ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE/β-secretase↓,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE/β-secretase↓, *ATP↑, *neuroP↑,
4315- VitB2,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
*GlucoseCon↑, *ATP↑, *Hcy/homoC↓, *ROS↓, *Aβ↓, *Aβ↓, *Inflam↓,
4317- VitB5,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Ach↑, *ROS↓, *Inflam↓, *p‑tau↓, *Aβ↓, *Acetyl-CoA↑, *ATP↑, *ChAT↑, *memory↑,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,
3145- VitC,    Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect
- in-vitro, CRC, HCT116
Warburg↓, TumCG↓, Glycolysis↓, GlucoseCon↓, ATP↓, lactateProd↓, selectivity↑, GLUT1↓, PKM2↓, LDHA↓, mTOR↓,
1067- VitC,    Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
- in-vivo, CRC, NA
PDK1↓, Hif1a↓, GLUT1↓, ATP↓, MMP↓,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, NA, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
630- VitC,    Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress
- in-vitro, BC, MCF7 - in-vitro, BC, HT-29
TCA↑, ATP↓, NAD↓, H2O2↑, GSH/GSSG↓,
623- VitC,    The Involvement of Ascorbic Acid in Cancer Treatment
- Review, NA, NA
ROS↑, GLUT1↓, ATP↓,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
4090- VitK2,  ProBio,    Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
- Review, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *memory↑, *NF-kB↓, *ROS↓, *GSH↑, *ATP↑, *p‑tau↓, *cardioP↑, *other↝, *cognitive↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 201 to 217 of 217
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 217

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   ROS↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 11,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 3,   NAD↓, 2,   PDK1↓, 1,   PFK↓, 1,   PGK1↓, 1,   PGM1↓, 1,   PKM2↓, 2,   TCA↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Casp↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   necrosis↑, 1,   p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

OV6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   EMT↓, 1,   EpCAM↓, 1,   ERK↑, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Rho↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,   SVCT-2∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 1,   eff↓, 1,   eff↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   OS↑, 2,   Risk↓, 1,   toxicity∅, 1,  
Total Targets: 59

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GSH↑, 2,   ROS↓, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↑, 1,   G6PD↑, 1,   GlucoseCon↑, 2,   NADPH↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 3,   other↝, 2,  

Migration(tgid=13) ⓘ

APP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChAT↑, 1,   p‑tau↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6,   BACE/β-secretase↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 2,   memory↑, 3,   neuroP↑, 2,   Risk↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
11 3-bromopyruvate
9 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
6 Berberine
6 Citric Acid
6 Resveratrol
6 Shikonin
5 Silver-NanoParticles
5 Alpha-Lipoic-Acid
5 Graviola
5 Quercetin
5 salinomycin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Curcumin
4 EGCG (Epigallocatechin Gallate)
4 Emodin
4 Hydrogen Gas
4 Melatonin
4 Urolithin
3 2-DeoxyGlucose
3 Apigenin (mainly Parsley)
3 Propolis -bee glue
3 immunotherapy
3 Crocetin
3 Copper and Cu NanoParticles
3 diet FMD Fasting Mimicking Diet
3 Honokiol
3 Isoliquiritigenin
3 Luteolin
3 Metformin
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
3 Ursolic acid
2 Radiotherapy/Radiation
2 Allicin (mainly Garlic)
2 DTS(dibenzyl trisulphide) from Anamu
2 chaetocin
2 Chrysin
2 Cucurbitacin
2 Diclofenac
2 Docosahexaenoic Acid
2 Chemotherapy
2 Ginkgo biloba-EGb 761
2 Formononetin
2 Galloflavin
2 Ginkgo biloba
2 Gossypol/AT-101
2 Pachymic acid
2 Phenethyl isothiocyanate
2 Thymoquinone
2 Vitamin B5,Pantothenic Acid
2 Vitamin K2
1 Sorafenib (brand name Nexavar)
1 cetuximab
1 Anthocyanins
1 Auranofin
1 Acetyl-l-carnitine
1 Andrographis
1 doxorubicin
1 Artemisinin
1 Aloe anthraquinones
1 Betulinic acid
1 Boron
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Carvacrol
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Cichoric acid / Chicoric acid
1 Dichloroacetate
1 Disulfiram
1 Electrical Pulses
1 Ferulic acid
1 Ginseng
1 Cisplatin
1 hydrogen sulfide
1 Hyperthermia
1 Isobavachalcone
1 Inositol
1 isoquercitrin
1 Ivermectin
1 Methylene blue
1 MCToil
1 Magnesium
1 Methylglyoxal
1 Pterostilbene
1 Radio Frequency
1 EMF
1 SonoDynamic Therapy UltraSound
1 triptolide
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B2,Riboflavin
1 Arsenic trioxide
1 probiotics
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:21  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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