MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
Source:
Type:
Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7808- IBC,    Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells
- in-vitro, Tong, Tca8113
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
8043- IVM,    Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, KYSE70 - in-vitro, ESCC, KYSE150
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, PAK1↓, ChemoSen↑, cl‑PARP↑, Casp3↑, TumMeta↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
4527- MAG,    Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, Eca109 - vitro+vivo, SCC, KYSE150
TumCP↓, TumCMig↓, MMP2↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑p38↓, TumCG↓,
8569- Matr,    Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway
- vitro+vivo, Cerv, NA
TumCG↓, Apoptosis↑, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, p38↓, TumCG↓, TumMeta↓,
8570- Matr,    Matrine suppresses invasion of castration-resistant prostate cancer cells by downregulating MMP-2/9 via NF-κB signaling pathway
- vitro+vivo, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, TumCMig↓, TumCI↓, MMP9↓, MMP2↓, p‑p65↓, NF-kB↓,
8576- Matr,    Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway
- vitro+vivo, CRC, NA
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑p38↓, TumMeta↓,
8542- Matr,    Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, p‑PI3K↓, CHK1↓, p‑Akt↓, Bcl-2↓, MTA1↓, Vim↓, MMP2↓, MMP9↓, γH2AX↑, E-cadherin↑, BAX↑, cl‑Casp3↑, Ki-67↓, TumCG↓,
8538- Matr,    Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling
- in-vitro, BC, MDA-MB-231 - ex-vivo, BC, MDA-MB-231
TumCP↓, Synergy↑, Apoptosis?, Bax:Bcl2↑, TumCI↓, MMP9↓, MMP2↓, Akt↓, NF-kB↓, VEGFR1↓, BioAv↝,
8530- Matr,    Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCI↓, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, EMT↓, PIP3↑, PTEN↑, p‑Akt↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8639- MBZ,    Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2 - in-vitro, AML, K562
ENOX2↓, MMP2↓, TumCI↓, RASSF1A↑, WFDC10A↑, METTL7A↑,
8640- MBZ,  GB,    Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231
Synergy↑, tumCV↓, EGFR↓, RCC1↓, MMP2↓, STAT4↓, IL6↓, IL1β↓, TNF-α↑, IFN-γ↓,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, Nor, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1/CCL2↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
3479- MF,    Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro Studies
- Review, Var, NA
*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,
3481- MF,    No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2
ITGA1∅, ITGB1∅, ITGA5∅, ITGB3∅, ITGB4∅, MMP2∅, MMP9∅, eff↑,
522- MF,    Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties
- in-vitro, Pca, PC3
MMP2↑, MMP9↑, miR-21↑, miR-155↑, miR-210↑, miR-200c↓, miR-126↓,
225- MFrot,  MF,    Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT
- vitro+vivo, Lung, NA
MMP2↓, MMP9↓, FOXP3↓, ROS↑, p‑Akt↓,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,

Showing Research Papers: 201 to 250 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 8,   Catalase↑, 2,   Copper↓, 1,   Copper↑, 1,   ENOX2↓, 1,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GSH↓, 21,   GSH↑, 4,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 2,   H2O2↑, 6,   HO-1↓, 11,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 10,   MDA↓, 4,   MDA↑, 2,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 11,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 150,   ROS⇅, 6,   ROS↝, 2,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 5,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 11,   CAIX/CA9↑, 1,   ECAR↓, 3,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 4,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlutMet↓, 2,   Glycolysis↓, 18,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK1↓, 1,   HK2↓, 8,   lactateProd↓, 9,   LDHA↓, 6,   LDL↓, 2,   NADPH↓, 3,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 8,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 9,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 7,   Bak↑, 7,   BAX↓, 2,   BAX↑, 80,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 92,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 25,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 2,   BIM↑, 4,   BNIP3↑, 2,   Casp↑, 23,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 100,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 15,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 65,   cl‑Casp9↑, 9,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 62,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 12,   DR5↑, 21,   Endon↑, 2,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 20,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↑, 5,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 8,   IAP2/BIRC3↓, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 21,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↓, 9,   p38↑, 8,   p‑p38↓, 5,   p‑p38↑, 3,   p‑p38↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 2,   survivin↓, 40,   TNFR 1↑, 3,   TRAIL↑, 3,   TRAILR↑, 3,   TumCD↑, 9,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 38,   AKT1↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↝, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 12,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 9,   IKKα↝, 1,   p‑IKKα↓, 2,   p‑IκB↓, 3,   JAK↓, 6,   p‑JAK↓, 1,   JAK1↓, 3,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 14,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 2,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 60,   mTOR↝, 2,   p‑mTOR↓, 10,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 94,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PKA↓, 1,   PKCδ↓, 11,   PTEN↓, 1,   PTEN↑, 24,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   RCC1↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   p‑Src↓, 2,   STAT↓, 4,   p‑STAT2↓, 1,   STAT3↓, 71,   STAT3↑, 2,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 4,   CBP↓, 1,   cJun↓, 8,   cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 7,   EZH2↓, 7,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   METTL7A↑, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-126↓, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 3,   miR-155↑, 1,   miR-17↓, 1,   miR-182-5p↓, 1,   miR-194↑, 1,   miR-195↑, 1,   miR-200b↑, 2,   miR-200c↓, 1,   miR-203↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 13,   other↓, 4,   other↑, 1,   other↝, 5,   other∅, 1,   PAX2↓, 1,   PhotoS↑, 1,   RASSF1A↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX9?, 1,   SOX9↓, 1,   SOX9↑, 1,   TCF-4↓, 1,   tumCV↓, 35,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 25,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 6,   TumAuto↓, 1,   TumAuto↑, 27,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 42,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 5,   P53?, 2,   P53↓, 2,   P53↑, 57,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 19,   cl‑PARP↑, 41,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 26,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 4,   TOP2↑, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 12,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 35,   CDK2↑, 2,   CDK4↓, 43,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 18,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   Ki-67↓, 17,   MAD↓, 1,   P21↓, 3,   P21↑, 43,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 24,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 118,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 2,   BMP2↓, 2,   BMPs↑, 1,   CD133↓, 8,   CD24↓, 3,   CD34↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 34,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 7,   HH↓, 7,   IGF-1↓, 6,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↑, 4,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 18,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 1,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 3,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 51,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 98,   TumCP↑, 4,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 38,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 2,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 30,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   p‑Cofilin↑, 2,   COL1↓, 3,   COL1A1↓, 1,   COL3A1↓, 2,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 70,   EMT↓, 98,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 15,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 10,   GIT1↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA1∅, 1,   ITGA5↓, 1,   ITGA5∅, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 10,   MMP13↓, 5,   MMP14↓, 1,   MMP16↓, 3,   MMP2?, 2,   MMP2↓, 322,   MMP2↑, 3,   MMP2⇅, 1,   MMP2↝, 2,   MMP2∅, 1,   proMMP2↓, 1,   MMP3↓, 11,   MMP7↓, 15,   MMP7∅, 1,   MMP9?, 2,   MMP9↓, 263,   MMP9↑, 3,   MMP9⇅, 1,   MMP9↝, 1,   MMP9∅, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 29,   MTA1↓, 2,   N-cadherin↓, 48,   NCAM↓, 1,   NCAM↑, 1,   PAK1↓, 2,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 6,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 2,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 40,   Snail↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 5,   TIMP1↑, 21,   TIMP2↓, 7,   TIMP2↑, 18,   TIMP3↑, 2,   TSP-1↑, 4,   TumCA↓, 5,   TumCA↑, 1,   TumCI↓, 123,   TumCI↑, 2,   TumCMig↓, 118,   TumCMig↑, 1,   TumMeta↓, 69,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 26,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 34,   uPAR↓, 6,   Vim?, 1,   Vim↓, 53,   Vim↑, 1,   Zeb1↓, 18,   ZEB2↓, 1,   ZEB2↑, 1,   α-SMA↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↓, 44,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74,   angioG↑, 1,   angioS↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 7,   Hif1a↓, 50,   Hif1a↑, 1,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 8,   NO↑, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 115,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 3,   CLDN2↓, 1,   EPR↑, 5,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 76,   MMP↑, 1,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   TRPM7↓, 3,   TRPV1↑, 3,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 14,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 79,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 13,   DR4↑, 8,   FOXP3↓, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 2,   IL12↓, 3,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 18,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↑, 2,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 19,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 2,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 128,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p50↓, 3,   p65↓, 13,   p‑p65↓, 4,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 24,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 34,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   PPARα↓, 2,   PPARα↑, 2,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 8,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 30,   BioAv↝, 9,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 100,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 6,   Dose↝, 29,   Dose∅, 8,   eff?, 1,   eff↓, 13,   eff↑, 41,   eff⇅, 1,   eff↝, 11,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 2,   RadioS↑, 35,   selectivity?, 1,   selectivity↑, 47,   Synergy?, 1,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALP↓, 2,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 4,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 4,   E6↓, 2,   E7↓, 2,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 12,   hTERT/TERT↓, 11,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 4,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 33,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 2,   AntiTum↑, 17,   cachexia↓, 3,   cardioP↑, 9,   chemoP?, 1,   chemoP↑, 20,   chemoPv↑, 14,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 5,   Pain↓, 1,   Pin1↓, 1,   radioP↑, 6,   RenoP↑, 6,   Risk↓, 6,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 12,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 1004

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 60,   Catalase↑, 20,   Copper↓, 1,   GPx↑, 17,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 21,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 23,   NRF2∅, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 71,   ROS∅, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 4,   Casp3?, 1,   Casp3↓, 6,   Casp3↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑LIMK1↑, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↑, 3,   PDGFR-BB↓, 1,   PI3K↑, 3,   PKCδ↑, 1,   PTEN↑, 1,   STAT3↓, 3,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 2,   other↝, 3,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 2,   Ki-67↓, 2,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   FGF↑, 2,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↝, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   Fibronectin↓, 1,   LAMs↑, 1,   p‑MLC2/MYL9↑, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP2↑, 6,   MMP3↓, 1,   MMP9↓, 7,   MMP9↑, 2,   MMPs↓, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   PAI-1/SERPINE1↓, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Smad1↑, 1,   Smad7↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↑, 1,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGF↑, 3,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   CLDN1↝, 1,   CLDN5↓, 1,   GastroP↑, 2,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 4,   OCLN↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 3,   IL10↓, 1,   IL10↑, 4,   IL12↓, 2,   IL17↓, 2,   IL1β↓, 12,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 5,   Imm↑, 11,   Inflam↓, 62,   Inflam↑, 1,   MCP1/CCL2↓, 3,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 29,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 21,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 4,   GABA↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   Estro↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 24,   BioAv↝, 14,   BioEnh↑, 2,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 1,   eff↑, 8,   Half-Life↓, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 3,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 3,   AST↓, 11,   BMD↑, 1,   BP↓, 2,   BUN↓, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 14,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 28,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↑, 7,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 21,   Learn↑, 1,   memory↑, 11,   motorD↑, 3,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 44,   Obesity↓, 5,   Pain↓, 4,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 17,   Diar↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 3,  
Total Targets: 321

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
14 Fisetin
14 Quercetin
10 Baicalein
10 Berberine
10 Matrine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Luteolin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Eugenol
6 Garcinol
6 Kaempferol
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Dandelion Root
5 Ellagic acid
5 Thymoquinone
4 Carvacrol
4 Chrysin
4 Formononetin
4 Magnolol
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Hydroxycinnamic-acid
3 Diindolylmethane
3 Emodin
3 Ferulic acid
3 Fucoidan
3 Gambogic Acid
3 Honokiol
3 Naringin
3 Nimbolide
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Boron
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Ginkgetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Hyperoside
2 mebendazole
2 Melatonin
2 Morin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Shikonin
1 1,8-Cineole
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Cisplatin
1 Aspirin
1 Aloe anthraquinones
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Zinc
1 Coenzyme Q10
1 Cucurbitacin
1 Ursolic acid
1 Cyclopamine
1 Cysteamine
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Sorafenib (brand name Nexavar)
1 Flaxseed/Linseed
1 5-fluorouracil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Juglone
1 Lactobacillus
1 gefitinib, erlotinib
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 tamoxifen
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Polyphenols
1 Parthenolide
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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