cardioP Cancer Research Results

cardioP, cardioProtective: Click to Expand ⟱
Source:
Type:
CardioProtective


Scientific Papers found: Click to Expand⟱
7791- ISQ,    Isoquercitrin: pharmacology, toxicology, and metabolism
- Review, Nor, NA
*BioAv↑, *chemoP↑, *ROS↓, *cardioP↑, *AntiDiabetic↑, *Dose↝, *antiAll↑,
8035- IVM,    Ivermectin and non-parasitic disorders: An update
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*AntiP↑, angioG↓, *AntiCan↓, mtDam↑, Apoptosis↑, necrosis↑, TumAuto↑, ROS↑, *neuroP↑, *Stroke↝, *cardioP↑,
7904- IVT,    Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress
- in-vivo, Nor, NA
*cardioP↑, *IL1β↓, *IL6↓, *TNF-α↓, *NQO1↑, *NRF2↑, *SIRT3↑, *NOX2↓, *ROS↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8104- KAE,    A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation
- Review, Nor, NA
*ROS↓, *Inflam↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *NF-kB↓, *hepatoP↑, *RenoP↑, *cardioP↑, *neuroP↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8058- KAE,    A randomized, placebo‐controlled trial evaluating the safety of excessive administration of kaempferol aglycone
- Trial, Nor, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *Dose↝, *toxicity↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8311- lign,    The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects
- Review, Nor, NA
*cardioP↑, *AntiDiabetic↑, *Obesity↓, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *neuroP↑, *antiOx↑, *lipid-P↓, *memory↑, *CREB↑, *BDNF↑, *PSD95↑, *β-Amyloid↓, *TNF-α↓, *IL6↓, *IL10↓, *GutMicro↑, *Endoglin↑, *END↑, *cognitive↑, *Akt↓, *IκB↓, *NF-kB↓, *HO-1↑, *VEGF↑, *p‑eNOS↑, *GRP78/BiP↓, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *SREBP1/SREBF1↓, *ROS↓, TumVol↓,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
2926- LT,    Luteolin ameliorates rat myocardial ischemia-reperfusion injury through peroxiredoxin II activation: LUT's cardioprotection through PRX II
- in-vitro, Nor, H9c2
*cardioP↑, *PrxII↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3263- Lyco,    Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
- in-vitro, Nor, H9c2 - in-vitro, Stroke, NA
*Apoptosis↓, *MMP↑, *Cyt‑c↓, *APAF1↓, *cl‑Casp9↓, *cl‑Casp3↓, *Bcl-2↑, *BAX↓, cardioP↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
3281- Lyco,  Chemo,    Lycopene Supplementation for Patients Under Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, Var, NA
eff↑, cardioP↑, eff?, PSA↓, RenoP↑,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2/PTGS2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4796- Lyco,    The Anti-proliferation Effects of Lycopene on Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,
8925- MBS,    A review on metabolites and pharmaceutical potential of food legume crop mung bean (Vigna radiata L. Wilczek)
- Review, Var, NA
*Inflam↓, *Bacteria↓, *AntiBio↑, *antiOx↑, *AntiTum↑, *Ingr↝, *Ingr↝, *GutMicro↑, *cardioP↑, *Ingr↝, *eff↑,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
4112- MF,    Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats
- in-vivo, Stroke, NA
*cardioP↑, *Bcl-2↑, *BAX↓, *ROS↓,
3467- MF,    Pulsed Magnetic Field Induces Angiogenesis and Improves Cardiac Function of Surgically Induced Infarcted Myocardium in Sprague-Dawley Rats
- in-vivo, Nor, NA
*angioG↑, *cardioP↑,
3482- MF,    Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in Mice
- in-vitro, Nor, NA
*cardioP↑, *VEGF↑, *VEGFR2/KDR/Flk1↑, *Hif1a↑, *FGF↑, *ITGB1↑, *angioG↑,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8677- MLT,    Evaluating the Cardioprotective Effects of Melatonin in Non-metastatic Breast Cancer Patients Receiving Doxorubicin Plus Cyclophosphamide: A Triple-Blind, Placebo-Controlled Randomized Controlled Trial
- Trial, BC, NA
cardioP↑, *other↑,
4705- MLT,    Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential
- Review, Nor, NA
*CLOCK↝, *BMD↑, *cardioP↑, *neuroP↑, *Sleep↑,
3837- MO,    Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑,
8619- MO,  doxoR,    Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells
- vitro+vivo, BC, MCF7
*Dose↝, *cardioP↑, *ROS↓, *lipid-P↓, *antiOx↑, *Inflam↓, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MPO↓, ChemoSen↑, *Dose↝, *AST↓, *CK/CK-MB↓, *SOD↑, Synergy↑, MDA↑, NO↑, GSH↓, ROS↑,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
1798- NarG,    Naringenin: A potential flavonoid phytochemical for cancer therapy
- Review, Var, NA
*Inflam↓, *antiOx↓, neuroP↑, hepatoP↑, AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, ROS↝, SOD↑, TGF-β↓, Treg lymp↓, IL1β↓, *BioAv↝, ChemoSen↑, cardioP↑,
8433- OM,    Toxicological Assessment of Origanum majorana L.: Evaluation of Its Cytotoxicity, Genotoxicity, and Acute Oral Toxicity
- in-vivo, Nor, NA
*toxicity↓, *hepatoP↑, *cardioP↑, *ALAT↓, *Astr↓, *LDH↓,
8452- OM,    Sweet Marjoram: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities
- Review, Nor, NA
*hepatoP↑, *cardioP↑, *AntiAg↑, *GastroP↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *TumMeta↓, *AntiTum↑, *AChE↓, *Ingr↝, *antiOx↑, Apoptosis↑, P53↑, Bcl-2↓, E-cadherin↑, MMP2↓, MMP9↓, TumMeta↓, *NO↓, *lipid-P↓,
2042- PB,    Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury
- in-vitro, Nor, NA
*HDAC↓, *toxicity↓, *LDH↓, *SOD2↑, *ROS↓, *cardioP↑, *antiOx↑,

Showing Research Papers: 201 to 250 of 321
Prev Page 5 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 5,   Catalase↑, 3,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 7,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 3,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 5,   NRF2↑, 6,   Prx↓, 1,   ROS↓, 19,   ROS↑, 63,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 4,   SOD↑, 5,   SOD1↑, 2,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 2,   compI↓, 1,   compIII↓, 1,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↑, 1,   OXPHOS↓, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY↓, 1,   ALAT↓, 4,   AMPK↑, 6,   AMPK↝, 1,   ATP↓, 5,   ATP↑, 1,   CRM↑, 2,   CRM↝, 1,   ECAR↓, 1,   FASN↓, 1,   FASN↑, 1,   glucose↓, 1,   GlucoseCon↓, 5,   GlutMet↓, 2,   Glycolysis↓, 8,   Glycolysis↝, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 2,   LDL↓, 2,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   PFK↓, 2,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 73,   Apoptosis∅, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 30,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 36,   Bcl-2↑, 2,   Bcl-xL↓, 5,   BID↑, 2,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 1,   BNIP3↑, 3,   Casp↑, 10,   Casp1↑, 1,   Casp12↑, 2,   Casp3↑, 41,   cl‑Casp3↑, 5,   cl‑Casp3⇅, 1,   Casp7↑, 6,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 16,   Casp9↓, 1,   Casp9↑, 26,   cl‑Casp9↑, 4,   proCasp9↓, 1,   cFLIP↓, 3,   Cyt‑c↑, 26,   Diablo↑, 1,   DR5↓, 1,   DR5↑, 6,   Endon↑, 1,   Fas↑, 6,   FasL↑, 1,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 3,   Mcl-1↓, 1,   p‑Mcl-1↓, 1,   MDM2↓, 3,   MDM2↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   p38↓, 3,   p38↑, 8,   Paraptosis↑, 1,   PUMA↑, 2,   survivin↓, 10,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 2,   XIAP↓, 6,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 51,   Akt↑, 2,   p‑Akt↓, 9,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 14,   ERK↑, 2,   p‑ERK↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 1,   IGF-1R↑, 1,   IGF-2R↑, 1,   IKKα↓, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   LIMK1↓, 1,   MAPK↓, 10,   MAPK↑, 5,   MAPK↝, 1,   MEK↓, 2,   mTOR↓, 25,   mTOR↝, 2,   mTORC2↓, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 39,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 3,   PTEN↑, 8,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 4,   cJun↓, 1,   cMyc↓, 13,   cMyc↑, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 2,   HDAC2↓, 3,   miR-106b↓, 2,   miR-124-3p↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   Myc↓, 1,   OCT4↓, 4,   other↑, 1,   other↝, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 2,   tumCV?, 1,   tumCV↓, 15,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 2,   ER Stress↑, 11,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   GRP78/BiP↝, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 3,   HTRA↓, 1,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 6,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 3,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   DNAdam↑, 15,   hTERT/TERT↓, 4,   P53↑, 27,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   PCNA↓, 14,   POLD1↓, 1,   Telomerase↓, 4,   TOP1↓, 3,   TOP2↓, 4,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 14,   CDK4↓, 14,   p‑CDK4↓, 1,   CDK6↓, 2,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 26,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   E2Fs↓, 1,   Ki-67↓, 13,   Ki-67↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA↑, 67,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 3,   CD133↓, 1,   CD24↓, 2,   cFos↓, 2,   CSCs?, 1,   CSCs↓, 7,   Diff↑, 1,   FGF↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 5,   IGFBP3↑, 1,   Ki-67↓, 13,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 2,   NOTCH↓, 7,   NOTCH1↓, 1,   NOTCH1↑, 3,   NOTCH3↓, 2,   Shh↓, 4,   Smo↓, 1,   TumCG↓, 32,   TumCG↑, 1,   TumCG⇅, 1,   TumCG∅, 2,   TumCP↓, 39,   Wnt↓, 6,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   AP-1↑, 1,   ASAP2↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2↑, 2,   p‑Cofilin↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 12,   EMT↓, 23,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 3,   Fibronectin↓, 2,   KRAS↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MMP-10↓, 1,   MMP13↓, 1,   MMP2↓, 32,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 31,   MMPs↓, 13,   MTA1↓, 1,   N-cadherin↓, 7,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 5,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 4,   TGF-β↓, 5,   TIMP1↑, 6,   TIMP2↓, 2,   TIMP2↑, 5,   TRIB3↑, 1,   TumCI↓, 25,   TumCI↑, 1,   TumCMig↓, 23,   TumMeta↓, 28,   TumMeta↑, 2,   Twist↓, 9,   uPA↓, 4,   Vim?, 1,   Vim↓, 6,   Zeb1↓, 2,   Zeb1↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 23,   NO↑, 1,   PGI2↓, 1,   VEGF↓, 32,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 36,   MMP↑, 3,   MPT↑, 1,   NHE1↓, 1,   TRPM7↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCR4↓, 2,   DR4↑, 2,   FOXP3↑, 2,   HMGB1↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 1,   IL6↓, 14,   IL8↓, 5,   Imm↑, 6,   Imm↝, 1,   Inflam↓, 15,   LRIG1↑, 1,   M2 MC↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 40,   NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 1,   NOD1↓, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 10,   PSA↓, 4,   SOCS-3↓, 1,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 11,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 22,   BioAv↝, 5,   CBR1↓, 1,   ChemoSen↑, 66,   ChemoSen⇅, 1,   ChemoSen∅, 2,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 21,   eff?, 1,   eff↓, 4,   eff↑, 16,   eff↝, 6,   eff∅, 2,   Half-Life↓, 3,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 17,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 21,   Synergy↑, 41,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AR↓, 2,   AST↓, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 14,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 1,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 5,   PSA↓, 4,   TP53↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 3,   AntiCan↑, 36,   AntiDiabetic↑, 2,   antiNeop↑, 2,   antiNeop∅, 1,   AntiTum↑, 10,   cardioP↑, 49,   chemoP↑, 28,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 4,   hepatoP↑, 15,   memory↑, 1,   neuroP↑, 12,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↓, 1,   OS↑, 10,   OS∅, 1,   Pain↓, 1,   PFS↑, 1,   PFS∅, 1,   QoL↑, 3,   radioP↑, 8,   RenoP↑, 6,   Risk↓, 17,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 9,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 2,  
Total Targets: 592

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 8,   antiOx↑, 142,   ARE↑, 2,   Catalase↑, 62,   GPx↑, 43,   GPx1↑, 1,   GPx4↑, 4,   GSH↓, 1,   GSH↑, 61,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 7,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 17,   H2O2↓, 7,   HDL↑, 9,   HDL∅, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 45,   HO-1⇅, 1,   Iron↑, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 2,   lipid-P↓, 62,   MDA↓, 47,   MPO↓, 14,   NADH↓, 1,   NOX↓, 1,   NOX2↓, 1,   NOX4↓, 5,   NQO1↑, 12,   NQO1↝, 1,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 4,   NRF2↑, 79,   PrxII↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 188,   ROS↑, 3,   mt-ROS↓, 1,   SOD↑, 81,   mt-SOD↑, 1,   SOD1↑, 1,   SOD2↑, 6,   TAC↑, 10,   TBARS↓, 4,   Thiols↑, 2,   Trx1↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   Insulin↓, 3,   Insulin↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 5,   mtDam↑, 1,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACLY↓, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 26,   AMPK↑, 12,   p‑AMPK↑, 2,   ATP↑, 8,   cAMP↑, 1,   CRM↑, 4,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 10,   glucose↑, 2,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 9,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HMG-CoA↓, 2,   LDL↓, 28,   lipidLev↓, 4,   NAD↑, 2,   NADPH↓, 6,   NADPH↑, 4,   PFK↓, 1,   PLA2↓, 2,   SIRT1↓, 1,   SIRT1↑, 16,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 17,   ASC↓, 1,   BAX↓, 16,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 12,   Casp↓, 2,   Casp1↓, 1,   Casp12↓, 2,   Casp3↓, 20,   cl‑Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 7,   cl‑Casp9↓, 1,   Cyt‑c↓, 6,   Fas↓, 2,   Ferroptosis↓, 6,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 21,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 15,   Akt↝, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↑, 2,   ERK↓, 7,   ERK↑, 4,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↑, 2,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 3,   MAPK↓, 10,   MAPK↑, 2,   MAPK↝, 1,   Mst1↓, 1,   mTOR↓, 4,   mTOR↑, 4,   p‑mTOR↓, 3,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 10,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,   PTEN↓, 2,   PTEN↑, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 4,   STAT3↝, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 7,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 2,   HDAC↓, 2,   HDAC↑, 1,   HDAC2↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 13,   other↝, 8,   other∅, 1,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   p‑eIF2α↓, 2,   ER Stress↓, 11,   GRP78/BiP↓, 5,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   DNArepair↑, 1,   p16↓, 1,   P53↓, 2,   PARP↓, 1,   PCNA↓, 2,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   CLOCK↝, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 25,   AP-1↓, 5,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 2,   p‑Ca+2↓, 1,   mt-Ca+2↓, 1,   Cartilage↑, 3,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   ITGB1↑, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 3,   MMPs↓, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   PROK2↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 5,   TGF-β↑, 2,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumMeta↓, 1,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 5,   Endoglin↑, 1,   eNOS↑, 4,   p‑eNOS↑, 2,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 15,   NO↑, 1,   TXA2↓, 3,   VCAM-1↓, 5,   VEGF↓, 3,   VEGF↑, 3,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   BBB↝, 1,   GastroP↑, 10,   GLUT1↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 10,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPV1↑, 2,   TRPV3↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 7,   COX2/PTGS2↓, 54,   CXCc↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 7,   IL10↑, 8,   IL12↓, 3,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 38,   IL2↓, 4,   IL22↓, 1,   IL33↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 2,   IL6?, 1,   IL6↓, 56,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 15,   Imm⇅, 1,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 180,   Inflam↑, 2,   IRF3↓, 2,   LPS↓, 2,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 1,   NF-kB↓, 68,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 13,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 16,   RAGE↓, 2,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 5,   TLR4↓, 13,   TLR4↑, 1,   TNF-α↓, 73,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   Ach↑, 1,   AChE↓, 29,   AChE↑, 1,   BChE↓, 8,   BDNF↑, 14,   ChAT↑, 2,   ChE↓, 1,   GABA↑, 5,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 33,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   tau↓, 9,   p‑tau↓, 3,   XO↓, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   END↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 6,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 46,   BioAv↑, 65,   BioAv⇅, 3,   BioAv↝, 37,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↑, 3,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↑, 5,   Dose⇅, 1,   Dose↝, 42,   eff↓, 5,   eff↑, 25,   eff↝, 2,   Half-Life↓, 8,   Half-Life↑, 6,   Half-Life↝, 14,   P-gp/ABCB1↓, 1,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 26,   ALP↓, 6,   AST↓, 30,   BG↓, 2,   BloodF↑, 1,   BMD↑, 4,   BP↓, 25,   BUN?, 1,   BUN↓, 3,   CK/CK-MB↓, 1,   creat↓, 9,   CRP↓, 8,   Ferritin↑, 1,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 56,   IL6↑, 1,   IRes↝, 1,   LDH↓, 19,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 4,   TMAO↓, 1,   TMAO↑, 1,   Urea↓, 2,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 13,   antiAll↑, 18,   AntiArt↑, 12,   AntiCan↓, 1,   AntiCan↑, 32,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 49,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 9,   BOLD↑, 1,   cardioP?, 3,   cardioP↓, 4,   cardioP↑, 268,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 12,   chemoPv↑, 7,   cognitive↓, 1,   cognitive↑, 48,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 78,   Learn↑, 1,   memory↑, 43,   memory∅, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 2,   MusCon↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 149,   Obesity↓, 25,   OS↑, 8,   Pain↓, 9,   QoL↑, 2,   radioP↑, 5,   RenoP↓, 2,   RenoP↑, 29,   Risk↓, 8,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 14,   Stroke↝, 1,   toxicity↓, 27,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 3,   Weight↓, 5,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 9,   AntiP↑, 1,   AntiViral↑, 13,   Bacteria↓, 31,   Diar↓, 4,   GutMicro↑, 32,   Sepsis↓, 6,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↑, 2,   Ingr↝, 13,   Phen↑, 1,   QC↑, 1,  
Total Targets: 559

Scientific Paper Hit Count for: cardioP, cardioProtective
17 doxorubicin
12 Lycopene
11 Quercetin
11 Thymoquinone
10 Resveratrol
9 Allicin (mainly Garlic)
8 Chlorogenic acid
8 EGCG (Epigallocatechin Gallate)
7 Carvacrol
7 Chrysin
6 Baicalein
6 Berberine
6 Cinnamon
6 Hydrogen Gas
6 Honokiol
6 Kaempferol
5 Alpha-Lipoic-Acid
5 Chocolate
5 Coenzyme Q10
5 Curcumin
5 Flaxseed/Linseed
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Aspirin
4 Atorvastatin
4 Centella asiatica / Gotu kola → asiaticoside
4 diet Fermented Foods
4 flavonoids
4 Hyperoside
4 Luteolin
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Thymol-Thymus vulgaris
3 Choline
3 Hydroxycinnamic-acid
3 Chemotherapy
3 Spermidine
3 Crocetin
3 Diclofenac
3 Emodin
3 Ferulic acid
3 Fisetin
3 SDG/lignans
3 Grapeseed extract
3 Metformin
3 Magnetic Fields
3 Melatonin
3 Rosmarinic acid
3 Urolithin
3 Vitamin K2
2 Baicalin
2 Beta-Caryophyllene
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Capsaicin
2 Selenium
2 Ellagic acid
2 Eugenol
2 Ginkgo biloba
2 Ginkgetin
2 iodine
2 Isoliquiritigenin
2 isoquercitrin
2 Isovitexin
2 Magnolol
2 Matrine
2 Marjoram (Origanum majorana)
2 Piperine
2 Pterostilbene
2 Rutin
2 Shikonin
2 Vitexin
1 1,8-Cineole
1 Anthocyanins
1 Astragalus
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Aloe anthraquinones
1 Berbamine
1 Biochanin A
1 bempedoic acid
1 Betulinic acid
1 Boron
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Date Fruit Extract
1 Dihydrocaffeic Acid
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 Dipyridamole
1 Dandelion Root
1 Evodiamine
1 Gallic acid
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 HydroxyTyrosol
1 phytic acid, Inositol hexakisphosphate
1 isoflavones
1 isoorientin
1 Ivermectin
1 Licorice
1 Linalool
1 Mung Bean Sprouts
1 Moringa oleifera
1 Lemon Balm/Melissa officinalis
1 Morin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phenylbutyrate
1 Propolis -bee glue
1 Piperlongumine
1 Psoralidin
1 Selenium NanoParticles
1 Shankhpushpi
1 Taurine
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin E
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1188  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page