TNF-α Cancer Research Results

TNF-α, TNF-α: Click to Expand ⟱
Source: HalifaxProj (block)
Type:
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6344- DRE,    Dandelion: Purported Benefits, Side Effects & More
- Review, Var, NA
*other↝, *hepatoP↑, *ALAT↓, *MDA↓, *TNF-α↓, *IL6↓, *antiOx↑, *Inflam↓, *proCasp3↓, Casp3↑, tumCV↓, TNF-α↑, IL1↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *ALB↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6358- DRE,    Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways
- in-vitro, CRC, NA
TLR4↓, NF-kB↓, TNF-α↓, IL4↓, IL6↓, tumCV↓,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
6613- Ech,    Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system
- Study, Nor, NA
*TNF-α↓, *IL8↓, Imm↑,
3227- EGCG,    Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury
- in-vivo, Nor, NA
*Rho↓, *IL1↓, *IL6↓, *TNF-α↓,
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3594- EGCG,    Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells
- in-vitro, AD, HMC1
*TNF-α↓, *IL6↓, *IL8↓, *Ca+2↓,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6818- EMD,    Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer's Disease-Like Features in Rats
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *PP2A↑, *cAMP↑, *5LO↓, *IL6↓, *TNF-α↓, *ROS↓, *DNMT1↓,
6827- EMD,    Mechanism of Emodin in the Treatment of Rheumatoid Arthritis
- Review, Arthritis, NA
*ALAT↓, *AST↓, *ROS↓, *cardioP↑, *TNF-α↓, *NF-kB↓, *Inflam↓, *AntiArt↑, *PGE2↓, *MMP3↓, *MMP13↓, *COX2/PTGS2↓, *AntiCan↑, *neuroP↑, *hepatoP↑, *antiAll↑,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
- Review, Nor, NA
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓, *antiAll↑,
6792- EPA,    Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico
- Trial, HNSCC, NA
Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, QoL↑,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *CompStab↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *Synergy↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑, *antiAll↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, Synergy↑, Synergy↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
1057- EVO,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
- in-vitro, Var, NA
NF-kB↓, TNF-α↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2/BIRC3↓, cFLIP↓, Bfl-1↓,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2/PTGS2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,
4070- FA,    Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial
- Trial, AD, NA
*cognitive↑, *Aβ↓, *TNF-α↓, *Inflam↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
6871- FA,  Sesame,    Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation
- in-vivo, Nor, NA
*GSH↑, *GPx↑, *SOD↓, *Catalase↑, *MDA↓, *IL6↓, *TNF-α↑, *DNAdam↓, *hepatoP↑, *BioAv↓, *BioAv↑, CompStab↓,
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
6886- FA,  MTX,    Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *p65↓, *BAX↓, *Casp3↓, *NRF2↑, *HO-1↑, *PPARγ↑, *Inflam↓,
6962- FA,  VitB12,    Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design
- Trial, AD, NA
*Hcy/homoC↝, *IL6↓, *TNF-α↓, *MCP1/CCL2↝, *Synergy↑, *cognitive↑, *Inflam↓,
6951- FA,    Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI
- Trial, AD, NA
*Dose↝, *cognitive↑, *Hcy/homoC↓, *IL6↓, *TNF-α↓,
6954- FA,    Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism
- Trial, AD, NA
*Inflam↓, *Aβ↓, *IL1β↓, *IL6↓, *TNF-α↓, *tau↓, *GABA↑, *5HT↑, *Ach↑, *ALB↑, *HemoG↑, *neuroP↑, *Hcy/homoC↓,
6919- FIS,    Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells
- in-vitro, Var, NA
TumCP↓, Inflam↓, NO↓, iNOS↓, COX2/PTGS2↓, IL6↓, TNF-α↓, NF-kB↓, p‑cJun↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
5392- FIS,  AsP,    Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging
- in-vivo, Nor, NA
eff↑, *antiOx↑, *MMP9↓, *TNF-α↓, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAge↑, *Inflam↓, *JNK↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6995- Form,    Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia
- Review, Nor, BV2
*TNF-α↓, *IL6↓, *IL1β↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *neuroP↑, *Inflam↓,

Showing Research Papers: 201 to 250 of 577
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 577

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 8,   Catalase↓, 10,   Catalase↑, 6,   Copper↓, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 7,   GPx4↓, 3,   GSH↓, 23,   GSH↑, 7,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 12,   Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 7,   MDA↓, 5,   MDA↑, 5,   MPO↓, 3,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 10,   NRF2↑, 18,   NRF2↝, 1,   OSI↑, 1,   Prx↓, 2,   PrxII↓, 1,   ROS?, 1,   ROS↓, 23,   ROS↑, 114,   ROS⇅, 4,   ROS↝, 1,   mt-ROS↑, 2,   SAM-e↝, 1,   selenoP↑, 1,   SOD?, 1,   SOD↓, 9,   SOD↑, 9,   SOD2↓, 3,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1,   CDC2↓, 3,   CDC25↓, 5,   EGF↓, 4,   ETC↓, 2,   Insulin↓, 2,   MFN2↑, 1,   mitResp↓, 2,   MKP5↑, 1,   mtDam↑, 11,   OCR↓, 2,   OXPHOS↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 6,   ACAA1↓, 1,   ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 10,   p‑AMPK↑, 1,   ATP↓, 6,   ATP↑, 1,   mt-ATP↓, 1,   BHB↑, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   ECAR∅, 1,   FABP4↓, 1,   FASN↓, 3,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 15,   GSK‐3β↓, 7,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 3,   Histones↝, 1,   HK2↓, 8,   HMG-CoA↓, 1,   HMGCS2↑, 1,   lactateProd↓, 4,   LDHA↓, 3,   LDL↓, 1,   lipoGen↓, 1,   NAD↝, 1,   NADPH↓, 1,   PCK1↓, 2,   PDK1 / PDPK1↓, 5,   PDK3↑, 1,   PFK↓, 2,   PKM2↓, 8,   p‑PKM2↓, 1,   PLIN1↓, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 3,   SREBP2↓, 1,   TCA↓, 2,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 102,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↓, 2,   BAD↓, 3,   BAD↑, 2,   Bak↓, 1,   Bak↑, 5,   BAX↓, 3,   BAX↑, 64,   BAX⇅, 2,   BAX↝, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 71,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 16,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 4,   BNIP3↑, 2,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 21,   Casp1↓, 2,   Casp1↑, 1,   proCasp1↓, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 82,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↑, 5,   cl‑Casp3⇅, 1,   Casp7↑, 6,   cl‑Casp7↑, 1,   Casp8↑, 26,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 49,   cl‑Casp9↑, 3,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 43,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↑, 13,   FADD↑, 4,   Fas?, 1,   Fas↓, 2,   Fas↑, 16,   FasL↓, 1,   FasL↑, 7,   Ferroptosis↑, 4,   GranB/GZMB↓, 1,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 10,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 24,   Mcl-1↓, 11,   MDM2↓, 4,   MDM2↑, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 1,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 3,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 2,   survivin↓, 28,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 3,   TumCD∅, 1,   XIAP?, 1,   XIAP↓, 18,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 72,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 18,   AKT1↓, 1,   Akt2↓, 1,   BRAF↝, 1,   cMET↓, 4,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   EGFR↓, 19,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 27,   ERK↑, 5,   p‑ERK↓, 7,   FGFR1↓, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 6,   HGF/c-Met↓, 2,   Hippo↑, 1,   HRAS↓, 1,   IGF-1R↓, 3,   p‑IGF-1R↓, 1,   IKKα↓, 7,   IκB↓, 3,   JAK↓, 3,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 9,   JAK3↓, 1,   JNK↓, 5,   JNK↑, 9,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 18,   MAPK↑, 7,   MAPK↝, 3,   p‑MEK↓, 1,   mTOR↓, 41,   mTOR↝, 2,   p‑mTOR↓, 2,   mTORC2↓, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 53,   PI3K↝, 2,   p‑PI3K↓, 3,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKA↓, 2,   PKCδ↓, 3,   PPP2R1A↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 1,   PTEN↑, 9,   PTEN↝, 2,   Raf↓, 1,   RAS↓, 8,   RAS↑, 1,   RCC1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 5,   STAT3↓, 47,   STAT3↑, 1,   p‑STAT3↓, 9,   STAT4↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 6,   CBP↓, 1,   cJun↓, 1,   cJun↑, 1,   p‑cJun↓, 1,   cMyc↓, 21,   cMyc↑, 1,   DNMT1↓, 6,   DNMT3A↓, 1,   DNMTs↓, 4,   EZH2↓, 3,   FOXM1↓, 2,   FOXO↑, 3,   FOXO1↓, 3,   FOXO1↑, 2,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   ac‑H4↑, 3,   HATs↓, 4,   HDAC↓, 19,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   IRF1↑, 1,   miR-124-3p↓, 1,   miR-134↑, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   Myc↓, 1,   MYCN↓, 1,   OCT4↓, 6,   other?, 1,   other↓, 5,   other↑, 4,   other↝, 3,   PAX2↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 2,   SOX9↓, 1,   tumCV↓, 29,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 12,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↑, 21,   GRP78/BiP↑, 6,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 9,   HSPs↓, 1,   HSPs↑, 1,   p‑IRE1↓, 1,   NQO2↑, 1,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 4,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   CTSK↓, 1,   LC3B-II↑, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 2,   TumAuto↓, 1,   TumAuto↑, 20,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 29,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC1↓, 1,   HR↓, 1,   hTERT/TERT↓, 8,   p16↑, 3,   P53?, 1,   P53↓, 4,   P53↑, 50,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 11,   cl‑PARP↓, 1,   cl‑PARP↑, 27,   cl‑PARP1↑, 1,   PCNA↓, 23,   RAD51↓, 1,   Telomerase↓, 4,   TOP1↓, 3,   TOP2↓, 3,   TOP2↑, 2,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 4,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK2↓, 17,   CDK2↑, 2,   CDK4↓, 24,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 6,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 15,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 43,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 7,   cycE1↓, 2,   E2Fs↓, 3,   GADD45A↑, 1,   Ki-67↓, 20,   mitA↑, 2,   P21↓, 4,   P21↑, 28,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 12,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 85,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 6,   ALDH1A1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 3,   CD133↑, 1,   CD34↓, 1,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 17,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 1,   EP2↓, 1,   FGF↓, 3,   Gli1↓, 2,   HH↓, 5,   IGF-1?, 1,   IGF-1↓, 8,   IGFBP3↑, 2,   Ki-67↓, 20,   Let-7↑, 2,   mTORC1↓, 3,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 1,   p300↓, 1,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 1,   STAT1↑, 1,   TumCG↓, 28,   TumCG↑, 1,   TumCP↓, 69,   TumCP↑, 1,   Wnt↓, 15,   Wnt↝, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AntiAg?, 1,   AP-1↓, 9,   AP-1↝, 1,   ASAP2↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2↑, 7,   Ca+2↝, 3,   i-Ca+2↑, 1,   cal2↓, 1,   Cartilage↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cofilin↓, 2,   COL1↓, 2,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 18,   EMT↓, 36,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   FAK↓, 6,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   ITGA11↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   KRAS↓, 2,   LAMB3↑, 1,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 4,   MMP2↓, 52,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 7,   MMP9↓, 55,   MMP9↑, 3,   MMPs↓, 23,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 19,   NCAM↑, 1,   NeuroT↓, 1,   PDGF↓, 4,   PGF↓, 1,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 4,   Slug?, 1,   Slug↓, 5,   Smad1↓, 1,   Snail?, 1,   Snail↓, 9,   TET1↑, 3,   TGF-β↓, 9,   TGF-β1↓, 1,   THBS2↓, 1,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 8,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 37,   TumCMig↓, 39,   TumCMig⇅, 1,   TumMeta↓, 33,   TumMeta↑, 4,   Twist↓, 11,   Tyro3↓, 1,   uPA↓, 8,   uPAR↓, 1,   Vim↓, 14,   Vim↑, 1,   Zeb1↓, 3,   ZEB2↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 20,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 53,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   Hif1a↓, 21,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 7,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 1,   VEGF↓, 69,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 4,   CLDN1↓, 2,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   MMP↓, 38,   MMP↑, 1,   MMP↝, 1,   MPT↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 2,   CD4+↑, 3,   CD44↓, 6,   CD47↓, 1,   CD59↑, 1,   CD8+↓, 1,   CD8+↑, 4,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   COX2/PTGS2∅, 1,   CXCL1↓, 1,   CXCR3↓, 1,   CXCR4↓, 12,   CXCR4↑, 1,   DR4↑, 3,   FOXP3↓, 1,   FOXP3↑, 1,   HCAR2↑, 2,   HMGB1↓, 3,   ICAM-1↓, 4,   IFN-γ↓, 9,   IFN-γ↑, 3,   IL1↓, 12,   IL1↑, 3,   IL10↓, 7,   IL10↑, 5,   IL12↓, 5,   IL12↑, 2,   IL13↓, 1,   IL17↓, 4,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 57,   IL1β↑, 5,   IL1β∅, 1,   IL2↓, 6,   IL2↑, 7,   IL22↓, 3,   IL23↓, 2,   IL28↓, 1,   IL33↑, 1,   IL4↓, 3,   IL4↑, 3,   IL6↓, 89,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 15,   IL8↑, 1,   Imm↑, 16,   Imm↝, 3,   INF-γ↓, 1,   Inflam↓, 42,   Inflam↑, 1,   IRAK4↓, 1,   LPS↓, 1,   LRIG1↑, 1,   M1↓, 1,   MCP1/CCL2↓, 7,   MIP‑1α/CCL3↓, 1,   MIP2↓, 3,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 116,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 7,   NLRP3↓, 6,   NLRP3↑, 3,   p50↓, 4,   p65↓, 6,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 8,   PGE1↓, 1,   PGE2↓, 20,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES↓, 1,   Resistin↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   Th1 response?, 1,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 9,   TNF-α↓, 153,   TNF-α↑, 25,   TNF-α↝, 2,   TNF-α∅, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   AR↝, 1,   BNP↓, 1,   ER-α36↓, 1,   ER(estro)↑, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 7,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 21,   BioAv↑, 24,   BioAv↝, 8,   BioEnh↑, 1,   ChemoSen↑, 86,   CompStab↓, 2,   CompStab↑, 1,   CompStab↝, 3,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 35,   Dose∅, 6,   eff↓, 4,   eff↑, 31,   eff⇅, 1,   eff↝, 6,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 3,   RadioS↑, 25,   selectivity↑, 37,   Synergy↑, 62,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 4,   ALP↓, 1,   AR↓, 8,   AR↝, 1,   ascitic↓, 1,   AST↓, 3,   BMD↑, 2,   BRAF↝, 1,   BRCA1↑, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 4,   CRP↓, 6,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 19,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   FOXM1↓, 2,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 8,   IL6↓, 89,   IL6↑, 2,   IL6↝, 1,   KRAS↓, 2,   LDH↓, 7,   LDH↑, 3,   LDH↝, 1,   i-LDH↓, 1,   Myc↓, 1,   NOS2↑, 1,   NSE↓, 1,   PD-L1↓, 8,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 33,   antiNeop↑, 1,   AntiTum↑, 14,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 8,   CardioT↓, 1,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 33,   chemoPv↑, 9,   ChemoSideEff↓, 4,   cognitive?, 1,   cognitive↑, 4,   hepatoP↓, 1,   hepatoP↑, 8,   K17↓, 1,   neuroP↑, 7,   NP/CIPN↓, 2,   Obesity↓, 1,   OS?, 1,   OS↑, 18,   Pain↓, 3,   PFS↑, 1,   QoL↑, 10,   radioP↑, 12,   RenoP↑, 9,   Risk↓, 10,   Sleep↑, 1,   toxicity↓, 9,   toxicity↑, 1,   TumVol↓, 16,   TumW↓, 6,   Weight↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 2,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 895

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 8,   antiOx↑, 162,   ARE↑, 4,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 107,   DPPH↓, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 3,   GPx↑, 68,   GPx1↑, 2,   GPx4↓, 1,   GPx4↑, 3,   GSH↓, 2,   GSH↑, 111,   GSH/GSSG↑, 1,   GSR↓, 3,   GSR↑, 10,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 18,   H2O2↓, 8,   HDL↑, 7,   HDL∅, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↓, 4,   HO-1↑, 95,   HO-1↝, 1,   hyperG↝, 1,   Iron↓, 2,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 79,   lipid-P↑, 2,   mt-lipid-P↓, 1,   MDA↓, 107,   MPO↓, 19,   NFE2L2↓, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 5,   NQO1↑, 23,   NQO1↝, 1,   Nrf1↑, 2,   NRF2?, 1,   NRF2↓, 5,   NRF2↑, 136,   PCO↓, 1,   Prx↑, 1,   RNS↓, 6,   ROS?, 2,   ROS↓, 262,   ROS↑, 3,   ROS⇅, 1,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 151,   SOD1↑, 5,   SOD2↑, 5,   TAC↑, 15,   TBARS↓, 6,   Thiols↑, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 11,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   FIS1↓, 1,   Insulin↓, 3,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 7,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 6,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   15-LOX/ALOX15↓, 1,   5LO↓, 9,   ACADS/SCAD↑, 1,   ACC↓, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 2,   ALAT↓, 42,   AMPK↓, 1,   AMPK↑, 22,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 14,   ATP↝, 1,   cAMP↑, 3,   CPT1A↑, 2,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   FFA/NEFA↓, 2,   glucose↓, 8,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 21,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 2,   HMG-CoA↓, 1,   KeyT↝, 1,   LDL↓, 18,   lipidLev↓, 4,   NAD↓, 1,   NAD↑, 2,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 8,   NADPH↑, 3,   PFK↓, 1,   PKM2↓, 1,   PLA2↓, 2,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 22,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 40,   ASC↓, 2,   BAD↓, 1,   BAX↓, 25,   BAX↑, 3,   Bax:Bcl2↓, 5,   Bcl-2↓, 6,   Bcl-2↑, 25,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 5,   Casp12↓, 3,   Casp3↓, 51,   Casp3↑, 2,   Casp3∅, 1,   cl‑Casp3↓, 4,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 3,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 20,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 8,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   GRP58↓, 1,   GSDMD↓, 1,   iNOS↓, 84,   iNOS↑, 2,   MLKL↓, 1,   necrosis↓, 3,   p38↓, 12,   p‑p38↓, 4,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 14,   Akt↑, 17,   Akt↝, 1,   p‑Akt↓, 3,   p‑Akt↑, 5,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 4,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 14,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 2,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 2,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 18,   p‑JNK↓, 8,   MAPK?, 1,   MAPK↓, 29,   MAPK↑, 3,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 6,   mTOR↝, 1,   p‑mTOR↓, 4,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 10,   PI3K↑, 12,   PI3K↝, 1,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 2,   RIP1↓, 2,   STAT↓, 2,   STAT3↓, 8,   STAT3↑, 4,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 4,   cJun↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HDAC↓, 5,   HDAC↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 3,   other↑, 14,   other↝, 19,   other∅, 1,   RUNX2↑, 1,   SOX2↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 11,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 13,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 2,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 5,   CTSZ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   P53↓, 5,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 4,   Ki-67↑, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CEBPA↓, 1,   Choline↑, 2,   Diff↑, 2,   Diff↝, 1,   FGF↑, 2,   IGF-1↑, 2,   IGFBP1↑, 1,   Ki-67↓, 4,   Ki-67↑, 1,   MSCs↑, 1,   Nestin↑, 1,   neuroG↑, 6,   NOTCH1↑, 1,   p‑STAT1↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 7,   AP-1↓, 8,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 15,   Ca+2↑, 2,   Ca+2↝, 3,   Cartilage↑, 7,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP-10↝, 1,   MMP1↓, 1,   MMP11↑, 1,   MMP13↓, 3,   MMP2↓, 6,   MMP2↑, 2,   MMP3↓, 4,   MMP3↑, 1,   MMP9↓, 15,   MMPs↓, 4,   MMPs↑, 1,   MUC1↑, 2,   Na+↑, 1,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Sema3A/PlexinA1↑, 1,   serineP↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 8,   TGF-β↑, 6,   TGF-β1↓, 2,   TGF-β1↑, 3,   TIMP1↓, 3,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 3,   uPA↑, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 6,   α-SMA↑, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   angioG↝, 1,   E-sel↓, 4,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 56,   NO↑, 5,   VCAM-1↓, 11,   VEGF↓, 4,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB?, 1,   BBB↓, 2,   BBB↑, 36,   BBB↝, 5,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN4↑, 1,   EPR↑, 1,   GastroP↑, 3,   GLUT2↑, 2,   GLUT3↑, 2,   GLUT4↑, 3,   IBI↑, 7,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 18,   MUC2↑, 1,   MUC5AC↓, 1,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 7,   OCLN↝, 1,   TJ↑, 5,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 4,   CD14↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 6,   COX1↑, 1,   COX2/PTGS2↓, 112,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCL15↓, 1,   CXCR4↓, 1,   DCells↑, 1,   Dectin1↑, 1,   Eos↓, 1,   FOXP3↑, 2,   HMGB1↓, 4,   ICAM-1↓, 12,   IFN-γ↓, 22,   IFN-γ↑, 7,   IL1?, 1,   IL1↓, 16,   IL1↑, 1,   IL10↓, 20,   IL10↑, 37,   IL12↓, 9,   IL13↓, 2,   IL13↑, 1,   IL17↓, 13,   IL18↓, 6,   IL1α↓, 1,   IL1β↓, 194,   IL1β↑, 1,   IL2↓, 14,   IL2↑, 3,   IL22↓, 3,   IL23↓, 2,   IL33↓, 2,   IL4↓, 13,   IL4↑, 11,   IL5↓, 5,   IL5↑, 1,   IL6?, 3,   IL6↓, 223,   IL6↑, 6,   IL8↓, 27,   IL8↑, 1,   IL9↓, 1,   Imm↓, 1,   Imm↑, 14,   Imm↝, 1,   INF-γ↓, 3,   Inflam?, 1,   Inflam↓, 280,   Inflam↑, 3,   IP-10/CXCL-10↓, 2,   IRF3↓, 3,   LPS↓, 3,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 20,   MCP1/CCL2↑, 1,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 4,   MIP2↓, 3,   MyD88↓, 5,   NeuroI↓, 7,   Neut↓, 1,   NF-kB↓, 179,   NF-kB↑, 3,   p‑NF-kB↓, 2,   NK cell↑, 2,   NLRP3↓, 30,   p65↓, 5,   p‑p65↓, 2,   PGE1↓, 1,   PGE2↓, 44,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 2,   RANTES↓, 3,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 6,   TLR4↓, 29,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 394,   TNF-α↑, 13,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 6,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 10,   Ach↑, 11,   AChE↓, 43,   ADAM10↑, 1,   BChE↓, 10,   BDNF↓, 2,   BDNF↑, 46,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 6,   ChE↓, 1,   DA↑, 1,   EndoR↑, 1,   GABA↓, 2,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 8,   MAOA↝, 1,   MAOB↓, 4,   monoA↑, 1,   NGF↑, 7,   PSD95?, 1,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 3,   SYN1↑, 1,   SYP↑, 1,   SYT1↑, 1,   TPH1↓, 1,   TrkB↑, 7,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APOE4↓, 1,   APP↓, 9,   cl‑APP↑, 1,   Aβ↓, 71,   Aβ42↓, 4,   BACE/β-secretase↓, 23,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 17,   p‑tau↓, 21,   β-Amyloid↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AHR↓, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   DHT↓, 1,   DHT↑, 1,   END↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 7,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 17,   p‑PPARγ↓, 1,   SHBG↓, 1,   testos↓, 1,   testos↑, 2,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 40,   BioAv↑, 61,   BioAv⇅, 1,   BioAv↝, 33,   BioEnh↑, 6,   ChemoSen↑, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 6,   Dose↓, 1,   Dose↑, 7,   Dose⇅, 2,   Dose↝, 69,   eff↓, 3,   eff↑, 37,   eff↝, 2,   Half-Life↓, 4,   Half-Life↑, 5,   Half-Life↝, 18,   MRP↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   P450↑, 2,   P450↝, 1,   selectivity↑, 2,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 42,   ALB↑, 2,   ALB↝, 1,   ALP↓, 8,   AST↓, 43,   BG↓, 3,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 4,   BP↓, 14,   BUN?, 1,   BUN↓, 7,   Calcium↑, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 16,   CRP↓, 16,   EGFR↓, 2,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 1,   hs-CRP↓, 4,   IL6?, 3,   IL6↓, 223,   IL6↑, 6,   KeyT↝, 1,   LDH↓, 11,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 3,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   TMAO↓, 1,   Urea↓, 3,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 2,   Analgesic↑, 3,   AntiAge↑, 12,   antiAll?, 1,   antiAll↑, 29,   AntiArt↑, 10,   AntiCan↑, 21,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 24,   antiPs↑, 3,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP?, 1,   cardioP↑, 72,   chemoP↑, 16,   chemoPv↑, 6,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 90,   cognitive↝, 1,   diuretic↑, 3,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 80,   Learn↑, 12,   memory↑, 71,   Mood↑, 6,   motorD↓, 2,   motorD↑, 16,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 168,   NP/CIPN↓, 1,   Obesity↓, 15,   OS↑, 7,   Pain↓, 11,   QoL↑, 2,   radioP↑, 11,   RenoP↓, 1,   RenoP↑, 36,   Risk↓, 8,   Sleep↑, 4,   Strength↑, 5,   Stress↓, 2,   Stroke↓, 18,   toxicity↓, 32,   toxicity↑, 1,   toxicity↝, 9,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 5,   AntiP↑, 1,   AntiViral↑, 13,   Bacteria↓, 16,   Dectin1↑, 1,   Diar↓, 2,   GutMicro↑, 40,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 11,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 1,   Ingr↝, 11,  
Total Targets: 760

Scientific Paper Hit Count for: TNF-α, TNF-α
21 Hydrogen Gas
19 Thymoquinone
17 Quercetin
17 Lycopene
16 Curcumin
15 Silymarin (Milk Thistle) silibinin
13 Silver-NanoParticles
13 Magnetic Fields
12 Boron
11 Propolis -bee glue
11 EGCG (Epigallocatechin Gallate)
10 isoorientin
10 Luteolin
9 Honokiol
9 Rosmarinic acid
9 Shikonin
8 Berberine
8 Beta-Caryophyllene
8 Sulforaphane (mainly Broccoli)
7 Chrysin
7 Resveratrol
7 Crocetin
7 Urolithin
6 Alpha-Lipoic-Acid
6 Baicalein
6 Cisplatin
6 Folic Acid, Vit B9
6 Boswellia (frankincense)
6 Chlorogenic acid
6 Dandelion Root
6 Emodin
6 Eugenol
6 Fisetin
6 Morin
5 Ashwagandha(Withaferin A)
5 α-Bisabolol / Chamomile oil
5 Selenium NanoParticles
5 Chemotherapy
5 Ferulic acid
5 Hyperoside
5 Kaempferol
5 Matrine
4 Astragalus
4 Anethole/trans-Anethole
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Radiotherapy/Radiation
4 Selenium
4 Capsaicin
4 Carvacrol
4 Celastrol
4 Centella asiatica / Gotu kola → asiaticoside
4 Isoliquiritigenin
4 Melatonin
4 Vitamin C (Ascorbic Acid)
3 5-fluorouracil
3 Citric Acid
3 doxorubicin
3 beta-glucans
3 Vitamin B12
3 Vitamin B3,Niacin
3 Butyrate
3 Thymol-Thymus vulgaris
3 Cichoric acid / Chicoric acid
3 Echinacea
3 Coenzyme Q10
3 Ginger/6-Shogaol/Gingerol
3 Docosahexaenoic Acid
3 D-limonene
3 Sesame seeds and Oil
3 Flaxseed/Linseed
3 Gallic acid
3 Ginkgo biloba
3 HydroxyTyrosol
3 Isovitexin
3 L-Theanine
3 Magnesium
3 Patchouli Oil (Pogostemon cablin)
3 Piperine
3 Pterostilbene
3 Rutin
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Astaxanthin
2 immunotherapy
2 Baicalin
2 Betulinic acid
2 borneol
2 buckwheat sprouts
2 Cat’s Claw
2 chitosan
2 Cinnamon
2 Ursolic acid
2 diet Short Term Fasting
2 Formononetin
2 Fucoidan
2 Gambogic Acid
2 Inositol
2 phytic acid, Inositol hexakisphosphate
2 lambertianic acid
2 Licochalcone A
2 Linalool
2 Magnolol
2 Magnetic Field Rotating
2 Lemon Balm/Melissa officinalis
2 Moringa oleifera
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Oleocanthal
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Selenite (Sodium)
2 Vitamin K2
1 2-DeoxyGlucose
1 Annona atemoya Seed Extract
1 Anthocyanins
1 entinostat
1 Paclitaxel/Taxol
1 alpha Linolenic acid
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 xanthohumol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 brusatol
1 Carnosic acid
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Chyawanprash
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 CUSP9
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 Diindolylmethane
1 Indole-3-carbinol
1 Ellagic acid
1 Docetaxel
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 methotrexate
1 Ascorbyl Palmitate
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Galloflavin
1 Garcinol
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Geraniol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Orlistat
1 Hibiscus sabdariffa
1 capecitabine
1 isoflavones
1 isoquercitrin
1 Juglone
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Lutein
1 Mung Bean Sprouts
1 mebendazole
1 gefitinib, erlotinib
1 methylseleninic acid
1 Zinc
1 Mangiferin
1 Methylene blue
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Phycocyanin
1 Piperlongumine
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Sulfasalazine
1 Spirulina(Arthrospira/Limnospira)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:309  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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