JNK Cancer Research Results

JNK, c-Jun N-terminal kinase (JNK): Click to Expand ⟱
Source:
Type:
JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function. Janus signaling promotes cancer cell survival.
JNK, or c-Jun N-terminal kinase, is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis (programmed cell death). JNK is activated in response to various stress signals, such as UV radiation, oxidative stress, and inflammatory cytokines.
JNK activation can promote apoptosis in cancer cells, acting as a tumor suppressor. However, in other contexts, it can promote cell survival and proliferation, contributing to tumor progression.

JNK is often unregulated in cancers, leading to increased cancer cell proliferation, survival, and resistance to apoptosis. This activation is typically associated with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
2279- VitK2,    Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, HEK293 - in-vitro, Nor, L02 - in-vivo, NA, NA
MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,
7916- VT,    Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway
- in-vitro, HCC, NA
*antiOx↑, *Inflam↓, *AntiTum↑, Apoptosis↑, Casp3↑, Bcl-2↓, LC3II↓, p‑JNK↑, p‑ERK↓,

Showing Research Papers: 201 to 203 of 203
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 203

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   lactateProd↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 2,   Cyt‑c↑, 2,   JNK↑, 1,   p‑JNK↑, 2,   p38↑, 1,   p‑p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   p‑ERK↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

Rho↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   eff↓, 2,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   OS↑, 1,   Risk↓, 1,   toxicity∅, 1,   TumVol↓, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   toxicity↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: JNK, c-Jun N-terminal kinase (JNK)
9 Berberine
9 Curcumin
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Apigenin (mainly Parsley)
6 Shikonin
6 Thymoquinone
5 Silver-NanoParticles
5 Allicin (mainly Garlic)
5 Capsaicin
5 Luteolin
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Baicalein
4 Chlorogenic acid
4 Chrysin
4 Copper and Cu NanoParticles
4 Disulfiram
4 Gambogic Acid
4 Magnetic Fields
4 Piperlongumine
3 Radiotherapy/Radiation
3 Artemisinin
3 Betulinic acid
3 Carvacrol
3 chaetocin
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 isoorientin
3 Lycopene
3 Propolis -bee glue
3 Phenethyl isothiocyanate
3 Quercetin
2 Astragalus
2 Vitamin C (Ascorbic Acid)
2 Cisplatin
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 brusatol
2 Thymol-Thymus vulgaris
2 Celastrol
2 Ursolic acid
2 Ferulic acid
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Magnolol
2 Magnetic Field Rotating
2 Phenylbutyrate
2 Plumbagin
2 Resveratrol
2 Vitamin K2
1 1,8-Cineole
1 Camptothecin
1 Anethole/trans-Anethole
1 Berbamine
1 Bromelain
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Crocetin
1 Cucurbitacin
1 Bicalutamide
1 Sulforaphane (mainly Broccoli)
1 Dihydrocaffeic Acid
1 Cynaropicrin
1 Dandelion Root
1 Emodin
1 Eugenol
1 5-fluorouracil
1 Evodiamine
1 Ascorbyl Palmitate
1 Garcinol
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginkgetin
1 Graviola
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Juglone
1 Melatonin
1 Niclosamide (Niclocide)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Parthenolide
1 Pterostilbene
1 Kaempferol
1 Perilla
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:168  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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