MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
5771- CAPE,  PBG,    Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
- in-vitro, HNSCC, NA
MMP↓, Casp3↑, survivin↓, XIAP↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5959- CEL,    Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-κB as a possible target
- in-vitro, Cerv, HeLa
Apoptosis↑, Casp8↑, Casp9↑, cl‑BID↑, MMP↓, NF-kB↑, Dose⇅, chemoPv⇅, COX2/PTGS2↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6630- CGA,    In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480
tumCV↓, DNAdam↑, mt-ROS↑, MMP↓, Casp3↑, eff↝,
7173- CHA,    Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations
- in-vitro, Lung, A549
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, CD47↓, *toxicity↓, MMP↓, Casp3↑, mtDam↓,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
7160- CHA,    Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
- in-vitro, Lung, A549
selectivity↑, eff↑, ROS↑, Apoptosis↓, HDAC↓, MMP↓, cl‑PARP↑, eff↑, eff↓, i-GSH∅,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
2804- CHr,  Rad,    Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway
- in-vitro, CRC, HT29
RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,
2806- CHr,  Se,    Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy
- in-vitro, Var, NA
ChemoSen↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓, *antiAll↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
2792- CHr,    Chrysin induces death of prostate cancer cells by inducing ROS and ER stress
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
DNAdam↑, TumCCA↑, MMP↓, ROS↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, PI3K↓, Akt↓, p70S6↓, MAPK↑,
1249- CHr,    Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes
- in-vitro, CLL, NA
ROS↑, MMP↓, ADP:ATP↑, Casp3↑, Apoptosis↑,
6631- Cic,    Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity.
- in-vitro, Nor, NA
*MMP↑, *BAX↓, *DNAdam↓, *Casp3↓, *NF-kB↓, *antiOx↑, *Inflam↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1579- Citrate,    Effect of Food Additive Citric Acid on The Growth of Human Esophageal Carcinoma Cell Line EC109
- in-vitro, ESCC, Eca109
TumCP↓, e-LDH↑, MMP↓, Ca+2?, PFK↓, Glycolysis↓,
4761- CoQ10,    Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE/RB, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, Nor, NA
*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6306- Cro,    Crocetin induces apoptosis of BGC-823 human gastric cancer cells
- in-vitro, GC, BGC-823
TumCP↓, MMP↓, Casp3↑, Cyt‑c↑,
6524- CRV,    d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells
- in-vitro, GC, AGS
ROS↑, MMP↝, JAK↓, STAT3↓, TumCD↑,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
6528- CRV,    D-carvone inhibits growth, migration, cell cycle at G0/G1 phase and induces apoptosis in A431 cells by disrupting mitochondrial membrane potential
- in-vitro, Melanoma, A431
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, TumCP↓,
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,
6176- Cu,    Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
- in-vitro, Liver, HepG2
ROS↑, P53↑, MMP↓, Bax:Bcl2↑, Apoptosis↑, *Bacteria↓, MDA↑, GSH↓, eff↓, Casp3↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, Var, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, Synergy↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
6189- Cuc,    Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, Cyt‑c↑, STAT3↓, Casp3↑, Casp9↑, MMP↓,

Showing Research Papers: 201 to 250 of 814
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 814

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 5,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 18,   Catalase↑, 4,   Ceru↓, 1,   Copper↑, 1,   CoQ10↝, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 4,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 17,   GSH↓, 76,   GSH↑, 7,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 7,   GSR↓, 2,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2?, 1,   H2O2↓, 1,   H2O2↑, 9,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 10,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 10,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   lipid-P↑, 32,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 13,   NADH↓, 5,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 20,   NRF2↑, 20,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   RNS↓, 1,   ROS?, 5,   ROS↓, 28,   ROS↑, 527,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 6,   m-ROS↑, 1,   mt-ROS↑, 16,   SOD↓, 22,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 3,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 5,   Trx↑, 2,   Trx1↓, 1,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 18,   TrxR↑, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2,   IronCh↑, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 3,   BCR↓, 1,   CDC2↓, 6,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 8,   compI↑, 1,   compII↓, 2,   compII↑, 1,   compIII↓, 5,   compV↓, 1,   EGF↓, 2,   ETC↓, 18,   ETC↝, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 2,   HTRA2/Omi/PARK13↑, 1,   IDH2↓, 1,   MFN2↓, 1,   mitResp↓, 9,   mitResp↑, 5,   MKK7↓, 1,   mRET↑, 1,   mtDam↓, 2,   mtDam↑, 56,   OCR↓, 20,   OCR↑, 1,   OXPHOS↓, 10,   OXPHOS↑, 4,   OXPHOS↝, 2,   OXPHOS∅, 1,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   p‑PDH↓, 2,   PGC-1α↑, 1,   PHB↑, 1,   PINK1↑, 6,   SDH↓, 1,   SIRT3↓, 3,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 1,   ACC↓, 1,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 2,   AMPK↓, 1,   AMPK↑, 33,   p‑AMPK↑, 4,   p‑AMT/GCST/T-protein↑, 1,   ANXA7↑, 2,   ATP↓, 60,   ATP↑, 3,   ATP↝, 1,   ATP∅, 1,   e-ATP↑, 1,   BHB↑, 1,   CAIX/CA9↓, 1,   DHODH↓, 2,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 6,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 18,   GlucoseCon↑, 1,   GlutMet↓, 1,   Glycolysis↓, 41,   GSK‐3β↓, 7,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK1↓, 1,   HK2↓, 29,   HMG-CoA↓, 2,   HMGCS2↑, 1,   lactateProd↓, 18,   lactateProd↑, 3,   LDHA↓, 11,   LDL↓, 4,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 3,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDKs↓, 6,   PFK↓, 8,   PFKP↓, 1,   PKM2↓, 15,   PKM2↑, 1,   PKM2∅, 1,   PPP↓, 1,   SCD1↓, 2,   SIRT1↓, 13,   SIRT1↑, 4,   SIRT2↓, 1,   SIRT2↑, 1,   SLC25A1↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 1,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 36,   AIF↝, 1,   APAF1↑, 12,   Apoptosis?, 4,   Apoptosis↓, 8,   Apoptosis↑, 385,   mt-Apoptosis↑, 4,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 21,   Bak↓, 1,   Bak↑, 15,   BAX↓, 4,   BAX↑, 189,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 57,   Bcl-2↓, 196,   Bcl-2↑, 2,   Bcl-2∅, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 41,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 15,   p‑BID↓, 1,   cl‑BID↑, 3,   BIM↓, 1,   BIM↑, 10,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 2,   BOK↑, 1,   Casp↓, 2,   Casp↑, 76,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 2,   Casp12↑, 11,   cl‑Casp12↑, 1,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 276,   cl‑Casp3↓, 2,   cl‑Casp3↑, 51,   proCasp3↓, 1,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 2,   Casp6↑, 2,   Casp7↑, 20,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 65,   Casp8∅, 2,   cl‑Casp8↑, 10,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 178,   cl‑Casp9↓, 1,   cl‑Casp9↑, 23,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 7,   Cupro↑, 2,   Cyt‑c↓, 4,   Cyt‑c↑, 243,   Cyt‑c↝, 1,   Diablo↑, 14,   DR5↑, 29,   Endon↑, 5,   FADD↑, 8,   Fap1↓, 2,   Fas?, 1,   Fas↓, 3,   Fas↑, 32,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 17,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 20,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   p‑MDM2↓, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 7,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 9,   NOXA↑, 3,   p38↓, 8,   p38↑, 27,   p‑p38↓, 2,   p‑p38↑, 5,   Paraptosis↑, 4,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 5,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 49,   TNFR 1↑, 3,   TRAIL↑, 8,   TRAIL⇅, 1,   TRAILR↑, 5,   TumCD↑, 46,   TUNEL↑, 1,   XIAP↓, 31,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 145,   Akt↑, 5,   p‑Akt↓, 37,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 1,   p‑cMET↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 9,   p‑ERK↓, 18,   p‑ERK↑, 7,   e-ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 1,   Hippo↓, 1,   Hippo↑, 1,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 3,   IKKα↑, 3,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 2,   JAK1↑, 2,   JAK2↓, 7,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 8,   MAP2K1/MEK1↓, 1,   MAPK↓, 32,   MAPK↑, 19,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 71,   mTOR↑, 1,   p‑mTOR↓, 14,   mTORC2↓, 3,   NRAS↓, 1,   p70S6↓, 3,   p‑p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 99,   PI3K↑, 3,   p‑PI3K↓, 6,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 12,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 18,   Raf↓, 6,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 15,   Src↑, 1,   STAT↓, 3,   STAT3↓, 61,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 3,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 12,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 6,   p‑cJun↑, 2,   cMyc↓, 20,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 7,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 26,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC6↓, 2,   HDAC8↓, 2,   HMTs↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-22↑, 2,   miR-34a↑, 4,   MTA2↓, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 12,   other↓, 7,   other↑, 9,   other↝, 12,   sonoS↑, 1,   SOX2↓, 11,   SOX4↓, 3,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 106,   tumCV↑, 1,   tumCV∅, 1,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 38,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   eIF2α↓, 1,   eIF2α↑, 9,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 3,   ER Stress↑, 71,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 24,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 8,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 12,   HSP90↑, 2,   HSPs↓, 1,   HTRA↓, 1,   IRE1↑, 6,   PDI↑, 1,   PERK↑, 13,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 17,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 3,   ATG5↑, 11,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 16,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 6,   LC3B-II↑, 3,   LC3II↑, 21,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↓, 1,   MitoP↑, 5,   p62↓, 11,   p62↑, 5,   PARK2↑, 5,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 71,   TumAuto⇅, 2,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 5,   BRCA1↓, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNA-PK↑, 2,   DNAdam↓, 5,   DNAdam↑, 121,   mt-DNAdam↑, 1,   DNArepair↓, 2,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 113,   P53↝, 2,   P53∅, 1,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype∅, 1,   PARP↓, 10,   PARP↑, 22,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 109,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 30,   POLD1↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1?, 1,   TOP1↓, 13,   TOP1∅, 1,   TOP2↓, 5,   TP53↓, 3,   TP53↑, 4,   TRF2↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 18,   CDK1↑, 2,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 38,   CDK2↑, 2,   CDK4↓, 43,   p‑CDK4↓, 1,   CDK6↓, 15,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   Chk2↓, 2,   Chk2↑, 3,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 23,   CycB/CCNB1↑, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 22,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   MAD↓, 1,   mitA↓, 1,   mitA↑, 2,   p19↑, 1,   P21?, 2,   P21↓, 5,   P21↑, 71,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 27,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 287,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 7,   ALDH1A1↓, 2,   BMI1↓, 1,   CD133↓, 9,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 7,   CSCs?, 1,   CSCs↓, 51,   Diff↓, 2,   Diff↑, 2,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 5,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 3,   PTCH1↓, 2,   Shh↓, 5,   Smo↓, 4,   TumCG?, 3,   TumCG↓, 139,   TumCG↑, 3,   TumCP↓, 183,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 29,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1,   AntiAg↓, 1,   AP-1↓, 6,   ASAP2↓, 1,   ATPase↓, 1,   ATPase↑, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 88,   Ca+2↝, 6,   i-Ca+2?, 1,   i-Ca+2↑, 5,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↑, 3,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 2,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 40,   EMT↓, 65,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 12,   p‑FAK↓, 3,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 2,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 4,   MET↓, 2,   MMP-10↓, 3,   MMP1↓, 3,   MMP13↓, 3,   MMP15↓, 1,   MMP2↓, 80,   MMP2↑, 1,   proMMP2↓, 1,   MMP3↓, 6,   MMP7↓, 8,   MMP9↓, 84,   MMP9↑, 1,   MMPs↓, 24,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 23,   PAK1↓, 3,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 27,   T-cadherin↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 3,   TIMP1↑, 8,   TIMP2↓, 5,   TIMP2↑, 8,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI?, 1,   TumCI↓, 70,   TumCI↑, 1,   TumCMig↓, 74,   TumCMig↑, 1,   TumMeta↓, 61,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 16,   uPA↓, 18,   uPA↝, 1,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 34,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 81,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   EGR1↑, 1,   Endoglin↑, 2,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 2,   NO↑, 8,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 81,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 6,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 13,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT4↓, 4,   IBI↑, 1,   memfluid↓, 1,   MMP?, 4,   MMP↓, 695,   MMP↑, 15,   MMP↝, 4,   MMP∅, 4,   MPT↑, 19,   NHE1↓, 2,   OCLN↑, 1,   SMCT1∅, 1,   sonoP↑, 1,   TJ↑, 1,   TRPM7↓, 2,   TRPV1↑, 8,   TRPV1↝, 1,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 17,   CD47↓, 2,   CD59↑, 1,   CD8+↑, 6,   cDC2↓, 1,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 61,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DCells↑, 1,   DR4↑, 9,   DR4∅, 1,   FOXP3↑, 2,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL12↑, 1,   IL17↓, 1,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   Imm↝, 2,   Inflam↓, 33,   IRAK1↓, 1,   IRAK4↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 131,   NF-kB↑, 12,   p‑NF-kB↓, 3,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 1,   p‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 17,   PSA↓, 9,   RAGE↓, 1,   RANTES?, 1,   SOCS-3↓, 1,   T-Cell↑, 3,   TCF↓, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TIGIT↓, 1,   TLR1↑, 1,   TLR4↓, 8,   TNF-α↓, 28,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 2,   pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,   TAMS↝, 1,   Temp∅, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 10,   AR↑, 2,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,   RANKL↓, 1,   SXR↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 35,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 157,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 1,   Dose?, 7,   Dose↓, 3,   Dose↑, 9,   Dose⇅, 2,   Dose↝, 61,   Dose∅, 18,   DrugR↓, 1,   eff↓, 120,   eff↑, 127,   eff↝, 18,   GSTA1↓, 1,   Half-Life↓, 10,   Half-Life↝, 12,   MDR1↓, 7,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 2,   selectivity↑, 167,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 105,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 10,   AR↑, 2,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BMD↑, 1,   BRCA1↓, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 9,   IL6↓, 37,   IL6↑, 1,   KRAS↓, 3,   LDH↓, 11,   LDH↑, 6,   LDH↝, 1,   e-LDH↑, 1,   i-LDH↓, 1,   Myc↓, 5,   PD-L1↓, 9,   PSA↓, 9,   PSADT↑, 1,   RAGE↓, 1,   TP53↓, 3,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 64,   antiNeop↑, 5,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 13,   chemoP↑, 29,   chemoPv↑, 27,   chemoPv⇅, 1,   ChemoSideEff↓, 3,   cognitive↑, 1,   fatigue∅, 1,   hepatoP↑, 11,   hepatoP∅, 1,   K17↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   Obesity↓, 2,   OS↑, 14,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 18,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 6,   TumNum↓, 1,   TumVol↓, 23,   TumVol↑, 1,   TumW↓, 9,   Weight↑, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 3,   GutMicro↑, 4,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 6,  
Total Targets: 1128

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 105,   i-antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 47,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 25,   GPx1↑, 3,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 41,   GSR↑, 7,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 5,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 25,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 32,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 24,   MDA↑, 2,   MPO↓, 6,   NADH↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↑, 51,   p‑NRF2↑, 1,   Prx↑, 2,   RNS↓, 2,   ROS?, 2,   ROS↓, 137,   ROS↑, 12,   ROS⇅, 1,   ROS∅, 8,   mt-ROS?, 1,   mt-ROS↓, 3,   SOD↓, 2,   SOD↑, 53,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 2,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   IronCh↝, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   compIV↑, 2,   DRP1/DNM1L↓, 2,   DRP1/DNM1L↑, 1,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN1↓, 1,   MFN2↓, 1,   MFN2↑, 2,   mitResp↓, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 1,   OCR↑, 3,   OPA1↓, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   PGC-1α↑, 9,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ALAT↓, 12,   ALDOA↑, 1,   AMPK↑, 14,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 15,   ATP∅, 1,   BMAL1↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 4,   glucose↝, 2,   GlucoseCon↑, 2,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GPI↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↑, 2,   KeyT↝, 1,   LDHA↑, 2,   LDL↓, 4,   lipidLev↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   PFKL↑, 2,   PFKM↑, 1,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↑, 11,   SIRT2↑, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 22,   Apoptosis∅, 1,   mt-Apoptosis↓, 1,   ASC↓, 1,   BAX↓, 12,   BAX↑, 5,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 7,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp↓, 1,   Casp1↓, 2,   cl‑Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 18,   Casp3↑, 6,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Casp9↑, 2,   cl‑Casp9↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 3,   Cyt‑c∅, 3,   Fas↑, 2,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 16,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 3,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 6,   p‑Akt↓, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 4,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   p‑PI3K↑, 1,   PTEN↑, 1,   Src↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↓, 2,   other↑, 7,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSPs↑, 2,   IRE1↓, 2,   PDI↓, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 4,   PARK2↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   p16↓, 1,   P53↓, 2,   P53↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↓, 3,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   IGFBP3↑, 1,   neuroG↑, 1,   TumCG↓, 2,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 3,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 3,   Cartilage↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 1,   PAI-1/SERPINE1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 4,   E-sel↓, 1,   Hif1a↑, 2,   NO↓, 8,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 14,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN5↓, 1,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 16,   MMP↑, 81,   MMP⇅, 1,   MMP↝, 2,   MMP∅, 4,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGCC↑, 1,   VGCC⇅, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL12↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 4,   IL12↓, 2,   IL17↓, 3,   IL18↓, 4,   IL1β↓, 21,   IL2↓, 2,   IL22↓, 1,   IL4↓, 3,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Inflam↓, 112,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 2,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 5,   NF-kB↓, 40,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 7,   p65↓, 1,   PAR-2↓, 1,   PGE2↓, 11,   PGE2↑, 1,   TLR1↓, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 29,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 4,   AChE↓, 20,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 11,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   NGF↑, 2,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 6,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   Estro↓, 1,   PPARα↑, 2,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 36,   BioAv↝, 15,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 2,   Dose⇅, 1,   Dose↝, 21,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 3,   AST↓, 14,   BG↓, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   BUN↓, 2,   creat↓, 6,   CRP↓, 4,   IL6↓, 19,   IL6↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 6,   LDH↑, 1,   NOS2↓, 2,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 19,   antiD↓, 1,   AntiDiabetic↑, 19,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 5,   ANXi↓, 1,   cardioP↓, 1,   cardioP↑, 35,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 24,   cough?, 1,   hepatoP↑, 31,   Learn↑, 4,   memory↑, 24,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 88,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   radioP↑, 5,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 1,   Stroke↓, 8,   toxicity↓, 40,   toxicity↑, 4,   toxicity↝, 9,   toxicity∅, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 8,   Bacteria↓, 20,   Diar↓, 1,   GutMicro↑, 13,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 517

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
32 Silver-NanoParticles
26 Quercetin
21 Betulinic acid
21 Capsaicin
18 Baicalein
18 Sulforaphane (mainly Broccoli)
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
16 Magnetic Fields
15 Apigenin (mainly Parsley)
15 Emodin
15 Shikonin
15 Thymoquinone
12 Luteolin
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Ivermectin
9 Magnolol
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Cisplatin
8 Dichloroacetate
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Morin
7 Radiotherapy/Radiation
7 Benzyl isothiocyanate
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Juglone
7 Linalool
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 doxorubicin
6 Beta-Caryophyllene
6 Carvacrol
6 Lycopene
6 Magnetic Field Rotating
6 Melatonin
6 Parthenolide
5 Allyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Rosmarinic acid
5 Diindolylmethane
5 Indole-3-carbinol
5 Eugenol
5 Ferulic acid
5 isoorientin
5 Vitexin
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Crocetin
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Isobavachalcone
4 Isorhamnetin
4 Licorice
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Isovitexin
3 Isothiocyanates
3 Boron
3 Thymol-Thymus vulgaris
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Paclitaxel/Taxol
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 isoquercitrin
3 Photodynamic Therapy
3 Matrine
3 Methyl Jasmonate
3 Mangiferin
3 Moringa oleifera
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Bullatacin
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Chlorella (Chlorella vulgaris)
2 Fenbendazole
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Methylene blue
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Nimbolide
2 Patchouli Oil (Pogostemon cablin)
2 Phycocyanin
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 carboplatin
1 isoflavones
1 itraconazole
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 1,8-Cineole
1 Lutein
1 methylseleninic acid
1 Moringin
1 Methylglyoxal
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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