, 1,   p62↓, 2,   p62↑, 2,   TumAuto↓, 2,   TumAuto↑, 21,   TumAuto↝, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA2↓, 5,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 4,   DNAdam↑, 51,   DNArepair↓, 8,   DNArepair↑, 1,   hTERT/TERT↓, 8,   P53↓, 1,   P53↑, 35,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 8,   cl‑PARP↑, 21,   PCNA↓, 5,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 6,   TOP2↓, 4,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 8,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 14,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 12,   CDK6↑, 1,   CDK8↓, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 26,   cycE/CCNE↓, 9,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 4,   P21↓, 2,   P21↑, 26,   p27/CDKN1B↑, 14,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 2,   TubPol↓, 1,   TumCCA↓, 4,   TumCCA↑, 82,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   CD133↓, 2,   CD34↓, 1,   cFos↓, 5,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 28,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 5,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 5,   IGF-1↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 9,   NOTCH1↓, 3,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 6,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 46,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 61,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 19,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 16,   Ca+2↝, 1,   i-Ca+2↑, 1,   Cav1↓, 1,   Cdc42↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 37,   EMT↝, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   Furin↓, 1,   IQGAP3↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   KRAS↓, 1,   MALAT1↓, 4,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 32,   MMP7↓, 5,   MMP9↓, 33,   MMP9↑, 1,   MMPs↓, 8,   MUC4↓, 1,   N-cadherin↓, 10,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 1,   Rac1↓, 3,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   Snail↓, 8,   TET1↑, 2,   TGF-β↓, 8,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   TumCA↓, 1,   TumCI↓, 33,   TumCMig↓, 27,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 27,   TumMeta↑, 1,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 6,   Vim?, 1,   Vim↓, 13,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 26,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 48,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 32,   Hif1a↑, 1,   Hypoxia↓, 7,   LOX1↓, 1,   NO↓, 1,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 46,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   CellMemb↑, 2,   CLDN1↓, 1,   CLDN2↓, 1,   CLDN2↑, 1,   EPR↑, 5,   EPR↝, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 41,   MMP↑, 2,   MPT↑, 3,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↝, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 7,   CD8+↑, 1,   p‑cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 3,   CXCR4↓, 5,   DCells↑, 1,   DR4↑, 1,   FOXP3↓, 2,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 10,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL6↓, 17,   IL8↓, 4,   IL8↑, 1,   Imm↑, 19,   Inflam↓, 21,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 74,   NF-kB↑, 5,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 3,   p65↓, 4,   p65↑, 1,   p‑p65↓, 2,   PD-1↓, 3,   PD-1↝, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PGE2↓, 10,   PSA↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   TLR4↓, 2,   TNF-α↓, 10,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↝, 3,   e-pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AKR1C3/17β-HSD5/PGF Synthase↓, 1,   AR↓, 7,   ER-α36↓, 2,   ER(estro)↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 30,   BioAv↝, 8,   BioEnh↑, 1,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 5,   ChemoSen↑, 153,   ChemoSen⇅, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 4,   CompStab↝, 2,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 4,   Dose↓, 2,   Dose↑, 9,   Dose↝, 36,   Dose∅, 8,   eff↓, 27,   eff↑, 85,   eff⇅, 1,   eff↝, 10,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 9,   Half-Life↑, 3,   Half-Life↝, 8,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 9,   P450↓, 1,   P450↝, 1,   RadioS?, 3,   RadioS↓, 6,   RadioS↑, 304,   RadioS↝, 2,   RadioS∅, 2,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 64,   Synergy↑, 72,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALAT↑, 1,   ALP↓, 1,   AR↓, 7,   AST↓, 2,   AST↑, 1,   BG↓, 2,   BloodF↑, 4,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CEA↓, 3,   CRP↓, 1,   EGFR↓, 14,   EGFR↑, 2,   EZH2↓, 1,   Ferritin↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 8,   IL6↓, 17,   KRAS↓, 1,   LDH↓, 5,   LDH↑, 1,   LDH↝, 1,   Myc↓, 4,   Myc↑, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 23,   antiNeop↑, 1,   AntiTum↑, 13,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 2,   chemoP↑, 20,   chemoPv↑, 7,   ChemoSideEff↓, 6,   CR↑, 1,   fatigue↓, 2,   hepatoP↑, 3,   hepatoP↝, 1,   LC↑, 1,   Mucositis↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   OS↑, 20,   OS∅, 2,   Pain↓, 3,   PFS↓, 1,   PFS∅, 1,   QoL↑, 5,   QoL∅, 1,   radioP↑, 17,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 13,   Risk↑, 1,   Risk∅, 1,   Sleep↑, 1,   toxicity↓, 23,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 5,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 2,   GutMicro↝, 2,   Sepsis↓, 1,  
Total Targets: 777

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 22,   Catalase↑, 12,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 17,   GSH/GSSG↑, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 5,   Keap1↓, 1,   Keap1↑, 1,   ox-Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 6,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 12,   ROS?, 1,   ROS↓, 34,   ROS↑, 2,   ROS↝, 1,   ROS∅, 2,   SOD↓, 1,   SOD↑, 13,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   OCR↑, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 3,   ATP↑, 2,   glucose↓, 1,   GlucoseCon↑, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↑, 1,   NADPH↑, 1,   NADPH∅, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↓, 2,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   JNK↓, 1,   MAPK↓, 1,   PI3K↓, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p300↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Cartilage↑, 1,   FAK↑, 1,   MMP13↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   HIF-1↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 6,   IL2↓, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 28,   NF-kB↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   GR↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 13,   BioAv↑, 10,   BioAv↝, 4,   BioEnh↑, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 7,   eff↑, 4,   eff↝, 1,   GSTA1↓, 1,   Half-Life↓, 2,   Half-Life↝, 4,   Half-Life∅, 1,   RadioS↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AST↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 7,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 6,   AntiTum↓, 1,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 6,   cognitive↑, 4,   hepatoP↑, 8,   memory↑, 4,   motorD↑, 2,   neuroP↑, 18,   Obesity↓, 2,   Pain↓, 2,   radioP↑, 8,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 1,   toxicity?, 1,   toxicity↓, 15,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 5,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 3,   Inf↓, 1,  
Total Targets: 175

Scientific Paper Hit Count for: RadioS, RadioSensitizer
93 Radiotherapy/Radiation
19 Curcumin
18 Hyperthermia
11 Silver-NanoParticles
9 Fisetin
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
7 Magnetic Fields
6 Chemotherapy
6 Cisplatin
6 Berberine
6 salinomycin
6 diet Methionine-Restricted Diet
6 Ellagic acid
5 Copper and Cu NanoParticles
5 Dichloroacetate
5 Disulfiram
5 Gold NanoParticles
5 mebendazole
5 Melatonin
5 Thymoquinone
4 Atorvastatin
4 Chrysin
4 Honokiol
4 Oxygen, Hyperbaric
4 Luteolin
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
4 Selenium NanoParticles
4 Selenite (Sodium)
3 Selenium
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 brusatol
3 Crocetin
3 Eugenol
3 diet FMD Fasting Mimicking Diet
3 Ferulic acid
3 Gambogic Acid
3 Kaempferol
3 Quercetin
3 Metformin
3 Piperlongumine
3 Parthenolide
3 Sulfasalazine
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Anti-oxidants
2 Vitamin C (Ascorbic Acid)
2 Astaxanthin
2 Beta-Caryophyllene
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 diet Short Term Fasting
2 Diindolylmethane
2 immunotherapy
2 EGCG (Epigallocatechin Gallate)
2 Geldanamycin
2 Gossypol/AT-101
2 Magnolol
2 Methyl Jasmonate
2 methylseleninic acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Vitamin A, Retinoic Acid
1 Artemisinin
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diclofenac
1 Electrical Pulses
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Ginkgolide B
1 Ginkgetin
1 Hydroxycinnamic-acid
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoflavones
1 low dose naltrexone
1 Lycopene
1 Mung Bean Sprouts
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methylglyoxal
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 doxorubicin
1 Oxaliplatin
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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