NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2/PTGS2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
1410- CUR,    Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway
- vitro+vivo, OS, MG63
tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT/SLC7A11↓, ROS↑, MDA↑, GSH↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2/PTGS2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, Var, NA
*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, ChemoSen↑, OS↓, chemoP↑,
6421- CUR,    Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1/PGC-1α pathway
- in-vivo, Nor, NA
*SIRT1↓, *PGC-1α↑, *NRF2↑, *DRP1/DNM1L↓, *Sepsis↓, *OS↑, *cardioP↑,
6213- CUR,    Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A Review
- Review, Var, NA
*antiOx↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *NF-kB↓, *NRF2↑, *Wound Healing↑, *eff↑,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *CompStab↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, Synergy↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *Synergy↑, Synergy↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6232- CUR,  Rad,  Chemo,    The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review
- Review, Var, NA
*VEGF↑, *Wound Healing↓, *NRF2↑, *Catalase↑, *SOD↑, *GSH↑, *ROS↓,
6225- CUR,    Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance
- Review, Var, NA
ox-Trx1↑, TrxR1↓, TrxR↓, ROS↑, GSH/GSSG↓, eff↓, Fenton↑, H2O2↑, *NRF2↑, *Keap1↓, *HO-1↑, *NQO1↑, ChemoSen↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6210- CUR,    Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
- in-vitro, Var, NA
Ferroptosis↑, *Ferroptosis↓, ROS↑, Fenton↑, *IronCh↑, GPx4↓, MDA↑, GSH↓, *NRF2↑, *HO-1↑,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2/PTGS2↑, *NF-kB↓, *ICAM-1↓, *MCP1/CCL2↓, *HO-1↑, CXCc↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
9103- CV,  Cisplatin,    Protective Impacts of Chlorella vulgaris on Cisplatin-Induced Toxicity in Liver, Kidney, and Spleen of Rats: Role of Oxidative Stress, Inflammation, and Nrf2 Modulation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *hepatoP↑, *RenoP↑, *NRF2↑, *antiOx↑, *Dose↝, *Ingr↝, *uricA↓, *creat↓, *MDA↓, *NO↓, *TNF-α↓, *IL6↓, *IL12↓,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
7451- CYN,    Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Apoptosis↑, TumCMig↓, TumCI↓, ERK↓, NF-kB↓, ROS↓, HO-1↑, NRF2↑, Bcl-2↓, NF-kB↓, other↝,
7450- CYN,    Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
PKM2↓, P53↑, PARP↓, TumCCA↑, selectivity↑, DNAdam↑, NRF2↓, NQO1↓, TrxR↓, Trx↓, ROS↑, MMP↓, Cyt‑c↑, Casp3↑, Apoptosis↑,
7441- CYN,    Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway
- in-vitro, Nor, NA
*ROS↓, *NRF2↑, *Inflam↓, *IL6↓, *TNF-α↓, *AhR↑, *NQO1↑,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,
6259- Cyste,    Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases
- Review, AD, NA - Review, Park, NA
*ROS↓, *neuroP↑, *BDNF↑, *NRF2↑, *BBB↑, *HSPs↑, *GSH↑, *TG2/TGase↓, Aβ↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, Var, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
8843- DIM,    3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis
- in-vitro, NSCLC, NA
tumCV↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, EMT↓, Ferroptosis↑, Iron↑, ROS↑, MDA↑, GSH↓, AhR↓, NRF2↓, GPx4↓, MMP↓, eff↓,
8853- DIM,    Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies
- Review, Var, NA
AhR↓, NRF2↑, *ROS↓, *p‑BRCA1↑, *COX2/PTGS2↓, CYP19↓, uPA↓, VEGF↓, MMP9↓, TumCMig↓, FOXM1↓, mTOR↓, Akt↓, radioP↑, ATM?, BioAv↑, BioAv↓, Dose↝, BioAv↑, Half-Life↝,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
5007- DSF,  Cu,    Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
- vitro+vivo, Oral, NA
AntiTum↑, TumCP↓, Ferroptosis↑, Iron↑, lipid-P↑, NRF2↓, HO-1↓,
5009- DSF,  Cu,    Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines
- vitro+vivo, lymphoma, NA
AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,
5006- DSF,  Cu,    Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
- vitro+vivo, lymphoma, NA
TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
3217- EGCG,    Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke
- in-vivo, Stroke, NA
*angioG↑, *neuroG↑, *NRF2↑,
3221- EGCG,    EGCG upregulates phase-2 detoxifying and antioxidant enzymes via the Nrf2 signaling pathway in human breast epithelial cells
- in-vitro, Nor, MCF10
*antiOx↑, *GSTA1↑, *NRF2↑,
3220- EGCG,    Dual Roles of Nrf2 in Cancer
- in-vitro, Lung, A549
NRF2↑, eff↓,
3219- EGCG,    Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling
- in-vitro, Lung, A549
ROS↑, RNS↓, MMP↓, NRF2↑, Keap1↓,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, Synergy↑, NRF2↑, HO-1↑,
3216- EGCG,    Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation
- in-vitro, Colon, Caco-2
NRF2↑, TumCP↓, mt-ROS↓, Keap1↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3209- EGCG,    Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1
- in-vitro, Diabetic, NA
*NRF2↑,
3210- EGCG,    Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells
- in-vitro, Nor, NA
*ROS↓, *NRF2↑, *Catalase↑, *antiOx↑,
3211- EGCG,    Antioxidation Function of EGCG by Activating Nrf2/HO-1 Pathway in Mice with Coronary Heart Disease
- in-vivo, CardioV, NA
*cardioP↑, *VEGF↓, *MMP2↓, *SOD↑, *ROS↓, *HO-1↑, *NQO1↑, *NRF2↑,
3212- EGCG,    EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells
- in-vitro, Lung, A549 - in-vivo, Lung, NCIH23
NRF2⇅, ChemoSen↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,
3213- EGCG,  Rad,    Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy
- in-vitro, CRC, HCT116
RadioS↑, TumCP↓, NRF2↑,
3214- EGCG,    EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway
- in-vitro, Nor, MRC-5 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
mTOR↓, AMPK↑, selectivity↑, ROS↑, selectivity↑, HO-1↓, *NRF2↑, NRF2↓, *HO-1↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
1974- EGCG,    Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes
- in-vitro, Nor, NA
*ROS↓, *NO↓, *MMP↑, *i-Ca+2↓, *HO-1↑, *Catalase↑, *NRF2↑, *Trx1↑, *antiOx↑, *SOD↑, *Apoptosis↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,

Showing Research Papers: 201 to 250 of 687
Prev Page 5 of 14 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 687

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 9,   ARE↓, 1,   ARE↑, 2,   ARE/EpRE↑, 1,   Catalase↓, 13,   Catalase↑, 11,   Copper↑, 1,   Fenton↑, 5,   frataxin↑, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 2,   GPx1⇅, 1,   GPx4↓, 30,   GSH↓, 47,   GSH↑, 12,   i-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 3,   GSTs↓, 2,   GSTs↑, 5,   GSTs↝, 1,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 33,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 1,   Iron↑, 19,   i-Iron↓, 1,   i-Iron↑, 3,   Keap1↓, 6,   Keap1↑, 4,   Keap1↝, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 23,   MDA↓, 5,   MDA↑, 20,   i-MDA↑, 1,   MPO↓, 2,   NADH↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX↑, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 8,   NQO1↑, 16,   NRF2↓, 119,   NRF2↑, 129,   NRF2⇅, 4,   NRF2↝, 7,   NRF2∅, 3,   p‑NRF2↓, 2,   p‑NRF2↑, 2,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↓, 1,   ROS?, 2,   ROS↓, 40,   ROS↑, 204,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 15,   SOD1↓, 1,   SOD1↑, 4,   SOD2↓, 8,   SOD2↑, 3,   T-SOD↓, 1,   Trx↓, 3,   Trx↑, 3,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR↑, 1,   TrxR1↓, 3,   TrxR1↑, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 9,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 2,   ETC↓, 5,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ACC-α↓, 1,   ACC1↓, 2,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 3,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 12,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlutMet↓, 2,   Glycolysis↓, 24,   GSK‐3β↓, 8,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK2↓, 13,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 6,   PCK1↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 6,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 4,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 2,   Apoptosis↓, 3,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   p‑ASK1↑, 1,   BAD↑, 3,   Bak↑, 3,   BAX↓, 4,   BAX↑, 63,   BAX↝, 2,   Bax:Bcl2↑, 13,   Bcl-2↓, 61,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 11,   Bcl-xL↝, 1,   BID↑, 4,   BIM↑, 6,   BNIP3↑, 2,   Casp↑, 20,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 3,   Casp3↓, 2,   Casp3↑, 66,   Casp3↝, 1,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 16,   Casp8∅, 2,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 9,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 55,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 20,   Fas↑, 11,   FasL↑, 5,   Ferroptosis↑, 38,   GranB/GZMB↝, 1,   GSDMD↑, 2,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   ICAD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↑, 4,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 11,   p‑p38↓, 2,   p‑p38↑, 3,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 4,   RIP3↑, 1,   survivin↓, 27,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 16,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 93,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 24,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↑, 1,   EF-1α↓, 1,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 22,   ERK↑, 6,   p‑ERK↓, 4,   p‑ERK↑, 3,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   HRAS↓, 1,   IKKα↓, 5,   IR↓, 1,   IκB↓, 2,   JAK↓, 3,   JAK↝, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 2,   JNK↑, 14,   JNK↝, 1,   p‑JNK↑, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 16,   MAPK↑, 17,   MAPK↝, 3,   p‑MAPK↑, 2,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 58,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 7,   p‑mTOR↑, 1,   mTORC2↓, 1,   p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 73,   PI3K↑, 4,   PI3K↝, 3,   p‑PI3K↓, 6,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKCδ↓, 6,   PKCδ↑, 1,   PTEN↓, 3,   PTEN↑, 15,   PTEN↝, 2,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 7,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   RIP1↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 10,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 53,   STAT3↑, 1,   p‑STAT3↓, 6,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 24,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 4,   DNMT3B↓, 1,   DNMTs↓, 11,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 5,   p‑FOXO3↓, 3,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 29,   HDAC↑, 1,   HDAC1↓, 6,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   KLF4↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-140↑, 1,   miR-155↓, 2,   miR-19b↓, 1,   miR-200c↑, 2,   miR-206↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 2,   OCT4↓, 11,   other?, 1,   other↓, 3,   other↑, 5,   other⇅, 1,   other↝, 9,   PhotoS↑, 1,   RUNX2↓, 1,   SOX2↓, 8,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 2,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 32,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 4,   ER Stress↑, 37,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   ac‑HSP90↑, 1,   HSPs↑, 1,   IRE1↑, 2,   NQO2↑, 1,   PERK↑, 7,   p‑PERK↑, 1,   UPR↑, 10,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 6,   p62↑, 3,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 28,   DNAdam⇅, 1,   DNArepair↓, 1,   m-FAM72A↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   P53?, 1,   P53↓, 4,   P53↑, 62,   P53↝, 3,   p‑P53↑, 3,   PARP↓, 4,   PARP↑, 10,   cl‑PARP↓, 2,   cl‑PARP↑, 37,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   SIRT6↓, 2,   Telomerase↓, 8,   TOP1↓, 2,   TOP2↓, 3,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 4,   CDK2↓, 28,   CDK2↑, 2,   CDK4↓, 28,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 40,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 12,   cycE/CCNE↑, 2,   Ki-67↓, 15,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 44,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 16,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 112,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 2,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 4,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 25,   Diff↑, 2,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 15,   Let-7↑, 1,   mTORC1↓, 4,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 3,   NOTCH2↑, 1,   NOTCH3↓, 2,   SCF↓, 1,   Shh↓, 5,   Smo↓, 3,   STAT1↓, 3,   TAZ↓, 1,   TumCG↓, 42,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 88,   TumCP↑, 4,   Wnt↓, 27,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AP-1↓, 9,   AP-1↑, 2,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 15,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 26,   EMT↓, 52,   EMT↝, 1,   FAK↓, 12,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 3,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP2⇅, 1,   MMP2↝, 1,   MMP3↓, 7,   MMP7↓, 9,   MMP9↓, 51,   MMP9↑, 2,   MMP9⇅, 1,   MMPs↓, 22,   N-cadherin↓, 20,   NFAT↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 6,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 7,   Smad1↓, 2,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 17,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 9,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCMig↓, 47,   TumMeta↓, 37,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 18,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 7,   α-SMA↓, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 56,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 54,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 73,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 3,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT4↓, 1,   MMP↓, 60,   MMP↑, 2,   MPT↑, 1,   TRPV1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 6,   DR4↑, 6,   Eos↑, 1,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 6,   IL10↓, 2,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   IL8↓, 10,   IL8↑, 1,   Imm↑, 6,   Imm↝, 2,   INF-γ↑, 1,   Inflam↓, 19,   Inflam↑, 1,   M1↓, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NAF1↓, 3,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 99,   NF-kB↑, 4,   NF-kB↝, 3,   p‑NF-kB↑, 1,   NK cell↑, 5,   NK cell⇅, 1,   NLRP3↓, 3,   NLRP3↑, 5,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 13,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   Th2↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 23,   TNF-α↑, 1,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↑, 1,   pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 8,   AR↝, 1,   COMT↑, 1,   CYP19↓, 1,   ER-α36↓, 4,   ER(estro)↓, 1,   Estro↝, 1,   FGF21↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 4,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 26,   BioAv↑, 28,   BioAv↝, 9,   BioEnh?, 1,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 118,   ChemoSen⇅, 1,   CYP1A1↓, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 26,   Dose∅, 2,   eff↓, 24,   eff↑, 47,   eff↝, 8,   eff∅, 1,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 9,   MDR1↓, 6,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P450↓, 3,   P450↝, 1,   RadioS↓, 2,   RadioS↑, 36,   selectivity?, 1,   selectivity↑, 45,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 76,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 8,   AR↝, 1,   AST↓, 2,   BP↓, 1,   BRAF↝, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 2,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   PSADT↑, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 1,   AntiCan↑, 30,   AntiCan∅, 2,   antiNeop↑, 2,   AntiTum↑, 18,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 2,   chemoP↑, 31,   chemoPv↑, 15,   ChemoSideEff↓, 5,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 6,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 8,   Pain↓, 3,   PFS↑, 1,   QoL↑, 5,   radioP↑, 13,   Remission↑, 1,   RenoP↑, 9,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 984

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 6,   antiOx↑, 194,   ARE↓, 1,   ARE↑, 15,   ARE↝, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 115,   Catalase↝, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 82,   GPx↝, 1,   GPx1↑, 3,   GPx4↓, 2,   GPx4↑, 12,   GPx4∅, 1,   GSH↓, 4,   GSH↑, 143,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 2,   GSR↑, 11,   GSS↑, 2,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 18,   H2O2↓, 11,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 5,   HO-1↑, 208,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   Keap1↓, 23,   Keap1↑, 1,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P↓, 81,   lipid-P↑, 4,   mt-lipid-P↓, 1,   MDA↓, 120,   MDA↑, 2,   MPO↓, 20,   MPO↑, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 7,   NQO1↑, 56,   NQO1↝, 2,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 18,   NRF2↑, 440,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 2,   p‑NRF2↑, 2,   ONOO↓, 1,   Prx↑, 4,   RNS↓, 4,   ROS?, 1,   ROS↓, 324,   ROS↑, 11,   ROS⇅, 4,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 167,   SOD↝, 1,   SOD1↑, 11,   SOD2↓, 1,   SOD2↑, 7,   TAC↑, 25,   TBARS↓, 6,   Thiols↑, 1,   TOS↓, 1,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↑, 3,   TrxR1↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 2,   FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 16,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 3,   EGF↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 17,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   3MST/MPST↑, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 3,   ACSL4∅, 1,   ALAT↓, 32,   ALDOC↑, 1,   AMPK↓, 2,   AMPK↑, 26,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 15,   Buty↑, 1,   cAMP↑, 3,   CBS↑, 1,   CRM↑, 3,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 3,   G6PD↑, 2,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 6,   Glycolysis↑, 3,   GSK‐3β↓, 24,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 6,   H2S↑, 3,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 12,   lipidLev↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 11,   NADPH↑, 9,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   SCFAs↑, 2,   SIRT1↓, 2,   SIRT1↑, 24,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   Apoptosis↓, 47,   Apoptosis↑, 2,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 23,   BAX↑, 3,   Bax:Bcl2↓, 7,   Bcl-2↓, 4,   Bcl-2↑, 20,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 39,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 9,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 12,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 2,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 21,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 53,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 3,   Pyro↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 29,   Akt↝, 1,   p‑Akt↑, 6,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 11,   ERK↑, 10,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↑, 2,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 10,   JNK↑, 2,   p‑JNK↓, 6,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 29,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 5,   p‑mTOR↓, 3,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 6,   PI3K↑, 24,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 3,   p‑PTEN↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3↓, 8,   STAT3↑, 2,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 9,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 15,   GRP78/BiP↓, 9,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↓, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 2,   p62↑, 6,   PARK2↑, 3,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 12,   DNArepair↑, 1,   P53↓, 4,   PARP↓, 1,   PARP∅, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 3,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   CHIP↑, 1,   Choline↑, 1,   Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 3,   Ki-67↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 9,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 3,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 11,   AP-1↓, 3,   AP-1↑, 1,   mt-ATPase↑, 1,   Ca+2↓, 11,   Ca+2↑, 2,   Ca+2↝, 3,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 2,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 1,   Na+↑, 1,   NFAT↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 9,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   ECM/TCF↑, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 37,   NO↑, 4,   TXA2↓, 1,   VCAM-1↓, 11,   VEGF↓, 5,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 43,   BBB↝, 1,   BBB∅, 2,   CLDN1↑, 2,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 24,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 9,   IFN-γ↓, 8,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 5,   IL10↓, 11,   IL10↑, 14,   IL12↓, 5,   IL12↑, 1,   IL17↓, 8,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 99,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 1,   IL6↓, 97,   IL6↑, 4,   IL8↓, 14,   Imm↓, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 248,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 11,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 3,   NeuroI↓, 8,   NF-kB↓, 146,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 39,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 23,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 2,   Th2↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 139,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 6,   Ach↑, 9,   AChE↓, 45,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 47,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↓, 1,   GABA↑, 3,   GDNF↑, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 9,   PSD95↑, 6,   RELN↑, 1,   SNAP25↑, 3,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 5,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 9,   Aβ↓, 54,   Aβ42↓, 6,   BACE/β-secretase↓, 25,   IDE↑, 2,   PSEN1/PS1↓, 1,   tau↓, 12,   p‑tau↓, 20,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 3,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   GR↝, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv?, 1,   BioAv↓, 44,   BioAv↑, 49,   BioAv↝, 32,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 39,   eff↓, 8,   eff↑, 40,   eff↝, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 18,   Half-Life∅, 1,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 32,   ALB↑, 1,   ALP↓, 6,   AR↓, 1,   AST↓, 33,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 4,   BP↓, 8,   BP↝, 2,   BP∅, 1,   p‑BRCA1↑, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   colonLen↑, 2,   creat↓, 13,   CRP↓, 10,   Ferritin↑, 2,   IL6↓, 97,   IL6↑, 4,   IRes↑, 1,   IRes↝, 1,   LDH↓, 12,   LDH↑, 3,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 3,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   Analgesic↑, 2,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 6,   AntiCan↑, 22,   antiCG↑, 2,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 8,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 79,   CardioT↓, 3,   chemoP↑, 19,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 86,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 3,   hepatoP↑, 73,   Learn↑, 14,   memory↑, 76,   Mood↑, 4,   motorD↓, 1,   motorD↑, 11,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 184,   NP/CIPN↓, 3,   Obesity↓, 17,   OS↑, 9,   Pain↓, 6,   QoL↓, 1,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 36,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 18,   toxicity?, 1,   toxicity↓, 32,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 11,   Bacteria↓, 19,   Diar↓, 3,   GutMicro↑, 35,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 7,  
Total Targets: 786

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
45 Sulforaphane (mainly Broccoli)
29 Curcumin
23 Luteolin
23 Quercetin
23 Thymoquinone
22 Resveratrol
19 Lycopene
17 EGCG (Epigallocatechin Gallate)
15 Shikonin
14 brusatol
14 Fisetin
13 Chemotherapy
13 Hydrogen Gas
13 Licochalcone A
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Baicalein
11 doxorubicin
11 Ashwagandha(Withaferin A)
10 Cisplatin
10 Apigenin (mainly Parsley)
10 Chrysin
10 isoorientin
9 Silver-NanoParticles
9 Selenite (Sodium)
9 Artemisinin
9 Radiotherapy/Radiation
9 Selenium
8 Vitamin C (Ascorbic Acid)
8 Phenethyl isothiocyanate
8 Boron
8 Chlorogenic acid
8 Propolis -bee glue
8 Isoliquiritigenin
8 Kaempferol
8 Morin
8 Pterostilbene
8 Rosmarinic acid
7 Carnosic acid
7 Hyperoside
7 Piperlongumine
6 Allyl isothiocyanate
6 Allicin (mainly Garlic)
6 Berberine
6 Beta-Caryophyllene
6 Isothiocyanates
6 Honokiol
6 Isovitexin
5 Benzyl isothiocyanate
5 Betulinic acid
5 Boswellia (frankincense)
5 Crocetin
5 isoquercitrin
5 Melatonin
5 Mushroom Lion’s Mane, Hericium erinaceus
4 5-fluorouracil
4 Selenium NanoParticles
4 Vitexin
4 Matrine
4 Urolithin
3 Astaxanthin
3 Berbamine
3 xanthohumol
3 Brucea javanica
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cichoric acid / Chicoric acid
3 Cynaropicrin
3 Diindolylmethane
3 Disulfiram
3 Copper and Cu NanoParticles
3 Emodin
3 Ferulic acid
3 Gallic acid
3 Ginger/6-Shogaol/Gingerol
3 Ginkgetin
3 Linalool
3 Lutein
3 Magnetic Fields
3 Parthenolide
2 1,8-Cineole
2 Auranofin
2 Lapatinib
2 Thymol-Thymus vulgaris
2 methotrexate
2 Cinnamon
2 Carvone
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Cysteamine
2 Eugenol
2 Ginkgo biloba
2 Ginseng
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Isorhamnetin
2 Licorice
2 Magnolol
2 methylseleninic acid
2 Metformin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Nimbolide
2 salinomycin
2 Taurine
1 Andrographis
1 Docetaxel
1 Baicalin
1 Biochanin A
1 Cannabidiol
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 Celastrol
1 chaetocin
1 chitosan
1 Calorie Restriction Mimetics
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Ursolic acid
1 Spirulina(Arthrospira/Limnospira)
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gossypol/AT-101
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 iodine
1 Juglone
1 lambertianic acid
1 Modified Citrus Pectin
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Moringin
1 Mangiferin
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Myricetin
1 Oleuropein
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phenolic Acids
1 Piperine
1 Plumbagin
1 Polyphenols
1 Sulfasalazine
1 Oxygen, Hyperbaric
1 irinotecan
1 acetazolamide
1 Salvia miltiorrhiza
1 Spermidine
1 erastin
1 Terminalia bellirica
1 Terpenoids
1 triptolide
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page