GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,
1741- VitD3,    Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging
- Review, Var, NA
*Inflam↓, *antiOx↑, *eff↑, *ROS↓, *NRF2↑, *GPx↑, *Dose↝, Dose↑,

Showing Research Papers: 201 to 202 of 202
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 202

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 2,   NRF2↑, 2,   ROS↓, 2,   SOD↑, 1,  

Migration(tgid=13) ⓘ

AP-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   Inflam↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Thymoquinone
8 Lycopene
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Melatonin
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hydrogen Gas
3 Sulforaphane (mainly Broccoli)
2 1,8-Cineole
2 Berberine
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Chemotherapy
2 Sesame seeds and Oil
2 Luteolin
2 Moringa oleifera
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Juglone
1 Magnolol
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Nimbolide
1 Phenethyl isothiocyanate
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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