BDNF Cancer Research Results

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱
Source:
Type:
Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.
Scientific Papers found: Click to Expand⟱
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
4214- Se,    Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway
- in-vivo, AD, NA
*memory↑, *other↑, *BDNF↑, *TrkB↑,
4189- Sesame,    Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
- in-vivo, AD, NA
*TNF-α↓, *IL1β↓, *ROS↓, *BDNF↑, *neuroP↑, *cognitive↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4200- SFN,    Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription
- in-vitro, AD, NA
*NRF2↑, *BDNF↑, *Inflam↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
4201- SFN,    Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
- in-vivo, AD, NA
*NRF2↑, *BDNF↑, *HDAC2↓, *Mood↑,
4202- SFN,    Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity
- Review, Park, NA
*NRF2↑, *BDNF↑,
4198- SFN,    Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways
- vitro+vivo, AD, NA
*TrkB↑, *CREB↑, CaMKII ↑, *ERK↑, *ac‑H3↑, *ac‑H4↑, *HDAC↓, *HDAC2↓, *BDNF↑,
4203- SIL,    Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders
- Review, AD, NA
*MAPK↝, *AMPK↝, *NF-kB↓, *mTOR↝, *PI3K↝, *Akt↝, *BioAv↝, *memory↑, *BDNF↑, *TNF-α↓,
4204- SIL,    Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels
- in-vivo, Stroke, NA
*OS↑, *BDNF↑, *IGF-1↑,
4205- SIL,    The Therapeutic Effect of Silymarin and Silibinin on Depression and Anxiety Disorders and Possible Mechanism in the Brain: A Systematic Review
- Review, AD, NA
*BDNF↑, *5HT↑, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *IL6↓, *IL1β↓,
4206- SIL,    Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response
- in-vivo, AD, NA
*BDNF↑, *5HT↑, *antiOx↑, *IL6↓, *TNF-α↓, *Mood↑,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
4207- SIL,    Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury
- in-vivo, AD, NA
*TNF-α↓, *BDNF↑, *cognitive↑,
3049- SK,    Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling
- in-vivo, Nor, NA - NA, Stroke, NA
*neuroP↑, *p‑PTEN↓, *p‑Akt↑, *Bcl-2↑, *BAX↓, *cognitive↑, *BDNF↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
4216- SSE,    Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways
- in-vitro, AD, NA
*BDNF↑, *TrkB↓, *PI3K↑, *Akt↑, *neuroP↑,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
4151- Taur,  Gins,    Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
- in-vitro, AD, NA
*BDNF↑, *antiOx↑, *neuroP↑, *eff↑,
4157- Taur,    Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2 subunit and BDNF in the hippocampus of diabetic rats
- in-vivo, AD, NA
*BDNF↑, *GABA↑,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, Nor, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
4172- TQ,    Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
- in-vivo, AD, NA
*cognitive↑, *BDNF↑, *p‑CREB↑, *ROS↓, *memory↑,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
3789- UA,  Ex,    Combined Ursolic Acid and Resistance/Endurance Training Improve Type 3 Diabetes Biomarkers-Related Memory Deficits in Hippocampus of Aged Male Wistar Rats
- in-vivo, AD, NA
*BDNF↑,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
- Review, Var, NA
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4878- Uro,    Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis
- Review, AD, NA
*memory↑, *SIRT1↑, *cognitive↑, *BDNF↑, *Apoptosis↓, *neuroG↑,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4181- VitB6,    Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis
- in-vivo, Var, NA
*BDNF↑, *memory↑,
4186- VitD3,    The Association of Vitamin D, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell-Derived Neurotrophic Factor (GDNF) with Development in Children
- Study, Nor, NA
*BDNF∅,
4187- VitD3,    Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF)
- in-vivo, AD, NA
*BDNF↑, *MDA↓, *Casp3↓,
4185- VitD3,    Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial
- Study, AD, NA
*other↑, *BDNF∅,
4184- VitD3,    Neuroplasticity-related effects of vitamin D relevant to its neuroprotective effects: A narrative review
- Review, AD, NA
*BDNF↑, *cognitive↑,
4182- VitD3,    The association between vitamin D and BDNF on cognition in older adults in Southern Brazil
- Study, AD, NA
*cognitive↑, *BDNF↑,
4183- VitD3,  Ex,    Combined Exercise and Vitamin D on Brain-Derived Neurotrophic Factor
- Review, Nor, NA
*BDNF↑, *Inflam↓, *other↝,
4179- VitE,    Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats
- in-vivo, AD, NA
*BDNF↑,
4188- VitK2,    Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
- in-vivo, AD, NA
*BDNF↑, *Aβ↓, *cognitive↑, *Ach↑, *Inflam↓,
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,
4166- Z,    Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*BDNF↑, *Mood↑,
4164- Z,    Zinc treatment induces cortical brain-derived neurotrophic factor gene expression
- Review, AD, NA
*BDNF↑,
4197- Z,    The Effect of Zinc Supplementation on Circulating Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, AD, NA
*BDNF↑, *other↓, *Synergy↑, *Inflam↓, *antiOx↑,
4196- Z,    The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis
- Review, AD, NA
*BDNF∅,
4165- Z,    Antidepressant-like activity of zinc: further behavioral and molecular evidence
- in-vivo, AD, NA
*BDNF↑,
4191- Zeax,  Lut,    Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance
- Trial, AD, NA
*BDNF↑, *IL1β↓, *cognitive↑, *memory↑,

Showing Research Papers: 201 to 245 of 245
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 245

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 2,   Catalase↑, 1,   GSH↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 6,   ROS⇅, 2,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 8,   BAX↑, 1,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Casp↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   FADD↑, 1,   Mcl-1↓, 1,   MOMP↑, 1,   PUMA↑, 1,   TNFR 1↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Akt2↓, 1,   CaMKII ↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 4,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   FOXO1↑, 1,   miR-34a↓, 1,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 3,   P53↓, 2,   PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   CSCs↓, 1,   Ki-67↓, 3,   NOTCH1↓, 1,   NOTCH1↑, 1,   TumCG↓, 6,   TumCP↓, 7,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 3,   Fibronectin↓, 1,   LAMs↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   MMP9↑, 1,   Slug↓, 2,   Snail↓, 1,   TET1↑, 1,   TRIB3↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 3,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   PD-1↓, 1,   PSA↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↝, 2,   CBR1↓, 1,   ChemoSen↑, 8,   CYP1A1↓, 1,   Dose↝, 3,   eff↑, 2,   Half-Life↓, 1,   Half-Life↑, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 4,   Synergy?, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   PSA↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Verbal↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cardioP↑, 1,   chemoP↑, 3,   cognitive↑, 3,   memory↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 63,   ARE↑, 5,   Bil↑, 1,   Catalase↓, 1,   Catalase↑, 26,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 20,   GPx4↑, 2,   GSH↑, 31,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 25,   Iron↓, 2,   Keap1↝, 1,   lipid-P↓, 23,   lipid-P↑, 1,   MDA↓, 31,   MDA↑, 1,   MPO↓, 2,   MPOD↑, 1,   NOX↓, 2,   NQO1↑, 6,   Nrf1↑, 2,   NRF2↑, 47,   ONOO↓, 1,   ROS?, 1,   ROS↓, 86,   mt-ROS?, 1,   SOD↓, 2,   SOD↑, 39,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 6,   OCR↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 5,   adiP↑, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 8,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 1,   FABP4↓, 1,   glucose↓, 2,   GSK‐3β↓, 12,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   LDL↓, 7,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   PFK↓, 1,   SIRT1↑, 15,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 19,   ASC↓, 1,   BAX↓, 12,   Bax:Bcl2↓, 5,   Bcl-2↓, 2,   Bcl-2↑, 10,   Casp1↓, 1,   Casp3↓, 22,   Casp3↑, 1,   cl‑Casp3↓, 3,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 2,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 11,   Akt↝, 2,   p‑Akt↓, 4,   p‑Akt↑, 6,   p‑AKT1↑, 1,   AMPKα↑, 1,   CREB↓, 2,   CREB↑, 26,   CREB∅, 1,   p‑CREB↑, 13,   ERK↑, 10,   p‑ERK↓, 1,   p‑ERK↑, 1,   IκB↓, 1,   IκB↑, 1,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 4,   p‑p70S6↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 9,   PI3K↝, 1,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   PTP1B↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cJun↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC↑, 1,   HDAC2↓, 3,   MEF2D↑, 1,   other↓, 3,   other↑, 6,   other↝, 1,   SOX2↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 3,   PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   PARP↓, 1,   PARP1↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   Ki-67↑, 2,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↑, 2,   Nestin↑, 1,   neuroG↑, 6,   NOTCH1↑, 1,   TumCG↓, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↝, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 1,   MUC1↑, 1,   TG2/TGase↓, 2,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumMeta↓, 1,   TXNIP↓, 2,   uPA↑, 1,   β-catenin/ZEB1↑, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   NO↓, 12,   NO↑, 1,   VCAM-1↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 24,   BBB↝, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 8,   OCLN↑, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 3,   COX2/PTGS2↓, 18,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 2,   IL10↑, 6,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 33,   IL23↓, 2,   IL33↓, 1,   IL4↑, 2,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   IL8↓, 6,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 71,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 8,   NF-kB↓, 36,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NLRP3↓, 11,   PAF↓, 1,   PGE2↓, 6,   RAGE↓, 1,   TLR1↓, 1,   TLR4↓, 6,   TNF-α↓, 49,   TRAF6↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 11,   Ach↑, 11,   AChE↓, 32,   AChE↑, 1,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 4,   BDNF↑, 233,   BDNF⇅, 1,   BDNF↝, 1,   BDNF∅, 8,   proBDNF↑, 2,   BrainVol↑, 1,   ChAT↑, 3,   GABA↓, 1,   GABA↑, 4,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOB↓, 2,   NGF↑, 13,   PSD95↑, 14,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 2,   TrkB↓, 1,   TrkB↑, 25,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APOE4↑, 1,   APP↓, 6,   Aβ↓, 41,   Aβ↑, 1,   Aβ42↓, 4,   BACE/β-secretase↓, 15,   PSEN1/PS1↓, 1,   tau↓, 6,   p‑tau↓, 15,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

END↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 11,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   Dose?, 4,   Dose↑, 3,   Dose↝, 22,   eff↑, 17,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ADC↓, 1,   ALAT↓, 5,   ALB↑, 1,   AST↓, 6,   Bil↑, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 2,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 5,   antiCG↑, 1,   antiD↑, 2,   AntiDiabetic↑, 6,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   ANXi↓, 2,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 91,   cognitive∅, 3,   hepatoP↑, 15,   Learn↑, 10,   memory↑, 82,   Mood↑, 21,   motorD↑, 10,   neuroP↑, 108,   NP/CIPN↓, 1,   Obesity↓, 6,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 6,   Stress↓, 1,   Stroke↓, 4,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 6,   Diar↓, 2,   GutMicro↑, 12,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 5,  
Total Targets: 411

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor
11 Exercise
10 Hydrogen Gas
10 Magnetic Fields
7 Lycopene
6 Curcumin
6 Sulforaphane (mainly Broccoli)
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Silymarin (Milk Thistle) silibinin
6 Vitamin D3
5 Apigenin (mainly Parsley)
5 Luteolin
5 Zinc
4 Ellagic acid
4 Ginseng
4 Honokiol
4 Huperzine A/Huperzia serrata
4 isoorientin
4 L-Theanine
4 Resveratrol
3 Aromatherapy
3 Carnosic acid
3 Caffeine
3 Cysteamine
3 Ferulic acid
3 Ginkgolide B
3 Magnesium
3 Morin
3 Naringin
3 Piperine
3 Urolithin
2 flavonoids
2 Baicalin
2 Berberine
2 Bacopa monnieri
2 Boron
2 Boswellia (frankincense)
2 Centella asiatica / Gotu kola → asiaticoside
2 Choline
2 Folic Acid, Vit B9
2 Chrysin
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Crocetin
2 Docosahexaenoic Acid
2 diet Short Term Fasting
2 Eugenol
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Hyperoside
2 Kaempferol
2 Mung Bean Sprouts
2 Lutein
2 Zeaxanthin
2 Magnolol
2 Melatonin
2 Moringa oleifera
2 Phenylbutyrate
2 Propolis -bee glue
2 Quercetin
2 Sesame seeds and Oil
2 Taurine
2 Thymoquinone
2 Ursolic acid
1 Annona atemoya Leaf Extract
1 isoquercitrin
1 Rutin
1 Anthocyanins
1 Alpha-Lipoic-Acid
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Artemisinin
1 Astaxanthin
1 Baicalein
1 Beta-Caryophyllene
1 Betulinic acid
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Carnosine
1 chitosan
1 Vitamin B12
1 Vitamin B2,Riboflavin
1 Echinacea
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 dietMediterranean
1 2-DeoxyGlucose
1 Calorie Restriction Mimetics
1 Diindolylmethane
1 Indole-3-carbinol
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Phosphatidylserine
1 Fisetin
1 Formononetin
1 Flaxseed/Linseed
1 Gallic acid
1 Galantamine
1 Bifidobacterium animalis subsp. lactis GCL2505
1 Isoliquiritigenin
1 Isothiocyanates
1 Licochalcone A
1 Lecithin
1 SDG/lignans
1 Matrine
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Marjoram (Origanum majorana)
1 Protocatechuic acid
1 Polyphenols
1 probiotics
1 Pterostilbene
1 Salvia officinalis
1 Rosmarinic acid
1 Selenium
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Safflower yellow
1 Turmerones
1 Vitamin B6,pyridoxine
1 Vitamin E
1 Vitamin K2
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1356  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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