β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
Type:
β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1194- SM,    Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition
- in-vivo, Diabetic, NA
β-catenin/ZEB1↓, TGF-β↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, EP2↓, EP4/PTGER4↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
1020- UA,    Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
- in-vitro, Melanoma, RPMI-8226
β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
4888- ZER,  5-FU,    Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts
- in-vitro, CRC, CT26
TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

Showing Research Papers: 201 to 217 of 217
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 217

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↑, 2,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MPO↓, 1,   ROS↓, 1,   ROS↑, 3,   ROS⇅, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 2,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 6,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 5,   Bak↑, 1,   BAX↑, 5,   Bcl-2↓, 4,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↓, 1,   BIM↓, 1,   Casp↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp7↑, 3,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 2,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 2,   Myc↓, 1,   p27/CDKN1B↑, 2,   p38↑, 3,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 7,   TRAIL↑, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↑, 1,   DNMT1↓, 1,   p16↑, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 1,   PCNA↑, 1,   UHRF1↓, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 9,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 3,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   cMET↓, 1,   CSCs↓, 2,   EMT↓, 5,   EP2↓, 1,   EP4/PTGER4↓, 1,   ERK↓, 5,   ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   NOTCH↓, 1,   p300↓, 1,   P70S6K↓, 1,   PI3K↓, 5,   p‑PI3K↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TCF↓, 1,   TOPflash↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   cal2↑, 1,   CD31/PECAM-1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   ITGA5↓, 1,   Ki-67↓, 2,   MET↓, 1,   MMP2↓, 4,   MMP7↓, 2,   MMP9↓, 4,   MMPs↓, 2,   N-cadherin↓, 5,   Slug↓, 1,   Snail↓, 3,   TGF-β↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 7,   TumMeta↓, 2,   Twist↓, 4,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 5,   Zeb1↓, 4,   ZO-1↑, 1,   β-catenin/ZEB1↓, 16,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   Hif1a↓, 3,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CXCL1↓, 1,   CXCR4↓, 3,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 2,   IL1β↓, 2,   IL2↑, 2,   IL6↓, 3,   Inflam↓, 1,   JAK2↓, 2,   MDSCs↓, 1,   NF-kB↓, 3,   p‑NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Dose↝, 2,   eff↓, 1,   eff↑, 1,   eff↝, 1,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   IL6↓, 3,   Ki-67↓, 2,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 3,   hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 191

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTA1↑, 1,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL4↓, 1,   Inflam↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   Half-Life↓, 1,   Half-Life↝, 1,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 2,   RenoP↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Lycopene
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 Luteolin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Ivermectin
1 Vitexin
1 lambertianic acid
1 Magnolol
1 Magnetic Field Rotating
1 Mushroom Chaga
1 Orlistat
1 isoflavones
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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