| Source: |
| Type: Proapototic |
| cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. P21 is a cyclin-dependent kinase inhibitor that plays a crucial role in regulating the cell cycle. It is encoded by the CDKN1A gene and is a key player in the cellular response to stress, including DNA damage. P21 is often considered a tumor suppressor because its expression is upregulated in response to p53 activation, a well-known tumor suppressor protein. When DNA damage occurs, p53 can activate the transcription of the CDKN1A gene, leading to increased levels of P21, which helps prevent the proliferation of damaged cells. In many cancers, the p53 pathway is disrupted, leading to decreased levels of P21. p21 is a apoptotic marker protein. Cell cycle arrest gene p21 |
| 5104- | SK, | Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression. |
| - | in-vitro, | GC, | AGS |
| 5339- | TFdiG, | Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line |
| - | in-vitro, | CRC, | HCT116 |
| 3413- | TQ, | Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase |
| - | in-vitro, | CRC, | HCT116 |
| 3401- | TQ, | Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review |
| - | Review, | Var, | NA |
| 3397- | TQ, | Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer |
| - | Review, | CRC, | NA |
| 3427- | TQ, | Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets |
| 3423- | TQ, | Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics |
| - | Review, | Var, | NA |
| 3421- | TQ, | Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer |
| - | Analysis, | Nor, | NA | - | in-vivo, | Nor, | NA | - | in-vitro, | BC, | MCF-7 | - | in-vitro, | Nor, | HaCaT |
| 4565- | TQ, | Thymoquinone in the clinical treatment of cancer: Fact or fiction? |
| - | Review, | BC, | NA |
| 2112- | TQ, | Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells |
| - | in-vitro, | BC, | MCF-7 |
| 2124- | TQ, | Thymoquinone: an emerging natural drug with a wide range of medical applications |
| - | Review, | Var, | NA |
| 2122- | TQ, | Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer |
| - | Review, | Var, | NA |
| 2119- | TQ, | Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant |
| - | Review, | Var, | NA |
| 2129- | TQ, | doxoR, | Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells |
| - | in-vitro, | BC, | MCF-7 |
| 2097- | TQ, | Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells |
| - | in-vitro, | Cerv, | HeLa |
| 2095- | TQ, | Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis |
| - | Review, | Var, | NA |
| 2100- | TQ, | Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant |
| - | Review, | NA, | NA |
| 2102- | TQ, | A review on therapeutic potential of Nigella sativa: A miracle herb |
| - | Review, | Var, | NA |
| 2103- | TQ, | Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells |
| - | in-vitro, | PC, | Hs766t | - | in-vitro, | PC, | MIA PaCa-2 |
| 2105- | TQ, | Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation |
| - | in-vitro, | PC, | AsPC-1 | - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | PC, | Hs766t | - | in-vivo, | NA, | NA |
| 2411- | UA, | Ursolic acid in health and disease |
| - | Review, | Var, | NA |
| 5017- | UA, | Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells |
| - | in-vitro, | Cerv, | INT-407 | - | in-vitro, | CRC, | HCT116 |
| 5022- | UA, | Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks |
| - | Review, | Var, | NA |
| 4857- | Uro, | Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study |
| - | in-vitro, | ESCC, | KYSE-30 |
| 4839- | Uro, | Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner |
| - | in-vitro, | Pca, | 22Rv1 | - | in-vitro, | Pca, | LNCaP |
| 4841- | Uro, | Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells |
| - | in-vitro, | CRC, | HT29 | - | in-vitro, | CRC, | SW480 | - | in-vitro, | CRC, | SW-620 |
| 4845- | Uro, | The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells |
| - | in-vitro, | Colon, | HCT116 |
| 4848- | Uro, | OXA, | Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells |
| - | in-vitro, | Colon, | HCT116 |
| 628- | VitC, | Mg, | Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation |
| - | in-vivo, | Colon, | CT26 | - | in-vitro, | NA, | MCF-7 | - | in-vitro, | NA, | SkBr3 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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