GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
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Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
4485- Se,    Selenium stimulates the antitumour immunity: Insights to future research
- Review, Var, NA
*antiOx↑, chemoPv↑, ROS↑, Imm↑, selenoP↑, *IL2↑, *IL4↑, *TNF-α↓, *TGF-β↓, *EMT↓, Risk↓, *GPx↑, *TrxR↑,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4717- Se,    A systematic review of Selenium as a complementary treatment in cancer patients
- Review, Var, NA
*antiOx↑, eff↝, radioP↑, chemoP↑, *selenoP↑, *GPx↑, TrxR↑, *ROS↓,
6047- SeNPs,  CGA,    Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis
- in-vitro, Nor, NA
*Dose↝, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *MAPK↝, *PI3K↝,
4612- SeNPs,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *Synergy↑,
4440- SeNPs,  AgNPs,    Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction
- Review, Nor, NA
*hepatoP↑, *antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *GPx↑, *lipid-P↓,
4441- SeNPs,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, *hepatoP↑, *selenoP↑, *ALAT↓, *AST↓, *GSH↑, *GPx↑, *TNF-α↓, *IL6↓, *NF-kB↓, *p65↓, *Dose⇅,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4452- SeNPs,  Chit,    Antioxidant capacities of the selenium nanoparticles stabilized by chitosan
- in-vitro, Nor, 3T3
*toxicity↓, *antiOx↑, *GPx↑, *ROS↓,
9281- SES, SSM,  LIGs,    A comprehensive review on the anti-cancer properties of sesame lignans: chemical composition, molecular mechanisms and prospects
- Review, Var, NA
Ingr↝, ChemoSen↑, *Sleep↑, *antiOx↑, *GPx↑, *GSR↑, *GSH↑, *MDA↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, P53↑, COX2/PTGS2↓, TumCP↓, Apoptosis↑, DNAdam↑, cl‑Casp3↑, NF-kB↓, ROS↑, MMP↓, VEGF↓, MMP9↓, Hif1a↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
1477- SFN,    Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling
- in-vitro, OS, MG63
tumCV↓, Apoptosis↑, Casp3↑, ROS↑, GSR↓, GPx↓,
3315- SIL,    Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
- in-vivo, Nor, NA
neuroP↑, *NRF2↑, *HO-1↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *NF-kB↓, *TNF-α↓, *JNK↓, *Bcl-2↑, *BAX↑,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, Synergy↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, Synergy↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3311- SIL,    Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells
- in-vitro, Nor, PC12
*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
4500- SSE,    Dietary selenium affects host selenoproteome expression by influencing the gut microbiota
- in-vivo, Nor, NA
*GutMicro↑, Risk↓, *GPx↑,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4494- SSE,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, OS↑, *CRP↓, *GPx↑, *Inflam↓, *ROS↓, *GutMicro↑, *selenoP↑, *other↓,
4716- SSE,    Selenium Substitution During Radiotherapy of Solid Tumours – Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients
- in-vivo, HNSCC, NA
Dose↝, *GPx↑, *ROS↓,
4733- SSE,    Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
- in-vitro, Nor, NA
*selenoP↑, *Trx↑, *GPx↑, *NRF2↑,
4718- SSE,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
1937- TQ,    Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models
- in-vitro, Wounds, 3T3
*ROS↓, *antiOx↓, *BioAv↓, *BioAv↑, *NO↑, *SOD↑, *GPx↑, *Catalase↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2087- TQ,    Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
- in-vivo, Nor, NA
*LDL↓, *SOD1↑, *Catalase↑, *GPx↑, *antiOx↑,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1/ATG6↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4854- Uro,    Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)
- Review, Pca, NA
AR↓, ROS↓, Apoptosis↑, selectivity↑, Dose↑, MDA↓, SOD↑, GPx↑, ROS↑, Casp3↑, Casp9↑,
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,
3110- VitC,    Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
- in-vivo, Nor, NA
*IL2↑, *IL6↑, *IL12↑, *NRF2↑, *Catalase↑, *SOD↑, *GPx↑, *GRP78/BiP↓, *ER Stress↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,
580- VitC,  MF,    Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum
- in-vivo, Nor, NA
*other↓, *MDA↓, *GPx∅, *SOD↑, *GSH∅,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, Var, NA
RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,
114- VitC,  QC,    Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
GPx↓, GSR↓, NQO1↓, NRF2↓, ROS↑,

Showing Research Papers: 201 to 250 of 252
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 9,   Catalase↓, 12,   Catalase↑, 13,   GPx↓, 20,   GPx↑, 28,   GPx4↓, 3,   GSH↓, 20,   GSH↑, 9,   GSH⇅, 1,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 2,   HO-1↑, 8,   Iron↑, 4,   Iron↝, 1,   lipid-P↓, 5,   lipid-P↑, 11,   MDA?, 1,   MDA↓, 5,   MDA↑, 6,   MPO↓, 2,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 12,   ROS↓, 15,   ROS↑, 71,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↑, 1,   SOD↓, 12,   SOD↑, 15,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↓, 1,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↑, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compIV↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 10,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 3,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 2,   ATP↓, 6,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 6,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 3,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 3,   Pyruv↓, 2,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 49,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 2,   Bcl-2↓, 29,   Bcl-2↑, 5,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 7,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 39,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 12,   Casp9↑, 27,   cl‑Casp9↑, 1,   Cyt‑c↑, 18,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 6,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 5,   Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 8,   TumCD↑, 5,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 33,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 6,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 5,   MAPK↑, 6,   MAPK↝, 1,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   mTOR↝, 1,   p‑mTOR↓, 3,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 25,   PI3K↑, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 2,   RAS↓, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 3,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 1,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 3,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 1,   tumCV↓, 14,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 9,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 6,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↑, 1,   P53↓, 3,   P53↑, 28,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 9,   cl‑PARP∅, 1,   PCNA↓, 13,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↑, 5,   pRB↓, 1,   pRB↑, 1,   RB1↑, 1,   TumCCA↑, 45,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 3,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 10,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 34,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 2,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 8,   EMT↓, 12,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 22,   MMP9↑, 2,   MMPs↓, 5,   N-cadherin↓, 9,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 18,   TumMeta↓, 17,   TumMeta↑, 3,   Twist↓, 2,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 18,   NO↓, 2,   NO↑, 2,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 18,   MMP↑, 2,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 2,   IL6↓, 15,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 8,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 5,   PSA↓, 2,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 14,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ER-α36↓, 1,   Estro↝, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 6,   BioAv↝, 4,   BioEnh?, 1,   ChemoSen↑, 43,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 5,   Dose↝, 15,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 1,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 13,   selectivity↑, 23,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 6,   AST↓, 2,   BP↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 6,   EGFR↑, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 15,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 2,   PSA∅, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 20,   antiNeop↑, 1,   AntiTum↑, 6,   Appetite↑, 1,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 7,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 8,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 10,   RenoP↑, 2,   Risk↓, 9,   Sleep↑, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 565

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 4,   antiOx↑, 102,   ARE↑, 2,   Bil↓, 2,   Catalase↓, 4,   Catalase↑, 123,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 6,   GPx↑, 202,   GPx↝, 1,   GPx∅, 1,   GPx4↓, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 89,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 25,   GSSG↓, 3,   GSTs↓, 2,   GSTs↑, 24,   H2O2↓, 9,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 5,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 8,   Keap1↝, 1,   lipid-P↓, 62,   MDA↓, 84,   MDA↑, 3,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 11,   NRF2↓, 1,   NRF2↑, 82,   Prx↓, 1,   Prx↑, 2,   RNS↓, 1,   ROS?, 2,   ROS↓, 164,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 5,   SOD?, 1,   SOD↓, 2,   SOD↑, 160,   SOD↝, 1,   SOD1↑, 4,   SOD2↑, 6,   TAC↑, 15,   TBARS↓, 3,   TBARS↑, 1,   Thiols↑, 2,   Trx↑, 3,   Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 7,   VitE↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTL↓, 1,   IronCh↑, 4,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   EGF↓, 1,   ETC↑, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN1↑, 1,   MFN2↑, 2,   mtDam↓, 2,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   mt-ACC⇅, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 25,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 11,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↑, 1,   glucose↓, 7,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 10,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 13,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDKs↑, 1,   PFK↓, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PONs↑, 1,   PPP↓, 1,   SCFAs↑, 2,   SIRT1↑, 14,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 18,   BAD↓, 1,   BAX↓, 15,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 11,   Bcl-2↝, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 26,   cl‑Casp3↓, 2,   proCasp3↑, 1,   Casp8↓, 1,   Casp9↓, 11,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 4,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 4,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 2,   IκB?, 1,   JAK2↓, 1,   JNK↓, 7,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 3,   PI3K↑, 4,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ?, 1,   PP2A↑, 1,   PTEN↓, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 2,   HDAC?, 1,   HDAC↓, 1,   miR-34a↓, 1,   other?, 1,   other↓, 7,   other↑, 12,   other↝, 3,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   P53↓, 1,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CHIP↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↑, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   AP-1↑, 1,   ATPase↑, 1,   Ca+2↓, 8,   Ca+2↝, 2,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MUC1↑, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 2,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Vim↓, 3,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 22,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   GastroP↑, 4,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 1,   MMP↑, 10,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPM7⇅, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 42,   COX2/PTGS2↑, 2,   Eos↓, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↓, 5,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 1,   IL10↓, 7,   IL10↑, 12,   IL12↓, 2,   IL12↑, 1,   IL13↓, 1,   IL17↓, 5,   IL18↓, 1,   IL1β↓, 43,   IL2↓, 3,   IL2↑, 2,   IL23↓, 2,   IL4↓, 4,   IL4↑, 3,   IL5↓, 2,   IL6↓, 44,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↓, 1,   Imm↑, 6,   INF-γ↓, 2,   Inflam↓, 106,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   NF-kB↓, 49,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 8,   p65↓, 1,   PGE2↓, 14,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 13,   TNF-α↓, 60,   TNF-α↑, 2,   TRAF6↓, 1,   TRIF↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 6,   Ach↑, 9,   AChE↓, 31,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 18,   BDNF⇅, 1,   ChAT↑, 8,   GABA↑, 3,   MAOA↓, 3,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 2,   BACE/β-secretase↓, 9,   tau↓, 8,   p‑tau↓, 8,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 5,   GR↝, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 40,   BioAv⇅, 1,   BioAv↝, 23,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 23,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 7,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 25,   ALAT↑, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 27,   AST↑, 1,   BG↓, 3,   Bil↓, 2,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BP↝, 1,   BUN↓, 3,   Calcium↑, 1,   CEA↓, 2,   creat↓, 5,   CRP↓, 8,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 44,   IL6↑, 1,   IRes↝, 1,   LDH↓, 10,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 5,   Urea↓, 3,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 12,   AntiArt↑, 4,   AntiCan↑, 12,   AntiDiabetic↑, 18,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↑, 1,   BOLD↑, 1,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 36,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 44,   Learn↑, 2,   memory↑, 37,   motorD↑, 6,   neuroP↑, 82,   NP/CIPN↓, 1,   Obesity↓, 12,   OS↑, 2,   Pain↓, 4,   radioP↑, 3,   RenoP↑, 14,   Risk↓, 7,   Sleep↑, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity↓, 14,   toxicity↝, 8,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 10,   GutMicro↑, 24,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 2,  
Total Targets: 535

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Lycopene
9 Thymoquinone
8 Melatonin
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Hydrogen Gas
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Sulforaphane (mainly Broccoli)
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hyperoside
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Luteolin
3 Moringa oleifera
3 Morin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Berberine
2 Phenethyl isothiocyanate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Sesame seeds and Oil
2 doxorubicin
2 isoorientin
2 Kaempferol
2 Matrine
2 Cisplatin
2 Methylsulfonylmethane
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Cichoric acid / Chicoric acid
1 Citicoline, CDP-Choline
1 Citric Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 Butein
1 Scopoletin
1 Isothiocyanates
1 Juglone
1 Lactoferrin/Talactoferrin
1 Vitamin E
1 Magnolol
1 Mung Bean Sprouts
1 methylseleninic acid
1 Magnetic Field Rotating
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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