TumCMig Cancer Research Results

TumCMig, Tumor cell migration: Click to Expand ⟱
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Tumor cell migration is a critical process in cancer progression and metastasis, which is the spread of cancer cells from the primary tumor to distant sites in the body.
Scientific Papers found: Click to Expand⟱
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6321- DRE,    Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1
- in-vitro, GC, NA
CCAT1↓, TumCP↓, TumCMig↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6361- DRE,    Taraxacum officinale Seed Extract Inhibits HeLa Cell Migration at Sub-cytotoxic Concentrations
- in-vitro, Cerv, HeLa
tumCV↓, TumCMig↓,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
7192- EGb 761,    Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases
- in-vitro, Nor, HMEC
Risk↓, *TumCP↓, *TumCMig↓, *angioG↓,
7220- EGb 761,    Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer
- vitro+vivo, GC, SGC-7901
TumCP↓, TumCMig↓, TumCI↓, p‑ERK↓, NF-kB↓, MMP2↓, eff↑, TumCG↓, TumMeta↓, Dose↝, TumVol↓,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
1072- EGCG,    Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways
- in-vitro, Thyroid, 8505C
EMT↓, TumCI↓, TumCMig↓, TGF-β↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓,
665- EGCG,    Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway
- in-vitro, NA, H1299
AMPK↑, TumCP↓, TumCMig↓, TumCI↓,
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
688- EGCG,  GEM,    Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
1319- EMD,    Emodin treatment of papillary thyroid cancer cell lines in vitro inhibits proliferation and enhances apoptosis via downregulation of NF‑κB and its upstream TLR4 signaling
- in-vitro, Thyroid, TPC-1 - in-vitro, Thyroid, IHH4
NF-kB↓, TLR4↓, TumCI↓, TumCMig↓,
1247- EMD,    Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
TumCP↓, TumCMig↓, TumCI↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, TumCG↓, CD133↓, OCT4↓, CSCs↓,
7045- EMD,  TSG,    Synergic effects and possible mechanism of emodin and stilbene glycosides on colorectal cancer
- vitro+vivo, CRC, NA
Apoptosis↑, TumCMig↓, TumVol↓, IL6↓, TGF-β↓, i-P53↓, i-STAT3↓,
6830- EMD,    Anticancer activity of emodin is associated with downregulation of CD155
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, E0771 - in-vitro, BC, 4T1
TumCP↓, TumCMig↓, TumCCA↑, CD155↓, Dose↓, other↝, TumCG↓,
6833- EMD,    Anticancer potential of emodin
- Review, Var, NA
Inflam↓, angioG↓, TumCCA↑, Apoptosis↑, HIF-1↓, TumCI↓, TumCMig↓, HER2/EBBR2↓, CK2↓, ROS↑, AR↓, JAK2↓, STAT3↓, Mcl-1↓, NAT↓, ChemoSen↑, survivin↓, XIAP↓, NF-kB↓, *neuroP↑, *hepatoP↑,
6793- EPA,    Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, ERK↓, PTK2B / PYK2↓, TumCG↓, ROS↑, TumCMig↓, TumCI↓,
2455- erastin,    Discovery of the Inhibitor Targeting the SLC7A11/xCT Axis through In Silico and In Vitro Experiments
- in-vitro, Cerv, HeLa
xCT/SLC7A11↓, GSH↓, ROS↑, TumCMig↓,
6580- EU,    Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-1
TumCMig↓, MMP2↓, EMT↓, E-cadherin↑, Akt↓, N-cadherin↓, TGF-β↓, Smad1↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6338- Eug,    Tumor suppressive roles of eugenol in human lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCMig↓, TumCI↓, Akt↓, MMP2↓, *lipid-P↓, *COX2/PTGS2↓, *ROS↓, PI3K↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, eff↑, eff↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6845- EVO,    Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, H1299
AntiCan↑, TumVol↓, NOTCH3↓, tumCV↓, TumCCA↑, TumCMig↓, CSCs↓, TumCP↓, Apoptosis↑, TumCI↓, ROS↑, TumCG↓, selectivity↑, DNMT1↓,
6843- EVO,    Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
- in-vivo, PC, PANC1 - in-vitro, PC, SW1990
Apoptosis↑, LC3II↓, p62↑, Akt↓, ERK↓, p38↓, TumW↓, TumCG↓, TumCMig↓,
1111- EVO,    Evodiamine exerts inhibitory roles in non‑small cell lung cancer cell A549 and its sub‑population of stem‑like cells
- in-vitro, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, EMT↓,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, eff↑, eff↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
7513- FA,    Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
- in-vitro, Thyroid, NA
cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,
7510- FA,    Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
- in-vitro, Lung, H1299
*antiOx↑, ROS↑, H2O2↑, TumCP↓, TumCMig↓, MMP2↓, MMP9↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6427- FEO,    Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
- vitro+vivo, HCC, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCG↓, survivin↓, mtDam↑, Casp3↑,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2840- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- NA, CCA, NA
ROS↑, TumCMig↓, TumCP↓,
6903- FIS,    Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ERK↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓,
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
6904- FIS,    Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway
- in-vitro, Cerv, NA
TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, uPA↓,
6922- FIS,    Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
- Review, Var, NA
*memory↑, *Inflam↓, *5LO↓, *lipid-P↓, *NF-kB↓, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, *ROS↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumCMig↓, MMPs↓, PSA↓,

Showing Research Papers: 201 to 250 of 500
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 500

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD155↓, 1,   CXCR3↓, 1,   NA↑, 1,   NAT↓, 1,   URGCP/URG4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GSH↓, 2,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 2,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   PARK2↑, 1,   PYCR1↓, 1,   ROS↓, 2,   ROS↑, 18,   mt-ROS↑, 1,   SOD↓, 2,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   EGF↓, 1,   ETC↓, 1,   FGFR1↓, 3,   MMP↓, 5,   mtDam↑, 4,   PINK1↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   p‑AMPK↑, 1,   CAIX↓, 1,   cMyc↓, 3,   Glycolysis↓, 1,   LDH↓, 1,   PKM2↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 21,   BAX↓, 1,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 1,   Casp1↑, 2,   Casp3↑, 13,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 3,   proCasp8↑, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   Chk2↑, 1,   CK2↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   DR4↑, 1,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 3,   Myc↑, 1,   NOXA↑, 2,   p38↓, 1,   p38↑, 1,   PUMA↑, 2,   survivin↓, 5,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   miR-25-5p↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   other↝, 1,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 2,   LC3II↑, 1,   p62↑, 2,   p‑p62↑, 1,   TumAuto↑, 1,   TumAuto⇅, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   CHK1↑, 1,   DNAdam↑, 4,   DNMT1↓, 1,   P53↑, 8,   i-P53↓, 1,   PARP↓, 2,   PARP↑, 3,   cl‑PARP↑, 3,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 5,   CDK4↓, 7,   cycA1/CCNA1↑, 1,   cycD1/CCND1↓, 8,   CycD3↓, 1,   cycE/CCNE↓, 5,   E2Fs↓, 1,   P21↓, 1,   P21↑, 3,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD133↓, 1,   CD44↓, 1,   cFos↓, 2,   CSCs↓, 6,   EMT↓, 13,   EpCAM↓, 1,   ERK↓, 6,   ERK↑, 1,   p‑ERK↓, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   Gli↓, 1,   Gli1↓, 2,   HH↓, 2,   HRAS↓, 1,   p‑IGFR↓, 1,   miR-34a↑, 1,   mTOR↓, 6,   mTORC1↓, 2,   mTORC2↓, 1,   mTORC2↑, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 4,   PI3K↓, 12,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   PTEN↑, 2,   Shh↓, 1,   Smo↓, 2,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   i-STAT3↓, 1,   STAT6↓, 2,   TCF-4↓, 1,   TumCG↓, 12,   tyrosinase↓, 2,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   CCAT1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 2,   FAK↓, 2,   GLI2↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   MMP1↓, 1,   MMP2↓, 12,   MMP7↓, 1,   MMP9↓, 11,   MMPs↓, 4,   N-cadherin↓, 2,   NEDD9↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   PTK2B / PYK2↓, 1,   Slug↓, 1,   Smad1↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 2,   TGF-β↓, 6,   TIMP1↑, 3,   TumCA↓, 1,   TumCI↓, 32,   TumCMig↓, 48,   TumCMig↑, 1,   TumCP↓, 19,   TumMeta↓, 3,   uPA↓, 5,   Vim↓, 4,   Zeb1↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 13,   ATF4↑, 2,   EGFR↓, 5,   HIF-1↓, 1,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 3,   JAK↓, 1,   JAK2↓, 3,   NF-kB↓, 15,   NF-kB↑, 2,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 1,   TLR4↓, 2,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 14,   Dose↓, 1,   Dose↝, 3,   eff↓, 3,   eff↑, 17,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   RadioS↑, 7,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 2,   AST↓, 2,   EGFR↓, 5,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   LDH↓, 1,   Myc↑, 1,   PD-L1↑, 1,   PSA↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↓, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   Risk↓, 1,   toxicity↓, 1,   TumVol↓, 5,   TumW↓, 2,  
Total Targets: 271

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Bil↓, 1,   Catalase↑, 3,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 4,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 4,   MDA↓, 2,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 10,   SOD↑, 2,   SOD1↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Casp1↓, 1,   iNOS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 1,   CEA↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 4,   Inflam↓, 7,   Inflam↑, 1,   NF-kB↓, 2,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 7,   BioAv⇅, 1,   BioAv↝, 4,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↓, 1,   CEA↓, 1,   GutMicro↑, 4,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 2,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 5,   Obesity↓, 1,   Pain↓, 1,   toxicity↓, 1,   toxicity↝, 2,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 71

Scientific Paper Hit Count for: TumCMig, Tumor cell migration
21 Curcumin
13 Honokiol
13 Quercetin
13 Shikonin
11 Berberine
10 Capsaicin
10 Fisetin
9 Apigenin (mainly Parsley)
9 Resveratrol
9 EGCG (Epigallocatechin Gallate)
9 Dandelion Root
9 Silymarin (Milk Thistle) silibinin
8 Betulinic acid
8 Magnolol
8 Magnetic Fields
8 Sulforaphane (mainly Broccoli)
7 Ashwagandha(Withaferin A)
7 Thymoquinone
7 Urolithin
6 Propolis -bee glue
6 Chlorogenic acid
6 Metformin
6 Ferulic acid
6 Piperlongumine
6 Rosmarinic acid
5 Silver-NanoParticles
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Baicalein
5 Radiotherapy/Radiation
5 Carvacrol
5 Emodin
5 Eugenol
5 Ginkgetin
5 Hyperoside
5 Phenethyl isothiocyanate
5 Piperine
4 Astragalus
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Boron
4 5-fluorouracil
4 Gallic acid
4 Ginkgolide B
4 Indole-3-carbinol
4 Isoliquiritigenin
4 Luteolin
4 Nimbolide
4 Pterostilbene
3 DTS(dibenzyl trisulphide) from Anamu
3 Berbamine
3 Bacopa monnieri
3 brusatol
3 Caffeic acid
3 Chrysin
3 Cinnamon
3 Crocetin
3 Copper and Cu NanoParticles
3 Cucurbitacin
3 CUSP9
3 Deguelin
3 Evodiamine
3 Formononetin
3 Fucoidan
3 Garcinol
3 Hydrogen Gas
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 Lycopene
3 salinomycin
3 Aflavin-3,3′-digallate
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Isovitexin
2 Aspirin
2 Arctigenin
2 Baicalin
2 Beta-Caryophyllene
2 Bufalin/Huachansu
2 Genistein (soy isoflavone)
2 Boswellia (frankincense)
2 Paclitaxel/Taxol
2 Carnosic acid
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chlorophyllin
2 Docetaxel
2 Carvone
2 Disulfiram
2 Ellagic acid
2 Ginkgo biloba-EGb 761
2 Ginkgolic acids
2 Ginkgo biloba
2 Geraniol
2 Grapeseed extract
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 isoflavones
2 isoorientin
2 isoquercitrin
2 Juglone
2 Plumbagin
2 Magnetic Field Rotating
2 Psoralidin
2 Cisplatin
2 Parthenolide
2 α-Santalol/Sandalwood oil
2 Ursolic acid
2 Vitamin C (Ascorbic Acid)
2 VitK3,menadione
1 3-bromopyruvate
1 Auranofin
1 Ajoene (compound of Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bevacizumab (brand Avastin)
1 Brucea javanica
1 Bromelain
1 selenomethionine
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cannabidiol
1 chitosan
1 Selenium NanoParticles
1 Hydroxycinnamic-acid
1 Citric Acid
1 Oxaliplatin
1 Electrical Pulses
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 D-limonene
1 Mistletoe/Viscum album Extracts
1 Tetrahydroxystilbene glucoside
1 eicosapentaenoic acid
1 erastin
1 Eurycomanone
1 Shilajit/Fulvic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Proanthocyanidins
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 Licorice
1 Linalool
1 Melatonin
1 Methyl salicylate / Sweet Birch oil
1 doxorubicin
1 immunotherapy
1 Myricetin
1 Naringin
1 Niclosamide (Niclocide)
1 Oroxylin A
1 Orlistat
1 Propyl gallate
1 temozolomide
1 raloxifen
1 tamoxifen
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 Sanguinarine
1 Sulfasalazine
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Arsenic trioxide
1 Vitexin
1 Zinc
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:326  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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