GSH Cancer Research Results

GSH, Glutathione: Click to Expand ⟱
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Glutathione (GSH) is a thiol antioxidant that scavenges reactive oxygen species (ROS), resulting in the formation of oxidized glutathione (GSSG). Decreased amounts of GSH and a decreased GSH/GSSG ratio in tissues are biomarkers of oxidative stress.
Glutathione is a powerful antioxidant found in every cell of the body, composed of three amino acids: cysteine, glutamine, and glycine. It plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting the immune system.
cancer cells can have elevated levels of glutathione, which may help them survive in the oxidative environment created by the immune response and chemotherapy. This can make cancer cells more resistant to treatment.
While glutathione can be obtained from certain foods (like fruits, vegetables, and meats), its absorption from supplements is debated. Some people take N-acetylcysteine (NAC) or other precursors to boost glutathione levels, but the effects on cancer prevention or treatment are still being studied.
Depleting glutathione (GSH) to raise reactive oxygen species (ROS) is a strategy that has been explored in cancer research and therapy.
Many cancer cells have altered redox states and may rely on GSH to survive. Increasing ROS levels can induce stress in these cells, potentially leading to cell death.
Certain drugs and compounds can deplete GSH levels. For example, agents like buthionine sulfoximine (BSO) inhibit the synthesis of GSH, leading to its depletion.
Cancer cells tend to exhibit higher levels of intracellular GSH, possibly as an adaptive response to a higher metabolism and thus higher steady-state levels of reactive oxygen species (ROS).

"...intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS)..."
"Cancer cells have a high level of GSH compared to normal cells."
"...cancer cells are affluent with high antioxidant levels, especially with GSH, whose appearance at an elevated concentration of ∼10 mM (10 times less in normal cells) detoxifies the cancer cells." "Therefore, GSH depletion can be assumed to be the key strategy to amplify the oxidative stress in cancer cells, enhancing the destruction of cancer cells by fruitful cancer therapy."

The loss of GSH is broadly known to be directly related to the apoptosis progression.
Scientific Papers found: Click to Expand⟱
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP/DDIT3↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
lipid-P↓, chemoPv↑, GSH↑, SOD↑, GSTs↑, glucose↓,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2/PTGS2↑, *NF-kB↓, *ICAM-1↓, *MCP1/CCL2↓, *HO-1↑, CXCc↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
2810- CUR,    Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*SOD↑, *lipid-P↓, *GSH↑, *Catalase↑, *ROS↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,
1410- CUR,    Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway
- vitro+vivo, OS, MG63
tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT/SLC7A11↓, ROS↑, MDA↑, GSH↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2/PTGS2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, Var, NA
*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, ChemoSen↑, OS↓, chemoP↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
3751- CUR,  Gala,    A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
- in-vivo, AD, NA
*AChE↓, *MDA↑, *GSH↑, *BBB↑,
7448- CYN,    Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs
- in-vitro, Pca, DU145
GSH↓, STAT3↓, Bcl-2↓, survivin↓, cl‑PARP↑, ChemoSen↑,
6259- Cyste,    Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases
- Review, AD, NA - Review, Park, NA
*ROS↓, *neuroP↑, *BDNF↑, *NRF2↑, *BBB↑, *HSPs↑, *GSH↑, *TG2/TGase↓, Aβ↓,
6257- Cyste,    Cystamine induces AIF-mediated apoptosis through glutathione depletion
- vitro+vivo, Var, NA
AIF↑, GSH↓, neuroP↑,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2/PTGS2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
1896- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, CRC, NA
TumCG↓, *GSH↓, RadioS↑, ChemoSen↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27/CDKN1B↑, Insulin↓, IGF-1↓,
2267- dietMet,    Role of amino acids in regulation of ROS balance in cancer
- Review, Var, NA
TumCG↓, GSH↓, ROS↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2273- dietMet,    Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
ROS↑, GSH↓, TumCP↓, TumAuto↑, LC3II↑,
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
5188- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, Var, NA
AntiAge↑, MethCyc↓, TumCG↓, ChemoSen↑, RadioS↑, OS↑, GSH↓,
5191- dietMet,    Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
- in-vitro, Colon, HT29
ChemoSen↑, RadioS↑, Ferroptosis↑, Synergy↑, eff↑, GSH↓, eff↓,
8843- DIM,    3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis
- in-vitro, NSCLC, NA
tumCV↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, EMT↓, Ferroptosis↑, Iron↑, ROS↑, MDA↑, GSH↓, AhR↓, NRF2↓, GPx4↓, MMP↓, eff↓,
6289- DL,    D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis
- in-vivo, Var, NA
COX2/PTGS2↓, *GSH↑, *GPx↑, *Catalase↑, Bcl-2↓, BAX↑, *chemoPv↑, *Inflam↓, *ROS↓, *RAS↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *ALB↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, *SOD↑, *Catalase↑, GPx↑, *GR↑, *GSTs↑, *GSH↑, *SIRT1↑, *PGC1A↑, *other↑,
5784- EGCG,    Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
- in-vivo, Nor, NA
*OS↑, *Inflam↓, *LDL↓, *AntiAge↑, *GSH↑, *SOD↑, *AMPKα↑, *Weight∅,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6815- EMD,    NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- in-vitro, Liver, HepG2
AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *AntiBio↑, *toxicity↝, tumCV↓, TumCP↓, Apoptosis↑, ALAT↓, glucose↓, GSH↓, ATP↓,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
- Review, Nor, NA
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
5046- erastin,  SAS,    The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
- Study, Var, NA
xCT/SLC7A11↓, ROS↑, TumCG↓, GSH↓, Ferroptosis↑,
5047- erastin,    The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- in-vitro, Ovarian, NA
xCT/SLC7A11↓, GSH↓, Ferroptosis↑, ChemoSen↑, Synergy↑,
2455- erastin,    Discovery of the Inhibitor Targeting the SLC7A11/xCT Axis through In Silico and In Vitro Experiments
- in-vitro, Cerv, HeLa
xCT/SLC7A11↓, GSH↓, ROS↑, TumCMig↓,
2204- erastin,    Regulation of ferroptotic cancer cell death by GPX4
- in-vitro, fibroS, HT1080
GSH↓, Ferroptosis↑, ROS↑, GPx↓, GPx4↓, lipid-P↑, eff↓, eff↑,
6355- Eug,    Pharmacological and Toxicological Properties of Eugenol
- Review, Var, NA
*Inflam↓, *antiOx↑, *NF-kB↓, *AntiArt↑, *lipid-P↓, *GSH↑, ROS↑, GSH↓, ChemoSen↑, Apoptosis↑, MMP↓, TumCG↓, TumCCA↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,

Showing Research Papers: 201 to 250 of 640
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 640

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 13,   antiOx⇅, 1,   Catalase↓, 26,   Catalase↑, 15,   Copper↑, 1,   cystine↓, 1,   Fenton↑, 11,   GCLM↑, 2,   GPx↓, 11,   GPx↑, 16,   GPx1↓, 1,   GPx1⇅, 1,   GPx4↓, 46,   GPx4↑, 1,   GSH?, 1,   GSH↓, 272,   GSH↑, 38,   GSH⇅, 2,   GSH↝, 2,   GSH∅, 3,   i-GSH↓, 1,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 8,   GSR↓, 3,   GSR↑, 5,   GSSG↓, 1,   GSSG↑, 7,   GSTs↓, 2,   GSTs↑, 8,   H2O2↓, 3,   H2O2↑, 16,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 18,   HO-1⇅, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 31,   Iron↝, 2,   i-Iron↑, 4,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 8,   lipid-P↑, 43,   lipid-P↝, 1,   MDA?, 1,   MDA↓, 12,   MDA↑, 41,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 3,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 26,   NRF2↑, 28,   NRF2⇅, 1,   NRF2∅, 1,   Prx4↑, 1,   PYCR1↓, 1,   RNS↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 29,   ROS↑, 267,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 20,   SOD1↑, 3,   SOD2↓, 3,   SOD2↑, 3,   T-SOD↓, 1,   TAC↓, 3,   TBARS↓, 1,   TBARS↑, 4,   Thiols↓, 7,   i-Thiols↓, 1,   TOS↑, 1,   Trx↓, 6,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 11,   TrxR1?, 1,   TrxR1↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 21,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 5,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 4,   Mets↑, 1,   NCOA4↑, 3,   Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↝, 1,   compI↓, 5,   compII↓, 3,   compIII↓, 2,   compV↓, 1,   EGF↓, 2,   ETC↓, 6,   Insulin↓, 3,   mitResp↓, 6,   mtDam↓, 1,   mtDam↑, 20,   OCR↓, 2,   OCR↑, 2,   OXPHOS↓, 3,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PDH↓, 1,   PDH↑, 1,   SDH↓, 1,   SIRT3↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 4,   ALAT↓, 7,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 1,   ATP↓, 25,   ATP↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 3,   FDG↓, 1,   G6PD↓, 3,   GAPDH↓, 4,   GLO-I↓, 1,   GLS↓, 2,   glucose↓, 3,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 26,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 14,   lactateProd↓, 7,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 2,   LDL↓, 2,   MethCyc↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PFKP↓, 2,   PKM2↓, 7,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 1,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 5,   SIRT2↑, 1,   SREBP2↓, 1,   TCA↓, 4,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 3,   Apoptosis↓, 5,   Apoptosis↑, 138,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 5,   BAX↓, 4,   BAX↑, 78,   Bax:Bcl2↑, 14,   Bcl-2↓, 78,   Bcl-2↑, 3,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 4,   BIM↓, 1,   BIM↑, 3,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 15,   Casp↝, 1,   Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 100,   cl‑Casp3↓, 1,   cl‑Casp3↑, 12,   cl‑Casp3∅, 1,   proCasp3↑, 3,   Casp6↑, 1,   Casp7↑, 16,   cl‑Casp7↑, 1,   Casp8↑, 26,   cl‑Casp8↑, 2,   Casp9↓, 2,   Casp9↑, 57,   cl‑Casp9↓, 1,   cl‑Casp9↑, 7,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 58,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 12,   FADD↑, 3,   Fas↑, 15,   FasL↑, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 57,   GranB/GZMB↝, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 9,   Mcl-1↓, 7,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 5,   p38↑, 14,   p‑p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 2,   RIP1↑, 3,   RIP3↑, 3,   survivin↓, 19,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 16,   XIAP↓, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 65,   Akt↑, 4,   p‑Akt↓, 13,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 3,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERK↓, 29,   ERK↑, 4,   p‑ERK↓, 3,   p‑ERK↑, 1,   FGFR1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 4,   IKKα↓, 5,   IKKα↑, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 3,   JNK↑, 13,   p‑JNK↓, 1,   p‑JNK↑, 3,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 15,   MAPK↑, 15,   MAPK↝, 2,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 1,   p‑MEK↓, 2,   mTOR↓, 36,   p‑mTOR↓, 4,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 41,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3K/Akt⇅, 1,   PI3K/Akt↝, 1,   PKCδ↓, 4,   PTEN↓, 2,   PTEN↑, 7,   PTEN↝, 1,   Raf↓, 6,   RAS↓, 6,   RAS↑, 1,   RET↓, 1,   Sp1/3/4↓, 8,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 35,   p‑STAT3↓, 7,   STAT6↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF3↑, 2,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 25,   DNMT1↓, 4,   DNMT1↑, 1,   DNMT3B↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↓, 1,   H4↓, 1,   ac‑H4↓, 1,   HATs↑, 1,   HDAC↓, 14,   HDAC1↓, 5,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC8↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-22↑, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 3,   miR-384↑, 1,   miR-422a↑, 1,   Myc↓, 1,   MYCN↓, 1,   OCT4↓, 5,   other↓, 7,   other↑, 8,   other⇅, 1,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 3,   SALL4↓, 1,   sonoS↑, 3,   SOX2↓, 6,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 40,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↑, 17,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 3,   ER Stress↑, 29,   GRP78/BiP↑, 8,   HSP27↓, 3,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 6,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 6,   p‑PERK↑, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 5,   p62↑, 2,   TumAuto↑, 17,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 46,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 2,   p16↑, 1,   P53↓, 4,   P53↑, 66,   P53↝, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   cl‑PARP∅, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 21,   SIRT6↓, 2,   Telomerase↓, 5,   TOP1↓, 1,   TOP1∅, 1,   TOP2↓, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 4,   CDK1↝, 1,   CDK2↓, 16,   CDK2↑, 2,   CDK4↓, 21,   CDK4↑, 1,   CDK6↓, 7,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 15,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 35,   cycE/CCNE↓, 9,   GADD45A↑, 2,   Ki-67↓, 21,   mitA↑, 2,   P21↓, 3,   P21↑, 41,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 108,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 3,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 15,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 21,   mTORC1↓, 2,   Nanog↓, 6,   Nestin↓, 1,   NOTCH↓, 3,   NOTCH1↓, 8,   SCF↓, 1,   Shh↓, 3,   STAT1↓, 1,   TumCG↓, 68,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 94,   Wnt↓, 12,   Wnt↝, 1,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 6,   ASAP2↓, 1,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 15,   Ca+2↝, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 35,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 4,   p‑FAK↓, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 2,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 38,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 40,   MMP9↑, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1-C↓, 1,   MUC4↓, 1,   N-cadherin↓, 15,   PCBP1↓, 1,   PDGF↓, 1,   proline↓, 1,   Rac1↓, 1,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 5,   Smad1↑, 1,   SMAD2↓, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI↓, 38,   TumCMig↓, 39,   TumCMig↑, 1,   TumMeta↓, 29,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 8,   Tyro3↓, 1,   uPA↓, 6,   uPAR↓, 2,   Vim↓, 16,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 21,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 42,   CD31/PECAM-1↓, 3,   EGR1↑, 1,   EGR4↓, 1,   HIF-1↓, 1,   HIF-1↑, 1,   Hif1a↓, 27,   LOX1↓, 1,   NO↓, 4,   NO↑, 10,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CTR1↑, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP?, 1,   MMP↓, 93,   MMP↑, 2,   MPT↑, 1,   OCLN↑, 1,   SLC12A5↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 9,   DR4↑, 3,   FOXP3↓, 1,   HMGB1↓, 4,   ICAM-1↓, 4,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 10,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 2,   IL6↓, 27,   IL8↓, 10,   Imm↑, 8,   INF-γ↝, 1,   Inflam↓, 22,   LRIG1↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 77,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 7,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 8,   PGE1↓, 1,   PGE2↓, 11,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AR↓, 9,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   BioAv↓, 19,   BioAv↑, 13,   BioAv↝, 10,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 108,   CompStab↓, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   Dose∅, 4,   eff?, 1,   eff↓, 51,   eff↑, 65,   eff↝, 5,   GSTA1↓, 1,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 2,   Half-Life?, 1,   Half-Life↓, 4,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS↓, 1,   RadioS↑, 38,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 7,   ALP↓, 2,   AR↓, 9,   AST↓, 4,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 3,   CEA↓, 2,   creat↓, 3,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 27,   KRAS↓, 2,   LDH↓, 8,   LDH↑, 4,   LDH↝, 1,   Myc↓, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 8,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Urea↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 43,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 9,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 14,   ChemoSideEff↓, 7,   cognitive↑, 5,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 15,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↓, 1,   OS↑, 15,   Pain↓, 2,   Pin1↓, 2,   QoL↑, 4,   QoL∅, 1,   radioP↑, 8,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 6,   toxicity↑, 4,   toxicity↝, 2,   TumVol?, 1,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 3,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 889

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 1,   antiOx↓, 9,   antiOx↑, 162,   ARE↑, 4,   Bil↓, 1,   Catalase↓, 7,   Catalase↑, 132,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 84,   GPx↝, 1,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 7,   GSH↓, 17,   GSH↑, 321,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↓, 1,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 19,   GSS↑, 1,   GSSG↓, 5,   GSSG∅, 1,   GSTs↓, 4,   GSTs↑, 28,   H2O2↓, 12,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 6,   HNE↓, 1,   HO-1↓, 4,   HO-1↑, 87,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 3,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 97,   lipid-P↑, 3,   MDA↓, 136,   MDA↑, 7,   MPO↓, 15,   MPO↑, 1,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   Nrf1↑, 3,   NRF2↓, 6,   NRF2↑, 144,   NRF2⇅, 1,   Prx↑, 5,   RNS↓, 3,   ROS?, 2,   ROS↓, 263,   ROS↑, 13,   ROS⇅, 2,   ROS∅, 5,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD?, 1,   SOD↓, 9,   SOD↑, 190,   SOD↝, 1,   SOD1↓, 2,   SOD1↑, 4,   SOD2↑, 4,   TAC↑, 16,   TBARS↓, 9,   TBARS↑, 1,   Thiols↑, 1,   TOS↓, 2,   Trx↑, 7,   Trx1↑, 3,   TrxR↑, 3,   TrxR1↑, 1,   uricA↓, 2,   VitC↑, 11,   VitE↑, 8,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 2,   FPN↑, 1,   FTH1↓, 1,   IronCh↓, 1,   IronCh↑, 19,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 6,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 2,   ACSL4↓, 1,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 49,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 15,   AMPK⇅, 1,   ATP↓, 2,   ATP↑, 14,   cAMP↑, 1,   CRM↑, 2,   FAO↑, 1,   FASN↓, 3,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 7,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 12,   GlutMet↑, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 5,   H2S↑, 4,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 16,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 7,   NADPH↑, 6,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PGC1A↑, 1,   PIP3↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   PONs↑, 1,   PPP↓, 1,   SIRT1↓, 1,   SIRT1↑, 18,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 27,   ASC↓, 1,   BAD↓, 1,   BAX↓, 20,   BAX↑, 3,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 18,   Bcl-2↝, 1,   Casp↓, 1,   Casp1↓, 3,   Casp3↓, 38,   Casp3↑, 1,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp7↓, 1,   Casp8↓, 2,   Casp9↓, 14,   cl‑Casp9↓, 1,   Cyt‑c↓, 10,   Cyt‑c↑, 1,   Fas↓, 1,   Ferroptosis↓, 8,   Ferroptosis↑, 2,   GSDMD↓, 1,   iNOS↓, 43,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p38↑, 2,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 7,   Akt↑, 19,   p‑Akt↓, 1,   p‑Akt↑, 1,   AMPKα↑, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 7,   ERK↑, 7,   p‑ERK↓, 2,   p‑ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 10,   JNK↑, 1,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 17,   PKA↑, 1,   PKCδ?, 1,   PKCδ↑, 4,   PP2A↑, 3,   PTEN↓, 4,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO1↝, 1,   FOXO3↑, 2,   HDAC↓, 3,   HDAC2↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 4,   other↑, 10,   other↝, 14,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 3,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSPs↓, 1,   HSPs↑, 3,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 16,   P53↓, 3,   P53↑, 1,   PARP↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP11↑, 1,   MMP13↓, 2,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 12,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 8,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 9,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   E-sel↓, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 39,   NO↑, 4,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 37,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 1,   GastroP↑, 8,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 2,   MMP↑, 20,   MMP↝, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 2,   HCAR2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 8,   IFN-γ↓, 11,   IFN-γ↑, 1,   IL1↓, 4,   IL10↓, 11,   IL10↑, 12,   IL12↓, 3,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 78,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 67,   IL6↑, 4,   IL8↓, 9,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 1,   Inflam↓, 163,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 5,   NeuroI↓, 5,   NF-kB↓, 95,   NF-kB↑, 2,   NLRP3↓, 14,   p65↓, 4,   PGE2↓, 16,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 1,   SOCS-3↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 21,   TNF-α↓, 103,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 9,   Ach↑, 10,   AChE↓, 46,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 3,   BChE↓, 10,   BDNF↓, 1,   BDNF↑, 28,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   EndoR↑, 1,   GABA↑, 2,   MAOA↓, 5,   MAOB↓, 3,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 6,   Aβ↓, 44,   Aβ42↓, 4,   BACE/β-secretase↓, 17,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 9,   p‑tau↓, 16,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   FGF21↑, 2,   GR↑, 4,   GR↝, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↑, 8,   RAAS↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 36,   BioAv↑, 51,   BioAv⇅, 1,   BioAv↝, 22,   BioEnh↑, 3,   ChemoSen↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   eff↓, 8,   eff↑, 31,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 5,   Half-Life↝, 8,   P-gp/ABCB1↓, 4,   P450↓, 3,   P450↑, 2,   P450↝, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 49,   ALAT↑, 1,   ALB↑, 1,   ALB↝, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 49,   AST↑, 1,   BG↓, 2,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 2,   BP↓, 8,   BP↝, 1,   BUN?, 1,   BUN↓, 4,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 10,   CRP↓, 9,   Ferritin↓, 1,   Ferritin↑, 2,   HemoG↑, 1,   IL6↓, 67,   IL6↑, 4,   IRes↝, 1,   LDH↓, 15,   LDH↑, 1,   NOS2↓, 3,   RAGE↓, 3,   RBC↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 11,   AntiArt↑, 10,   AntiCan↑, 17,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 26,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 59,   CardioT↓, 2,   chemoP↑, 14,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 66,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 82,   Learn↑, 7,   memory↑, 63,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 139,   NP/CIPN↓, 2,   Obesity↓, 11,   OS↑, 3,   Pain↓, 6,   radioP↑, 12,   RenoP↓, 1,   RenoP↑, 32,   RenoP↝, 1,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 12,   toxicity?, 2,   toxicity↓, 31,   toxicity↑, 3,   toxicity↝, 8,   toxicity∅, 11,   Weight↓, 3,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 9,   AntiFungal↑, 6,   AntiViral↑, 9,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 25,   Inf↓, 1,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 658

Scientific Paper Hit Count for: GSH, Glutathione
32 Thymoquinone
28 Curcumin
22 Silver-NanoParticles
21 Quercetin
20 Piperlongumine
19 Silymarin (Milk Thistle) silibinin
18 Alpha-Lipoic-Acid
17 Shikonin
15 Radiotherapy/Radiation
15 Luteolin
13 Sulforaphane (mainly Broccoli)
12 Resveratrol
12 Phenethyl isothiocyanate
11 Sulfasalazine
11 Lycopene
11 Selenite (Sodium)
10 Cisplatin
10 Allicin (mainly Garlic)
10 Artemisinin
10 Boron
10 Chrysin
10 Rosmarinic acid
9 Selenium
8 Melatonin
8 Chemotherapy
8 diet Methionine-Restricted Diet
8 Juglone
7 3-bromopyruvate
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Matrine
7 Propolis -bee glue
7 Selenium NanoParticles
6 Betulinic acid
6 Chlorogenic acid
6 Carvone
6 Copper and Cu NanoParticles
6 Eugenol
6 Gallic acid
6 Propyl gallate
5 Apigenin (mainly Parsley)
5 Baicalein
5 erastin
5 Rutin
5 Carvacrol
5 Crocetin
5 D-limonene
5 Ferulic acid
5 Hyperoside
5 Magnetic Fields
5 Vitamin C (Ascorbic Acid)
4 Berberine
4 Carnosic acid
4 Emodin
4 Fisetin
4 Honokiol
4 Kaempferol
4 Linalool
4 Morin
4 Parthenolide
3 2-DeoxyGlucose
3 Auranofin
3 chitosan
3 Cysteamine
3 Isoliquiritigenin
3 Licochalcone A
3 methylseleninic acid
3 Magnetic Field Rotating
3 Piperine
3 Pterostilbene
3 Aflavin-3,3′-digallate
3 Turmerones
2 Anethole/trans-Anethole
2 Ascorbyl Palmitate
2 Beta-Caryophyllene
2 Bromelain
2 brusatol
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Gemcitabine (Gemzar)
2 Chocolate
2 Cichoric acid / Chicoric acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Date Fruit Extract
2 Docetaxel
2 Dandelion Root
2 Ellagic acid
2 EGCG (Epigallocatechin Gallate)
2 Sesame seeds and Oil
2 Formononetin
2 Fucoidan
2 Ginkgo biloba
2 Lemon Balm/Melissa officinalis
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoorientin
2 Isovitexin
2 Lactoferrin/Talactoferrin
2 Methylsulfonylmethane
2 salinomycin
2 Vitexin
1 1,8-Cineole
1 cetuximab
1 Anthocyanins
1 Astragalus
1 Photodynamic Therapy
1 Camptothecin
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Aloe anthraquinones
1 Baicalin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Butyrate
1 Capsaicin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 chemodynamic therapy
1 chaetocin
1 Chlorophyllin
1 Zinc
1 Chyawanprash
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Black phosphorus
1 SonoDynamic Therapy UltraSound
1 Cucurbitacin
1 Galantamine
1 Cynaropicrin
1 Diindolylmethane
1 Exercise
1 Shilajit/Fulvic Acid
1 Gambogic Acid
1 Garcinol
1 Salvia officinalis
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Isobavachalcone
1 Butein
1 Scopoletin
1 isoquercitrin
1 Lapatinib
1 Lapachol
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Magnolol
1 Methyl Jasmonate
1 Metformin
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 N-Acetyl-Cysteine
1 Naringin
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 Plumbagin
1 Orlistat
1 Scoulerine
1 polyethylene glycol
1 Anti-oxidants
1 Shankhpushpi
1 Squalene
1 Glutathione
1 Taurine
1 methotrexate
1 Ursolic acid
1 Urolithin
1 Vitamin B12
1 Folic Acid, Vit B9
1 VitK3,menadione
1 immunotherapy
1 Vitamin K2
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:137  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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