survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
6450- SAO,    Survivin Down-regulation by α-Santalol Is Not Mediated Through PI3K-AKT Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
survivin↓,
9276- SES, SSM,    Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products
- in-vitro, Var, NA
TumCP↓, Apoptosis↑, Bcl-2↓, survivin↓, cycD1/CCND1↓, Inflam↓, COX2/PTGS2↓, TumCI↓, MMP9↓, ICAM-1↓, NF-kB↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
9188- SFN,    Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside
- Review, Pca, NA
chemoPv↑, antiNeop↑, Risk↓, Ingr↝, NRF2↑, NQO1↑, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, STAT3↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, HDAC↓, DNMTs↓, HDAC3↓, HDAC6↓, Akt↓, TumCG↓, BioAv↑, Half-Life↝, PSA↓, PSADT↑,
8778- SFN,    Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
tumCV↓, IL6↓, STAT3↓, Dose↝, JAK2↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, DNAdam↑, chemoPv↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, Var, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1/SREBF1↓, toxicity↑,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, Synergy↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2/PTGS2↓, PGE1↓,
2120- TQ,    Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3
- in-vitro, Melanoma, A431
ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,
2121- TQ,    Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2085- TQ,    Anticancer Activities of Nigella Sativa (Black Cumin)
- Review, Var, NA
MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ChemoSen↑,
2083- TQ,    Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- in-vitro, GC, HGC27 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vivo, NA, NA
p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, Var, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
4565- TQ,    Thymoquinone in the clinical treatment of cancer: Fact or fiction?
- Review, BC, NA
Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, EGFR↓, ROS↑,
3412- TQ,    Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28 - in-vivo, NA, NA
Apoptosis↑, JAK2↓, STAT3↓, cycD1/CCND1↓, survivin↓, ROS↑, eff↓,
3414- TQ,    Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells
- in-vitro, RCC, Caki-1
tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4888- ZER,  5-FU,    Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts
- in-vitro, CRC, CT26
TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,
9131- ZYF,    Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets
- vitro+vivo, PC, NA
TumCP↓, ChemoSen↑, Apoptosis↑, NF-kB↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, Bcl-2↓, IAP1↓, VEGF↓, survivin↓, ICAM-1↓, CXCR4↓, TumCG↓, Ki-67↓, MMP9↓,

Showing Research Papers: 201 to 241 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   antiOx⇅, 1,   Catalase↓, 1,   Copper↑, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 14,   GSH↑, 2,   GSTs↑, 2,   HO-1↓, 5,   HO-1↑, 9,   HO-2↓, 1,   lipid-P↓, 3,   lipid-P↑, 3,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 3,   NRF2↓, 7,   NRF2↑, 13,   Prx4↑, 1,   ox-PrxI↑, 1,   ROS↓, 9,   ROS↑, 97,   ROS⇅, 5,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC?, 1,   TAC↑, 1,   Thiols↓, 1,   Trx2↓, 1,   TrxR↓, 3,   TrxR1↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 7,   CDC25↓, 11,   compI↓, 1,   compIII↓, 1,   ETC↓, 1,   HSP60/HSPD1↓, 3,   HTRA2/Omi/PARK13↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PHB↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 10,   ATP↓, 11,   ECAR↝, 1,   FASN↓, 1,   FBI-1↓, 1,   GLO-I↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 11,   GSK‐3β↓, 10,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 3,   LDHA↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 4,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 6,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 70,   BAX⇅, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 115,   Bcl-2↑, 4,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 57,   Bcl-xL↝, 1,   BID↓, 3,   BID↑, 6,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 1,   Casp↑, 22,   Casp↝, 2,   cl‑Casp↑, 1,   Casp10↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 90,   cl‑Casp3↑, 14,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↝, 1,   Casp7?, 1,   Casp7↑, 17,   cl‑Casp7↑, 3,   Casp8↑, 24,   cl‑Casp8↑, 5,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 56,   cl‑Casp9↑, 8,   proCasp9↑, 1,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 50,   Cyt‑c↝, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 11,   DR5↓, 1,   DR5↑, 21,   FADD↑, 4,   Fas↓, 1,   Fas↑, 13,   FasL↑, 7,   Ferroptosis↑, 4,   IAP1↓, 21,   IAP1↑, 1,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 33,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 5,   p38↑, 15,   p‑p38↓, 2,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 6,   Pyro↑, 1,   survivin↓, 238,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↑, 1,   XIAP?, 1,   XIAP↓, 63,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 63,   Akt↑, 6,   p‑Akt↓, 14,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 2,   cMET↓, 5,   p‑cMET↑, 1,   p‑CREB↑, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 12,   IκB↓, 2,   IκB↑, 1,   JAK↓, 4,   JAK1↓, 5,   JAK2↓, 17,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 14,   p‑JNK↓, 1,   p‑JNK↑, 1,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 1,   mTOR↓, 39,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   PI3K↓, 42,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 17,   PTPN6↑, 1,   Raf↓, 2,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 5,   RIP1↓, 1,   p‑RSK↑, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 3,   c-Src↓, 1,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 61,   p‑STAT3↓, 12,   p‑STAT3↑, 1,   STAT5↓, 3,   STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 2,   ATF4↝, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 42,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMTs↓, 7,   EZH2↓, 2,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↑, 2,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 4,   HDAC2↓, 1,   HDAC3↓, 3,   HDAC6↓, 2,   HDAC8↓, 2,   HES1↓, 2,   IRF1↑, 1,   miR-134↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 11,   OCT4↑, 1,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 5,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 2,   SOX9↓, 2,   tumCV↓, 39,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 13,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP27↑, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 9,   HTRA↓, 2,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   LC3s↑, 2,   p62↓, 3,   p62↑, 1,   RUBCN↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 22,   DNArepair↓, 1,   ERCC1↓, 2,   HR↓, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   p16↑, 4,   P53↓, 1,   P53↑, 58,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↑, 12,   cl‑PARP↑, 61,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 17,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 1,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 6,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1?, 1,   CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 17,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 17,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 16,   cycD1/CCND1↓, 83,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 5,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 19,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 4,   P21↑, 44,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 19,   PLK1↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 82,   WEE1↑, 4,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 3,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 5,   CD34↓, 1,   cFos↓, 2,   CSCs↓, 22,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 4,   IGF-1↓, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 19,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH2↓, 1,   NOTCH3↓, 1,   OGFr↑, 2,   p300↓, 2,   PTCH1↓, 5,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 4,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 50,   TumCG↑, 1,   TumCP↓, 74,   Wnt↓, 19,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   Ca+2↓, 3,   Ca+2↑, 9,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cav1↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 15,   EM↑, 1,   EMT↓, 32,   EMT↑, 1,   EpCAM↓, 1,   FAK↓, 10,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LEF1↓, 3,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 40,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 55,   MMPs↓, 17,   MUC4↓, 3,   N-cadherin↓, 11,   NCAM↑, 1,   pax↓, 1,   PDGF↓, 2,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 1,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 22,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 6,   TIMP2↑, 9,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 39,   TumCI↑, 1,   TumCMig↓, 30,   TumMeta↓, 37,   TumMeta↑, 3,   Twist↓, 14,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 19,   Zeb1↓, 8,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 29,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 1,   CD31/PECAM-1↓, 3,   Endoglin↑, 1,   HIF-1↓, 3,   Hif1a↓, 26,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 71,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 48,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 16,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↑, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 23,   IL7↓, 1,   IL8↓, 4,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 17,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 87,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NLRP3↑, 1,   p50↓, 1,   p65↓, 6,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TLR4↝, 1,   TNF-α↓, 17,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 9,   ER-α36↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 14,   BioAv↑, 19,   BioAv↝, 7,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 71,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 3,   Dose↓, 1,   Dose↝, 29,   Dose∅, 2,   eff↓, 24,   eff↑, 34,   eff↝, 4,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 2,   RadioS↑, 17,   selectivity?, 1,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AR↓, 9,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   LDH↓, 1,   Myc↓, 5,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 3,   PSADT↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 17,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 2,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 1,   QoL∅, 1,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↓, 1,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 3,   TumVol↓, 20,   TumW↓, 10,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 776

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 24,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 8,   GPx1↑, 1,   GSH↑, 7,   GSTs↑, 4,   HO-1?, 1,   HO-1↑, 4,   lipid-P↓, 8,   MDA↓, 4,   MPO↑, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 8,   ROS↓, 26,   ROS↑, 1,   ROS∅, 3,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   5LO↝, 1,   ALAT↓, 2,   AMPK↑, 1,   FASN↓, 1,   glucose↝, 1,   GSK‐3β↓, 1,   NAD↑, 1,   NADPH↑, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   IAP1↓, 1,   iNOS↓, 3,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   JAK2↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP27↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   MMP13↓, 1,   MMP3↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MUC5AC↓, 1,   TRPA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 8,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL5↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 26,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 10,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 6,   BioAv↝, 6,   CompStab↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↝, 5,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   CRP↓, 1,   IL6↓, 9,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 8,   AntiArt↑, 4,   AntiCan↑, 5,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   Stroke↓, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 5,   Bacteria↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 151

Scientific Paper Hit Count for: survivin, BIRC5
19 Thymoquinone
8 Resveratrol
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
7 Quercetin
6 Sulforaphane (mainly Broccoli)
6 Gambogic Acid
6 Ginkgetin
6 Silymarin (Milk Thistle) silibinin
5 Matrine
4 Artemisinin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Boswellia (frankincense)
4 Fisetin
4 Garcinol
4 Honokiol
4 Licochalcone A
4 Nimbolide
4 Marjoram (Origanum majorana)
4 Piperlongumine
3 Cisplatin
3 Apigenin (mainly Parsley)
3 Docetaxel
3 Berbamine
3 Berberine
3 Beta-Caryophyllene
3 Betulinic acid
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Capsaicin
3 Deguelin
3 Eugenol
3 Ginger/6-Shogaol/Gingerol
3 Magnolol
3 Luteolin
3 Magnetic Fields
3 Morin
2 1,8-Cineole
2 5-fluorouracil
2 Silver-NanoParticles
2 Allyl isothiocyanate
2 Alpha-Lipoic-Acid
2 immunotherapy
2 Carnosic acid
2 Chemotherapy
2 Cucurbitacin
2 Dichloroacetate
2 Ellagic acid
2 Emodin
2 Fucoidan
2 doxorubicin
2 Geraniol
2 Isoliquiritigenin
2 lambertianic acid
2 low dose naltrexone
2 Licorice
2 Lycopene
2 Mangiferin
2 Naringin
2 Terpinen-4-ol / Tea Tree Oil
2 Rosmarinic acid
2 salinomycin
2 Aflavin-3,3′-digallate
1 Coenzyme Q10
1 Açaí, Euterpe oleracea
1 Andrographis
1 Gemcitabine (Gemzar)
1 chitosan
1 Bufalin/Huachansu
1 Isothiocyanates
1 brusatol
1 Bruteridin(bergamot juice)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 chaetocin
1 Chlorophyllin
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Radiotherapy/Radiation
1 Cynaropicrin
1 Dandelion Root
1 Butyrate
1 Genistein (soy isoflavone)
1 Eurycomanone
1 Fennel Oil/Foeniculum vulgare
1 Flaxseed/Linseed
1 Grapeseed extract
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 iodine
1 MCT, metronomic chemo
1 Juglone
1 Vitamin C (Ascorbic Acid)
1 Kaempferol
1 Methyl Jasmonate
1 Moringin
1 Melatonin
1 Mushroom Shiitake, AHCC
1 Neem
1 Oleuropein
1 Phenylbutyrate
1 Purple Corn / Purple Maize
1 Piperine
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Shikonin
1 Selenite (Sodium)
1 Ursolic acid
1 Urolithin
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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