P21 Cancer Research Results

P21, P21/CDKN1A: Click to Expand ⟱
Source:
Type: Proapototic
cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli.
P21 is a cyclin-dependent kinase inhibitor that plays a crucial role in regulating the cell cycle. It is encoded by the CDKN1A gene and is a key player in the cellular response to stress, including DNA damage.
P21 is often considered a tumor suppressor because its expression is upregulated in response to p53 activation, a well-known tumor suppressor protein. When DNA damage occurs, p53 can activate the transcription of the CDKN1A gene, leading to increased levels of P21, which helps prevent the proliferation of damaged cells.
In many cancers, the p53 pathway is disrupted, leading to decreased levels of P21. p21 is a apoptotic marker protein.
Cell cycle arrest gene p21
Field Suggested Entry
Target CDKN1A / p21 / p21Cip1/Waf1
Full Name Cyclin-dependent kinase inhibitor 1A
Target Class CIP/KIP-family cyclin-dependent kinase inhibitor
Main Binding Partners CDK2, CDK1, CDK4/6, cyclin complexes, PCNA
Primary Biology p53-mediated cell-cycle arrest, DNA damage response, senescence, differentiation, CDK inhibition, RB/E2F pathway suppression, apoptosis regulation
Cancer Relevance High but context-dependent: p21 can suppress tumor growth through cell-cycle arrest and senescence, but can also support apoptosis resistance, senescent-cell survival, and therapy resistance in some tumors
AD Relevance Medium: indirect relevance through neuronal cell-cycle re-entry, senescence, p53 stress signaling, and aging-related cell-cycle dysregulation
Therapeutic Direction Context-dependent. Restore/activate p21 for tumor-suppressive arrest where appropriate; inhibit or bypass p21 where it promotes apoptosis resistance, senescent-cell survival, or treatment resistance.


Scientific Papers found: Click to Expand⟱
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
8402- LT,    Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
- vitro+vivo, CRC, T24/HTB-9
tumCV↓, TumCCA↑, p‑S6↓, P21↑, Trx1↑, ROS↓, Ki-67↓, mTOR↓, TumCP↓,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1/CCND1↓, P21↑, Hif1a↓, Glycolysis↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8519- MAG,    Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
- vitro+vivo, Gall, NA
TumCG?, TumCCA↑, mt-Apoptosis↑, P53↑, P21↑, cycD1/CCND1↓, CDC25↓, CDK2↓, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, cl‑PARP↑,
8497- MAG,    Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, *TumCCA↑, *ROS↑, *MMP↓, *Cyt‑c↑, *AIF↑, *BAX↑, *P21↑, *P53↑, *Bcl-2↓, *CycB/CCNB1↓, *CDK1↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4536- MAG,    Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
- in-vitro, Liver, HepG2 - in-vivo, CRC, COLO205
AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
4518- MAG,  Cisplatin,    Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells
- in-vitro, GC, MKN45
ChemoSen↑, tumCV↓, BAX↑, Bcl-2↓, P21↑, P53↑, MMP9↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8636- MBZ,    Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer
- in-vivo, Ovarian, SKOV3
TumCG?, P53↑, P21↑, Synergy↑, Dose↝,
8641- MBZ,  ONC201,    The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma
- in-vitro, GBM, NA
TumCCA↑, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Synergy↑, ChemoSen↑,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
8742- MeSA,    Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells
- in-vitro, Pca, DU145
TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, p27/CDKN1B↑, P21↑, Apoptosis↑, Akt↓, ERK↓,
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
487- MF,    Extremely Low-Frequency Electromagnetic Fields Cause G1 Phase Arrest through the Activation of the ATM-Chk2-p21 Pathway
- in-vitro, NMSC, HaCaT
ATM↑, Chk2↑, P21↑, TumCCA↑,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
9156- MG, MIC-1,    Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors
- in-vitro, neuroblastoma, SH-SY5Y
TumCG↓, TumCCA↑, P53↑, P21↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, NF-kB↓,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,
8910- MO,    Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study
- vitro+vivo, lymphoma, NA
TumCP↓, MMP↓, TumCCA↑, P53↑, P21↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↑, Apoptosis↑, MEK↓, ERK↓,
8897- MOR,    Morin promotes prostate cancer cells chemosensitivity to paclitaxel through miR-155/GATA3 axis
- vitro+vivo, Pca, DU145 - in-vitro, Pca, PC3
tumCV↓, GATA3↑, ChemoSen↑, Dose↝, miR-155↓, MMP?, Casp3↑, Casp9↑, P21↑, BAD↑, Bcl-xL↓, STAT3↓,
8898- MOR,    Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells
- in-vitro, Cerv, HeLa
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, WEE1↑, CDK1↓, CDC25↓, survivin↓, CycB/CCNB1↓, Chk2↓, BAX↑, BAD↑, Cyt‑c↑, APAF1↑, Casp9↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, Casp10↑, PARP↑, PI3K↑, Akt↑, mTOR↑, p70S6↑, Diablo↑, Bcl-2↓, Bcl-xL↓, AMPK↓, IAP1↓, NF-kB↓, ROS↑,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
8774- MSM,    Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells
- in-vitro, Oral, YD-38
P21↑, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, Cyt‑c↑, TumCCA↑,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27/CDKN1B↑,
1797- NarG,    Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway
- in-vitro, BC, MDA-MB-231
TumCG↓, β-catenin/ZEB1↓, AntiTum↑, Apoptosis↑, TumCCA↑, P21↑, survivin↓,
1311- NarG,  Rad,    Naringenin sensitizes lung cancer NCI-H23 cells to radiation by downregulation of akt expression and metastasis while promoting apoptosis
- in-vitro, Lung, H23
tumCV↓, ROS↑, Casp3↑, p‑Akt↓, Akt↓, MMP2↓, P21↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Vim↓, Slug↓, E-cadherin↑, CSCs↓, P21↑, survivin↝, OCT4↑, Nanog↑, SOX4↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8427- OM,    Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
- in-vitro, BC, MDA-MB-231
tumCV↓, Dose↝, mitA↑, Apoptosis↑, TNF-α↑, Casp3↑, Casp8↑, cl‑PARP↑, survivin↓, p53 Wildtype↓, P21↑, ac‑H3↑, ac‑H4↑, γH2AX↑, DNAdam↑, TumCCA↑,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,

Showing Research Papers: 201 to 250 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 4,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 2,   GSH↓, 21,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↑, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 12,   HO-2↓, 1,   Iron↓, 1,   i-Iron↑, 1,   lipid-P↓, 6,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 4,   MPO↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 20,   NRF2↝, 1,   PAO↑, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 21,   ROS↑, 159,   ROS⇅, 8,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD↓, 5,   SOD↑, 6,   SOD1↑, 2,   SOD2↓, 2,   SOD2↑, 1,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 3,   TrxR↑, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 8,   CDC2↑, 1,   CDC25↓, 19,   CDC25↑, 1,   compI↓, 1,   compIII↓, 1,   EGF↓, 3,   ETC↓, 3,   HSP60/HSPD1↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 14,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5-HETE↓, 1,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 2,   ALAT↝, 1,   ALDOA↓, 1,   AMPK↓, 2,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 9,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 5,   G6PD↓, 1,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   Glycolysis↓, 17,   GSK‐3β↓, 11,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 1,   HK2↓, 12,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd∅, 1,   LDHA↓, 5,   LDL↓, 3,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PKM2↓, 9,   polyA↓, 1,   p‑S6↓, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 2,   SSAT↑, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 7,   Apoptosis?, 2,   Apoptosis↓, 6,   Apoptosis↑, 153,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASK1↑, 1,   BAD↑, 11,   Bak↑, 8,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 2,   BAX∅, 1,   Bax:Bcl2↑, 35,   Bcl-2↓, 95,   Bcl-2↑, 6,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 36,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 1,   BTG3↑, 1,   Casp↑, 28,   Casp1↑, 3,   Casp10↑, 2,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 116,   Casp3↝, 2,   cl‑Casp3↑, 23,   proCasp3↓, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 15,   cl‑Casp7↑, 2,   Casp8↑, 29,   Casp8∅, 1,   cl‑Casp8↑, 6,   proCasp8↓, 1,   Casp9↑, 78,   cl‑Casp9↑, 10,   proCasp9↓, 2,   cFLIP↓, 3,   Cyt‑c↓, 2,   Cyt‑c↑, 67,   Cyt‑c↝, 4,   mt-Cyt‑c↓, 1,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 16,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 7,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 6,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 11,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 11,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 13,   MDM2↑, 1,   necrosis↑, 1,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↑, 4,   PUMA↓, 1,   PUMA↑, 7,   RIP3↑, 1,   survivin↓, 47,   survivin↝, 1,   TRAIL↑, 7,   TRAILR↑, 1,   TumCD↑, 13,   TUNEL↑, 1,   XIAP↓, 20,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 83,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 25,   p‑Akt↑, 1,   AKT1↓, 2,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 3,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 33,   ERK↑, 6,   p‑ERK↓, 8,   p‑ERK↑, 2,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 2,   IKKα↓, 5,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 5,   p‑JAK2↓, 1,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 6,   JNK↑, 23,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 26,   MAPK↑, 10,   MAPK↝, 2,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 46,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p‑p42↓, 1,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 4,   P90RSK↓, 1,   PDGFR-BB↓, 2,   PI3K↓, 58,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3K/mTOR/ETS2↓, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKCδ↓, 7,   p‑PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 16,   PTEN↝, 2,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   S6K↓, 1,   Sp1/3/4↓, 9,   Src↓, 2,   STAT↓, 2,   STAT3↓, 47,   STAT3↑, 2,   p‑STAT3↓, 6,   STAT5↓, 2,   STAT6↓, 1,   STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↑, 2,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 1,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 4,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 3,   p‑H3↑, 1,   ac‑H3↑, 8,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 6,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 31,   HDAC1↓, 8,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 5,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   IRF1↑, 1,   miR-106b↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-29b↑, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 7,   MYCN↓, 1,   MYCN↑, 1,   OCT4↓, 9,   OCT4↑, 1,   OLIG2↓, 1,   other?, 1,   other↑, 1,   other↝, 6,   PAX2↓, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 2,   SOX9↓, 2,   SUV39H↓, 2,   TCF-4↓, 2,   TET3↑, 1,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 30,   GRP78/BiP↓, 2,   GRP78/BiP↑, 10,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 4,   PERK↑, 4,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   p62↓, 3,   p62↑, 3,   TumAuto↓, 2,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   ATR↑, 3,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 56,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 10,   MDMX↓, 1,   MSH2↑, 1,   p16↑, 6,   P53↓, 6,   P53↑, 134,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 56,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 29,   PCNA↝, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 2,   TOP2↓, 7,   TP53↓, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 11,   p‑γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 21,   CDK1↑, 4,   p‑CDK1↓, 2,   CDK2↓, 61,   CDK2↑, 1,   CDK4↓, 71,   CDK4↑, 2,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 24,   CDK6↑, 3,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 2,   cellSen↑, 1,   CHK1↓, 4,   CHK1↑, 4,   Chk2↓, 4,   Chk2↑, 6,   p‑Chk2↑, 1,   Cyc↓, 6,   Cyc↝, 1,   cycA1/CCNA1↓, 22,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 116,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 45,   cycE/CCNE↑, 1,   cycE/CCNE↝, 1,   cycE1↓, 1,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   GADD45A↑, 4,   Ki-67↓, 18,   mitA↑, 1,   p19↑, 1,   P21?, 2,   P21↓, 22,   P21↑, 316,   P21↝, 2,   p‑P21↑, 1,   p27/CDKN1B↓, 8,   p27/CDKN1B↑, 86,   pRB↓, 4,   pRB↑, 3,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   cl‑RB1↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 219,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 3,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 2,   cFos↓, 7,   CSCs↓, 22,   Diff↑, 3,   EIF4E↓, 1,   EP300↑, 1,   EP4/PTGER4↑, 1,   Gli1↓, 3,   HH↓, 1,   HMGCR↓, 2,   IGF-1↓, 7,   IGFBP3↑, 3,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 18,   Let-7↑, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH1↓, 8,   NOTCH2↑, 1,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↑, 1,   TumCG?, 2,   TumCG↓, 60,   TumCG↑, 1,   TumCP↓, 119,   TumCP↑, 1,   TumCP⇅, 1,   Wnt?, 1,   Wnt↓, 24,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 13,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 20,   Ca+2↝, 1,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↓, 1,   cal2↑, 2,   Cdc42↑, 1,   COL1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 22,   EMT?, 1,   EMT↓, 39,   F-actin↓, 1,   FAK↓, 9,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   ITGA5↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 2,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 48,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 61,   MMP9↑, 1,   MMPs↓, 17,   MUC4↓, 2,   N-cadherin↓, 13,   p44↓, 1,   p‑p44↓, 1,   PAK1↓, 1,   PDGF↓, 5,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 9,   SMAD3↓, 1,   SMAD3↑, 1,   SMAD4↑, 1,   Snail↓, 15,   TET1↑, 2,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 46,   TumCI↑, 1,   TumCMig↓, 43,   TumMeta↓, 43,   TumMeta↑, 5,   Twist↓, 17,   TXNIP↑, 1,   uPA↓, 13,   uPAR↓, 1,   Vim↓, 22,   Zeb1↓, 9,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 44,   angioG↑, 2,   CD31/PECAM-1↓, 2,   Endoglin↑, 2,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 39,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 1,   NO↑, 4,   VCAM-1↓, 2,   VEGF↓, 62,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 76,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SVCT-2↝, 1,   TRPM7↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD44↓, 13,   CD59↑, 1,   CD8+↑, 1,   cDC2↓, 6,   COX1?, 1,   COX1↓, 3,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCR4↓, 8,   DCells↑, 1,   DR4↑, 4,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   Igs↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL4↑, 3,   IL6↓, 19,   IL6↝, 1,   IL7↓, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 7,   Imm↝, 1,   Inflam↓, 17,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 103,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 2,   p50↓, 1,   p65↓, 8,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 5,   PGD2↓, 1,   PGE2↓, 13,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 5,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 2,   AR↓, 19,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ER(estro)↑, 1,   Estro↝, 1,   FGF21↓, 1,   GR↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 24,   BioAv↑, 19,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↓, 4,   ChemoSen↑, 90,   ChemoSen⇅, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↑, 4,   Dose↝, 32,   Dose∅, 10,   eff↓, 29,   eff↑, 44,   eff↝, 3,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 7,   Half-Life↝, 9,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 14,   P450↓, 5,   P450↝, 1,   RadioS↑, 30,   selectivity?, 1,   selectivity↑, 60,   selectivity↝, 1,   Synergy↑, 49,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 19,   AR↝, 1,   AST↓, 2,   AST↝, 1,   B2M↓, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 19,   IL6↝, 1,   LDH↓, 5,   LDH↑, 1,   Maspin↑, 2,   Myc↓, 7,   PD-L1↓, 5,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 35,   AntiTum↑, 10,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 6,   OS?, 1,   OS↑, 10,   OS⇅, 1,   Pain↓, 2,   PFS↑, 1,   QoL↑, 5,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 7,   Risk↓, 10,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 18,   TumW↓, 8,   Weight↓, 1,   Weight↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 921

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 40,   Catalase↑, 16,   GPx↓, 1,   GPx↑, 14,   GSH↑, 23,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 5,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 5,   Iron∅, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 2,   MPO↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 19,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 39,   ROS↑, 3,   SOD↓, 1,   SOD↑, 20,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx↓, 1,   Trx↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 2,   FASN↓, 1,   glucose↓, 2,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   NAD↓, 1,   NADPH↑, 1,   PONs↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   Fas↓, 1,   Fas↑, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 1,   other↑, 1,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 4,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK5↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 6,   P21↑, 6,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 2,   Rho↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT2↑, 1,   GLUT4↑, 1,   MMP↓, 3,   MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 15,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 1,   IL10↓, 3,   IL17↓, 2,   IL1β↓, 7,   IL23↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 3,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 38,   Inflam↑, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 15,   NK cell↑, 2,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 4,   TNF-α↓, 13,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 5,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 2,   Half-Life↝, 2,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 7,   BMD↑, 1,   BP↓, 2,   BP↝, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 10,   LDH↓, 3,   LDH↑, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 5,   AntiDiabetic↑, 7,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 13,   chemoP↑, 5,   chemoPv↑, 3,   cognitive↑, 4,   hepatoP↑, 14,   Learn↑, 1,   memory↑, 7,   neuroP↑, 27,   Obesity↓, 3,   OS↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 14,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 2,   AntiViral↑, 1,   Bacteria↓, 7,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 270

Scientific Paper Hit Count for: P21, P21/CDKN1A
19 Thymoquinone
14 Curcumin
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Fisetin
9 Silver-NanoParticles
8 EGCG (Epigallocatechin Gallate)
8 Lycopene
8 Quercetin
7 Magnolol
7 Propolis -bee glue
7 Resveratrol
6 Eugenol
6 Phenethyl isothiocyanate
5 Berberine
5 Indole-3-carbinol
5 Emodin
5 phytic acid, Inositol hexakisphosphate
5 Luteolin
5 Phenylbutyrate
5 Piperlongumine
5 Urolithin
4 Gemcitabine (Gemzar)
4 Allicin (mainly Garlic)
4 Cisplatin
4 Biochanin A
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Cucurbitacin
4 Ursolic acid
4 Ellagic acid
4 Diindolylmethane
4 Gallic acid
4 Honokiol
4 Morin
4 Shikonin
3 Allyl isothiocyanate
3 Baicalein
3 Benzyl isothiocyanate
3 Capsaicin
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Ferulic acid
3 Isoliquiritigenin
3 Licochalcone A
3 Magnetic Fields
3 Melatonin
3 Naringin
3 Patchouli Oil (Pogostemon cablin)
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Zyflamend
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Ashwagandha(Withaferin A)
2 Astaxanthin
2 Berbamine
2 Betulinic acid
2 Caffeic acid
2 Carnosic acid
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chlorogenic acid
2 chaetocin
2 Crocetin
2 diet Methionine-Restricted Diet
2 Fenbendazole
2 Garcinol
2 Genistein (soy isoflavone)
2 HydroxyTyrosol
2 Kaempferol
2 lambertianic acid
2 Linalool
2 mebendazole
2 doxorubicin
2 Oleuropein
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Plumbagin
2 Rosmarinic acid
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 Camptothecin
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Artemisinin
1 Atorvastatin
1 epirubicin
1 Bufalin/Huachansu
1 Boron
1 brusatol
1 Bruteridin(bergamot juice)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 D-limonene
1 Docetaxel
1 Dandelion Root
1 Butyrate
1 Cinnamon
1 Formononetin
1 Flaxseed/Linseed
1 SDG/lignans
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inositol
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Lactobacillus
1 Lactoferrin/Talactoferrin
1 Matrine
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Methylsulfonylmethane
1 Radiotherapy/Radiation
1 Nimbolide
1 Rutin
1 buckwheat sprouts
1 acetazolamide
1 Aflavin-3,3′-digallate
1 Oxaliplatin
1 Vitamin C (Ascorbic Acid)
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:234  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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