JNK Cancer Research Results

JNK, c-Jun N-terminal kinase (JNK): Click to Expand ⟱

Source:

Type:

JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function. Janus signaling promotes cancer cell survival.
JNK, or c-Jun N-terminal kinase, is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis (programmed cell death). JNK is activated in response to various stress signals, such as UV radiation, oxidative stress, and inflammatory cytokines.
JNK activation can promote apoptosis in cancer cells, acting as a tumor suppressor. However, in other contexts, it can promote cell survival and proliferation, contributing to tumor progression.

JNK is often unregulated in cancers, leading to increased cancer cell proliferation, survival, and resistance to apoptosis. This activation is typically associated with poor prognosis and aggressive tumor behavior.

Scientific Papers found: Click to Expand⟱

3315-

SIL,

Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

-

in-vivo,

Nor,

NA

rats

neuroP↑, *NRF2↑, *HO-1↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *NF-kB↓, *TNF-α↓, *JNK↓, *Bcl-2↑, *BAX↑,

3304-

SIL,

Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells

-

in-vitro,

GC,

AGS

0, 20, 40, 60, 80, 100 and 120 µg/ml for 24 h

-

in-vivo,

NA,

NA

100 mg/kg silymarin injection group mice

BAX↑, p‑JNK↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Apoptosis↑, tumCV↓,

3305-

SIL,

Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis

-

in-vitro,

BC,

MDA-MB-231

0, 25, 50, 75, 100, 150 or 200 µg/ml silymarin for 24 h

-

in-vitro,

BC,

MCF7

-

in-vivo,

NA,

NA

mice

TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,

3301-

SIL,

Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

-

Review,

Var,

NA

Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,

3296-

SIL,

Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway

-

in-vitro,

Oral,

Ca9-22

 0, 50, 100, 200 μM silibinin for 48 h

-

in-vivo,

Oral,

YD10B

TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,

3293-

SIL,

Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer

-

Review,

Var,

NA

hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,

3319-

SIL,

Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms

-

Review,

AD,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,

5102-

SK,

GEM,

Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway

-

vitro+vivo,

PC,

NA

TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,

2355-

SK,

Pharmacological properties and derivatives of shikonin-A review in recent years

-

Review,

Var,

NA

AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,

2231-

SK,

Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

-

in-vitro,

CRC,

SNU-407

3 µM after 48 h

Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP/DDIT3↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,

2196-

SK,

Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species

-

Review,

Var,

NA

*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,

2228-

SK,

Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells

-

in-vitro,

CRC,

HCT116

0.25, 0.5, 1, 1.5, 2, 2.5 and 3 μM

-

in-vitro,

CRC,

HCT15

-

in-vivo,

NA,

NA

 intraperitoneal injection (3 mg/kg, 3 times per week

mouse

Apoptosis↑, Bcl-2↓, Casp3↑, Casp9↑, cl‑PARP↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, JNK↑, eff↓, ER Stress↑, ROS↑, TumCG↓,

3042-

SK,

The protective effects of Shikonin on lipopolysaccharide/D -galactosamine-induced acute liver injury via inhibiting MAPK and NF-kB and activating Nrf2/HO-1 signaling pathways

-

in-vivo,

Nor,

NA

mice

*TNF-α↓, *IL1β↓, *IL6↓, *IFN-γ↓, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *JNK↓, *ERK↓, *p38↓, *NF-kB↓, *p‑IKKα↓, *SOD↑, *GSH↑, *HO-1↑, *NRF2↑, *hepatoP↑,

1195-

SM,

Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways

-

in-vitro,

Lung,

A549

-

in-vitro,

Liver,

HepG2

-

in-vitro,

CRC,

HCT116

T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,

5333-

TFdiG,

Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts

-

vitro+vivo,

OS,

MG63

tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,

2121-

TQ,

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,

4173-

TQ,

Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons

-

in-vivo,

Nor,

NA

 TQ (20 mg kg-1 d-1 )

 15 days to adult rats

*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

-

Review,

CRC,

NA

6-112uM (table 1)

ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

3425-

TQ,

Advances in research on the relationship between thymoquinone and pancreatic cancer

-

in-vitro,

PC,

NA

Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,

3427-

TQ,

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

-

in-vitro,

Var,

NA

ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

3559-

TQ,

Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,

2411-

UA,

Ursolic acid in health and disease

-

Review,

Var,

NA

Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

3107-

VitC,

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

-

Review,

Var,

NA

Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, Synergy↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, Synergy↑, TET1↑,

1818-

VitK2,

New insights on vitamin K biology with relevance to cancer

-

Review,

Var,

NA

TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,

2279-

VitK2,

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways

-

in-vitro,

Bladder,

T24/HTB-9

0-100uM

-

in-vitro,

Bladder,

J82

-

in-vitro,

Nor,

HEK293

-

in-vitro,

Nor,

L02

-

in-vivo,

NA,

NA

mice

MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,

7916-

VT,

Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway

-

in-vitro,

HCC,

NA

*antiOx↑, *Inflam↓, *AntiTum↑, Apoptosis↑, Casp3↑, Bcl-2↓, LC3II↓, p‑JNK↑, p‑ERK↓,

Showing Research Papers: 201 to 226 of 226
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 226

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, antiOx⇅, 1, Catalase↓, 4, Catalase↑, 1, Fenton↑, 5, GPx↓, 3, GPx4↓, 4, GSH↓, 15, GSH↑, 1, GSH/GSSG↓, 2, GSR↓, 1, GSTs↓, 1, H2O2↑, 3, HNE↑, 1, HO-1↓, 5, HO-1↑, 8, Iron↓, 1, Iron↑, 3, i-Iron↑, 1, lipid-P↓, 2, lipid-P↑, 6, lipid-P↝, 1, MDA↓, 2, MDA↑, 3, MPO↓, 1, NADH↓, 1, NQO1↓, 1, NQO1↑, 2, NRF2↓, 10, NRF2↑, 9, NRF2↝, 1, Prx↓, 1, ROS?, 2, ROS↓, 8, ROS↑, 109, ROS⇅, 3, ROS↝, 1, ROS∅, 1, i-ROS↓, 1, m-ROS↑, 1, mt-ROS↑, 3, SOD↓, 6, SOD↑, 1, SOD1↓, 2, SOD2↓, 3, Trx↓, 4, Trx1↓, 2, TrxR↓, 4, TrxR1↓, 3, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1, CDC2↓, 3, CDC25↓, 4, CDC25↑, 1, CS↓, 1, ETC↓, 2, mitResp↓, 2, mtDam↑, 5, OXPHOS↓, 2, PDH↓, 1, PDH↑, 1, PGC-1α↑, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 1, ACLY↓, 1, ACSL4↑, 1, ALDOA↓, 1, ALDOB↑, 1, AMPK↓, 1, AMPK↑, 12, ATP↓, 8, ATP↑, 1, CAIX/CA9↑, 1, ENO1↓, 1, ENO3↑, 1, FAO↑, 1, FASN↓, 4, FBP1↑, 1, G6PD↓, 1, GAPDH↓, 1, GLO-I↓, 1, GlucoseCon↓, 6, glut↓, 1, GlutaM↓, 1, Glycolysis↓, 10, GSK‐3β↓, 5, GSK‐3β↑, 4, p‑GSK‐3β↓, 4, HK2↓, 5, HK3↑, 1, lactateProd↓, 7, lactateProd↑, 1, LDHA↓, 3, MCT4↓, 1, NADPH↓, 1, NADPH↑, 2, PCK1↑, 1, p‑PDK1 / PDPK1↓, 1, PFK↓, 1, PFK1↓, 1, PGK2↑, 1, PGM1↑, 1, PGM3↑, 1, PKLR↑, 1, PKM2↓, 6, PKM2↑, 1, p‑S6↓, 1, SCD1↓, 1, SIRT1↓, 3, SIRT1↑, 2, SREBP1/SREBF1↓, 1, TCA↓, 1, Warburg↓, 4,

Cell Death(tgid=5) ⓘ

AIF↑, 9, AIF↝, 1, APAF1↑, 3, Apoptosis↓, 1, Apoptosis↑, 88, Apoptosis↝, 1, mt-Apoptosis↑, 2, ASC↓, 1, ASK1↑, 2, BAD↑, 4, BAX↑, 47, BAX⇅, 1, BAX↝, 1, Bax:Bcl2↑, 9, Bcl-2↓, 49, Bcl-2↑, 2, Bcl-2↝, 1, cl‑Bcl-2↓, 1, Bcl-xL↓, 13, Bcl-xL↝, 1, BID↓, 1, BID↑, 3, p‑BID↓, 1, BNIP3↝, 1, Casp↑, 13, Casp1↓, 1, Casp10↑, 1, Casp12↑, 1, Casp2↑, 1, Casp3↓, 2, Casp3↑, 66, Casp3↝, 1, cl‑Casp3↑, 11, proCasp3↑, 1, Casp6↑, 2, Casp7↑, 4, cl‑Casp7↑, 1, Casp8↑, 20, cl‑Casp8↑, 3, Casp9↑, 45, cl‑Casp9↑, 4, cFLIP↓, 1, Cyt‑c↓, 1, Cyt‑c↑, 45, Cyt‑c↝, 2, Diablo↑, 3, DR5↑, 16, Endon↑, 2, FADD↑, 1, Fap1↓, 1, Fas↓, 1, Fas↑, 13, FasL↓, 1, FasL↑, 7, Ferroptosis↑, 4, GranB/GZMB↝, 1, GRP58↓, 1, GSDMD↑, 1, IAP1↓, 3, IAP2/BIRC3↓, 2, cl‑IAP2/BIRC3↑, 1, ICAD↓, 1, iNOS↓, 8, Mcl-1↓, 13, Mcl-1↑, 1, p‑Mcl-1↓, 1, MDM2↓, 2, MDM2↑, 1, p‑MDM2↓, 1, Necroptosis↑, 1, p38↓, 7, p38↑, 31, p‑p38↓, 4, p‑p38↑, 15, p‑p38↝, 1, Paraptosis↑, 1, Perforin↝, 1, PUMA↑, 1, Pyro↑, 3, RIP1↓, 2, RIP3↓, 1, survivin↓, 24, TRAIL↑, 2, TumCD↑, 10, TumCD∅, 1, XIAP↓, 11, YAP/TEAD↓, 2, YAP/TEAD↑, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 56, Akt↑, 2, Akt↝, 2, p‑Akt↓, 8, p‑Akt↑, 2, AKT1↓, 1, Akt2↓, 1, CK2↓, 2, cMET↓, 2, CREB↓, 1, cSrc↓, 1, DDIT4↑, 1, EF-1α↓, 1, EGFR↓, 11, EGFR↑, 1, EGFR↝, 1, p‑EGFR↓, 1, ERK↓, 33, ERK↑, 15, ERK↝, 1, p‑ERK↓, 15, p‑ERK↑, 9, p‑ERK⇅, 1, p‑ERK↝, 1, HER2/EBBR2↓, 4, HGF/c-Met↓, 1, IGF-1R↓, 1, IKKα↓, 2, IKKα↑, 3, IKKα↝, 1, p‑IKKα↓, 1, IR↓, 1, IκB↑, 1, p‑IκB↓, 1, JAK↓, 3, JAK1↓, 1, JAK2↓, 3, JNK↓, 30, JNK↑, 104, JNK↝, 3, p‑JNK↓, 13, p‑JNK↑, 24, p‑JNK↝, 1, cl‑JNK↑, 1, MAP2K1/MEK1↓, 1, MAPK↓, 16, MAPK↑, 18, MAPK↝, 1, p‑MAPK↓, 1, p‑MAPK↑, 5, MEK↓, 2, MEK↑, 1, p‑MEK↓, 1, MKP1↓, 1, MKP2↓, 1, mTOR↓, 23, mTOR↝, 1, p70S6↓, 1, p‑p70S6↓, 1, p‑p70S6↑, 1, P70S6K↓, 4, PAK↓, 1, PHKG1↑, 1, PI3K↓, 40, PI3K↑, 1, PI3K↝, 2, p‑PI3K↓, 2, PIK3CA↓, 1, p‑PIK3R1↓, 1, PKCδ↓, 6, p‑PKCδ↓, 1, PPP2R1A↑, 1, PTEN↓, 1, PTEN↑, 8, PTEN↝, 1, Raf↓, 2, c-Raf↓, 1, RAS↓, 2, Sp1/3/4↓, 6, Src↓, 1, p‑Src↓, 1, STAT↓, 3, STAT3↓, 26, STAT3↑, 1, p‑STAT3↓, 3, STAT4↓, 1, STAT5↓, 1, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1, ATF3↓, 1, ATF4↑, 3, CBP↓, 1, cJun↓, 3, cJun↑, 3, p‑cJun↓, 1, p‑cJun↑, 1, cMyc↓, 9, p‑cMyc↑, 1, DNMT1↓, 2, DNMTs↓, 1, EZH2↓, 1, FOXM1↓, 2, FOXO↑, 3, FOXO1↓, 1, FOXO3↓, 1, FOXO3↑, 3, FOXO4↑, 1, H3↓, 2, H3↑, 1, H3K4↓, 1, H3K9↓, 1, H4↓, 1, H4↑, 2, HATs↓, 2, HATs↑, 1, HDAC↓, 5, HDAC1↓, 1, HDAC2↓, 1, HMTs↓, 3, miR-124-3p↓, 1, miR-133a-3p↑, 1, miR-218↑, 1, Myc↓, 1, Myc↑, 1, MYCN↓, 1, OCT4↓, 5, other?, 1, other↓, 3, other↑, 2, other↝, 2, SOX2↓, 3, SOX4↓, 2, SOX9↓, 1, SOX9↑, 1, SUV39H↓, 1, tumCV↓, 21, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, cl‑ATF6↑, 1, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 15, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 1, eIF2α↑, 4, p‑eIF2α↓, 3, p‑eIF2α↑, 2, ER Stress↓, 2, ER Stress↑, 31, GRP78/BiP↓, 3, GRP78/BiP↑, 7, GRP94↑, 1, HSP27↓, 2, HSP27↑, 1, HSP70/HSPA5↓, 2, HSP90↓, 5, HSPs↓, 2, HSPs↑, 1, IRE1↑, 4, p‑IRE1↓, 1, PERK↑, 4, p‑PERK↓, 1, UPR↑, 7, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5, ATG7↑, 3, Beclin-1/ATG6↑, 10, LC3B-II↑, 1, LC3I↑, 1, LC3II↓, 1, LC3II↑, 8, p62↓, 1, p62↑, 1, SESN2↑, 1, TumAuto↑, 21,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3, p‑ATM↑, 2, BRCA1↑, 1, p‑BRCA1↑, 1, BRCA2↑, 1, DNAdam↓, 1, DNAdam↑, 22, DNArepair↓, 1, DNArepair↑, 1, hTERT/TERT↓, 2, p16↑, 2, P53↓, 2, P53↑, 34, P53↝, 1, p‑P53↑, 2, PARP↓, 2, PARP↑, 8, cl‑PARP↓, 1, cl‑PARP↑, 32, cl‑PARP1↑, 1, PCNA↓, 11, SAPK↑, 1, Telomerase↓, 5, TOP1↓, 3, TOP2↓, 3, UHRF1↓, 1, γH2AX↑, 3,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10, CDK1↑, 1, p‑CDK1↓, 1, CDK2↓, 16, CDK4↓, 17, p‑CDK4↓, 1, CDK6↓, 7, CDK6↑, 2, Cyc↓, 1, Cyc↝, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 11, CycB/CCNB1↑, 1, cycD1/CCND1↓, 23, cycD1/CCND1↑, 2, cycD1/CCND1↝, 1, p‑cycD1/CCND1↓, 1, cycE/CCNE↓, 8, E2Fs↓, 2, Ki-67↓, 9, P21?, 1, P21↓, 2, P21↑, 30, P21↝, 1, p27/CDKN1B↓, 1, p27/CDKN1B↑, 11, pRB↑, 1, p‑pRB↓, 1, p‑RB1↓, 2, TumCCA↓, 1, TumCCA↑, 65, WEE1↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2, ALDH1A1↓, 1, CD133↓, 2, CD24↓, 1, CD34↓, 2, cFos↓, 2, cFos↑, 1, p‑cFos↓, 1, CSCs↓, 12, Diff↓, 1, FGF↓, 1, Gli1↓, 2, HH↓, 2, IGF-1↓, 2, IGFBP3↑, 2, Jun↓, 1, Ki-67↓, 9, mTORC1↓, 3, Nanog↓, 5, Nestin↓, 1, NICD↓, 1, NOTCH↓, 4, NOTCH1↓, 6, NOTCH3↓, 3, p300↓, 1, Shh↓, 1, Smo↓, 1, STAT1↓, 1, TAZ↓, 1, TumCG↓, 28, TumCG↑, 1, TumCP↓, 47, TumCP↑, 1, TumCP∅, 1, Wnt↓, 13, Wnt/(β-catenin)↓, 2, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg↑, 2, AP-1↓, 9, AP-1↑, 1, AP-1↝, 1, ATPase↓, 1, AXL↓, 3, Ca+2↓, 1, Ca+2↑, 20, i-Ca+2?, 1, mt-Ca+2↑, 1, CAFs/TAFs↓, 1, cal2↓, 1, cal2↑, 1, CCN2/CTGF↓, 1, Cdc42↓, 1, Cdc42↑, 1, DLC1↑, 1, E-cadherin↓, 2, E-cadherin↑, 8, EMMPRIN↓, 1, EMT↓, 20, EMT↝, 1, F-actin↓, 1, FAK↓, 11, fascin↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB4↓, 1, LAMs↓, 1, MALAT1↓, 2, MET↓, 2, p‑MET↓, 1, MMP-10↓, 1, MMP1↓, 2, MMP13↓, 2, MMP2↓, 22, MMP2↝, 1, MMP3↓, 1, MMP7↓, 4, MMP9↓, 38, MMPs↓, 10, MUC1↓, 1, MUC4↓, 1, N-cadherin↓, 8, PDGF↓, 3, Rac1↓, 1, Rho↓, 2, ROCK1↑, 1, Slug↓, 2, Smad1↝, 1, Snail?, 1, Snail↓, 2, TET1↑, 1, TGF-β↓, 7, TGF-β↑, 1, TGF-β↝, 1, TGF-β1↓, 1, TIMP1↓, 1, TIMP1↑, 4, TIMP2↓, 2, TIMP2↑, 5, TRIB3↑, 1, TumCI↓, 20, TumCMig↓, 19, TumMeta↓, 22, TumMeta↑, 1, TumPF↓, 1, Twist↓, 4, Tyro3↓, 1, uPA↓, 9, uPAR↓, 1, Vim↓, 6, Vim↑, 1, Zeb1↓, 3, ZEB2↓, 1, β-catenin/ZEB1↓, 16, β-catenin/ZEB1↑, 1, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21, angioG↑, 1, CD31/PECAM-1↓, 2, eNOS↓, 1, HIF-1↓, 2, Hif1a↓, 17, Hif1a↑, 3, NO↓, 3, NO↑, 2, VEGF↓, 34, VEGF↝, 1, VEGFR2/KDR/Flk1↓, 8,

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1, GLUT1↓, 3, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 2, MMP↓, 47, MMP↑, 1, MPT↑, 1, TRPM7↓, 2, TRPV1↑, 2, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↑, 2, CD44↓, 4, CD47↓, 1, CD8+↑, 2, p‑cDC2↓, 1, COX2/PTGS2↓, 25, COX2/PTGS2↝, 1, CXCL1↓, 1, CXCR4↓, 7, DR4↑, 4, FOXP3↓, 1, FOXP3↑, 1, ICAM-1↓, 2, IFN-γ↓, 2, IFN-γ↑, 1, IL1↓, 2, IL10↓, 1, IL10↑, 1, IL12↓, 2, IL18↓, 1, IL1β↓, 4, IL2↓, 2, IL2↑, 2, IL4↓, 2, IL4↑, 1, IL5↓, 1, IL6↓, 13, IL6↑, 1, IL6↝, 1, IL8↓, 5, Imm↑, 3, Imm↝, 2, Inflam↓, 15, M2 MC↓, 2, MCP1/CCL2↓, 2, NF-kB↓, 58, NF-kB↑, 1, NF-kB↝, 3, p‑NF-kB↑, 2, NK cell↑, 2, NLRP3↓, 2, NLRP3↑, 1, p65↓, 6, p‑p65↓, 1, PD-1↓, 1, PD-L1↓, 2, PD-L1↑, 1, PGE2↓, 7, PSA↓, 2, PSA↝, 1, RAGE↓, 1, T-Cell↑, 3, Th1 response↑, 1, TLR1↑, 1, TLR2↑, 1, TLR4↑, 1, TLR4↝, 1, TNF-α↓, 11, TNF-α↑, 3, TNF-α↝, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1, Treg lymp↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1, AR↓, 8, AR↝, 1, ER-α36↓, 1, ER(estro)↓, 1, cl‑PPARα↓, 1, PPARγ↓, 1, PPARγ↑, 3, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2, BioAv↓, 9, BioAv↑, 17, BioAv↝, 2, chemoR↓, 1, ChemoSen↓, 1, ChemoSen↑, 47, CompStab↓, 2, CompStab↑, 1, CompStab↝, 1, CYP1A1↓, 3, CYP1A2↓, 1, CYP1B1↑, 1, Dose?, 1, Dose↝, 21, Dose∅, 2, eff↓, 31, eff↑, 32, eff↝, 4, eff∅, 1, Half-Life↓, 6, Half-Life↑, 2, Half-Life↝, 5, MDR1↓, 3, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 6, P-gp/ABCB1↑, 1, P450↓, 1, RadioS↑, 17, selectivity?, 2, selectivity↑, 29, selectivity∅, 1, Synergy↑, 30, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, AR↓, 8, AR↝, 1, BMD↑, 1, BRCA1↑, 1, p‑BRCA1↑, 1, CEA↓, 1, EGFR↓, 11, EGFR↑, 1, EGFR↝, 1, p‑EGFR↓, 1, EZH2↓, 1, FOXM1↓, 2, HER2/EBBR2↓, 4, hTERT/TERT↓, 2, IL6↓, 13, IL6↑, 1, IL6↝, 1, LDH↓, 2, LDH↑, 2, Myc↓, 1, Myc↑, 1, NSE↓, 1, PD-L1↓, 2, PD-L1↑, 1, PSA↓, 2, PSA↝, 1, RAGE↓, 1, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11, antiNeop↑, 1, AntiTum↑, 7, cachexia↓, 1, cardioP↑, 1, chemoP↑, 11, chemoPv↑, 10, ChemoSideEff↓, 2, cognitive?, 1, cognitive↑, 2, hepatoP↑, 4, neuroP↑, 6, NP/CIPN↓, 1, OS↑, 4, PFS↑, 1, QoL↑, 2, radioP↑, 5, RenoP↑, 2, Risk↓, 3, toxicity?, 1, toxicity↓, 1, toxicity∅, 1, TumVol↓, 7, TumW↓, 3, Weight↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1, Bacteria↓, 1, Diar↓, 1, GutMicro↑, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 744

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 34, ARE↑, 2, Bil↑, 1, Catalase↓, 1, Catalase↑, 24, Fenton↓, 1, GCLC↑, 2, GCLM↑, 2, GPx↑, 16, GPx1↑, 1, GPx4↑, 4, GSH↑, 23, GSR↓, 1, GSR↑, 2, GSTs↓, 1, GSTs↑, 6, H2O2↓, 1, H2O2↑, 1, HDL↑, 1, HO-1↓, 1, HO-1↑, 16, Iron↓, 1, i-Iron↓, 1, Keap1↓, 2, lipid-P↓, 15, MDA↓, 18, MPO↓, 4, NOX↓, 1, NQO1↑, 2, NRF2↓, 1, NRF2↑, 26, RNS↓, 1, ROS↓, 51, ROS↑, 2, ROS∅, 1, SOD↓, 1, SOD↑, 30, SOD1↑, 2, SOD2↑, 1, TBARS↓, 1, Trx1↑, 1, VitC↑, 2, VitE↑, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1, IronCh↑, 2, TfR1/CD71↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1, compIII↑, 1, Insulin↑, 1, mtDam↓, 3,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 15-LOX/ALOX15↓, 1, 5LO↓, 2, ACSL4↓, 1, adiP↑, 1, ALAT↓, 6, AMPK↑, 8, p‑AMPK↑, 1, ATP↑, 1, cAMP↑, 2, FABP4↓, 1, glucose↓, 1, glucose↝, 2, GSK‐3β↓, 2, p‑GSK‐3β↑, 1, H2S↑, 1, HMG-CoA↓, 1, LDL↓, 1, NADPH↓, 2, SIRT1↑, 2, SIRT1∅, 1,

Cell Death(tgid=5) ⓘ

APAF1↓, 1, Apoptosis↓, 10, ASK1↓, 1, BAX↓, 7, BAX↑, 1, Bax:Bcl2↝, 1, Bcl-2↓, 1, Bcl-2↑, 5, Casp↓, 1, Casp12↓, 2, Casp3↓, 9, Casp3∅, 2, cl‑Casp3↓, 1, Casp6↓, 1, Casp9↓, 7, Casp9∅, 1, Cyt‑c↓, 2, Cyt‑c∅, 2, Fas↓, 1, Ferroptosis↓, 5, GranB/GZMB↓, 1, GRP58↓, 1, iNOS↓, 12, iNOS↑, 3, necrosis↓, 1, p38↓, 12, p‑p38↓, 7,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 5, Akt↝, 1, p‑Akt↑, 2, CREB↑, 1, ERK↓, 9, ERK↑, 5, p‑ERK↓, 3, p‑ERK↑, 3, HGF/c-Met↑, 1, p‑IKKα↓, 2, p‑IκB↓, 1, JNK↓, 30, JNK↑, 4, p‑JNK↓, 13, p‑JNK↑, 4, MAPK↓, 12, MAPK↑, 1, MAPK↝, 1, p‑MAPK↓, 2, MEK↓, 1, p‑MKK4↑, 1, Mst1↓, 1, mTOR↓, 1, mTOR↑, 2, p‑P70S6K↑, 1, PI3K↓, 1, PI3K↑, 2, p‑PI3K↑, 1, PKCδ↓, 1, STAT3↝, 1, STAT4↓, 1, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF4↓, 1, p‑cJun↓, 1, cMyc↓, 1, p‑cMyc↑, 1, FOXO↑, 1, FOXO3↑, 1, HDAC↓, 1, other↓, 1, other↑, 4, other↝, 7, RUNX2∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3, CHOP/DDIT3↑, 2, p‑eIF2α↓, 1, cl‑eIF2α↑, 1, ER Stress↓, 7, GRP78/BiP↓, 6, GRP78/BiP↑, 2, GRP94↑, 1, HSP70/HSPA5↑, 2, HSPs↑, 1, IRE1↓, 3, p‑PERK↑, 1, UPR↓, 1, XBP-1↓, 2,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3B↑, 1, LC3II↑, 1, p62↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 3, PARP∅, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1, neuroG↑, 1, STAT1↓, 1, TumCP↓, 2, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 4, AP-1↓, 3, ARG1/2↑, 1, Ca+2↓, 2, Ca+2↝, 1, COL1∅, 1, EMT↑, 1, heparanase↑, 1, MMP1↓, 1, MMP13↓, 1, MMP2↓, 1, MMP3↓, 1, MMP9↓, 5, TGF-β↓, 1, TGF-β↑, 2, TGF-β1↑, 1, TumCI↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, E-sel↓, 2, Hif1a↓, 1, NO↓, 9, NO↑, 1, TXA2↓, 1, VCAM-1↓, 4, VEGF↓, 2,

Barriers & Transport(tgid=15) ⓘ

BBB?, 1, BBB↑, 6, BBB↝, 1, BBB∅, 2, CLDN4↑, 1, GLUT2↑, 1, IBI↑, 1, MMP↓, 1, MMP↑, 7, MMP∅, 1, MUC19↓, 1, MUC2↓, 1, MUC5AC↓, 1, OCLN↑, 1, TJ↑, 2, TRPC1↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1, CB2 / CNR2↑, 1, CCL11↓, 1, CD4+↑, 1, COX1↓, 3, COX2/PTGS2↓, 18, CXCR4↓, 1, HMGB1↓, 1, ICAM-1↓, 4, IFN-γ↓, 3, IL1↓, 2, IL10↑, 5, IL12↓, 1, IL17↓, 2, IL18↓, 2, IL1β↓, 21, IL4↓, 3, IL4↑, 1, IL6↓, 23, IL8↓, 3, Imm↑, 5, Inflam?, 1, Inflam↓, 50, IRF3↓, 1, LPS↓, 1, Macrophages↓, 1, MCP1/CCL2↓, 1, MyD88↓, 2, NeuroI↓, 1, Neut↓, 1, NF-kB↓, 30, p‑NF-kB↓, 2, NLRP3↓, 6, p65↓, 1, p‑p65↓, 1, PGE2↓, 5, PGE2↑, 1, RAGE↓, 1, Th1 response↓, 2, Th17↓, 1, Th2↑, 2, TLR2↓, 1, TLR4↓, 7, TLR4∅, 1, TNF-α↓, 30, TRIF↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 8, BChE↓, 2, BDNF↑, 7, BDNF∅, 1, ChAT↑, 1, NGF↑, 1, PSD95↑, 2, SNAP25↑, 2,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, APP↓, 1, Aβ↓, 11, Aβ42↓, 1, BACE/β-secretase↓, 2, tau↓, 2, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1, GR↑, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 1, p‑PPARγ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12, BioAv↑, 7, BioAv↝, 9, Dose?, 1, Dose↑, 2, Dose⇅, 1, Dose↝, 6, eff↑, 7, eff↝, 1, GSTA1↑, 2, Half-Life↝, 5, P450↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6, ALP↓, 2, ALP∅, 1, AST↓, 6, BG↓, 2, Bil↑, 1, BP↓, 4, creat↓, 1, CRP↓, 3, IL6↓, 23, LDH↓, 3, LDH↑, 1, OCN∅, 1, RAGE↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3, antiAll↑, 5, AntiArt↑, 3, AntiCan↑, 4, AntiDiabetic↓, 1, AntiDiabetic↑, 4, antiPs↑, 1, AntiTum↑, 1, cardioP↑, 12, CardioT↓, 1, chemoP↑, 2, chemoPv↑, 1, cognitive↑, 15, diuretic↑, 1, hepatoP↓, 1, hepatoP↑, 16, Learn↑, 2, memory↑, 13, motorD↓, 1, motorD↑, 2, neuroP↑, 37, Obesity↓, 1, Pain↓, 2, radioP↑, 4, RenoP↑, 5, Strength↑, 1, Stroke↓, 4, toxicity?, 1, toxicity↓, 10, toxicity↝, 2, toxicity∅, 2, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, AntiP↑, 1, AntiViral↑, 4, Bacteria↓, 7, Diar↓, 1, GutMicro↑, 5, Inf↓, 1, Sepsis↓, 3,
Total Targets: 350

Scientific Paper Hit Count for: JNK, c-Jun N-terminal kinase (JNK)

9 Berberine
9 Curcumin
9 Luteolin
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Apigenin (mainly Parsley)
6 Shikonin
6 Thymoquinone
5 Silver-NanoParticles
5 Allicin (mainly Garlic)
5 Capsaicin
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Baicalein
4 Chlorogenic acid
4 Chrysin
4 Copper and Cu NanoParticles
4 Disulfiram
4 Gambogic Acid
4 Kaempferol
4 Licochalcone A
4 Magnolol
4 Magnetic Fields
4 Piperlongumine
3 Radiotherapy/Radiation
3 Cisplatin
3 Artemisinin
3 Betulinic acid
3 Carvacrol
3 chaetocin
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 isoorientin
3 Lycopene
3 Melatonin
3 Propolis -bee glue
3 Phenethyl isothiocyanate
3 Quercetin
2 Astragalus
2 Vitamin C (Ascorbic Acid)
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 brusatol
2 Thymol-Thymus vulgaris
2 Celastrol
2 Ursolic acid
2 Ferulic acid
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Juglone
2 Magnetic Field Rotating
2 Phenylbutyrate
2 Plumbagin
2 Resveratrol
2 Vitamin K2
1 1,8-Cineole
1 Camptothecin
1 Anethole/trans-Anethole
1 Berbamine
1 Bromelain
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Crocetin
1 Cucurbitacin
1 Sulforaphane (mainly Broccoli)
1 Dihydrocaffeic Acid
1 Bicalutamide
1 Cynaropicrin
1 Dandelion Root
1 Emodin
1 Eugenol
1 5-fluorouracil
1 Evodiamine
1 Ascorbyl Palmitate
1 Garcinol
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginkgetin
1 Graviola
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Linalool
1 Matrine
1 Morin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Parthenolide
1 Pterostilbene
1 Perilla
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:168  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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