Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Scientific Papers found: Click to Expand⟱
1582- Citrate,    Clinical report: A patient with primary peritoneal mesothelioma that has improved after taking citric acid orally
- Case Report, PerC, NA
Dose∅, Weight↑, OS↑,
1581- Citrate,    Hypothesis proved. . .citric acid (citrate) does improve cancer:A case of a patient suffering from medullary thyroid cancer
- Case Report, Thyroid, NA
OS↑, Weight↑, Dose∅, eff↑,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
5808- CPT,    Repair of Topoisomerase I-Mediated DNA Damage
- Review, Var, NA
TOP1↓, AntiCan↑, Dose?, CHK1↑, Chk2↑,
5791- CRMs,  HCA,  NAD,  Sper,  RES  Caloric Restriction Mimetics in Nutrition and Clinical Trials
- Review, Nor, NA
*Dose↝, *Glycolysis↓,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP↓, *Dose↝,
1639- Cu,  HCAs,    Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
angioG↓, tumCV↓, Dose↓, ROS↑,
1569- Cu,    Copper Nanoparticles as Therapeutic Anticancer Agents
- Review, NA, NA
Dose∅, Dose∅, ROS↑,
1598- Cu,    Targeting copper in cancer therapy: 'Copper That Cancer'
- Review, NA, NA
eff↓, eff↑, Dose∅, eff↑, angioG↑, ROS↑,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1616- CUR,  EA,    Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid
- in-vitro, Nor, NA
*MAOA↓, *Dose∅, Dose?,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
1977- CUR,    Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
TrxR↓, Dose↝, eff↑,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2↓,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
*BioAv↓, *BioAv↑, Dose↑, *Dose↝, *BBB↑, *cognitive↑, *BioAv↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
151- CUR,    Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP
AR↓, PSA↓, Dose↑,
120- CUR,    A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation
- Human, Pca, NA
PSA↓, Dose↝,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
2816- CUR,    NEUROPROTECTIVE EFFECTS OF CURCUMIN
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *AP-1↓, *NF-kB↓, *HATs↓, *HDAC↑, Dose↑, *ROS↓, *cognitive↑, *Aβ↓,
1910- CUSP9,    A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
- Analysis, GBM, NA
Dose↝, QoL↑, Dose↝,
1877- DCA,    Non-Hodgkin′s Lymphoma Reversal with Dichloroacetate
- Case Report, lymphoma, NA
Remission↑, p‑PDKs↓, Glycolysis↓, i-Ca+2↓, toxicity↓, Dose∅,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1879- DCA,    Long-term stabilization of metastatic melanoma with sodium dichloroacetate
- Case Report, Melanoma, NA
OS↑, toxicity↓, Dose∅, Dose∅, Dose∅, QoL∅,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,
1868- DCA,  MET,    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
- Case Report, NA, NA
eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,
2152- dietFMD,    Prolonged Nightly Fasting and Breast Cancer Prognosis
- Analysis, BC, NA
eff↑, Dose↓, Risk↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
2165- dietP,  SFN,    Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
- Trial, PC, NA
Dose↝, OS↑, eff↝,
5065- dietSTF,  dietFMD,    Nutrition, GH/IGF-I Signaling, and Cancer
- Review, Var, NA
GH↓, IGF-1↓, glucose↓, IGFBP1↑, OS↑, Imm↑, neuroP↑, BMD↑, Dose↝, Risk↓, other↑, TumCP↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5386- docx,  AsP,    Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
- vitro+vivo, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Pca, PC3
Dose↝, ROS↑, eff↑, eff↑,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
Dose∅, GSTs↓,

Showing Research Papers: 201 to 250 of 575
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 575

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GSTs↓, 1,   H2O2↓, 1,   HO-1↓, 2,   HO-2↓, 1,   lipid-P↑, 1,   OXPHOS↑, 2,   ROS↓, 2,   ROS↑, 15,   SOD↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↑, 1,   Insulin↓, 3,   MMP↓, 3,   OCR↓, 1,   OCR↑, 1,   SDH↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 1,   citrate↓, 1,   cMyc↓, 1,   CPT1A↓, 1,   CREB↓, 1,   ECAR↝, 1,   ECAR∅, 1,   FASN↑, 2,   FBPase↑, 1,   glucoNG↑, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GLUT2↓, 1,   Glycolysis↓, 7,   HK2↓, 1,   KeyT↑, 1,   lactateProd↓, 3,   PDH↓, 1,   p‑PDH↑, 1,   PDK1?, 2,   PDK1↓, 1,   PDKs↓, 2,   p‑PDKs↓, 1,   PFK1↓, 1,   PFK2?, 1,   PFK2↓, 1,   PKM2↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   TCA↓, 2,   TCA↑, 1,   Warburg↓, 3,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 5,   Apoptosis∅, 1,   ATF2↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-xL↓, 2,   Casp2↑, 2,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 3,   Chk2↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 3,   MDM2↓, 1,   Myc↓, 1,   Myc↑, 1,   NOXA↑, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   p‑eIF2α↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   Beclin-1↑, 1,   LAMP2↑, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CHK1↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 4,   P53↑, 3,   cl‑PARP↑, 4,   SIRT6↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 2,   p‑RB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CDK8↓, 1,   CSCs↓, 2,   EMT↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   FOXO↑, 1,   GH↓, 1,   HDAC↓, 1,   IGF-1↓, 4,   IGF-1↑, 1,   IGF-1R↓, 3,   p‑IGF-1R↓, 1,   IGFBP1↑, 1,   IGFR↓, 1,   mTOR↓, 3,   mTORC1↓, 1,   NOTCH↓, 1,   PI3K↓, 1,   PTEN↑, 5,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   STAT5↓, 1,   TOP1↓, 1,   TumCG↓, 8,   TumCG∅, 2,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   p‑FAK↓, 1,   MMP2↓, 2,   MMP9↓, 1,   MMPs↓, 1,   PKCδ↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   Treg lymp↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 5,   TumMeta↓, 4,   Twist↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 7,   angioG↑, 1,   EGFR↓, 1,   Endoglin↑, 1,   Hif1a↓, 3,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 2,   NHE1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

CD14↓, 1,   COX1↓, 1,   COX2↓, 2,   IFN-γ↑, 1,   IL1↑, 1,   IL10↑, 1,   IL6↓, 1,   Imm↑, 3,   Inflam↓, 2,   JAK↓, 1,   JAK1↓, 1,   M2 MC↓, 1,   NF-kB↓, 5,   NK cell↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↓, 2,   T-Cell↑, 1,   T-Cell↝, 1,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 7,   ChemoSen∅, 2,   Dose?, 4,   Dose↓, 3,   Dose↑, 7,   Dose↝, 19,   Dose∅, 19,   eff↓, 2,   eff↑, 32,   eff↝, 3,   Half-Life↑, 1,   RadioS↑, 8,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

AR↓, 1,   BG↓, 4,   BMD↑, 1,   EGFR↓, 1,   Ferritin↓, 1,   GutMicro↑, 2,   IL6↓, 1,   Myc↓, 1,   Myc↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 3,   antiNeop∅, 1,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 3,   ChemoSideEff↓, 2,   neuroP↑, 1,   OS↑, 6,   QoL↑, 3,   QoL∅, 2,   Remission↑, 2,   Risk↓, 5,   toxicity↓, 3,   toxicity↝, 3,   toxicity∅, 3,   Weight↑, 2,  

Infection & Microbiome ⓘ

CD8+↑, 2,   Sepsis↓, 1,  
Total Targets: 233

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GSH↑, 2,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 2,   NRF2↑, 2,   OXPHOS↑, 1,   ROS↓, 7,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1,   AMPK↑, 2,   CRM↓, 1,   Glycolysis↓, 1,   LDL↓, 2,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   other↑, 1,   other↝, 1,   other∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   HDAC↑, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 1,   mTORC1↓, 1,  

Migration ⓘ

AP-1↓, 2,   CDK5↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 2,   Inflam↓, 4,   NF-kB↓, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   MAOA↓, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 4,   Dose?, 1,   Dose↝, 10,   Dose∅, 1,   eff↑, 4,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 3,   cardioP↑, 2,   cognitive↑, 3,   memory↑, 2,   neuroP↑, 3,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 4,  
Total Targets: 71

Scientific Paper Hit Count for: Dose, Dosage
31 Selenium NanoParticles
30 Magnetic Fields
21 Curcumin
19 Resveratrol
18 Silver-NanoParticles
17 Vitamin C (Ascorbic Acid)
16 Selenium
16 Selenite (Sodium)
15 Radiotherapy/Radiation
14 Apigenin (mainly Parsley)
14 Propolis -bee glue
14 Hydrogen Gas
12 Chemotherapy
12 Carvacrol
12 Chlorogenic acid
11 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
9 Baicalein
8 Auranofin
8 Lycopene
8 Magnetic Field Rotating
7 3-bromopyruvate
7 Capsaicin
7 chitosan
7 Citric Acid
7 Ellagic acid
7 Exercise
7 Silymarin (Milk Thistle) silibinin
7 Whole Body Vibration
6 5-Hydroxytryptophan
6 Astaxanthin
6 Melatonin
6 nicotinamide adenine dinucleotide
6 Copper and Cu NanoParticles
6 Dichloroacetate
6 Electrical Pulses
6 SonoDynamic Therapy UltraSound
6 Phenethyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Allicin (mainly Garlic)
5 Acetyl-l-carnitine
5 Metformin
5 Aspirin -acetylsalicylic acid
5 Boron
5 Spermidine
5 Hydroxycinnamic-acid
5 diet FMD Fasting Mimicking Diet
5 Bicarbonate(Sodium)
5 Phenylbutyrate
5 Rosmarinic acid
5 Vitamin D3
5 VitK3,menadione
4 cetuximab
4 Ashwagandha(Withaferin A)
4 Berberine
4 Boswellia (frankincense)
4 Butyrate
4 Caffeic acid
4 Celastrol
4 immunotherapy
4 Chocolate
4 Coenzyme Q10
4 Oxygen, Hyperbaric
4 Shilajit/Fulvic Acid
4 Propyl gallate
4 Thymoquinone
3 Astragalus
3 Artemisinin
3 Aloe anthraquinones
3 beta-glucans
3 Bromelain
3 borneol
3 Cat’s Claw
3 Calorie Restriction Mimetics
3 HydroxyCitric Acid
3 Disulfiram
3 Fisetin
3 Honokiol
3 metronomic chemo
3 Methylsulfonylmethane
3 Piperlongumine
3 Shikonin
3 Aflavin-3,3′-digallate
3 Urolithin
3 Vitamin B1/Thiamine
3 Vitamin E
3 Vitamin K2
2 Glucose
2 almonertinib
2 Bevacizumab (brand Avastin)
2 Anti-oxidants
2 Ascorbyl Palmitate
2 Paclitaxel
2 Atorvastatin
2 Betulinic acid
2 beta-carotene(VitA)
2 Bicalutamide
2 Calcium
2 Sorafenib (brand name Nexavar)
2 Celecoxib
2 Chrysin
2 doxorubicin
2 Garcinol
2 diet Plant based
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Gambogic Acid
2 Potassium
2 Luteolin
2 capecitabine
2 Iron
2 Niclosamide (Niclocide)
2 probiotics
2 Bifidobacterium
2 Silicic Acid
2 Vitamin B5,Pantothenic Acid
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Cisplatin
1 Aromatherapy
1 Baicalin
1 Biochanin A
1 bempedoic acid
1 Bufalin/Huachansu
1 Brucea javanica
1 Bacopa monnieri
1 Bortezomib
1 brusatol
1 Bruteridin(bergamot juice)
1 urea
1 Catechins
1 Cannabidiol
1 Chlorophyllin
1 Choline
1 Camptothecin
1 Crocetin
1 CUSP9
1 diet Ketogenic
1 Docetaxel
1 Zinc
1 Emodin
1 Ferulic acid
1 Fenbendazole
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Huperzine A/Huperzia serrata
1 itraconazole
1 Juglone
1 MCToil
1 nivolumab
1 magnetic nanoparticles
1 Mushroom Lion’s Mane
1 Naringin
1 Nimbolide
1 Oleuropein
1 Hyperthermia
1 Phosphatidylserine
1 Pterostilbene
1 Quercetin
1 Ramucirumab (CYRAMZA)
1 Radio Frequency
1 salinomycin
1 Sulfasalazine
1 irinotecan
1 Taurine
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin B6,pyridoxine
1 Vitamin B12
1 Transarterial Chemoembolization
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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