BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
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Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
3619- RosA,    Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion
- Review, AD, NA
*BioAv↓, *BBB↝, *monoA↑, *TGF-β↓, *Aβ↓,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
7376- RS,    RENESE-R- polythiazide and reserpine tablet
- Review, Nor, NA
*BP↓, *BioAv↑, *Half-Life↑, *BBB↑, *diuretic↑, *toxicity↝,
3937- RT,    Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*p‑tau↓, *Inflam↓, *NF-kB↓, *cognitive↑, *Aβ↓, *memory↑, *neuroP↑, *BioAv↓, *BBB↑,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2/PTGS2↓, *NF-kB↓, *iNOS↓,
3932- RT,    Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action
- Review, AD, NA
*cognitive↑, *BBB↑, *Aβ↓, *ROS↓, *Inflam↓,
4115- SAMe,    Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
- Review, AD, NA
*Mood↑, *BBB↑,
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,
6063- SeNPs,    Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer's Disease
- in-vivo, AD, NA
*eff↑, *BioAv↑, *ROS↓, *Aβ↓, *memory↓, *neuroP↑, *BBB↑, *cognitive↑,
6052- SeNPs,    Sialic acid (SA)-modified selenium nanoparticles coated with a high blood-brain barrier permeability peptide-B6 peptide for potential use in Alzheimer's disease
- Study, AD, NA
*BBB↑, *eff↑, *Aβ↓,
6061- SeNPs,  MET,    Multifunctional mesoporous nanoselenium delivery of metformin breaks the vicious cycle of neuroinflammation and ROS, promotes microglia regulation and alleviates Alzheimer's disease
- in-vivo, AD, NA
*BBB↑, *eff↑, *cognitive↑, DDS↑,
6060- SeNPs,    Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer's Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation
- Study, AD, NA
*BBB↑, *ROS↓, *Aβ↓, *p‑tau↓, *neuroP↑,
6059- SeNPs,    Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice
- in-vivo, AD, NA
*Dose↝, *Aβ↓, *BBB↑, *GutMicro↑, *NLRP3↓, *Inflam↓,
6057- SeNPs,    Dual-functional selenium nanoparticles bind to and inhibit amyloid β fiber formation in Alzheimer's disease
- in-vitro, AD, PC12
*Aβ↓, *BBB↑, *ROS↓,
6055- SeNPs,  CUR,  RES,    Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems
- Review, AD, NA
*DDS↑, *Dose↝, *p‑Akt↑, *GSK‐3β↓, *NF-kB↓, *BBB↑, *AChE↓,
6048- SeNPs,    Unravelling the in vitro and in vivo potential of selenium nanoparticles in Alzheimer's disease: A bioanalytical review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *Aβ↓, *tau↓, *neuroP↑, *cognitive↑,
6046- SeNPs,  CGA,    Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles
- Study, AD, NA
*AChE↓, *BChE↓, *Aβ↓, *eff↑, *BBB↑, *Dose↝, *IronCh↑, *antiOx↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3661- SFN,    Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression
- in-vitro, AD, NA
*cognitive↑, *HDAC1↓, *HDAC2↓, *HDAC3↓, *H3↑, *H4↑, *Aβ↓, *BioAv↑, *BBB↑, *neuroP↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3951- Taur,    Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats
- in-vivo, Nor, NA
*BP↓, *Inflam↓, *ROS↓, *cardioP↑, *GutMicro↑, *BBB↑,
3561- TQ,    Studi In Silico Potensi Piperine, Piperlongumine, dan Thymoquinone Sebagai Obat Alzheimer
- in-vivo, AD, NA
*AChE↓, *BBB↑,
3570- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *IRF3↓, *TLR4↓, *memory↑, *NF-kB↓, *MyD88↓, *TRIF↓, *BBB↑, *cognitive↑,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
6460- TUR,  CUR,    Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
- in-vivo, AD, NA
*memory↑, *lipid-P↓, *GSH↑, *AChE↑, *Catalase↑, *BioAv↑, *P-gp/ABCB1↓, *BioAv↑, *SOD↑, *BBB↑, *ROS↓,
6412- Uro,  EGCG,    A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease
- in-vivo, AD, NA
*Aβ↓, *Synergy↑, *cognitive↑, *neuroG↑, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *p‑tau↓, *FIS1↓, *ATP↑, *lipid-P↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE/β-secretase↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, *Mood↑, *neuroP↑, *Inflam↓, *TNF-α↓, *BBB↝, *other↝, *Dose↝,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,

Showing Research Papers: 201 to 238 of 238
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 238

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   antiOx⇅, 1,   Catalase↓, 2,   Catalase↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 1,   Iron↝, 1,   lipid-P↑, 6,   MDA↓, 1,   MDA↑, 4,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 3,   p66Shc↓, 1,   ROS↓, 5,   ROS↑, 31,   ROS⇅, 2,   mt-ROS↑, 3,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   mitResp↓, 1,   mtDam↑, 3,   OCR↓, 2,   OCR↑, 1,   OXPHOS↑, 1,   mt-OXPHOS↑, 1,   PINK1↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 2,   ATP↓, 1,   mt-ATP↓, 1,   ECAR↓, 1,   FASN↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   GSK‐3β↑, 3,   lactateProd↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 22,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 2,   BNIP3↑, 1,   Casp↑, 4,   cl‑Casp↑, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 17,   cl‑Casp3↑, 2,   proCasp3↓, 1,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 7,   Casp9↑, 13,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↑, 17,   DR5↑, 4,   Fas↑, 2,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   ICD↑, 1,   iNOS↓, 1,   Mcl-1↑, 1,   MDM2↓, 1,   MOMP↑, 2,   p38↑, 2,   p‑p38↓, 1,   Perforin↝, 1,   survivin↓, 3,   TumCD↑, 1,   XIAP↓, 2,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 18,   p‑Akt↓, 5,   BRAF↓, 1,   cSrc↓, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 3,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 3,   p‑ERK↓, 2,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IKKα↓, 1,   JAK1↓, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 5,   MAPK↑, 1,   MEK↓, 1,   mTOR↓, 8,   p‑mTOR↓, 1,   PI3K↓, 12,   PTEN↑, 6,   c-Raf↓, 1,   RAS↓, 3,   Sp1/3/4↓, 1,   STAT3↓, 11,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↑, 1,   cMyc↓, 3,   DNMTs↓, 2,   FOXM1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   H3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   HIST1H3B?, 1,   miR-19b↓, 1,   Myc↓, 1,   OCT4↓, 1,   other↑, 2,   other↝, 3,   SOX2↓, 1,   SOX4↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↑, 2,   CTSK↓, 1,   LC3II↑, 2,   MitoP↑, 1,   PARK2↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   DNArepair↓, 1,   hTERT/TERT↓, 2,   P53?, 1,   P53↑, 11,   P53↝, 1,   PARP↑, 2,   cl‑PARP↑, 9,   PARP1↑, 1,   PCNA↓, 2,   Telomerase↓, 3,   TOP1↓, 3,   TOP2↓, 1,   TOP2↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 5,   CDK4↓, 2,   CDK6↓, 1,   CHK1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 4,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   Ki-67↓, 2,   mitA↑, 1,   P21?, 1,   P21↑, 2,   p27/CDKN1B↑, 1,   p‑RB1↓, 1,   TubPol↓, 1,   TumCCA↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 2,   cFos↓, 1,   CSCs↓, 2,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 3,   IGF-1↓, 1,   Ki-67↓, 2,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   PTCH2↓, 1,   Shh↓, 1,   TumCG↓, 13,   TumCP↓, 14,   TumCP↑, 2,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Ca+2↝, 1,   E-cadherin↑, 3,   EMT↓, 8,   FAK↓, 1,   p‑FAK↓, 2,   fascin↓, 1,   MMP2↓, 9,   MMP7↓, 1,   MMP9↓, 11,   MMP9↑, 2,   MMPs↓, 6,   N-cadherin↓, 2,   Rac1↓, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Snail↓, 2,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 7,   TumCMig↓, 7,   TumMeta?, 1,   TumMeta↓, 10,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 4,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 6,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   HIF-1↓, 1,   Hif1a↓, 10,   Hif1a↑, 1,   NO↝, 1,   VCAM-1↓, 1,   VEGF↓, 14,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 35,   BBB↝, 1,   BBB∅, 2,   EPR↑, 5,   EPR↝, 1,   GLUT1↓, 1,   MMP↓, 15,   MPT↑, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   COX2/PTGS2↓, 7,   CXCR2↓, 1,   CXCR4↓, 1,   DR4↑, 1,   ICAM-1↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL1β↓, 7,   IL2↑, 1,   IL6↓, 4,   IL8↓, 1,   IL8↑, 1,   Imm↑, 2,   Inflam↓, 7,   M1↑, 1,   M2 MC↑, 1,   NF-kB↓, 20,   NF-kB↑, 1,   NOD1↓, 1,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 3,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   ADRB2↓, 1,   AR↓, 1,   GR↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 11,   BioAv↝, 6,   BioEnh↑, 4,   ChemoSen?, 1,   ChemoSen↑, 25,   DDS↑, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 9,   eff↓, 4,   eff↑, 21,   eff↝, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 7,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   RadioS?, 1,   RadioS↑, 10,   selectivity↑, 8,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRAF↓, 1,   CEA↓, 1,   EGFR↓, 3,   EGFR↑, 1,   p‑EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 4,   Myc↓, 1,   NOS2↑, 1,   PD-L1↓, 2,   TF-Ag↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 4,   cardioP↑, 4,   chemoP↑, 7,   chemoPv↑, 3,   cognitive?, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 7,   Pain↓, 1,   QoL↑, 2,   RenoP↑, 1,   Risk↑, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 1,   GutMicro↝, 1,  
Total Targets: 381

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 3,   antiOx↑, 81,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↓, 1,   Catalase↑, 25,   Copper↓, 1,   CoQ10↑, 1,   Fenton↓, 2,   GPx↑, 18,   GPx4↑, 3,   GSH↑, 43,   GSR↓, 1,   GSR↑, 10,   GSTs↓, 3,   GSTs↑, 5,   H2O2↓, 2,   H2O2∅, 1,   HDL↑, 1,   HO-1↑, 25,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 4,   Keap1↓, 2,   Keap1↑, 2,   lipid-P↓, 31,   mt-lipid-P↓, 1,   MDA↓, 21,   MDA↑, 3,   MPO↓, 5,   NQO1↑, 7,   NQO1↝, 1,   NRF2↑, 50,   RNS↓, 4,   ROS?, 1,   ROS↓, 116,   ROS↑, 1,   SOD↓, 1,   SOD↑, 43,   mt-SOD↑, 1,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 3,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 16,   Mets↝, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   compIV↑, 3,   compV↑, 1,   ETC↑, 3,   FIS1↓, 1,   mitResp↑, 1,   mtDam↓, 2,   OCR↑, 4,   PDH↑, 1,   PGC-1α↑, 5,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 2,   adiP↑, 2,   ALAT↓, 5,   AMPK↑, 10,   p‑AMPK↑, 1,   ATP↑, 10,   cAMP↑, 2,   DHA↑, 1,   ECAR↓, 1,   FAO↓, 1,   G6PD↑, 1,   glucose↓, 1,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 5,   Glycolysis↓, 1,   GSK‐3β↓, 16,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 3,   H2S↑, 1,   LDL↓, 5,   NADH:NAD↑, 1,   NADPH↓, 2,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PDKs↓, 1,   SIRT1↓, 1,   SIRT1↑, 8,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 14,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 13,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp6↓, 1,   Casp9↓, 4,   Casp9↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   Ferroptosis↓, 5,   iNOS↓, 20,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   p‑p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 10,   p‑Akt↑, 3,   AKT1↓, 1,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 4,   ERK↑, 3,   p‑ERK↓, 1,   p‑ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JNK↓, 3,   p‑JNK↓, 2,   MAPK↓, 9,   MAPK↑, 3,   mTOR↓, 5,   mTOR↑, 2,   p‑mTOR↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 4,   PI3K↑, 7,   PKCδ?, 1,   PKCδ↑, 3,   PTEN↓, 3,   PTP1B↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   H3↑, 1,   H4↑, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   MEF2D↑, 1,   other?, 2,   other↓, 4,   other↑, 8,   other↝, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 3,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↑, 1,   HSPs↑, 2,   IRE1↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSZ↓, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,   P53↓, 2,   SIRT6↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↝, 1,   E2Fs↑, 1,   Ki-67↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   GH↑, 1,   Ki-67↑, 1,   neuroG↑, 8,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 3,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP9↓, 9,   MMPs↓, 1,   N-cadherin↑, 1,   NFAT↓, 1,   Rho↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 2,   TGF-β1↑, 1,   TregCell↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   eNOS↑, 1,   Hif1a↑, 1,   NO↓, 15,   NO↑, 1,   VCAM-1↓, 6,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 3,   BBB↓, 10,   BBB↑, 171,   BBB↝, 14,   BBB∅, 4,   CellMemb↑, 1,   CLDN1↝, 1,   CLDN4↑, 1,   CLDN5↑, 1,   CX43/GJA1↑, 1,   EPR↑, 1,   GastroP↑, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   memfluid↑, 1,   MMP↑, 14,   MUC19↓, 1,   MUC2↓, 1,   OCLN↑, 2,   THBD↑, 1,   TJ↑, 2,   TJ↝, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 4,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 28,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 33,   IL2↓, 3,   IL23↓, 1,   IL33↓, 1,   IL4↓, 4,   IL6↓, 28,   IL6↑, 2,   IL8↓, 5,   Imm↑, 3,   INF-γ↓, 2,   INF-γ↑, 1,   Inflam↓, 96,   Inflam↑, 2,   IRF3↓, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 36,   NF-kB↑, 2,   p‑NF-kB↓, 3,   NLRP3↓, 14,   p65↓, 1,   PGE2↓, 7,   RAGE↓, 1,   RANTES↓, 2,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 45,   TRAF6↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 8,   Ach↑, 10,   AChE↓, 35,   AChE↑, 1,   ADAM10↑, 2,   ADAM10↝, 1,   BChE↓, 7,   BDNF↑, 26,   BrainVol↑, 1,   CARTPT↑, 1,   ChAT↑, 7,   GABA↓, 1,   GABA↑, 3,   MAOA↓, 5,   MAOB↓, 1,   monoA↑, 1,   NGF↑, 3,   PSD95↑, 3,   SNAP25↑, 2,   TrkB↑, 4,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APOE4↓, 1,   APP↓, 8,   cl‑APP↑, 1,   Aβ↓, 76,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   BACE/β-secretase↝, 1,   PSEN1/PS1↑, 1,   tau↓, 18,   p‑tau↓, 18,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,   PPARα↑, 1,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 30,   BioAv↑, 52,   BioAv⇅, 1,   BioAv↝, 20,   BioAv∅, 1,   BioEnh↑, 4,   ChemoSen↑, 1,   CompStab↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 33,   Dose∅, 1,   eff↓, 3,   eff↑, 35,   eff↝, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 14,   Half-Life∅, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   anemia↓, 1,   AST↓, 6,   BG↓, 1,   BloodF↑, 3,   BP↓, 8,   BP↝, 1,   BP∅, 1,   creat↓, 2,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 28,   IL6↑, 2,   LDH↓, 3,   NOS2↓, 1,   RAGE↓, 1,   RBC↑, 1,   TC↓, 1,   TMAO↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 3,   AntiCan↑, 9,   AntiDiabetic↑, 4,   AntiMyl↑, 1,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 17,   chemoP↑, 1,   cognitive↓, 1,   cognitive↑, 86,   cognitive↝, 1,   cognitive∅, 2,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 2,   hepatoP↑, 10,   Learn↑, 4,   memory↓, 1,   memory↑, 68,   memory∅, 1,   Mood↑, 6,   motorD↑, 15,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 110,   NP/CIPN↓, 1,   Obesity↓, 3,   OS↑, 2,   Pain↓, 3,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 5,   Risk↓, 3,   Sleep↑, 5,   Strength↑, 5,   Stress↓, 3,   Stroke↓, 9,   toxicity↓, 17,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 3,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 4,   Bacteria↓, 7,   GutMicro↑, 18,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 449

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
14 Selenium NanoParticles
13 Alpha-Lipoic-Acid
11 borneol
10 Curcumin
10 Hydrogen Gas
7 Honokiol
6 Luteolin
6 Methylene blue
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Urolithin
5 Chlorogenic acid
5 Carvacrol
5 EGCG (Epigallocatechin Gallate)
5 Pterostilbene
4 Silver-NanoParticles
4 Berberine
4 Mung Bean Sprouts
4 Ferulic acid
4 Lycopene
4 Quercetin
4 Resveratrol
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 Bacopa monnieri
3 Choline
3 Gamma-aminobutyric acid
3 Rosmarinic acid
3 Licochalcone A
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 almonertinib
2 Baicalein
2 beta-carotene(VitA)
2 Caffeic acid
2 Carnosic acid
2 Cinnamon
2 Fisetin
2 Isobavachalcone
2 Isoliquiritigenin
2 Ivermectin
2 Lactoferrin/Talactoferrin
2 Matrine
2 Melatonin
2 Vitamin B3,Niacin
2 S-adenosyl-L-methionine
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Turmerones
2 Vitamin B5,Pantothenic Acid
1 1,8-Cineole
1 acetaminophen
1 Anthocyanins
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 Bevacizumab (brand Avastin)
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Brucea javanica
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Chrysin
1 Propolis -bee glue
1 Coenzyme Q10
1 Crocetin
1 Galantamine
1 Cysteamine
1 Deguelin
1 Diclofenac
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Evodiamine
1 Fucoidan
1 Gambogic Acid
1 Geraniol
1 Glabrescione B
1 Gold NanoParticles
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Inositol
1 isoflavones
1 isoorientin
1 isoquercitrin
1 Magnolol
1 Isovitexin
1 Vitexin
1 mebendazole
1 MCT oil
1 Magnetic Fields
1 Mangiferin
1 Moringa oleifera
1 Methylsulfonylmethane
1 L-Theanine
1 Myricetin
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Olive Oil
1 HydroxyTyrosol
1 Oleuropein
1 Protocatechuic acid
1 Propranolol
1 Rauwolfia serpentina/Indian Snakeroot
1 Metformin
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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