MAPK Cancer Research Results

MAPK, mitogen-activated protein kinase: Click to Expand ⟱
Source: CGL-CS
Type:
Mitogen-activated protein kinases (MAPKs) are a group of proteins involved in transmitting signals from the cell surface to the nucleus, playing a crucial role in various cellular processes, including growth, differentiation, and apoptosis (programmed cell death).

MAPK Pathways: The MAPK family includes several pathways, the most notable being:
1.ERK (Extracellular signal-Regulated Kinase): Often associated with cell proliferation and survival.
2.JNK (c-Jun N-terminal Kinase): Typically involved in stress responses and apoptosis.
3.p38 MAPK: Associated with inflammatory responses and apoptosis.

Inhibitors: Targeting the MAPK pathway has become a strategy in cancer therapy. For example, BRAF inhibitors (like vemurafenib) are used in treating melanoma with BRAF mutations.
Altered Expression Levels:
Overexpression: Many cancers exhibit overexpression of MAPK pathway components, such as RAS, BRAF, and MEK. This overexpression can lead to increased signaling activity, promoting cell proliferation and survival.
Downregulation: In some cases, negative regulators of the MAPK pathway (e.g., MAPK phosphatases) may be downregulated, leading to enhanced MAPK signaling.
The expression levels of MAPK pathway components can serve as biomarkers for cancer diagnosis, prognosis, and treatment response. For example, high levels of phosphorylated ERK (p-ERK) may indicate active MAPK signaling and poor prognosis in certain cancers.

Numerous reports indicate that the MAPK pathway plays a major role in tumor progression and invasion, while inhibition of MAPK signaling reduces invasion.
Scientific Papers found: Click to Expand⟱
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3266- Lyco,    Effects of lycopene on number and function of human peripheral blood endothelial progenitor cells cultivated with high glucose
- in-vitro, Nor, NA
*p38↓, *MAPK↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
2533- M-Blu,  PDT,    Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells
- in-vitro, Lung, A549
MMP↓, p‑MAPK↑, ROS↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, eff↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4515- MAG,    Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↑, angioG↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, NF-kB↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
8715- MeJa,    Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells
- in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, memfluid↓, TNFR 1↑, MAPK↑, Casp8↑, MMP↓, Apoptosis↑, p38↑, ERK↑, Casp3↑,
6540- MeSal,    Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK
- in-vitro, CRC, HCT116
Apoptosis↑, p38↑, MAPK↑,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, Nor, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
3487- MF,  Rad,    High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
- Review, Var, NA
radioP↑, *Ca+2↑, RAS↑, MAPK↓,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
773- Mg,    Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells
- in-vitro, BC, MCF7
TRPM7↓, ROS↑, ER Stress↑, MAPK↑, ATP↓,
9089- MGF,    Mangiferin targeting HSP90α induces DNA damage in cutaneous squamous cell carcinoma via the ROS/MAPK signaling pathway
- in-vitro, SCC, NA
TumCP↓, Apoptosis↑, TumCCA↑, HSP90↓, ROS↑, mtDam↑, eff↓, toxicity↓, MAPK↑,
1890- MGO,    The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches
- Review, Var, NA
AntiCan?, TumCG↓, GAPDH↓, Apoptosis↑, TumCCA↑, MAPK↑, Bcl-2↓, MMP9↓, ChemoSen↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8671- MLT,    Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives
- Review, RCC, NA
OXPHOS↑, Warburg↓, ROS↑, Akt↓, mTOR↓, NF-kB↓, HIF-1↓, VEGF↓, MAPK↓, TumCG↓, angioG↓, TumCI↓, Apoptosis↑, TumAuto↑, Synergy↑, *toxicity↓,
8685- MLT,    Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
- vitro+vivo, RCC, 786-O
Synergy↑, Casp↑, LC3II↑, TumAuto↑, Apoptosis↑, MAPK↑, TumCG↓, MMP?, Bax:Bcl2↑,
8885- MOR,    Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
IL1β↓, IL18↓, IL6↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, uPAR↓, uPA↓, EMT↓, Fibronectin↓, N-cadherin↓, Vim↓, NLRP3↓, MAPK↓,
8944- MushCha,    Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑MAPK↓, p‑PI3K↓, p‑Akt↓, COX2/PTGS2↓, NF-kB↓,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4972- Nimb,    Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms
- Review, Var, NA
Apoptosis↑, TumCP↓, NF-kB↓, Wnt↓, PI3K↓, MAPK↓, JAK↓, STAT↓,
1225- OLST,    Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
- vitro+vivo, PC, NA
TumCMig↓, TumCI↓, Ferroptosis↑, MAPK↓,
8424- OM,    Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells
- in-vitro, CRC, HT-29
tumCV?, mTOR↓, P70S6K↓, Casp8↑, Casp9↑, p38↑, MAPK↑,
1811- Oxy,    Hyperbaric oxygen therapy and cancer—a review
- Review, Var, NA
toxicity∅, AntiTum↑, MAPK↑, ERK↓, ChemoSen↑, ChemoSen↑, RadioS↑,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,
1682- PBG,    Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
- Review, Var, NA
i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3252- PBG,    Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies
- Review, Nor, NA
*Inflam↓, *TNF-α↓, *NF-kB↓, *MAPK↓, *ERK↓, *antiOx↑, *NRF2↑, *cardioP↑, *Glycolysis↑, *Ca+2↓, *HO-1↑, *NRF2↑, *neuroP↑,
8982- PCorn,    Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways
- vitro+vivo, Pca, LNCaP
TumCP↓, cycD1/CCND1↓, TumCCA↑, Dose↝, TumCG↓, Ki-67↓, ERK↓, MAPK↓, Ingr↝, PSA↓,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
5217- PG,    Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells
- in-vitro, AML, THP1 - in-vitro, AML, Jurkat - in-vitro, AML, HL-60
tumCV↓, Casp3↑, Casp8↑, Casp9↑, P53↑, BAX↑, Fas↑, FasL↑, MAPK↑, NRF2↓, GSH↓,
9017- Phyco,    Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
eff↑, TumCP↓, Tumccf↓, TumCCA↑, cycE/CCNE↓, CDK2↓, P21↑, Apoptosis↑, γH2AX↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, TumCMig↓, TumCA↑, angioG↓, COX2/PTGS2↓, PGE2↓, MAPK↓, toxicity↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP/DDIT3↑, Dose↝,

Showing Research Papers: 201 to 250 of 311
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 311

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   antiOx⇅, 1,   Catalase↓, 6,   Catalase↑, 3,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GPx4↑, 1,   GSH↓, 21,   GSH↑, 5,   GSH/GSSG↓, 2,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 3,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 10,   Iron↓, 1,   Iron↑, 4,   Iron↝, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 8,   MDA↓, 3,   MDA↑, 6,   MPO↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 8,   NRF2↑, 13,   NRF2↝, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 131,   ROS⇅, 6,   ROS∅, 1,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 6,   SOD↑, 6,   SOD1↓, 1,   SOD2↓, 1,   TAC↓, 1,   TOS↑, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7,   CDC25↓, 7,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 3,   mtDam↑, 9,   OCR↓, 2,   OXPHOS↑, 2,   OXPHOS↝, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   adiP↑, 1,   AMPK?, 1,   AMPK↑, 14,   ATGL/PNPLA2↓, 1,   ATP↓, 9,   ATP↑, 1,   CAIX/CA9↑, 1,   DHODH↓, 1,   ECAR↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 12,   GSK‐3β↓, 3,   GSK‐3β↑, 6,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 3,   LDHA↓, 3,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 2,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PKM2↓, 5,   Pyruv↓, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SREBP2↓, 1,   TCA↓, 2,   TumCM/A↑, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 7,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 118,   mt-Apoptosis↑, 2,   ASC↓, 1,   BAD↑, 6,   Bak↑, 7,   BAX↑, 69,   Bax:Bcl2↑, 10,   Bcl-2↓, 70,   Bcl-xL↓, 14,   BID↓, 1,   BID↑, 6,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 26,   cl‑Casp↑, 1,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 65,   cl‑Casp3↑, 16,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 3,   Casp8↑, 20,   cl‑Casp8↑, 1,   Casp9↑, 51,   cl‑Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 49,   Diablo↑, 2,   DR5↑, 20,   FADD↑, 2,   Fas↓, 2,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 12,   Mcl-1↑, 1,   MDM2↓, 4,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 2,   p38↓, 6,   p38↑, 30,   p‑p38↓, 2,   p‑p38↑, 5,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 2,   survivin↓, 22,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 6,   XIAP↓, 13,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 91,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 13,   p‑Akt↑, 2,   AKT1↓, 1,   Akt2↓, 2,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 15,   EGFR↑, 1,   p‑EGFR↓, 2,   EphB4↓, 1,   ERK↓, 47,   ERK↑, 14,   ERK↝, 2,   p‑ERK↓, 9,   p‑ERK↑, 3,   p‑ERK⇅, 1,   FGFR1↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 3,   IGF-1R↓, 2,   IKKα↓, 5,   p‑IKKα↓, 2,   IR↓, 1,   JAK↓, 8,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 9,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 4,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 123,   MAPK↑, 75,   MAPK↝, 6,   p‑MAPK↓, 6,   p‑MAPK↑, 12,   MEK↓, 3,   p‑MEK↓, 2,   mTOR↓, 45,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 2,   NRAS↓, 1,   p42↑, 1,   p‑p42↑, 1,   p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 5,   PAK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 80,   PI3K↑, 3,   PI3K↝, 3,   p‑PI3K↓, 3,   PI3K/Akt↓, 3,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 3,   PTEN↑, 9,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 8,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 5,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 5,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 4,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 5,   CBP↓, 1,   cJun↓, 2,   cJun↑, 2,   cMyc↓, 12,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMTs↓, 3,   EZH2↓, 1,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 2,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   H4↓, 1,   H4↑, 2,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 10,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 2,   HDAC8↓, 1,   miR-107↑, 2,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-200b↑, 2,   miR-21↓, 6,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-330-5p↑, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-384↑, 1,   miR-422a↑, 2,   Myc↓, 1,   MYCN↓, 1,   NDRG1↑, 2,   OCT4↓, 3,   other↓, 3,   other↑, 3,   other↝, 2,   Shc↓, 1,   SOX2↓, 6,   SOX4↓, 1,   TCF-4↓, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 22,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 12,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 4,   p‑eIF2α↑, 1,   ER Stress↑, 23,   GRP78/BiP?, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 13,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↓, 1,   LAMP2↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 15,   LC3s↑, 1,   p62↓, 3,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 2,   TumAuto↑, 30,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   DNAdam↑, 34,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 6,   p16↑, 1,   P53↓, 1,   P53↑, 55,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↑, 26,   PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 6,   TOP2↓, 3,   TOP2↑, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 6,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 10,   CDK1↑, 3,   CDK2↓, 21,   CDK2↑, 2,   CDK4↓, 28,   CDK4↑, 2,   CDK6↓, 6,   CDK6↑, 3,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 36,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE/CCNE↑, 1,   E2Fs↓, 1,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   Ki-67↓, 14,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 34,   p27/CDKN1B↑, 17,   p‑pRB↓, 4,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 106,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   Axin2↑, 1,   BMP7/OP1↓, 1,   CD133↓, 4,   CD24↓, 2,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 16,   CSCsMark↓, 2,   Diff↓, 1,   Diff↑, 2,   FGF↓, 2,   FGF↑, 1,   Gli1↓, 1,   IGF-1↓, 9,   IGFBP1↑, 1,   IGFBP3↑, 2,   Jun↓, 2,   Ki-67↓, 14,   Let-7↑, 1,   mTORC1↓, 3,   Nanog↓, 4,   Nestin↓, 1,   NOTCH↓, 12,   NOTCH1↓, 5,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 3,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 31,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 81,   TumCP↑, 3,   TumCP∅, 1,   Wnt↓, 29,   Wnt↝, 1,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 2,   AP-1↓, 8,   AP-1↑, 3,   ATPase↓, 1,   AXL↓, 2,   Ca+2↓, 1,   Ca+2↑, 24,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 20,   EMT↓, 37,   EMT↑, 1,   F-actin↓, 2,   FAK↓, 14,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 2,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB4↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP11↓, 1,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 48,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 54,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 22,   MUC4↓, 1,   N-cadherin↓, 13,   NEDD9↓, 1,   NFAT↑, 1,   p44↑, 1,   p‑p44↑, 1,   PAK1↓, 1,   PDGF↓, 5,   Rac1↓, 2,   Rho↓, 4,   ROCK1↓, 2,   Slug↓, 3,   Smad1↝, 1,   SMAD3↓, 2,   Snail↓, 6,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 1,   TGF-β↓, 13,   TGF-β↑, 2,   TGF-β↝, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 1,   TIMP2↑, 4,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI↓, 46,   TumCMig↓, 36,   TumCMig↑, 1,   TumMeta↓, 44,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 3,   Vim↓, 17,   Vim↑, 1,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 47,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 24,   Hif1a↝, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 48,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 2,   CLDN1↑, 1,   EPR↑, 3,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 54,   MPT↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 5,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD8+↑, 1,   COX2/PTGS2↓, 39,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 3,   IL1↓, 6,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL5↓, 1,   IL6↓, 23,   IL8↓, 6,   Imm↑, 6,   Inflam↓, 21,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MDSCs↓, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 84,   NF-kB↑, 2,   NF-kB↝, 1,   NK cell↑, 5,   NLRP3↓, 4,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 6,   T-Cell↑, 1,   Th1 response↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 18,   TNF-α↑, 2,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 8,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 23,   BioAv↑, 27,   BioAv↝, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 78,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 20,   Dose∅, 2,   DrugR↓, 1,   eff↓, 20,   eff↑, 37,   eff↝, 6,   Half-Life↓, 9,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 11,   P450↓, 1,   RadioS↑, 23,   selectivity↑, 30,   selectivity∅, 1,   Synergy↑, 43,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALB↝, 1,   AR↓, 8,   ascitic↓, 1,   BG↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 15,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 6,   IL6↓, 23,   IRes↓, 1,   LDH↓, 2,   LDH↑, 1,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 6,   TP53↑, 2,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 34,   AntiCan?, 1,   antiCG↓, 1,   AntiDiabetic↑, 2,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 16,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 16,   chemoPv↑, 8,   ChemoSideEff↓, 5,   cognitive↑, 1,   hepatoP↑, 7,   neuroP↑, 6,   OS↑, 7,   Pain↓, 1,   QoL↑, 1,   radioP↑, 5,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 7,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 1,   TumW∅, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 816

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 66,   ARE↑, 3,   Bil↑, 2,   Catalase↑, 32,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 22,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 33,   GSR↓, 1,   GSR↑, 8,   GSTs↓, 1,   GSTs↑, 6,   H2O2↓, 3,   H2O2∅, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1↓, 1,   HO-1↑, 32,   hyperG↝, 1,   Keap1↓, 3,   lipid-P?, 1,   lipid-P↓, 28,   MDA↓, 29,   MPO↓, 5,   NQO1↑, 6,   NRF2↓, 3,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS↓, 82,   ROS↑, 2,   SOD↓, 1,   SOD↑, 45,   SOD1↑, 5,   SOD2↑, 2,   TAC↑, 8,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 4,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT?, 1,   ALAT↓, 5,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 11,   AMPK↝, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 1,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 4,   NADPH↑, 2,   SCFAs↑, 1,   SIRT1↑, 5,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 14,   BAD↓, 1,   BAX↓, 4,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp3?, 1,   Casp3↓, 15,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   Casp8↓, 3,   cl‑Casp8↓, 1,   Casp9↓, 5,   Casp9∅, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 3,   HEY1↑, 1,   iNOS↓, 22,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 7,   p38↑, 4,   p‑p38↓, 5,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 20,   Akt↝, 2,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 2,   EGFR↓, 2,   ERK↓, 8,   ERK↑, 8,   p‑ERK↓, 5,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IGF-1R↑, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 1,   p‑JNK↓, 6,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 70,   MAPK↑, 15,   MAPK↝, 4,   p‑MAPK?, 1,   p‑MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 3,   mTOR↝, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 15,   PI3K↝, 2,   PKA↑, 3,   PKCδ↓, 3,   PKCδ↑, 3,   PP2A↑, 1,   PTEN↓, 4,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   Src↓, 1,   p‑Src↑, 1,   STAT↓, 3,   STAT3↓, 4,   STAT3↝, 1,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   other↓, 2,   other↑, 3,   other↝, 5,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 2,   P53↓, 4,   P53↑, 1,   PARP↓, 1,   PARP∅, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   IGFBP3↑, 1,   Jun↓, 1,   neuroG↑, 3,   NOTCH↑, 1,   STAT1↓, 1,   TumCP↓, 2,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 5,   ARG1/2↑, 1,   Ca+2↓, 4,   Ca+2↑, 2,   Ca+2↝, 1,   Cartilage↑, 3,   COL1↓, 1,   FAK↑, 1,   p‑FAK↑, 1,   Fibrosis↓, 1,   heparanase↑, 1,   MLC2/MYL9↝, 1,   MMP2↓, 2,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 2,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   E-sel↓, 2,   eNOS↑, 2,   Hif1a↓, 1,   NO↓, 15,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB?, 1,   BBB↑, 16,   CLDN1↓, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↑, 8,   MUC19↓, 1,   MUC2↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 29,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↑, 9,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 32,   IL2↓, 1,   IL4↓, 4,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 1,   IL8↓, 7,   Imm↑, 2,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 86,   Inflam↑, 1,   IRF3↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   Neut↓, 1,   NF-kB↓, 70,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 13,   NLRP3↑, 1,   p65↓, 1,   p‑p65↓, 1,   PAF↓, 1,   PGE1↓, 1,   PGE2↓, 13,   RAGE↓, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th17↓, 1,   TLR1↓, 1,   TLR2↓, 3,   TLR4↓, 12,   TLR4↑, 1,   TNF-α↓, 45,   TNF-α↑, 2,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 4,   Ach↑, 2,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 2,   BDNF↑, 9,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 1,   NGF↑, 2,   TPH1↓, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 17,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   IDE↑, 1,   tau↓, 5,   p‑tau↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↓, 3,   PPARγ↑, 4,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25,   BioAv↑, 23,   BioAv↝, 12,   BioEnh↑, 2,   ChemoSen↑, 1,   CYP2D6↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 12,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 4,   P450↓, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 5,   ALP↓, 1,   anemia↓, 1,   AST↓, 5,   Bil↑, 2,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   BP↝, 1,   BUN↓, 1,   CEA↓, 1,   colonLen↑, 1,   CRP↓, 6,   EGFR↓, 2,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 5,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   RBC↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 8,   antiCG↑, 2,   AntiDiabetic↓, 1,   AntiDiabetic↑, 6,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 23,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 22,   diuretic↑, 2,   hepatoP↓, 1,   hepatoP↑, 22,   memory↑, 21,   motorD↑, 2,   Mucositis↓, 1,   neuroP↑, 59,   Obesity↓, 5,   Pain↓, 2,   radioP↑, 4,   RenoP↑, 7,   Risk↓, 1,   Strength↑, 2,   Stroke↓, 6,   toxicity?, 1,   toxicity↓, 13,   toxicity↝, 6,   toxicity∅, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 7,   Bacteria↓, 8,   Diar↓, 2,   GutMicro↑, 9,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 450

Scientific Paper Hit Count for: MAPK, mitogen-activated protein kinase
13 Quercetin
9 Thymoquinone
8 Allicin (mainly Garlic)
8 Berberine
8 Luteolin
7 Chlorogenic acid
7 Curcumin
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Chrysin
6 Fisetin
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Isovitexin
5 Betulinic acid
5 Propolis -bee glue
5 Emodin
4 Alpha-Lipoic-Acid
4 Cisplatin
4 Baicalein
4 Caffeic acid
4 Carvacrol
4 EGCG (Epigallocatechin Gallate)
4 isoorientin
4 Kaempferol
4 Lycopene
4 Magnolol
4 Resveratrol
3 beta-glucans
3 Boron
3 Copper and Cu NanoParticles
3 Sulforaphane (mainly Broccoli)
3 Piperine
3 Formononetin
3 Fucoidan
3 Gallic acid
3 Gambogic Acid
3 Garcinol
3 Hyperoside
3 Lactoferrin/Talactoferrin
3 Melatonin
3 Urolithin
3 Vitamin K2
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Chemotherapy
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Bromelain
2 Boswellia (frankincense)
2 brusatol
2 Carnosic acid
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Echinacea
2 Cynaropicrin
2 diet FMD Fasting Mimicking Diet
2 Disulfiram
2 Ellagic acid
2 Evodiamine
2 Ferulic acid
2 Flaxseed/Linseed
2 Ginseng
2 Honokiol
2 Isoliquiritigenin
2 Vitexin
2 Juglone
2 Naringin
2 Nimbolide
2 Oxygen, Hyperbaric
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Pterostilbene
2 Rutin
2 salinomycin
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 3-bromopyruvate
1 Silver-NanoParticles
1 Paclitaxel/Taxol
1 DTS(dibenzyl trisulphide) from Anamu
1 Bicarbonate(Sodium)
1 Astaxanthin
1 Baicalin
1 Berbamine
1 Benzyl isothiocyanate
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Mung Bean Sprouts
1 Capsaicin
1 Celastrol
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Deguelin
1 immunotherapy
1 Eurycomanone
1 Eugenol
1 Trastuzumab
1 Ginkgo biloba
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 Isobavachalcone
1 Inositol
1 isoquercitrin
1 Ivermectin
1 L-Theanine
1 Licorice
1 Linalool
1 Methylene blue
1 Photodynamic Therapy
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 Radiotherapy/Radiation
1 Magnetic Field Rotating
1 Magnesium
1 Mangiferin
1 Methylglyoxal
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Orlistat
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phycocyanin
1 Plumbagin
1 Rosmarinic acid
1 buckwheat sprouts
1 Salvia officinalis
1 Oxaliplatin
1 Sanguinarine
1 Selenium
1 Selenium NanoParticles
1 Shikonin
1 Terminalia bellirica
1 5-fluorouracil
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:181  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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