TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
Scientific Papers found: Click to Expand⟱
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, eff↑, *toxicity↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
7174- CHA,    Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
- vitro+vivo, OS, OS-RC-2
SUV39H↓, TumCG↓, NOTCH1↓, CD31/PECAM-1↓, VEGF↓, toxicity↓, Ki-67↓, angioG↓,
7178- CHA,    SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis
- in-vitro, GC, NA
tumCV↓, TumCG↓, SUV39H↓,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
7185- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, p‑ATM↑, YAP/TEAD↑, p‑JNK↑, TumPF↓, SUV39H↓, TrxR↓, Casp3↑, Trx1↓, H3↓, lactateProd↓, ATP↓, GlucoseCon↓, TumCG↓, Dose↝,
7173- CHA,    Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations
- in-vitro, Lung, A549
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, CD47↓, *toxicity↓, MMP↓, Casp3↑, mtDam↓,
7171- CHA,    Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201
- vitro+vivo, GBM, DIPG
TumCG↓, TumCP↓, Apoptosis↓, OS↑, H3K9↓, SUV39H↓, eff↑, CSCs↓, SOX9↓, HGF/c-Met↓, FGF21↓, EGFR↓, PDGFR-BB↓, Wnt↓, MYCN↑, OLIG2↓, AURKB↓, HO-1↑, P21↑,
7170- CHA,    Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A–GATA3–STAT3 Circuit
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, selectivity↑, CSCs↓, SUV39H↓, GATA3↓, STAT3↓, TumCG↓, OS↑,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6124- CHr,  EGCG,    The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
- in-vitro, HCC, HepG2
TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, eff↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,
2798- CHr,    Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
HDAC↓, HDAC8↓, TumCG↓, Diff↑,
2800- CHr,    Chrysin Activates Notch1 Signaling and Suppresses Tumor Growth of Anaplastic Thyroid Carcinoma In vitro and In vivo
- in-vitro, Thyroid, NA
TumCG↓, NOTCH↑, cl‑PARP↑, Apoptosis↑,
2805- CHr,    Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
- in-vitro, ESCC, KYSE150 - in-vivo, ESCC, NA
FAK↓, GlucoseCon↓, Casp3↑, Casp7↑, p‑Akt↓, TumCG↓, Weight∅,
2793- CHr,    Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H157 - in-vivo, NA, NA
TumCG↓, M2 MC↑, CDK1↓,
1033- CHr,    Chrysin inhibits hepatocellular carcinoma progression through suppressing programmed death ligand 1 expression
- vitro+vivo, HCC, NA
TumCG↓, CD4+↑, CD8+↑, PD-L1↓,
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Apoptosis↑, PI3K↓, Akt↓, TumCG↓, TumCCA↑, HSP60/HSPD1↓, Ki-67↓, ChemoSen↑,
952- Cin,    Cinnamon Extract Reduces VEGF Expression Via Suppressing HIF-1α Gene Expression and Inhibits Tumor Growth in Mice
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U251 - in-vivo, Ovarian, SKOV3
VEGF↓, Hif1a↓, p‑STAT3↓, p‑Akt↓, angioG↓, TumCG↓, TumW↓, ascitic↓,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
4761- CoQ10,    Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
4772- CoQ10,    The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1↑, TumAuto↑, ROS↑,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6291- Cro,    Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
- vitro+vivo, PC, MIA PaCa-2 - vitro+vivo, PC, Bxpc-3 - vitro+vivo, PC, Capan1 - vitro+vivo, PC, AsPC-1
TumCG↓, EGFR↓, Apoptosis↑, Bax:Bcl2↑, TumCP↓, TumCCA↑, Dose↝,
6316- Cro,    Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCI↓, Apoptosis↑, TLR4↓, NF-kB↓, IKKα↓, NLRP3↓, TumCG↓,
6312- Cro,    Crocin from Crocus Sativus Possesses Significant Anti-Proliferation Effects on Human Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48 - in-vitro, CRC, HT29
tumCV↓, TumCG↓, selectivity↑,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6305- Cro,    Bridging Preclinical and Clinical Evidence on Crocin in Breast Cancer
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, TumCG↓, ChemoSen↑,
6303- Cro,    Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation
- in-vitro, CRC, HCT116 - in-vitro, CRC, DU145
NF-kB↓, VEGF↓, MMP9↓, Inflam↓, HMGB1↓, IL6↓, IL8↓, TumCG↓, Apoptosis↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6522- CRV,    l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation
- in-vivo, Var, NA
*Inflam↓, TumCG↓, VEGF↓, ChemoSen↑, FAK↓, ITGB1↓,
7413- CS,  Poly,    Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines
- in-vitro, SCC, SCC25
AntiCan↑, tumCV↓, TumCG↓, Apoptosis↑, selectivity↑, BAX↑, Casp9↑, Bcl-2↓, TumCCA↑, other↝, hepatoP↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6196- Cuc,    Cucurbitacins – A Promising Target for Cancer Therapy
- Review, Var, NA
STAT3↓, toxicity↝, COX2/PTGS2↓, TumCG↓, TumCCA↑, Apoptosis↑, STAT3↓, JAK2↓,
6186- Cuc,    Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
- vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-453
STAT3↓, JAK2↓, TumCG↓,

Showing Research Papers: 201 to 250 of 831
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 831

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AURKB↓, 1,   CD47↓, 1,   H3K9↓, 1,   HSP60/HSPD1↓, 1,   MYCN↑, 1,   OLIG2↓, 1,   SUV39H↓, 7,  

Redox & Oxidative Stress(tgid=1) ⓘ

ATF3↑, 1,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 2,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 1,   NADPH/NADP+↓, 1,   NRF2↓, 1,   NRF2↑, 2,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 16,   ROS↝, 1,   SOD2↓, 1,   SOD2↑, 1,   TBARS↓, 1,   Trx↓, 1,   Trx1↓, 1,   ox-Trx1↑, 1,   TrxR↓, 3,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 5,   i-ATP↑, 1,   ETC↓, 1,   mitResp↓, 2,   MMP↓, 6,   MPT↑, 1,   mtDam↓, 1,   mtDam↑, 2,   OCR↓, 4,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 2,   ECAR↓, 1,   ECAR∅, 1,   ENO1↓, 1,   FGF21↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 5,   HK2↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   PFK1↓, 1,   PFKP↓, 1,   Pyruv↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 5,   Apoptosis↓, 3,   Apoptosis↑, 25,   Apoptosis∅, 1,   BAX↑, 4,   Bax:Bcl2↑, 5,   Bcl-2↓, 7,   Bcl-xL↓, 2,   Casp↑, 3,   Casp3↑, 8,   cl‑Casp3↑, 2,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 2,   Cupro↑, 1,   Cyt‑c↑, 5,   DR5↑, 1,   Ferroptosis↑, 2,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   p‑JNK↑, 1,   Mcl-1↓, 2,   p27/CDKN1B↑, 1,   p38↑, 1,   Proteasome↓, 1,   survivin↓, 1,   TumCD↑, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   HER2/EBBR2↓, 1,   SOX9↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   other↝, 4,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 1,   ERStress↑, 1,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   LC3s↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

p‑ATM↑, 1,   DNAdam↑, 2,   p16↑, 1,   P53↑, 1,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 5,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   cycD1/CCND1↓, 2,   P21↑, 3,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   Diff↑, 2,   EMT↓, 2,   EMT↝, 1,   GATA3↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC8↓, 1,   HMTs↓, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   NOTCH↑, 1,   NOTCH1↓, 1,   P70S6K↓, 1,   PI3K↓, 5,   PTEN↑, 2,   STAT3↓, 5,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 50,   TumCG↑, 1,   TumCG∅, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   CD31/PECAM-1↓, 1,   CLDN1↓, 1,   E-cadherin↑, 2,   FAK↓, 2,   ITGB1↓, 1,   Ki-67↓, 3,   MMP15↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 3,   SPARC↑, 2,   TumCI↓, 6,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 15,   TumCP↑, 1,   TumMeta↓, 5,   TumMeta↑, 1,   TumPF↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   angioG↑, 1,   EGFR↓, 2,   EPR↑, 1,   Hif1a↓, 6,   PDGFR-BB↓, 1,   VEGF↓, 5,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   cellSen↑, 1,   COX2/PTGS2↓, 1,   HMGB1↓, 1,   IKKα↓, 1,   IL1↑, 1,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   Inflam↝, 1,   JAK2↓, 2,   pol-M1↑, 1,   M2 MC↑, 1,   pol-M2 MC↓, 1,   NF-kB↓, 5,   p65↓, 1,   PD-L1↓, 1,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 9,   ChemoSen∅, 2,   DDS↑, 1,   Dose?, 1,   Dose↝, 5,   Dose∅, 2,   eff↓, 9,   eff↑, 13,   RadioS↑, 2,   selectivity↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ascitic↓, 1,   EGFR↓, 2,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 3,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop∅, 1,   AntiTum↑, 3,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 2,   hepatoP↑, 1,   OS↑, 4,   radioP↑, 1,   Risk↓, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 247

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 5,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 1,   LDH↓, 1,   PPARα↝, 1,  

Cell Death(tgid=5) ⓘ

Casp↓, 1,   JNK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   TLR4↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 2,   chemoPv↑, 2,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 2,   OS↑, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 47

Scientific Paper Hit Count for: TumCG, Tumor cell growth
29 Curcumin
27 Magnetic Fields
17 Phenethyl isothiocyanate
16 Quercetin
14 Berberine
14 EGCG (Epigallocatechin Gallate)
14 Sulforaphane (mainly Broccoli)
13 Silver-NanoParticles
13 Chemotherapy
13 Shikonin
12 Vitamin C (Ascorbic Acid)
12 Magnetic Field Rotating
12 Bicarbonate(Sodium)
11 Alpha-Lipoic-Acid
11 Baicalein
11 Garcinol
11 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 Capsaicin
10 Apigenin (mainly Parsley)
10 chaetocin
10 Fisetin
9 Cucurbitacin
9 Silymarin (Milk Thistle) silibinin
9 Resveratrol
9 Dichloroacetate
9 Deguelin
9 Formononetin
8 Astragalus
8 Artemisinin
8 salinomycin
8 diet FMD Fasting Mimicking Diet
8 Emodin
8 Gambogic Acid
8 Ginkgetin
8 Honokiol
8 Phenylbutyrate
8 Pterostilbene
8 Urolithin
7 Radiotherapy/Radiation
7 Allicin (mainly Garlic)
7 HydroxyCitric Acid
7 Ashwagandha(Withaferin A)
7 immunotherapy
7 Boron
7 Boswellia (frankincense)
7 Crocetin
6 Metformin
6 Cisplatin
6 Betulinic acid
6 Chrysin
6 Coenzyme Q10
6 Gemcitabine (Gemzar)
6 diet Methionine-Restricted Diet
6 Sulfasalazine
6 Isoliquiritigenin
6 Magnolol
6 Indole-3-carbinol
6 Inulin Prebiotic
6 Lycopene
6 Magnesium
6 Rosmarinic acid
6 α-Santalol/Sandalwood oil
5 chitosan
5 Melatonin
5 Berbamine
5 Beta-Caryophyllene
5 Centella asiatica / Gotu kola → asiaticoside
5 Citric Acid
5 Dandelion Root
5 Eugenol
5 Gallic acid
5 Graviola
5 isoquercitrin
5 Juglone
4 3-bromopyruvate
4 Fenbendazole
4 Paclitaxel/Taxol
4 Astaxanthin
4 Atorvastatin
4 Dipyridamole
4 Brucea javanica
4 Butyrate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Cynaropicrin
4 Docosahexaenoic Acid
4 Disulfiram
4 Evodiamine
4 Genistein (soy isoflavone)
4 Hydrogen Gas
4 Hyperoside
4 Isobavachalcone
4 Luteolin
4 Nimbolide
4 Piperine
4 Piperlongumine
4 Selenite (Sodium)
4 Thymoquinone
4 Vitamin K2
4 VitK3,menadione
3 Caffeic acid
3 Diclofenac
3 doxorubicin
3 Baicalin
3 Bufalin/Huachansu
3 brusatol
3 Bruteridin(bergamot juice)
3 Carvacrol
3 Celastrol
3 Chlorogenic acid
3 Selenium NanoParticles
3 Copper and Cu NanoParticles
3 Photodynamic Therapy
3 tamoxifen
3 Ellagic acid
3 eicosapentaenoic acid
3 Fucoidan
3 Geraniol
3 Ginger/6-Shogaol/Gingerol
3 Glabrescione B
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Inositol
3 Niclosamide (Niclocide)
3 Propyl gallate
3 Plumbagin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
2 2-DeoxyGlucose
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Anethole/trans-Anethole
2 Fennel Oil/Foeniculum vulgare
2 Ascorbyl Palmitate
2 Biochanin A
2 Bifidobacterium
2 Bromelain
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Polyphenols
2 Cyclopamine
2 Oxygen, Hyperbaric
2 diet Short Term Fasting
2 D-limonene
2 Ginkgo biloba-EGb 761
2 ferumoxytol
2 Galloflavin
2 Ginkgo biloba
2 Ginkgolide B
2 Grapeseed extract
2 Hydroxycinnamic-acid
2 iodine
2 metronomic chemo
2 Isovitexin
2 Linalool
2 Methylene blue
2 Oroxylin-A
2 Oleuropein
2 Orlistat
2 Psoralidin
2 Hyperthermia
2 EMF
2 Oxaliplatin
2 Spermidine
2 Ursolic acid
2 Vitexin
2 Whole Body Vibration
1 1,8-Cineole
1 5-fluorouracil
1 Anzaroot, Astragalus fasciculifolius Bioss
1 octreotide
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 Anti-oxidants
1 5-Aminolevulinic acid
1 Aloe anthraquinones
1 beta-glucans
1 temozolomide
1 Bacopa monnieri
1 Caffeine
1 urea
1 Cat’s Claw
1 Cannabidiol
1 Celecoxib
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Bicalutamide
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dasatinib/Phyrago
1 Bortezomib
1 Date Fruit Extract
1 diet Ketogenic
1 diet Plant based
1 Aspirin
1 Zinc
1 Echinacea
1 PXD, phenoxodiol
1 Sorafenib (brand name Nexavar)
1 Electrical Pulses
1 erastin
1 Eurycomanone
1 Shilajit/Fulvic Acid
1 Ginkgolic acids
1 Hibiscus sabdariffa
1 itraconazole
1 Ivermectin
1 Laetrile B17 Amygdalin
1 Licorice
1 mebendazole
1 Methylglyoxal
1 Mushroom Chaga
1 Naringin
1 Noscapine
1 Parthenolide
1 raloxifen
1 Salvia officinalis
1 Vorinostat
1 Selenium
1 irinotecan
1 Salvia miltiorrhiza
1 Saikosaponin B1 and D
1 Sutherlandioside D
1 cetuximab
1 Taurine
1 Tomatine
1 triptolide
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Transarterial Chemoembolization
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:323  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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