Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
6504- BCP,    β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer Cells
- in-vitro, CRC, CT26 - in-vitro, CRC, HCT116
RadioS↑, TumCCA↑, γH2AX↑, DNAdam↑, p‑Akt↓, cycD1/CCND1↓, PPARγ↑, Bax:Bcl2↑, Casp3↑, Apoptosis↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
5592- BetA,    Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
Casp3↑, Casp9↑, cl‑PARP↑, Apoptosis↑, Cyt‑c↑, MMP↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2717- BetA,    Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma
- in-vitro, Melanoma, U266 - in-vivo, Melanoma, NA - in-vitro, Melanoma, RPMI-8226
Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,
2722- BetA,    Betulinic Acid for Cancer Treatment and Prevention
- Review, Var, NA
MMP↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, ROS↑, NF-kB↑, TOP1↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, Synergy↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
2734- BetA,    Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,
2755- BetA,    Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines
- in-vitro, Colon, HT29 - in-vitro, BC, MCF7 - in-vitro, Lung, H460
eff↑, Casp3↑, Casp7↑, NF-kB↓,
2744- BetA,    Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
- Review, Var, NA
Apoptosis↓, TumCCA↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, MMP↓, ROS↑, TOP1↓, NF-kB↓,
2752- BetA,    Betulinic acid: a natural product with anticancer activity
- Review, Var, NA
selectivity↑, ChemoSen↑, RadioS↑, MMP↓, cl‑Casp3↑, Cyt‑c↑, ROS↑, NF-kB↑, TOP1↓,
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, Synergy↑,
5724- BF,    A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice
- vitro+vivo, Lung, A549
Apoptosis↑, Casp3↑, cl‑PARP↑,
5725- BF,  TMZ,    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide
- in-vitro, GBM, NA
TumCG↓, TumCP↓, CSCs↓, cl‑Casp3↑, PARP↑, Telomerase↓, eff↑,
5726- BF,    Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
- Review, neuroblastoma, SK-N-BE
Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,
5728- BF,    Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2/PTGS2↝, p‑VEGFR2/KDR/Flk1↓, EGFR↓, Akt↓, NF-kB↓, p44↓,
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,
9203- BITC,    Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,
9206- BITC,    Inhibitory effects of benzyl isothiocyanate on the proliferation of prostate and breast cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Dose↝, tumCV↓, TumCP↓, eff↝, survivin↓, TGFβR1↓, Casp3↑,
9207- BITC,    Benzyl isothiocyanate–induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, Apoptosis↑, selectivity↑, DNAdam↑, MMP↓, Cyt‑c↑, ROS↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑,
9211- BITC,    Apoptosis induced by benzyl isothiocyanate in gefitinib-resistant lung cancer cells is associated with Akt/MAPK pathways and generation of reactive oxygen species
- in-vitro, NSCLC, NA
AntiTum↑, TumCG↓, Apoptosis↑, Casp3↑, TumCCA↑, ROS↑, GSH↓, eff↑,
9182- BITC,    Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells
- in-vitro, Oral, NA
AntiCan↑, ROS↑, Ca+2↝, tumCV↓, Casp3↑, Casp9↑, MMP↓, BAX↑, BAD↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, DNAdam↑,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
9169- BITC,    CNOT2 /c-Myc/STAT3 signaling is critically involved in glycolysis mediated apoptosis of benzyl isothiocyanate in hepatocellular carcinoma
- in-vitro, adrenal, SK-HEP-1 - in-vitro, Liver, HUH7
HK2↓, PKM2↓, LDH↓, proCasp3↓, proPARP↓, Apoptosis↑, Warburg↓, Glycolysis↓, GlucoseCon↓,
9167- BITC,    Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, CD31/PECAM-1↓, VEGF↓, PCNA↓, CDK4↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓,
9164- BITC,    Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3
TumCG↓, MMP↓, Casp3↑, Casp7↑, DNAdam↑, ROS↑, eff↓,
9163- BITC,    Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells
- in-vitro, PC, Capan1
Apoptosis?, p‑ERK↑, JNK↑, ROS↑, GSH↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, selectivity↑,
9161- BITC,    Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, NA, MCF10
TumCG↓, TumCCA↑, Apoptosis↑, selectivity↑, CycB/CCNB1↓, CDK1↓, CDC25↓, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, Cyt‑c↑, ROS?, cl‑Casp9↑, cl‑Casp8↑, cl‑Casp3↑,
5688- BJ,    Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes
- vitro+vivo, PC, MIA PaCa-2
TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE/β-secretase↓, TOP2↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5692- BJ,    Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells
- vitro+vivo, AML, NA
Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1/ATG6↑, p62↑, PARP↑,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, Melanoma, NA
COX2/PTGS2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE/β-secretase↓, *cognitive↑, *BioAv↑, memory↑, P-gp/ABCB1↓, BioEnh↑,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1/ATG6↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
740- Bor,    Anti-cancer effect of boron derivatives on small-cell lung cancer
- in-vitro, Lung, DMS114 - in-vitro, Nor, MRC-5
Apoptosis↑, TumCCA↑, P53↑, Casp3↑, *toxicity↓,
742- Bor,    In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
- in-vitro, Thyroid, NA
NOXA↑, APAF1↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, miR-21↓,
744- Bor,    Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
TumCCA↑, SLC12A5↓, ATF6↑, CHOP/DDIT3↑, GRP78/BiP↑, Casp3↑, ER Stress↝, *toxicity↓, *eff↓,
748- Bor,    A Study on the Anticarcinogenic Effects of Calcium Fructoborate
- in-vitro, BC, MDA-MB-231
p‑ATM↑, p‑P53↑, Casp9↑, PARP↓, VEGF↓, Casp3↑,

Showing Research Papers: 201 to 250 of 1195
Prev Page 5 of 24 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1195

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 3,   NA↑, 6,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 7,   antiOx↑, 16,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 17,   Catalase↑, 12,   Ceru↓, 1,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 4,   frataxin↑, 1,   GCLM↓, 1,   GPx↓, 8,   GPx↑, 9,   GPx4↓, 11,   GSH↓, 82,   GSH↑, 16,   mt-GSH↓, 1,   GSH/GSSG↓, 9,   GSR↓, 3,   GSR↑, 5,   GSS↑, 1,   GSSG↓, 1,   GSSG↑, 1,   GSTs↓, 4,   GSTs↑, 5,   H2O2↓, 1,   H2O2↑, 15,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 13,   HO-1↑, 22,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 11,   lipid-P↑, 22,   lipid-P↝, 1,   MDA↓, 8,   MDA↑, 20,   MPO↓, 4,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 32,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   OSI↑, 2,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 48,   ROS↑, 523,   ROS⇅, 14,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 17,   RPM↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 14,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 8,   TAC↓, 2,   TAC↑, 2,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   TOS↑, 2,   Trx↓, 3,   Trx1↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 12,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   IronCh↑, 4,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 4,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 23,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 3,   compII↓, 1,   compIII↓, 2,   compIV↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 8,   EGF↑, 1,   ETC↓, 9,   ETC↝, 1,   HSP60/HSPD1↑, 1,   MCU↓, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 56,   OCR↓, 11,   OCR↑, 2,   OXPHOS↓, 7,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 4,   PDH↓, 3,   PDH↑, 3,   PDH↝, 1,   p‑PDH↓, 1,   PINK1↑, 4,   SDH↓, 4,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 4,   ACC↑, 5,   p‑ACC↑, 1,   Acetyl-CoA↓, 1,   ACLY↓, 5,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALDOA↓, 2,   AMP↑, 2,   AMPK↓, 3,   AMPK↑, 39,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 39,   ATP↝, 1,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   citrate↓, 1,   CPT1A↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 8,   FASN↑, 2,   FBI-1↓, 1,   FBPase↑, 2,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   glucoNG↑, 2,   glucose↓, 1,   GlucoseCon↓, 24,   GlutaM↓, 1,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 55,   GSK‐3β↓, 18,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 9,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK1↓, 2,   HK2↓, 33,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   IDO1↓, 1,   lactateProd↓, 26,   lactateProd↑, 1,   LDHA↓, 13,   LDL↓, 2,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↓, 5,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 10,   PDKs↓, 3,   PFK↓, 4,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PGK1↓, 1,   PKM2↓, 19,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 12,   SIRT1↑, 7,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 6,   TCA↑, 2,   TS↓, 2,   TumCM/A↓, 1,   Warburg↓, 9,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 27,   APAF1↑, 19,   Apoptosis?, 4,   Apoptosis↓, 11,   Apoptosis↑, 587,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 4,   BAD?, 1,   BAD↓, 5,   BAD↑, 32,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 23,   BAX?, 1,   BAX↓, 9,   BAX↑, 410,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 85,   Bcl-2↓, 421,   Bcl-2↑, 13,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 84,   Bcl-xL↑, 4,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 18,   p‑BID↓, 1,   cl‑BID↑, 4,   BIM↓, 1,   BIM↑, 14,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 1,   Casp↑, 28,   Casp1↓, 2,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 11,   Casp12↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 5,   Casp3?, 4,   Casp3↓, 15,   Casp3↑, 833,   Casp3↝, 4,   Casp3∅, 2,   cl‑Casp3↓, 3,   cl‑Casp3↑, 204,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 8,   proCasp3↑, 9,   pro‑Casp3↓, 1,   pro‑Casp3↑, 2,   pro‑Casp3↝, 1,   CASP4↑, 3,   Casp6↓, 1,   Casp6↑, 6,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 88,   cl‑Casp7↑, 11,   Casp8↓, 3,   Casp8↑, 144,   Casp8↝, 1,   Casp8∅, 3,   cl‑Casp8↑, 27,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 2,   Casp9↓, 4,   Casp9↑, 380,   Casp9↝, 1,   Casp9∅, 1,   cl‑Casp9↓, 2,   cl‑Casp9↑, 64,   proCasp9↓, 4,   proCasp9↑, 5,   pro‑Casp9↑, 1,   CellShr↑, 1,   cFLIP↓, 16,   Cupro↑, 1,   Cyt‑c↓, 5,   Cyt‑c↑, 280,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 12,   DIDO1/DIO-1↑, 1,   DR5↑, 48,   Endon↑, 2,   FADD↑, 14,   Fap1↓, 2,   Fas↓, 3,   Fas↑, 45,   FasL↑, 28,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GranB/GZMB↝, 1,   GRP58↓, 1,   GSDME↑, 2,   cl‑GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 2,   IAP1↓, 15,   IAP2/BIRC3↓, 6,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 26,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 61,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 17,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 3,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 10,   NAIP↓, 2,   Necroptosis↑, 8,   necrosis↑, 6,   NOXA↑, 7,   p38↓, 7,   p38↑, 45,   p‑p38↓, 5,   p‑p38↑, 11,   Paraptosis↑, 1,   PDCD4↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA↝, 1,   Pyro↑, 9,   RIP3↓, 1,   RIP3↑, 5,   p‑RIP3↑, 3,   survivin↓, 107,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 3,   TRAIL↑, 11,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 5,   TumCD↑, 48,   TumCD∅, 1,   TUNEL↑, 2,   XIAP↓, 54,   XIAP↑, 1,   YAP/TEAD↓, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 226,   Akt↑, 14,   Akt↝, 1,   p‑Akt↓, 87,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   BRAF↓, 2,   BRAF↝, 1,   CaMKII ↓, 3,   CIP2A↓, 2,   CK2↓, 4,   cMET↓, 4,   p‑cMET↑, 2,   p‑CREB↓, 2,   CREB2↓, 1,   cSrc↓, 6,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 78,   ERK↑, 17,   ERK↝, 1,   p‑ERK↓, 30,   p‑ERK↑, 8,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   HRAS↓, 1,   IGF-1R↓, 8,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 9,   IKKα↑, 2,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 3,   p‑IκB↓, 3,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 11,   JAK1↑, 2,   p‑JAK1↓, 2,   JAK2↓, 21,   p‑JAK2↓, 5,   JNK↓, 9,   JNK↑, 55,   JNK↝, 1,   p‑JNK↓, 4,   p‑JNK↑, 12,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 47,   MAPK↑, 27,   MAPK↝, 3,   p‑MAPK↓, 3,   p‑MAPK↑, 3,   MARK4↓, 1,   MEK↓, 11,   p‑MEK↓, 4,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 111,   mTOR↑, 5,   mTOR↝, 2,   p‑mTOR↓, 27,   mTORC2↓, 4,   NIK↓, 1,   p70S6↓, 2,   P70S6K↓, 9,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 151,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 21,   PI3K/Akt↓, 5,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 4,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 12,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 4,   PTEN↑, 38,   PTEN↝, 2,   p‑PTEN↓, 2,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 12,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 3,   RPS6KA1↓, 1,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 5,   Sp1/3/4↓, 13,   Src↓, 5,   Src↑, 1,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 2,   STAT3↓, 97,   STAT3↑, 5,   p‑STAT3↓, 27,   p‑STAT3↑, 2,   STAT5↓, 3,   p‑STAT5↓, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 24,   ATF4↝, 1,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 2,   cMyc↓, 59,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT1↑, 1,   DNMT3A↓, 4,   DNMTs↓, 9,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 4,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↑, 2,   GATA3↑, 1,   H3↓, 5,   H3↑, 2,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 2,   HDAC↓, 33,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC8↓, 3,   HES1↓, 2,   HMTs↓, 2,   HOXB-AS1↓, 1,   KCNQ1OT1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 4,   miR-17↓, 2,   miR-195↑, 1,   miR-200b↑, 1,   miR-21↓, 10,   miR-21↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-340↑, 1,   miR-34a↓, 2,   miR-34a↑, 5,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-497↑, 1,   miR-590-3p↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 17,   OCT4↑, 1,   other?, 1,   other↓, 5,   other↑, 10,   other↝, 13,   PhotoS↑, 2,   SALL4↓, 1,   sonoS↑, 2,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 2,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 3,   TCF-4↓, 2,   TET3↑, 1,   tumCV?, 3,   tumCV↓, 196,   tumCV↑, 1,   tumCV∅, 1,   ZBTB10↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 6,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 57,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 14,   p‑eIF2α↓, 1,   p‑eIF2α↑, 13,   ER Stress↓, 5,   ER Stress↑, 94,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 34,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 10,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 10,   HSP70/HSPA5↑, 4,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 16,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 9,   p‑IRE1↑, 1,   PDI↑, 1,   PERK↑, 17,   p‑PERK↑, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 16,   XBP-1↓, 2,   XBP-1↑, 8,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 19,   ATG5↝, 1,   ATG7↑, 5,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 34,   Beclin-1/ATG6↝, 1,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3A↑, 3,   LC3B↑, 6,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 2,   LC3II↓, 3,   LC3II↑, 29,   LC3s↓, 1,   LC3s↑, 3,   MitoP↑, 2,   p62↓, 13,   p62↑, 10,   PARK2↑, 4,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↑, 93,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   APE1/APEX1↓, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 3,   ATR↑, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 2,   DFF45↑, 3,   DNA-PK↑, 2,   DNAdam↓, 4,   DNAdam↑, 154,   mt-DNAdam↑, 2,   DNArepair↓, 5,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 18,   Ku70/XRCC6↓, 2,   MGMT↓, 2,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 6,   P53↑, 204,   P53↝, 3,   P53∅, 2,   p‑P53↓, 1,   p‑P53↑, 12,   ac‑P53↑, 1,   p53 Wildtype↓, 2,   PARP↓, 11,   PARP↑, 65,   PARP↝, 2,   p‑PARP↑, 5,   cl‑PARP↓, 4,   cl‑PARP↑, 247,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 2,   PARP1↓, 1,   PARP1↑, 9,   cl‑PARP1↑, 6,   PCNA↓, 52,   RAD51↓, 1,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 18,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 3,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 21,   γH2AX↝, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CDK1↓, 31,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 55,   CDK2↑, 5,   p‑CDK2↓, 1,   CDK4↓, 67,   CDK4↑, 6,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 28,   CDK6↑, 5,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 50,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 150,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 33,   cycE/CCNE↑, 1,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 53,   MAD↓, 1,   mitA↑, 6,   p19↑, 2,   P21?, 2,   P21↓, 14,   P21↑, 129,   P21↝, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 51,   pRB↓, 1,   pRB↑, 3,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 7,   Securin↓, 2,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 10,   TumCCA↑, 386,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 3,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD24↓, 2,   CD34↓, 2,   CEBPA↑, 1,   cFos↓, 10,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 48,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 2,   FGF↓, 4,   Gli↓, 3,   Gli1↓, 13,   HH↓, 11,   IGF-1↓, 13,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGF-2↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 53,   Let-7↓, 1,   Let-7↑, 4,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 19,   NOTCH1↓, 17,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 5,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   PTCH2↓, 2,   SCF↓, 2,   Shh↓, 14,   Smo↓, 7,   STAT1↓, 2,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 188,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 300,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 13,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↑, 60,   Ca+2↝, 8,   i-Ca+2?, 1,   i-Ca+2↑, 6,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 6,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 2,   E-cadherin↓, 9,   E-cadherin↑, 64,   EM↑, 1,   EMT?, 1,   EMT↓, 89,   EMT↑, 3,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 23,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 6,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 3,   ITGB3↓, 2,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 4,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 127,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 45,   MTA1↓, 2,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 46,   p44↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 2,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   proline↓, 1,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 4,   Rho↑, 1,   ROCK1↓, 3,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 4,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 1,   p‑SMAD4↓, 2,   Snail?, 1,   Snail↓, 43,   TET1↑, 6,   TGF-β↓, 20,   TGF-β↑, 5,   TGF-β1↓, 1,   THBS1↑, 1,   TIMP1↓, 5,   TIMP1↑, 18,   TIMP2↓, 4,   TIMP2↑, 17,   TIMP3↑, 1,   TPM4↓, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 124,   TumCI↑, 1,   TumCMig↓, 119,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 87,   TumMeta↑, 5,   TumPF↓, 4,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 26,   uPA↝, 1,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 49,   Vim↑, 1,   Zeb1↓, 15,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 117,   angioG↑, 2,   CD31/PECAM-1↓, 12,   EGR1↑, 1,   Endoglin↑, 3,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 4,   Hif1a↓, 90,   Hif1a↑, 2,   NO↓, 5,   NO↑, 4,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 151,   VEGF↑, 2,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 2,   CLDN2↑, 1,   CX43/GJA1↓, 1,   EPR↑, 6,   GLUT1↓, 18,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   IBI↑, 1,   KCNH2/hERG↓, 1,   memfluid↓, 1,   MMP?, 3,   MMP↓, 329,   MMP↑, 4,   MMP↝, 1,   MMP∅, 2,   MPT↑, 14,   NHE1↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 17,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 5,   p‑cDC2↓, 1,   p‑cDC2↑, 1,   COX1?, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 110,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 3,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 12,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 4,   Igs↓, 1,   IL1↓, 5,   IL1↑, 2,   IL10↓, 8,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 5,   IL2↓, 2,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   Imm↑, 16,   Imm↝, 3,   Inflam↓, 47,   pol-M1↑, 1,   MCP1/CCL2↓, 6,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 211,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p50↓, 3,   p65↓, 11,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 26,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES?, 1,   SOCS-3↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 11,   TLR4↝, 1,   TNF-α↓, 52,   TNF-α↑, 11,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   IM↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   PTN↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ACE/ACE1↓, 1,   AhR↑, 1,   AR↓, 21,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 5,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 4,   cl‑PPARα↓, 1,   PPARγ↓, 4,   PPARγ↑, 8,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 48,   BioAv↑, 56,   BioAv↝, 11,   BioEnh↑, 6,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 201,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 5,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   CYP3A4↓, 2,   DDS↑, 2,   Dose?, 12,   Dose↓, 5,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 92,   Dose∅, 18,   eff↓, 138,   eff↑, 136,   eff↝, 16,   eff∅, 5,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 5,   RadioS?, 1,   RadioS↑, 60,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 166,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 140,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 4,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 21,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   AST↑, 1,   AST↝, 1,   BG↓, 1,   BloodF↓, 1,   BRAF↓, 2,   BRAF↝, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 3,   E6↓, 5,   E7↓, 4,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   Ferritin↓, 3,   FOXM1↓, 8,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 18,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   LDH?, 1,   LDH↓, 22,   LDH↑, 11,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 3,   TRIB3↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 76,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 37,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 4,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 37,   chemoPv↑, 31,   ChemoSideEff↓, 11,   ChemoSideEff∅, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 11,   memory↑, 2,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↑, 20,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 7,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 13,   Risk↓, 20,   Sleep↑, 1,   Strength↑, 4,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 8,   toxicity↝, 10,   toxicity∅, 2,   TumNum↓, 3,   TumVol↓, 58,   TumVol↑, 2,   TumW↓, 27,   Weight↓, 1,   Weight↑, 4,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 4,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 3,   Ingr↝, 9,  
Total Targets: 1449

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↓, 7,   antiOx↑, 133,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   Fenton↓, 3,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 54,   GPx1↑, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 78,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 10,   GSTs↓, 3,   GSTs↑, 19,   H2O2↓, 6,   HDL↑, 4,   HO-1↓, 4,   HO-1↑, 35,   hyperG↝, 1,   Iron↓, 3,   Keap1↓, 3,   Keap1↑, 2,   Keap1↝, 2,   lipid-P↓, 50,   MDA?, 1,   MDA↓, 57,   MDA↑, 4,   MPO↓, 10,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 2,   NQO1↑, 5,   NQO1↝, 1,   NRF2↓, 2,   NRF2↑, 70,   Prx↑, 2,   RNS↓, 6,   ROS?, 1,   ROS↓, 180,   ROS↑, 9,   ROS⇅, 1,   ROS∅, 5,   mt-ROS?, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 91,   SOD1↑, 4,   SOD2↑, 3,   TAC↑, 9,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 3,   IronCh↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   FIS1↓, 1,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 1,   mtDam↓, 5,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 3,   adiP↑, 1,   ALAT↓, 23,   AMPK↓, 1,   AMPK↑, 15,   ATP↓, 3,   ATP↑, 11,   cAMP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   NH3↓, 1,   PLA2↓, 2,   SIRT1↑, 11,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 2,   Apoptosis↓, 46,   Apoptosis∅, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 47,   BAX↑, 4,   Bax:Bcl2↓, 8,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-2↑, 31,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 3,   Casp3?, 1,   Casp3↓, 104,   Casp3↑, 10,   Casp3∅, 2,   cl‑Casp3↓, 20,   cl‑Casp3↑, 1,   proCasp3↓, 2,   proCasp3↑, 1,   Casp7↓, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 27,   Casp9↑, 4,   Casp9∅, 1,   cl‑Casp9↓, 3,   cl‑Casp9↑, 1,   Cyt‑c↓, 17,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   GSDMD↓, 1,   iNOS↓, 26,   iNOS↑, 3,   MLKL↓, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 10,   p‑Akt↓, 4,   p‑Akt↑, 9,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 4,   p‑CREB↑, 3,   EGFR↓, 1,   ERK↓, 6,   ERK↑, 5,   p‑ERK↓, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 6,   JNK↑, 3,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   Mst1↓, 1,   mTOR↓, 3,   mTOR↑, 4,   p‑mTOR↓, 4,   p‑mTOR↑, 2,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 8,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↓, 2,   RAS↓, 1,   RIP1↓, 2,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 4,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 6,   other↝, 12,   RUNX2↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   ER Stress↓, 8,   GRP78/BiP↓, 7,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 5,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 3,   PERK↓, 2,   UPR↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3II↓, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   p16↓, 1,   P53↓, 7,   P53↑, 2,   PARP↓, 2,   PARP∅, 1,   p‑PARP↓, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 2,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 4,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 2,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCG↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 9,   AP-1↓, 3,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 2,   COL1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 6,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   Hif1a↑, 1,   NO?, 1,   NO↓, 21,   NO↑, 5,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN5↓, 1,   GastroP↑, 6,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 6,   MMP↑, 23,   MMP∅, 1,   MUC5AC↓, 1,   OCLN↓, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,   ZO-1↓, 4,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 9,   IL10↑, 8,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1β↓, 51,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL33↓, 1,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 59,   IL6↑, 1,   IL8↓, 7,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 2,   Inflam↓, 161,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 65,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 10,   p65↓, 2,   PAF↑, 1,   PGE2↓, 20,   PGE2↑, 3,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 9,   TNF-α↓, 85,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 25,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 24,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 4,   DA↑, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 5,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 6,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 7,   p‑tau↓, 7,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Estro↓, 1,   FGF21↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 9,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 48,   BioAv↑, 47,   BioAv⇅, 1,   BioAv↝, 22,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 2,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 22,   Dose∅, 2,   eff↓, 5,   eff↑, 21,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 14,   Half-Life∅, 3,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 23,   ALB↝, 1,   ALP↓, 6,   anemia↓, 1,   AST↓, 24,   BG↓, 1,   Bil↓, 1,   BloodF↑, 2,   BMD↑, 2,   BP↓, 5,   BUN?, 1,   BUN↓, 4,   CEA↓, 1,   colonLen↑, 1,   creat↓, 9,   CRP↓, 7,   EGFR↓, 1,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 59,   IL6↑, 1,   IRes↝, 1,   LDH↓, 12,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 7,   antiAll↑, 22,   AntiArt↑, 12,   AntiCan↑, 26,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 35,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 7,   cardioP?, 1,   cardioP↑, 55,   chemoP↑, 12,   chemoPv↑, 6,   cognitive↓, 1,   cognitive↑, 36,   diuretic↑, 3,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 53,   Learn↑, 4,   memory↑, 34,   Mood↑, 1,   motorD↑, 7,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 100,   Obesity↓, 12,   OS↑, 3,   Pain↓, 4,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 19,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 14,   toxicity?, 1,   toxicity↓, 60,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 11,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 15,   Bacteria↓, 32,   Diar↓, 3,   GutMicro↑, 17,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 6,   Phen↑, 1,   QC↑, 1,  
Total Targets: 616

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
38 Silver-NanoParticles
35 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
23 Sulforaphane (mainly Broccoli)
22 Luteolin
21 Baicalein
21 Berberine
18 EGCG (Epigallocatechin Gallate)
18 Emodin
18 Fisetin
17 Shikonin
16 Cisplatin
16 Propolis -bee glue
16 Chrysin
16 Honokiol
14 Artemisinin
14 Magnetic Fields
14 Allicin (mainly Garlic)
14 Capsaicin
14 Licochalcone A
14 Magnolol
13 Ashwagandha(Withaferin A)
13 Radiotherapy/Radiation
13 Kaempferol
12 Betulinic acid
12 Benzyl isothiocyanate
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 doxorubicin
11 Eugenol
11 Gambogic Acid
11 Hyperoside
11 Morin
10 Chlorogenic acid
10 Ginkgetin
10 Graviola
10 isoorientin
10 Juglone
10 Lycopene
10 Matrine
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Carvacrol
9 Phenylbutyrate
8 5-fluorouracil
8 D-limonene
8 Phenethyl isothiocyanate
8 Citric Acid
8 Dandelion Root
8 Formononetin
8 Garcinol
8 Ivermectin
7 Allyl isothiocyanate
7 Melatonin
7 Gallic acid
7 Isobavachalcone
7 Vitexin
7 L-Theanine
7 mebendazole
7 Piperlongumine
7 Rosmarinic acid
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 chaetocin
6 chitosan
6 Ferulic acid
6 phytic acid, Inositol hexakisphosphate
6 Isoliquiritigenin
6 Licorice
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Caffeic acid
5 Chemotherapy
5 Centella asiatica / Gotu kola → asiaticoside
5 Crocetin
5 Ursolic acid
5 Dichloroacetate
5 salinomycin
5 Ellagic acid
5 Paclitaxel/Taxol
5 Evodiamine
5 Isorhamnetin
5 isoquercitrin
5 lambertianic acid
5 Linalool
5 Magnetic Field Rotating
5 Mangiferin
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Anethole/trans-Anethole
4 Astaxanthin
4 Photodynamic Therapy
4 Bromelain
4 borneol
4 Carvone
4 Cucurbitacin
4 Geraniol
4 Isovitexin
4 Lemongrass Extract/Citral
4 Lutein
4 methylseleninic acid
4 Moringa oleifera
4 Naringin
4 Marjoram (Origanum majorana)
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Açaí, Euterpe oleracea
3 Auranofin
3 Metformin
3 Berbamine
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Cynaropicrin
3 Deguelin
3 Date Fruit Extract
3 Docetaxel
3 Echinacea
3 Fenbendazole
3 Fucoidan
3 Ginkgo biloba
3 Ginkgolide B
3 Gossypol/AT-101
3 Hydrogen Gas
3 Hydroxycinnamic-acid
3 Hibiscus sabdariffa
3 Helleborus niger extracts – Christmas Rose
3 Rutin
3 itraconazole
3 Laetrile B17 Amygdalin
3 Methylsulfonylmethane
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 entinostat
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Aloe anthraquinones
2 brusatol
2 Bullatacin
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Citicoline, CDP-Choline
2 Copper and Cu NanoParticles
2 Oxaliplatin
2 Diclofenac
2 diet FMD Fasting Mimicking Diet
2 Ginkgo biloba-EGb 761
2 Electrical Pulses
2 Eurycomanone
2 Flaxseed/Linseed
2 carboplatin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Inositol
2 low dose naltrexone
2 Lactoferrin/Talactoferrin
2 Methyl Jasmonate
2 Magnesium
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
2 Zyflamend
1 5-Aminolevulinic acid
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Beetroot
1 Black turtle bean
1 Butyrate
1 Mung Bean Sprouts
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Polyphenols
1 CUSP9
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Cannabichromene
1 eicosapentaenoic acid
1 ferumoxytol
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 Galloflavin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 hydrogen sulfide
1 Orlistat
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 Inulin Prebiotic
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 Purple Corn / Purple Maize
1 topotecan
1 isoflavones
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Sesamin
1 Lignans
1 Spirulina(Arthrospira/Limnospira)
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page