AChE Cancer Research Results

AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA
-Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage
-AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss
-adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended

- Natural AChE inhibitors paper
Scientific Papers found: Click to Expand⟱
3316- SIL,  Chemo,    Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis
- in-vivo, Nor, NA
Inflam↓, antiOx↓, neuroP↑, cognitive↑, NRF2↑, HO-1↑, memory↑, AChE↓, Casp3↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3555- TQ,    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
- in-vivo, AD, NA
*memory↑, *BAX↓, *Aβ↓, *p‑tau↓, *AChE↓, *p‑Akt↓, *Ach↑, *Inflam↓,
3557- TQ,    Thymoquinone protects against lipopolysaccharides-induced neurodegeneration and Alzheimer-like model in mice.
- in-vivo, AD, NA
*Inflam↓, *antiOx↑, *cognitive↑, *TNF-α↓, *IL1β↓, *AChE↓, *IL10↑, *ChAT↑, *Aβ↓,
3560- TQ,    Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *TAC↑, *AChE↓, *MDA↓, *NO↓, *TNF-α↓, *Bcl-2↑, *Ach↑, *neuroP↑,
3561- TQ,    Studi In Silico Potensi Piperine, Piperlongumine, dan Thymoquinone Sebagai Obat Alzheimer
- in-vivo, AD, NA
*AChE↓, *BBB↑,
3562- TQ,    ACETYLCHOLINESTERASE AND GROWTH INHIBITORY EFFECTS–VARIOUS GRADES OF N. SATIVA OILS
- Review, AD, NA - Review, Var, NA
*AChE↓, *other↓,
3565- TQ,    Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model
- in-vivo, AD, NA
*cognitive↑, *ROS↓, *SOD↑, *AChE↝, *Aβ↓,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
6460- TUR,  CUR,    Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
- in-vivo, AD, NA
*memory↑, *lipid-P↓, *GSH↑, *AChE↑, *Catalase↑, *BioAv↑, *P-gp/ABCB1↓, *BioAv↑, *SOD↑, *BBB↑, *ROS↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
8439- UA,  OM,    Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase
- Study, AD, NA
*AChE↓, *Ingr↝, *Dose↝, *eff↑,
7834- VA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *memory↑, *Learn↑, *Aβ↓, *BACE/β-secretase↓, *NeuroI↓, *RAGE↓, *antiOx↑, *NRF2↑, *HO-1↑, *GSK‐3β↓, *ROS↓, *AChE↓, *Dose↝,
7915- VT,    A Brief Review on the Neuroprotective Mechanisms of Vitexin
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *cognitive↓, *motorD↑, *BACE/β-secretase↓, *LDH↓, *AChE↓, *BChE↓, *ROS↓,
7913- VT,    Review of the effects of vitexin in oxidative stress-related diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *lipid-P↓, *memory↑, *Stroke↓, *cardioP↑, *neuroP↑, *Inflam↓, *NRF2↑, *HO-1↑, *NQO1↑, *GRP78/BiP↑, *CHOP/DDIT3↓, *BACE/β-secretase↓, *ChE↓, *AChE↓, *BChE↓, *GSH↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL33↓, *LDH↓, *MDA↓, *SOD↑,
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,
4084- Z,    Role of micronutrients in Alzheimer's disease: Review of available evidence
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *memory↑,

Showing Research Papers: 201 to 221 of 221
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 221

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   Catalase↑, 1,   GSH↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 3,   HO-1↝, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 3,   ROS↑, 7,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 1,   SOD↑, 2,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   mitResp↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 1,   ATP↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 13,   Bak↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-2↑, 1,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 3,   Casp↝, 1,   Casp1↑, 1,   Casp3↓, 2,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp8↑, 4,   Casp9↑, 8,   cl‑Casp9↑, 1,   proCasp9↓, 1,   Cyt‑c↑, 5,   DR5↑, 1,   Fas↑, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p‑p38↑, 1,   TumCD↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 10,   Akt↑, 1,   p‑Akt↓, 2,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 4,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 1,   JAK↓, 1,   MAPK↑, 2,   mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PKCδ↓, 2,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cMyc↓, 3,   FOXO1↑, 1,   HATs↓, 1,   miR-34a↑, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 9,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 2,   PCNA↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 2,   CDK6↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 4,   Ki-67↓, 1,   mitA↑, 1,   P21↑, 3,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs?, 1,   CSCs↓, 1,   FGF↓, 1,   Ki-67↓, 1,   NOTCH↓, 1,   TumCG↓, 7,   TumCG↑, 1,   TumCP↓, 11,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   EMT↓, 3,   EMT↝, 1,   FAK↓, 2,   LAMs↓, 1,   MMP2↓, 7,   MMP7↓, 1,   MMP9↓, 7,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 2,   Snail↓, 1,   TIMP2↑, 2,   TumCI↓, 4,   TumCMig↓, 7,   TumMeta↓, 6,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 6,   VEGF↓, 8,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL12↓, 1,   IL2↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   NLRP3↓, 1,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↓, 1,   AChE↓, 4,   AChE↑, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 10,   CYP1A1↓, 1,   DDS↑, 1,   Dose↝, 3,   eff↑, 3,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 4,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   NOS2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 222

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 99,   ARE↑, 3,   Catalase↓, 1,   Catalase↑, 40,   GPx↑, 30,   GPx4↑, 3,   GSH↑, 48,   GSR↓, 1,   GSR↑, 5,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 8,   H2O2↓, 5,   HDL↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 32,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 2,   Iron↝, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 47,   lipid-P↑, 1,   MDA↓, 41,   MDA↑, 2,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 44,   ONOO↓, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 118,   ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↓, 3,   SOD↑, 60,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 6,   Thiols↑, 2,   TOS↓, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 10,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 6,   ACC↑, 1,   ALAT↓, 4,   ALAT∅, 1,   AMPK↑, 7,   ATP↑, 8,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 4,   GSK‐3β↓, 18,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   LDL↓, 9,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   SIRT1↑, 5,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 14,   BAD↓, 1,   BAX↓, 9,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 8,   Casp↓, 2,   Casp3↓, 16,   Casp9↓, 3,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 15,   p‑Akt↓, 3,   p‑Akt↑, 3,   AMPKα↑, 1,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 3,   p‑ERK↓, 1,   HER2/EBBR2↓, 1,   IKKα↓, 1,   JNK↓, 4,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 6,   p‑mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 11,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PTP1B↓, 2,   STAT3↓, 1,   STEP↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HATs↓, 1,   HDAC↓, 1,   HDAC↑, 1,   other?, 1,   other↓, 18,   other↑, 4,   other↝, 7,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 3,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↑, 1,   Choline↑, 1,   HH↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 5,   AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   CD31/PECAM-1↑, 1,   Hif1a↓, 1,   NO↓, 19,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 33,   BBB↝, 2,   GastroP↑, 6,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 14,   MMP↝, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 2,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 6,   IL12↓, 2,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 30,   IL1β↑, 1,   IL2↓, 1,   IL23↓, 3,   IL33↓, 1,   IL4↓, 1,   IL4↑, 3,   IL6↓, 21,   IL6↑, 2,   IL8↓, 3,   Imm↑, 6,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 97,   Inflam↑, 2,   IRF3↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MyD88↓, 2,   NeuroI↓, 6,   NF-kB↓, 36,   NF-kB↑, 1,   NLRP3↓, 6,   PGE2↓, 5,   RAGE↓, 1,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 43,   TRAF6↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 7,   Ach?, 1,   Ach↑, 22,   AChE↓, 210,   AChE↑, 3,   AChE↝, 2,   AChE∅, 5,   ADAM10↑, 2,   BChE?, 1,   BChE↓, 36,   BChE∅, 1,   BDNF↓, 1,   BDNF↑, 34,   proBDNF↑, 1,   ChAT↑, 12,   ChE↓, 1,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 11,   MAOA↝, 1,   MAOB↓, 8,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN3↓, 1,   TrkB↓, 1,   TrkB↑, 7,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 4,   APP↓, 10,   Aβ↓, 69,   Aβ↑, 1,   Aβ42↓, 6,   BACE/β-secretase↓, 29,   BACE/β-secretase↝, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↓, 1,   QPCT/QC↓, 1,   tau↓, 15,   p‑tau↓, 22,   XO↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   ERβ/ESR2↑, 1,   GR↑, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 31,   BioAv⇅, 1,   BioAv↝, 11,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   DDS↑, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 28,   eff↑, 22,   eff↝, 1,   eff∅, 1,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALAT∅, 1,   ALP↓, 3,   AST↓, 5,   AST∅, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 6,   creat↓, 2,   CRP↓, 4,   Ferritin↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 21,   IL6↑, 2,   IRes↓, 1,   IRes↝, 1,   LDH↓, 6,   NOS2↓, 3,   RAGE↓, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 8,   antiCG↑, 1,   antiD↑, 1,   AntiDiabetic↑, 15,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 2,   ANXi↓, 1,   cardioP↑, 30,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 92,   cognitive∅, 2,   hepatoP↓, 1,   hepatoP↑, 23,   Learn↑, 10,   memory↑, 91,   Mood?, 1,   Mood↑, 8,   motorD↑, 12,   Mucositis↓, 1,   neuroP↑, 125,   NP/CIPN↓, 2,   Obesity↓, 10,   OS↑, 3,   Pain↓, 6,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 1,   Sleep↑, 5,   Strength↑, 2,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 19,   toxicity↑, 1,   toxicity∅, 2,   Weight↓, 1,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 7,   AntiViral↑, 6,   Bacteria↓, 13,   Diar↓, 3,   GutMicro↑, 12,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 10,  
Total Targets: 450

Scientific Paper Hit Count for: AChE, acetylcholinesterase
18 Curcumin
12 Chlorogenic acid
11 Huperzine A/Huperzia serrata
11 Rosmarinic acid
10 Crocetin
9 Ferulic acid
8 Thymoquinone
7 Berberine
7 Mung Bean Sprouts
7 Vitexin
7 Moringa oleifera
6 Quercetin
6 Caffeic acid
6 Salvia officinalis
6 Marjoram (Origanum majorana)
5 Aromatherapy
5 Luteolin
5 Carvacrol
5 Centella asiatica / Gotu kola → asiaticoside
5 Isovitexin
5 Shankhpushpi
4 EGCG (Epigallocatechin Gallate)
4 α-Bisabolol / Chamomile oil
4 Selenium NanoParticles
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Boswellia (frankincense)
3 Galantamine
3 Resveratrol
3 Magnolol
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Naringin
2 Alpha-Lipoic-Acid
2 Angelica archangelica / Garden Angelica
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Boron
2 Rutin
2 D-limonene
2 flavonoids
2 Garcinol
2 Ginkgo biloba
2 Lemon Balm/Melissa officinalis
2 Geraniol
2 Honokiol
2 Hyperoside
2 Kaempferol
2 Licochalcone A
2 Lycopene
2 Matrine
2 Turmerones
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chrysin
1 Chyawanprash
1 Cinnamon
1 Citicoline, CDP-Choline
1 Radiotherapy/Radiation
1 Vitamin E
1 Ginger/6-Shogaol/Gingerol
1 Capsaicin
1 Rivastigmine
1 Diindolylmethane
1 Indole-3-carbinol
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Protocatechuic acid
1 Emodin
1 Formononetin
1 Gallic acid
1 Gamma-aminobutyric acid
1 isoorientin
1 isoquercitrin
1 Lactoferrin/Talactoferrin
1 MCT oil
1 Magnetic Field Rotating
1 Magnetic Fields
1 Melatonin
1 Morin
1 Zeolite
1 Methylsulfonylmethane
1 Myricetin
1 Nimbolide
1 Oregano
1 Propolis -bee glue
1 Purple Corn / Purple Maize
1 Carnosic acid
1 Caffeine
1 Selenium
1 Sesame seeds and Oil
1 Chemotherapy
1 Safflower yellow
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vanillic Acid
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1329  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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