VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
3716- FA,    Ferulic Acid as a Protective Antioxidant of Human Intestinal Epithelial Cells
- in-vitro, IBD, NA - in-vivo, NA, NA
*antiOx↑, *Inflam↓, *ER Stress↓, *other↑, *angioG↑, *Hif1a↑, *VEGF↑, *NO↓, *SIRT1↑, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *GutMicro↑,
6912- FIS,    Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers
- Review, Var, NA
TumMeta↓, chemoPv↑, VEGF↓, VEGFR1↓, EGFR↓, Necroptosis↑, Hippo↝,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
6978- Form,    Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway
- vitro+vivo, Nor, HUVECs
*angioG↑, *VEGF↑, *MYPT1 / PPP1R12A↑, *MMP2↑, *MMP9↑, *p‑MYPT1 / PPP1R12A↑, *p‑MLC2/MYL9↑, *p‑LIMK1↑, *p‑Cofilin↑, *ROCK1↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6986- Form,    Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway
- in-vitro, Var, NA
other↝, AntiCan↑, VEGF↓, Apoptosis↑, Bax:Bcl2↑, cl‑Casp3↑, cl‑Casp9↑, Cyt‑c↑, Hif1a↓, MEK↓, ERK↓, VEGFR2/KDR/Flk1↓, angioG↓,
6967- Form,  BTZ,    Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
- in-vivo, Melanoma, U266 - in-vivo, Melanoma, RPMI-8226
Synergy↑, NF-kB↓, PI3K↓, Akt↓, AP-1↓, COX2/PTGS2↓, MMP9↓, Casp3↑, cl‑PARP↑, Dose↝, Ki-67↓, VEGF↓,
8304- FS,    Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer
- Trial, Pca, NA
NF-kB↓, VEGF↓, Ki-67↓, TumCP↓,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
948- Fuc,    Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia
- vitro+vivo, Bladder, T24/HTB-9 - in-vitro, Nor, HUVECs
p‑PI3k/Akt/mTOR↓, p‑p70S6↓, p‑4E-BP1↓, angioG↓, Hif1a↓, VEGF↑, TumCG↓, TumVol↓, TumW↓, Iron∅, ROS↓,
1114- Fuc,    The Potential Effect of Fucoidan on Inhibiting Epithelial-to-Mesenchymal Transition, Proliferation, and Increase in Apoptosis for Endometriosis Treatment: In Vivo and In Vitro Study
- vitro+vivo, Var, NA
tumCV↓, TumCMig↓, VEGF↓, EMT↓, Apoptosis↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
7033- GA,  OL,    Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line
- in-vitro, OS, U2OS
tumCV↓, angioG↓, DNAdam↑, Apoptosis↑, cl‑PARP↓, Bcl-2↓, BAX↑, ROS↓, Synergy↑, TumCMig↓, VEGF↓, Casp9↑, P53↑, selectivity↑,
947- GA,    Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells
- in-vitro, Ovarian, OVCAR-3 - in-vitro, Melanoma, A2780S - in-vitro, Nor, IOSE364 - Human, NA, NA
TumCG↓, VEGF↓, angioG↓, p‑Akt↓, Hif1a↓, PTEN↑, BioAv↑, *toxicity↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7060- GamB,    New targets for the antitumor activity of gambogic acid in hematologic malignancies
- Review, Melanoma, RPMI-8226
AntiCan↑, TumCP↓, Apoptosis↑, SRC3↓, DIDO1/DIO-1↑, KCNH2/hERG↓, ROS↑, Bcl-2↓, P53↑, cMyc↓, VEGF↓, Casp3↑, cl‑PARP1↑, eff↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
7088- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC4
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, selectivity↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7089- GAR,    Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, PC, NA
STAT3↓, TumCI↓, NF-kB↓, uPA↓, VEGF↓, MMP9↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
810- GAR,  GEM,    Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, Var, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
7199- GGB,    Ginkgolide B Promotes Angiogenesis After Oxygen-Glucose Deprivation by Regulating AKT1 in bEnd.3 Cells
- in-vitro, Stroke, NA
*neuroP↑, *VEGF↑, *AKT1↑, *angioG↑, *Stroke↓,
7289- GGB,    The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
- Review, Var, NA
ORR↑, ChemoSen↑, OS↑, Weight↓, VEGF↑,
7288- GGB,    Anti-Angiogenic Properties of Ginsenoside Rg3 Epimers: In Vitro Assessment of Single and Combination Treatments
- in-vitro, BC, MDA-MB-231
TumCMig↓, TumCP↓, Apoptosis↑, VEGF↓, AQPs↓, Akt↓, p‑mTOR↓, eff↑,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
7249- Gink,  RES,    Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer
- vitro+vivo, CRC, NA
VEGF↓, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑,

Showing Research Papers: 201 to 250 of 466
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 466

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 26,   GSH↑, 5,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 9,   HO-1↑, 15,   HO-2↓, 1,   Iron↑, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 5,   MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 24,   NRF2↑, 24,   NRF2↝, 1,   p‑NRF2↓, 1,   OSI↑, 1,   Prx4↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 175,   ROS⇅, 12,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 6,   SOD2↓, 4,   TAC↓, 3,   Thiols↓, 1,   TOS↑, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 8,   CDC25↓, 8,   EGF↓, 6,   ETC↓, 2,   HSP60/HSPD1↓, 2,   mitResp↓, 4,   MKK7↓, 2,   Mortalin↓, 1,   mtDam↑, 10,   OCR↓, 3,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   AApath↓, 1,   ACC↑, 2,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 20,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 14,   ATP↑, 1,   ATP↝, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 7,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 10,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 7,   HK2↓, 12,   IDO1↓, 1,   lactateProd↓, 11,   lactateProd↑, 1,   e-lactateProd↓, 1,   LDHA↓, 9,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 11,   PKM2↑, 1,   p‑S6↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 152,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 9,   Bak↑, 11,   BAX↓, 2,   BAX↑, 86,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 116,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 4,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 33,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 118,   Casp3↝, 1,   cl‑Casp3↑, 17,   proCasp3↑, 1,   Casp6↑, 1,   Casp7?, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 6,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 69,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 67,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   Endon↑, 1,   FADD↑, 3,   Fas↑, 22,   FasL↑, 6,   Ferroptosis↑, 7,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICAD↑, 1,   iNOS↓, 21,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 10,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 68,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAIL⇅, 1,   TRAILR↑, 4,   TumCD?, 1,   TumCD↑, 6,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 4,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 36,   BRAF↓, 1,   Brk/PTK6↓, 1,   CK2↓, 5,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 3,   DYRK1B↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 52,   ERK↑, 7,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 16,   p‑ERK↑, 2,   ERK5↓, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 14,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   JNK↓, 6,   JNK↑, 20,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 29,   MAPK↑, 12,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 10,   MKK4↓, 2,   mTOR↓, 81,   mTOR↝, 1,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p70S6↓, 2,   P70S6K↓, 5,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 30,   PTEN↝, 1,   p‑PTEN↓, 1,   PTPN6↑, 1,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 2,   SHP1↑, 4,   Sp1/3/4↓, 17,   Src↓, 4,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   p‑STAT3↓, 20,   p‑STAT3↑, 3,   STAT5↓, 4,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 46,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 8,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 5,   FOXO3↑, 5,   FOXO3↝, 1,   FOXO4↓, 2,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 27,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 2,   HOTAIR↓, 1,   KISS1↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 9,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 6,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 1,   Prot↓, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 24,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   HSP27↓, 3,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 7,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 14,   Beclin-1/ATG6↝, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↓, 2,   LC3II↑, 12,   LC3s↑, 1,   p62↓, 9,   p62↑, 3,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 1,   p‑ATM↑, 2,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 45,   DNArepair↓, 3,   DNArepair↑, 2,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   p16↑, 5,   P53?, 1,   P53↓, 4,   P53↑, 74,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 4,   PARP↓, 3,   PARP↑, 18,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 57,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 9,   TOP2↓, 6,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 37,   CDK2↑, 1,   CDK4↓, 46,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 21,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 15,   cycE/CCNE↑, 2,   cycE1↓, 2,   cycF↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 24,   mitA↑, 2,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 27,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   TubPol↓, 1,   TumCCA↓, 6,   TumCCA↑, 151,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 5,   CD133↑, 1,   CD24↓, 1,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 2,   CSCs↓, 39,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 10,   HH↓, 7,   IGF-1?, 1,   IGF-1↓, 11,   IGF-2↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 5,   MCM2↓, 1,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 17,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 3,   p300↓, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 2,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 79,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt↑, 2,   Wnt/(β-catenin)↓, 9,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   ANGPT2↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 28,   Ca+2↝, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 10,   E-cadherin↑, 45,   EM↑, 1,   EMT?, 1,   EMT↓, 72,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 22,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   LAMs↓, 3,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 1,   MMP2↓, 115,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 13,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 42,   MMPs↝, 1,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 28,   NCAM↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 11,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 5,   ROCK1↑, 2,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 24,   TGF-β↑, 2,   TGF-β1↓, 3,   TIMP1↓, 2,   TIMP1↑, 12,   TIMP2↓, 3,   TIMP2↑, 14,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 5,   TumCA↓, 2,   TumCI↓, 68,   TumCMig↓, 73,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 72,   TumMeta↑, 5,   Twist↓, 26,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 29,   uPAR↓, 4,   UroPA↓, 1,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 4,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 169,   angioG↑, 5,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 14,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 4,   HIF-1↓, 11,   Hif1a↓, 141,   LOX1↓, 3,   NO↓, 8,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 412,   VEGF↑, 5,   VEGF↝, 2,   VEGFR1↓, 7,   VEGFR2/KDR/Flk1↓, 29,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 2,   CX43/GJA1↓, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 20,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 67,   MMP↑, 5,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 2,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 10,   IL10↓, 8,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL1α↓, 2,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 7,   IL4↓, 2,   IL4↑, 1,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IL8↓, 16,   Imm↑, 10,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 26,   LIF↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 2,   mPGES-1↓, 3,   MyD88↓, 1,   MyD88↑, 1,   NF-kB↓, 157,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 9,   NLRP3↓, 4,   NLRP3↑, 2,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 11,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 8,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 39,   TNF-α↑, 4,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 18,   AR↝, 1,   CYP19↓, 2,   ER-α36↓, 2,   ER-α36↝, 1,   ER(estro)↓, 2,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 3,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 42,   BioAv↑, 48,   BioAv↝, 6,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 128,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 9,   Dose↝, 33,   Dose∅, 7,   eff↓, 16,   eff↑, 54,   eff↝, 15,   eff∅, 1,   Half-Life↓, 13,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 2,   MDR1↓, 10,   MRP1/ABCC1↓, 6,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS?, 1,   RadioS↑, 46,   selectivity↑, 50,   Synergy↑, 90,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 18,   AR↝, 1,   ascitic↓, 3,   AST↓, 4,   AST↑, 1,   AST↝, 1,   BloodF↓, 1,   BloodF↑, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 6,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 14,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   LDH↓, 2,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 9,   NSE↓, 1,   PD-L1↓, 11,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 40,   AntiCan∅, 1,   antiNeop↑, 7,   AntiTum↑, 14,   cachexia↓, 2,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 23,   chemoPv↑, 19,   ChemoSideEff↓, 7,   fatigue↓, 2,   hepatoP↑, 5,   Mucositis↓, 1,   neuroP↑, 7,   NP/CIPN↓, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 19,   Pain↓, 1,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 24,   TumW↓, 11,   Weight↓, 1,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 1080

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 1,   antiOx↑, 64,   Catalase↓, 1,   Catalase↑, 36,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 20,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 6,   GSTs↑, 9,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 18,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 40,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 93,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 3,   TBARS↓, 2,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PDH↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↑, 2,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↑, 8,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 14,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 10,   iNOS↑, 2,   p38↓, 3,   p38↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 6,   p‑Akt↑, 2,   AKT1↑, 1,   CREB↑, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 4,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↑, 5,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 6,   other↝, 4,   SOX18↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   HSPs↑, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↓, 1,   CD133↑, 1,   Diff↑, 2,   FGF↑, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   MSCs↑, 1,   neuroG↑, 1,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 3,   MMPs↑, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 2,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↑, 1,   SLIT2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,   TGF-β↓, 3,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 15,   angioG↝, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 6,   Hif1a∅, 1,   NO↓, 14,   NO↑, 3,   VCAM-1↓, 6,   VEGF↓, 22,   VEGF↑, 32,   VEGFR2/KDR/Flk1↓, 1,   VEGFR2/KDR/Flk1↑, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 9,   BBB↝, 1,   GLUT2↑, 1,   GLUT3↑, 3,   GLUT4↑, 3,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↓, 1,   TRPC1↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 5,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 9,   IL12↓, 2,   IL13↓, 1,   IL17↓, 3,   IL18↓, 3,   IL1β↓, 20,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 1,   IL5↓, 3,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 89,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 2,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 9,   p65↓, 1,   PGE2↓, 13,   PGE2↑, 2,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 5,   TLR4∅, 1,   TNF-α↓, 34,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 13,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 3,   p‑tau↓, 8,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 32,   BioAv↑, 24,   BioAv↝, 9,   BioEnh↑, 2,   CompStab↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 5,   ascitic↓, 1,   AST↓, 18,   BMD↑, 2,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 4,   EGFR↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 16,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 14,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 32,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 18,   diuretic↑, 1,   hepatoP↑, 31,   Learn↑, 2,   memory↑, 21,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 58,   Obesity↓, 9,   OS↑, 2,   Pain↓, 5,   QoL↑, 1,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 8,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 9,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 3,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 13,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 437

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
17 Thymoquinone
16 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
12 Resveratrol
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
10 Garcinol
9 Baicalein
9 Berberine
9 Chrysin
8 Silver-NanoParticles
8 Propolis -bee glue
8 Fisetin
8 Kaempferol
7 Artemisinin
7 Boswellia (frankincense)
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Fucoidan
6 Luteolin
6 Melatonin
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Emodin
5 Formononetin
5 Gambogic Acid
5 Hydrogen Gas
5 Honokiol
4 Cisplatin
4 Ashwagandha(Withaferin A)
4 Bevacizumab (brand Avastin)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Ferulic acid
4 Isoliquiritigenin
4 Juglone
4 Lycopene
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Chemotherapy
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Diindolylmethane
3 Eugenol
3 Flaxseed/Linseed
3 Ginkgolide B
3 iodine
3 phytic acid, Inositol hexakisphosphate
3 Licochalcone A
3 Magnolol
3 mebendazole
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chaetocin
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gallic acid
2 Gemcitabine (Gemzar)
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Hyperoside
2 MCT, metronomic chemo
2 lambertianic acid
2 Licorice
2 SDG/lignans
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 Docetaxel
1 Bortezomib
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Inositol
1 Extracorporeal Shock Wave Therapy
1 isoflavones
1 isoorientin
1 itraconazole
1 Lactoferrin/Talactoferrin
1 Methyl Jasmonate
1 vp16, etoposide
1 Moringa oleifera
1 tamoxifen
1 Mistletoe/Viscum album Extracts
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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