hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8551- Matr,    Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
- Review, Nor, NA
*BioAv↓, *toxicity↑, *AntiTum↑, *AntiViral↑, *Inflam↓, *hepatoP↑, *Analgesic↑, *Half-Life↓, *toxicity↓,
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,
8549- Matr,    Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
- in-vitro, Var, NA
toxicity↑, *hepatoP↓, *SOD↓, *GSH↓, *MDA↑, *ROS↑, *lipid-P↑, *Iron↝, *Ferroptosis↑, *FTH1↓, *NRF2↓, *xCT/SLC7A11↓, *GPx4↓, *HO-1↓, *toxicity↝,
8548- Matr,    The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway
- in-vitro, LiverDam, NA
*insect↑, *hepatoP↓, *ALAT↑, *AST↑, *CYP51/14LDM↑, *DHCR7↑, *toxicity↝,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1/SREBF1↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3842- MO,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
3837- MO,    Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑,
8912- MO,    Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review
- Review, Oral, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *chemoPv↑, *Ingr↝, *AntiDiabetic↑, *hepatoP↑, *Bacteria↓, *AntiFungal↑, Apoptosis↑, ROS↑, DNAdam↑, Casp3↑, TumCCA↑, ROS↓, chemoP↑,
8874- MOR,    The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives
- Review, Var, NA
AntiCan↑, selectivity↑, *ROS↓, *Inflam↓, *p‑Akt↓, *NF-kB↓, ChemoSen↑, chemoPv↑, *toxicity↓, BioAv↑, BioAv↓, MRP1/ABCC1↝, BioAv↑, PCNA↓, hepatoP↑, NF-kB↓, TNF-α↓, IL6↓, PGE2↓, MMP2↓, MMP9↓, Apoptosis↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, ROS↑, MMP↓, BAX↑, Bcl-xL↓, Casp9↑, Casp3↑, EMT↓, Akt↓, Hippo↑,
8887- MOR,    Morin hydrate ameliorates Di-2-ethylhexyl phthalate (DEHP) induced hepatotoxicity in a mouse model via TNF-α and NF-κβ signaling
- in-vivo, Nor, NA
*Dose↝, *hepatoP↑, *ALAT↓, *AST↓, *Bil↓, *ROS↓, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *TNF-α↓, *NF-kB↓,
8922- MP,    A Comprehensive Review of the Therapeutic Potential of Mucuna Pruriens
- Review, Park, NA
*Inflam↓, *AntiBio↑, *neuroP?, *Ingr↝, *Ingr↝, *AntiDiabetic↑, *hepatoP↑, *Imm↑, *Dose?, *neuroP↑, *glucose↓,
8802- MT/VAE,    Pharmakokinetics of Mistletoe Lectins after Intravenous Application of a Mistletoe Product in Healthy Subjects
- Trial, Nor, NA
*Dose↝, *hepatoP↑, *Half-Life↝, *ALAT↑, *AST↑, toxicity↝, Dose↝,
8942- MushCha,    Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiCan↑, *AntiDiabetic↑, *Obesity↓, *hepatoP↑, *RenoP↑, *fatigue↓, *Bacteria↓, *AntiViral↑, *toxicity↓, Ingr↝,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
1798- NarG,    Naringenin: A potential flavonoid phytochemical for cancer therapy
- Review, Var, NA
*Inflam↓, *antiOx↓, neuroP↑, hepatoP↑, AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, ROS↝, SOD↑, TGF-β↓, Treg lymp↓, IL1β↓, *BioAv↝, ChemoSen↑, cardioP↑,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
8433- OM,    Toxicological Assessment of Origanum majorana L.: Evaluation of Its Cytotoxicity, Genotoxicity, and Acute Oral Toxicity
- in-vivo, Nor, NA
*toxicity↓, *hepatoP↑, *cardioP↑, *ALAT↓, *Astr↓, *LDH↓,
8452- OM,    Sweet Marjoram: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities
- Review, Nor, NA
*hepatoP↑, *cardioP↑, *AntiAg↑, *GastroP↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *TumMeta↓, *AntiTum↑, *AChE↓, *Ingr↝, *antiOx↑, Apoptosis↑, P53↑, Bcl-2↓, E-cadherin↑, MMP2↓, MMP9↓, TumMeta↓, *NO↓, *lipid-P↓,
7290- PacT,  Aidi,    Clinical efficacy and safety of Aidi injection plus paclitaxel-based chemotherapy for advanced non-small cell lung cancer: A meta-analysis of 31 randomized controlled trials following the PRISMA guidelines
- in-vitro, NSCLC, NA
Dose↝, QoL↑, hepatoP↑, GastroP↑, chemoP↑, Dose↝,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
5209- PI,    Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells
- in-vitro, Pca, DU145
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,
5213- PI,    Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation
- in-vitro, Cerv, HeLa
Apoptosis↑, TumCG↓, ROS↑, MMP↓, DNAdam↑, Casp3↑, TumCCA↑, *Inflam↓, *antiOx↓, *hepatoP↑, ChemoSen↑, CSCs↓,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
7431- Poly,    Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression
- vitro+vivo, BC, 4T1
other↝, AntiTum↑, Dose↝, TumCG↓, ALAT↓, AST↓, hepatoP↑, COX2/PTGS2↓, MMP2↓, MMP9↓,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, Var, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
*HK2↓, *PFKP↓, *PKM2↓, *hepatoP↑, *ALAT↓, *AST↓, *Glycolysis↓, *lactateProd↓, *GlucoseCon↓, *CXCL1↓, *Inflam↓,
5857- RES,  CAP,  Rad,    Resveratrol and capsaicin as safer radiosensitizers for colorectal cancer compared to 5-fluorouracil
- in-vivo, Var, NA
RadioS↑, hepatoP↝, toxicity↓,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,

Showing Research Papers: 201 to 250 of 321
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 3,   Catalase↑, 3,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 13,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 8,   Iron↑, 2,   lipid-P↓, 4,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 8,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 13,   ROS↑, 63,   ROS⇅, 1,   ROS↝, 3,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 4,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 2,   compII↓, 1,   ETC↓, 2,   mitResp↓, 1,   mtDam↑, 5,   OXPHOS↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 13,   AMP↑, 1,   AMPK↑, 4,   ATP↓, 10,   ATP↑, 1,   mt-ATP↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 1,   HK2↓, 7,   lactateProd↓, 5,   LDHA↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 61,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 4,   BAX↓, 1,   BAX↑, 40,   Bax:Bcl2↑, 9,   Bcl-2↓, 38,   Bcl-2↑, 2,   Bcl-xL↓, 10,   Bcl-xL↑, 1,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 10,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 40,   cl‑Casp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 15,   Casp9↓, 1,   Casp9↑, 27,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 25,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 3,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 3,   iNOS↓, 4,   Mcl-1↓, 5,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   necrosis↑, 1,   p38↓, 1,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 13,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 9,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 5,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 21,   ERK↑, 2,   p‑ERK↓, 3,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 3,   JNK↑, 4,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 12,   MAPK↑, 6,   p‑MAPK↑, 1,   MEK↓, 2,   mTOR↓, 21,   p‑mTOR↓, 1,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 33,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   RET↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 4,   STAT3↓, 27,   STAT3↑, 2,   p‑STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 2,   ChrMod↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 17,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   p‑FOXO3↓, 1,   p‑H3↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 3,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-203↑, 1,   miR-34a↓, 2,   miR-34a↑, 1,   MYCN↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↑, 2,   other↝, 4,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   tumCV?, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 1,   GRP78/BiP↝, 1,   HSP90↓, 3,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 6,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 2,   TumAuto↑, 12,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   DNAdam↑, 14,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 24,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 12,   PCNA↓, 13,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   CDK2↓, 9,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 3,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   cycD1/CCND1↓, 23,   cycE/CCNE↓, 3,   cycE/CCNE↑, 1,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 1,   P21↑, 20,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 6,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   TumCCA↑, 61,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 9,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 3,   NOTCH1↑, 3,   Shh↓, 3,   Smo↓, 1,   TumCG↓, 26,   TumCP↓, 44,   Wnt↓, 13,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↑, 9,   i-Ca+2↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 9,   EMT↓, 21,   EMT↝, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 21,   MMP2↑, 1,   MMP7↓, 2,   MMP9↓, 26,   MMP9↑, 2,   MMPs↓, 14,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 5,   p44↑, 1,   PDGF↓, 3,   Rho↓, 2,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 2,   Smad1↑, 1,   SMAD4↓, 1,   Snail↓, 2,   TET1↑, 2,   TGF-β↓, 5,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 20,   TumCMig↓, 24,   TumMeta↓, 27,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 8,   Vim↓, 4,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 20,   Hif1a↝, 1,   LOX1↓, 1,   TBXAS1/TxAS↓, 1,   VEGF↓, 29,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 27,   NHE1↓, 1,   TRPM7↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 22,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 6,   DCells↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL6↓, 17,   IL8↓, 4,   Imm↑, 6,   Imm↝, 2,   INF-γ↝, 1,   Inflam↓, 21,   Inflam↝, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 45,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 7,   PSA↓, 2,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 16,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARγ↓, 2,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 14,   BioAv↑, 17,   BioAv↝, 5,   BioEnh?, 1,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose?, 1,   Dose↝, 26,   eff↓, 2,   eff↑, 18,   eff↝, 6,   eff∅, 1,   Half-Life↓, 4,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 21,   selectivity∅, 1,   Synergy↑, 35,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   AFP↑, 1,   ALAT↓, 13,   ALB↑, 1,   ALP↓, 3,   AR↓, 5,   AST?, 1,   AST↓, 9,   BP↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BUN↓, 2,   creat↓, 3,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 10,   ERα/ESR1↓, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IBIL↓, 1,   IL6↓, 17,   Maspin↑, 1,   PC↑, 1,   PD-L1↓, 5,   PSA↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 33,   AntiDiabetic↑, 1,   AntiTum↑, 9,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 16,   CardioT↑, 1,   chemoP↑, 32,   chemoPv↑, 9,   cognitive↑, 1,   hepatoP↓, 3,   hepatoP↑, 55,   hepatoP↝, 2,   hepatoP∅, 2,   Mucositis↓, 2,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↓, 1,   OS↑, 6,   OS⇅, 1,   Pain↓, 3,   PFS↑, 1,   QoL↑, 4,   radioP↑, 8,   RenoP↑, 11,   RenoP∅, 1,   Risk↓, 4,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol?, 1,   TumVol↓, 4,   TumW↓, 1,   Weight?, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 555

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 9,   antiOx↑, 132,   ARE↑, 4,   Bil↓, 4,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 63,   DPPH↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 48,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 3,   GSH↑, 82,   GSH/GSSG↑, 1,   GSR↑, 5,   GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 4,   HDL↓, 2,   HDL↑, 5,   HDL∅, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 38,   HO-1⇅, 1,   hyperG↓, 1,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 6,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 63,   lipid-P↑, 1,   MDA↓, 65,   MDA↑, 3,   MPO↓, 11,   NADH↓, 1,   NQO1↑, 9,   NQO1↝, 2,   NRF2?, 1,   NRF2↓, 3,   NRF2↑, 69,   RNS↓, 3,   ROS?, 2,   ROS↓, 171,   ROS↑, 7,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 3,   SOD↑, 89,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 3,   Thiols↑, 2,   TOS↓, 1,   TOS↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compI↑, 1,   compII↑, 1,   compIII↓, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   ETC↓, 1,   Insulin↓, 2,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 6,   PDH↑, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   5LO↝, 1,   ACADS/SCAD↑, 1,   ACC↓, 2,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 77,   ALAT↑, 4,   AMPK↓, 1,   AMPK↑, 20,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 6,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 3,   CYP51/14LDM↑, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   glucose↓, 10,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 16,   lipidLev↓, 5,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 4,   NADPH↑, 2,   NH3↓, 1,   PDKs↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↑, 14,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 20,   ASC↓, 1,   BAX↓, 13,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 8,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 22,   cl‑Casp3↓, 3,   proCasp3↓, 1,   Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 8,   Cyt‑c↓, 5,   Fas↓, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 22,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 1,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   ERK↓, 4,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 10,   MAPK↑, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   MEK↓, 1,   mTOR↓, 4,   mTOR↑, 4,   p‑mTOR↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 5,   PI3K↑, 6,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↑, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 7,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 3,   other↑, 6,   other↝, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 9,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   DNArepair↑, 1,   P53↓, 4,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 12,   AP-1↓, 4,   BACH1↓, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 4,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 2,   EMT↓, 3,   Fibronectin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 3,   Vim↑, 1,   α-SMA↓, 10,   α-SMA↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   eNOS↑, 1,   Hif1a↓, 3,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 20,   TXA2↓, 1,   VCAM-1↓, 6,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 10,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 10,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 11,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 10,   IL1?, 1,   IL1↓, 1,   IL10↓, 6,   IL10↑, 10,   IL12↓, 1,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 39,   IL2↓, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IL8↓, 9,   Imm↓, 1,   Imm↑, 20,   Imm↝, 3,   Inflam↓, 158,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 2,   NF-kB↓, 67,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 3,   PGE2↓, 14,   RAGE↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR4↓, 16,   TNF-α↓, 70,   TNF-α↑, 3,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 4,   Ach↑, 3,   AChE↓, 24,   AChE∅, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 13,   ChAT↑, 3,   DHCR7↑, 1,   GABA↑, 2,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   SNAP25↑, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 1,   Aβ↓, 22,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   tau↓, 4,   p‑tau↓, 5,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Leptin↓, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 39,   BioAv↝, 23,   BioEnh↑, 3,   ChemoSen↑, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 47,   eff↑, 19,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 13,   P-gp/ABCB1↓, 3,   P450↓, 2,   P450↑, 2,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 77,   ALAT↑, 4,   ALB↑, 1,   ALP↓, 16,   AST↓, 75,   AST↑, 4,   BG↓, 5,   Bil↓, 4,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 6,   BP↓, 6,   BUN?, 1,   BUN↓, 4,   creat↓, 11,   CRP↓, 7,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IRes↑, 1,   IRes↝, 1,   LDH↓, 16,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 4,   TMAO↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 9,   antiAll↑, 18,   AntiArt↑, 10,   AntiCan↑, 35,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 47,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 9,   cardioP?, 1,   cardioP↑, 76,   cardioP⇅, 1,   chemoP↑, 12,   chemoPv↑, 5,   cognitive↑, 27,   cough?, 1,   diuretic↑, 5,   fatigue↓, 3,   hepatoP↓, 10,   hepatoP↑, 255,   Learn↑, 1,   memory?, 1,   memory↑, 29,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 1,   neuroP?, 3,   neuroP↓, 2,   neuroP↑, 106,   Obesity↓, 20,   OS↑, 4,   Pain↓, 4,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 9,   RenoP↓, 1,   RenoP↑, 46,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 32,   toxicity↑, 1,   toxicity↝, 15,   toxicity∅, 4,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 10,   AntiViral↑, 13,   Bacteria↓, 33,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 23,   insect↑, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↝, 12,   Phen↑, 1,   QC↑, 1,  
Total Targets: 574

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
23 Silymarin (Milk Thistle) silibinin
20 Thymoquinone
11 Silver-NanoParticles
10 Baicalein
9 Carvacrol
8 Emodin
8 Selenium NanoParticles
7 Resveratrol
7 Ferulic acid
7 Hydrogen Gas
6 Chlorogenic acid
6 Chrysin
6 Dandelion Root
6 Matrine
5 Allicin (mainly Garlic)
5 Curcumin
5 Ashwagandha(Withaferin A)
5 Kaempferol
5 Licochalcone A
5 Piperine
5 Rosmarinic acid
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Centella asiatica / Gotu kola → asiaticoside
4 Crocetin
4 EGCG (Epigallocatechin Gallate)
4 Isoliquiritigenin
4 Luteolin
4 Moringa oleifera
4 Quercetin
3 Berberine
3 Boron
3 buckwheat sprouts
3 Rutin
3 Chemotherapy
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Radiotherapy/Radiation
3 Hibiscus sabdariffa
3 Honokiol
3 Hyperoside
3 Isobavachalcone
3 Isovitexin
3 Linalool
3 Lycopene
3 Shikonin
2 Alpha-Lipoic-Acid
2 isoquercitrin
2 Apigenin (mainly Parsley)
2 Baicalin
2 doxorubicin
2 Betulinic acid
2 Selenium
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Vitamin C (Ascorbic Acid)
2 Propolis -bee glue
2 methotrexate
2 Hydroxycinnamic-acid
2 Polyphenols
2 Cucurbitacin
2 Date Fruit Extract
2 Indole-3-carbinol
2 Flaxseed/Linseed
2 Fucoidan
2 Graviola
2 Licorice
2 Cisplatin
2 Mung Bean Sprouts
2 Vitexin
2 Metformin
2 Magnetic Fields
2 Morin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Ursolic acid
1 1,8-Cineole
1 Astragalus
1 Gold NanoParticles
1 Acer okamotoanum
1 Artemisinin
1 Ascorbyl Palmitate
1 Melatonin
1 Astaxanthin
1 Biochanin A
1 Bacopa monnieri
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Chlorophyllin
1 Choline
1 Chyawanprash
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 Carvone
1 Diclofenac
1 diet Fermented Foods
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Sesame seeds and Oil
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 L-ornithine
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Naringin
1 Neem
1 Paclitaxel/Taxol
1 Aidi injection
1 Propyl gallate
1 Piperlongumine
1 Pterostilbene
1 Capsaicin
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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