β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
Type:
β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
1673- PBG,    An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, MALAT1↓, P53↑, RadioS↑, OS↑, ROS↑, NF-kB↓, p65↑, MMP↓, ROS↑, MMP9↓, β-catenin/ZEB1↓, Vim↓, E-cadherin↓, VEGF↓, EMT↓,
9012- Phyco,    Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies
- Review, Var, NA
*Ingr↝, *antiOx↑, *Inflam↓, Imm↑, AntiCan↑, *toxicity↓, *Dose↝, *GutMicro↑, *IBI↑, Apoptosis↑, TumCCA↑, DNArepair↓, ROS↑, Cyt‑c↑, BAX↑, cl‑PARP1↑, CellShr↑, TumCMig↓, COX2/PTGS2↓, E-cadherin↑, MMP2↓, MMP9↓, HIF-1↓, angioG↓, MCP1/CCL2↓, MIP-1β↑, Ca+2↑, Cal9↑, Wnt↓, β-catenin/ZEB1↓, PPARα↑, PPARγ↑, eff↝, Half-Life↓, Synergy↑, ChemoSen↑, chemoP↑, EMT↓, N-cadherin↓, E-cadherin↑, TumCMig↓, TumCI↓, selectivity↑,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
1131- PI,    Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,
1258- PI,    Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
- in-vivo, CRC, NA
COX2/PTGS2↓, IL6↓, EMT↓, β-catenin/ZEB1↓, Snail↓, Symptoms∅,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2952- PL,    Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization
- in-vitro, Bladder, T24/HTB-9 - in-vivo, Bladder, NA
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
4701- PTS,  RES,    Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene
- Review, Var, NA
CSCs↓, E-cadherin↑, NF-kB↓, EMT↓, GRP78/BiP↓, CD133↓, COX2/PTGS2↓, β-catenin/ZEB1↓, NOTCH↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
46- QC,    Quercetin, but Not Its Glycosidated Conjugate Rutin, Inhibits Azoxymethane-Induced Colorectal Carcinogenesis in F344 Rats
- in-vitro, Colon, F344
β-catenin/ZEB1↓, BioAv↓,
53- QC,    Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer
- in-vitro, BC, MDA-MB-231 - NA, NA, MDA-MB-468
E-cadherin↑, Vim↓, cycD1/CCND1↓, cMyc↓, EMT↓, TumCG↓, TumCMig↓, β-catenin/ZEB1↓, ChemoSen↑,
87- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, BAX↑, PUMA⇅, β-catenin/ZEB1↓, Shc↓, TAp63α↑, MAPK↑, p‑p42↑, p‑p44↑, BIM↑,
85- QC,    Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)
- in-vitro, Pca, PC3
uPA↓, uPAR↓, EGFR↓, NRAS↓, Jun↓, NF-kB↓, β-catenin/ZEB1↓, p38↑, MAPK↑, cJun↓, cFos↓, Raf↓, TumCI↓, TumCMig↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, Var, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3085- RES,    Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1
- in-vitro, Cerv, NA
TET1↑, Wnt↓, β-catenin/ZEB1↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
4662- RES,    A Promising Resveratrol Analogue Suppresses CSCs in Non-Small-Cell Lung Cancer via Inhibition of the ErbB2 Signaling Pathway
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
CSCs↓, CD133↓, OCT4↓, β-catenin/ZEB1↓, HER2/EBBR2↓, TumCP↓, PI3K↓, Akt↓, ALDH1A1↓, eff↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
5001- Sal,    Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex
- in-vitro, CRC, NA
CSCs↓, β-catenin/ZEB1↓, Wnt↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
- in-vitro, Var, NA
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP/DDIT3↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
6446- SAO,    Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
- in-vitro, BC, NA
Wnt↓, β-catenin/ZEB1↓, TumCMig↓, Wound Healing↓,
6440- SAO,    Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids
- Review, Var, NA
AntiCan↑, *Bacteria↓, *antiOx↑, *Inflam↓, *ROS↓, AntiTum↑, TumCG↓, tumCV↓, β-catenin/ZEB1↓, TumCMig↓, chemoPv↑,
1014- SFN,    Sulforaphane Modulates Cell Migration and Expression of β-Catenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
Zeb1↓, Apoptosis↑, Fibronectin↓, CLDN1↓, β-catenin/ZEB1↓, EMT↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1194- SM,    Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition
- in-vivo, Diabetic, NA
β-catenin/ZEB1↓, TGF-β↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, EP2↓, EP4/PTGER4↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,

Showing Research Papers: 201 to 250 of 256
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 256

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 2,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 6,   GPx4↝, 1,   GSH↓, 13,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 9,   HO-2↑, 1,   Iron↑, 2,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 6,   lipid-P↑, 5,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 9,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 13,   ROS↑, 74,   ROS⇅, 4,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 4,   SOD2↓, 2,   TAC?, 1,   TrxR↓, 3,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 3,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 5,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 2,   ALAT↝, 1,   AMACR↓, 1,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 19,   ATP↓, 4,   CAIX/CA9↓, 1,   ECAR↓, 1,   FAO↓, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   Glycolysis↓, 15,   GSK‐3β↓, 16,   GSK‐3β↑, 9,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 9,   HK1↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   lipoGen↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PKM2:PKM1↓, 2,   SCD1↓, 1,   SIRT1↓, 7,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 86,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 2,   aSmase↝, 1,   BAD↑, 2,   Bak↑, 4,   BAX↓, 2,   BAX↑, 38,   BAX↝, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 44,   Bcl-2↑, 4,   Bcl-2↝, 1,   Bcl-xL↓, 6,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   Casp↓, 1,   Casp↑, 15,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 48,   Casp3↝, 1,   cl‑Casp3↑, 13,   proCasp3↓, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 30,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 3,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 34,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 17,   FADD↑, 1,   Fas↓, 1,   Fas↑, 11,   FasL↑, 2,   Ferroptosis↑, 9,   HEY1↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 2,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 4,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 10,   p‑p38↑, 2,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↝, 1,   p‑Akt↓, 17,   AKT1↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   CREB↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   EphB4↓, 1,   ERK↓, 25,   ERK↑, 5,   p‑ERK↓, 7,   FGFR1↓, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 7,   JAK↓, 6,   JAK1↓, 3,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 9,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   Mst1↑, 1,   mTOR↓, 51,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   NRAS↓, 1,   p‑p42↓, 1,   p‑p42↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 62,   PI3K↝, 1,   p‑PI3K↓, 3,   PIAS-3↑, 1,   PKCδ↓, 4,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 8,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 49,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 6,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 41,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO4↑, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 2,   miR-205↑, 1,   miR-21↓, 6,   miR-210↓, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↑, 5,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 9,   other↓, 2,   other↑, 2,   other↝, 3,   PCAF↓, 1,   Shc↓, 1,   SOX2↓, 7,   SOX4↓, 3,   SOX4↑, 1,   SPP1↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 20,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 23,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 10,   LC3s↓, 1,   p62↓, 3,   p62↑, 2,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 17,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 19,   DNArepair↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 31,   P53↝, 1,   ac‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 26,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 12,   PCNA↑, 1,   SIRT6↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 19,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 2,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 58,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 4,   Ki-67↓, 11,   MAD↓, 1,   P21?, 1,   P21↑, 28,   P21↝, 1,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   Securin↓, 2,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 76,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 14,   CD24↓, 3,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   cFos↑, 1,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 49,   CSCs↑, 1,   Diff↑, 3,   EP2↓, 1,   EP4/PTGER4↓, 1,   FBXW7↝, 1,   Gli↓, 2,   Gli1↓, 9,   HH↓, 10,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 11,   Let-7↑, 2,   LRP6↓, 6,   p‑LRP6↓, 2,   mTORC1↓, 5,   Nanog↓, 9,   Nestin↓, 3,   NKD2↑, 2,   NOTCH↓, 17,   NOTCH⇅, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH2↓, 2,   NOTCH3↓, 3,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 8,   Smo↓, 5,   STAT1↓, 1,   p‑STAT1↓, 1,   TOPflash↓, 2,   TumCG↓, 40,   TumCP?, 1,   TumCP↓, 76,   TumCP↑, 1,   Wnt↓, 123,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 12,   AP-1↝, 2,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   Ca+2↝, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 45,   EMT↓, 70,   F-actin↓, 1,   FAK↓, 7,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 3,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB4↓, 1,   KRAS↓, 1,   LEF1↓, 5,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP14↓, 1,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 45,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 49,   MMPs↓, 18,   N-cadherin↓, 29,   N-cadherin↑, 1,   NCAM↓, 1,   NM23↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 3,   SMAD3↓, 2,   p‑SMAD3↓, 2,   Snail↓, 36,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 56,   TumCMig↓, 59,   TumCMig↑, 1,   TumMeta↓, 39,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 47,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 15,   ZEB2↑, 1,   β-catenin/ZEB1↓, 235,   β-catenin/ZEB1↑, 6,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   ECM/TCF↓, 1,   HIF-1↓, 2,   Hif1a↓, 25,   Hif1a↝, 1,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 47,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   CLDN1↓, 5,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 8,   MMP↓, 35,   MPT↑, 3,   NHE1↓, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 19,   CD44↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 12,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 3,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 6,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↝, 1,   IL8↓, 3,   Imm↑, 11,   Imm↝, 1,   Inflam↓, 16,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 79,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PGE2↓, 14,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TCF↓, 10,   TCF↑, 1,   TCF7/TCF1↓, 2,   TNF-α↓, 11,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 10,   AR↝, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 14,   BioAv↑, 13,   BioAv↝, 6,   BioEnh?, 1,   BioEnh↑, 3,   ChemoSen↑, 76,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↑, 3,   Dose↝, 17,   Dose∅, 4,   eff↓, 9,   eff↑, 27,   eff↝, 6,   GSTA1↑, 1,   Half-Life↓, 7,   Half-Life↝, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P450↓, 2,   P450↝, 1,   RadioS↑, 26,   selectivity↑, 27,   selectivity↝, 1,   Synergy↑, 43,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALB↑, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 10,   AR↝, 1,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 2,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 19,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 3,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   TBIL↓, 1,   TP53↑, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 7,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 14,   chemoPv↑, 14,   ChemoSideEff↓, 4,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 3,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↑, 3,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 7,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 8,   Sleep↑, 1,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 874

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 29,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 6,   GPx4↑, 2,   GSH↑, 7,   GSTs↑, 4,   H2O2↑, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 10,   i-Iron↓, 1,   lipid-P↓, 7,   MDA↓, 7,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 30,   ROS↑, 2,   mt-ROS↓, 1,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   GSK‐3β↓, 5,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 1,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Ferroptosis↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↑, 2,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   miR-34b-5p↓, 1,   other↝, 1,   RUNX2↑, 1,   TCF-4↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↑, 1,   Diff↑, 2,   FGF↑, 1,   Ki-67↑, 1,   TumCP↓, 1,   Wnt↓, 2,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 1,   EMT↓, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 3,   MUC1↑, 1,   OPN↑, 1,   Smad1↑, 1,   Smad7↑, 1,   STAC2↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 10,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   GLUT4↓, 1,   IBI↑, 2,   MMP↑, 1,   MUC19↓, 1,   MUC2↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 4,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 35,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 10,   p‑NF-kB↓, 1,   NLRP3↓, 2,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 6,   BDNF↑, 6,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 2,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 9,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   eff↑, 4,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   ALP↑, 1,   AST↓, 4,   BMD↑, 3,   CRP↓, 1,   IL6↓, 7,   IRes↑, 1,   LDH↓, 1,   LDH↑, 1,   OCN↑, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 7,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 4,   chemoP↑, 1,   chemoPv↑, 5,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 12,   Learn↑, 1,   memory↑, 11,   motorD↑, 1,   neuroP↑, 23,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 14,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 4,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 264

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Matrine
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Luteolin
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Ivermectin
5 Lycopene
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Kaempferol
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 phytic acid, Inositol hexakisphosphate
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 itraconazole
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Magnolol
2 Melatonin
2 Morin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Vitexin
1 lambertianic acid
1 methylseleninic acid
1 Magnetic Field Rotating
1 Zeolite
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
1 Orlistat
1 Phycocyanin
1 isoflavones
1 Rutin
1 buckwheat sprouts
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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