Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Scientific Papers found: Click to Expand⟱

3350-

QC,

Quercetin and the mitochondria: A mechanistic view

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,

69-

QC,

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

-

in-vitro,

Pca,

DU145

 10, 50, 100 uM

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

LNCaP

TRAIL↑, Casp3↑, Casp9↑, Casp8↑, DR5↑,

71-

QC,

Role of Bax in quercetin-induced apoptosis in human prostate cancer cells

-

in-vitro,

Pca,

LNCaP

 10, 30, 50 100 uM

-

in-vitro,

Pca,

PrEC

-

in-vitro,

Pca,

YPEN-1

-

in-vitro,

Pca,

HCT116

Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓, Cyt‑c↑, selectivity↑,

41-

QC,

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

-

vitro+vivo,

AML,

HL-60

Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, cl‑PARP↑, MMP↓, eff↓,

91-

QC,

The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells

-

in-vitro,

Pca,

PC3

 50-200 uM

CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,

79-

QC,

Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats

-

in-vivo,

Pca,

NA

 200 mg/kg/3x/week

 rats

GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,

923-

QC,

Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health

-

Review,

Var,

NA

ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,

914-

QC,

Quercetin and Cancer Chemoprevention

-

Review,

Var,

NA

GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,

3008-

RosA,

Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells

-

in-vitro,

Melanoma,

SK-MEL-28

tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,

7951-

RT,

BuckWS,

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

-

Review,

Nor,

NA

*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,

6442-

SAO,

Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review

-

Review,

RCC,

NA

AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,

1459-

SFN,

AF,

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

-

in-vitro,

Liver,

Hep3B

 auranofin (0.5, 1, 1.5, and 2 μM) or sulforaphane (2.5, 5, 7.5, and 10 μM)

-

in-vitro,

Liver,

HepG2

eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,

1463-

SFN,

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

-

in-vitro,

Bladder,

5637

tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,

1458-

SFN,

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

-

Review,

Bladder,

NA

HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

-

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1481-

SFN,

docx,

Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines

-

in-vitro,

Pca,

LNCaP

6.55 µM SFN and 0.0675 µM DCT

Prostate cancer cell lines LNCaP and PC-3 were treated with individual IC50 doses of SFN and DCT and half-reduced IC50 values for the SFN:DCT combination.

-

in-vitro,

Pca,

PC3

1.1 µM SFN and 0.0005 µM DCT

ChemoSen↑, Casp3↑, ROS↑, Casp8↑, Cyt‑c↑, Glycolysis↓, GSH↓, GSH/GSSG↓, *toxicity↓,

1726-

SFN,

Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

-

Review,

Var,

NA

Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,

1730-

SFN,

Sulforaphane: An emergent anti-cancer stem cell agent

-

Review,

Var,

NA

BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,

2167-

SFN,

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

PC,

PANC1

Casp8↑, MMP↓, Casp3↑, Apoptosis↑, GSH↓, GSH↑,

3289-

SIL,

Silymarin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,

5100-

SK,

Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression

-

vitro+vivo,

NPC,

NA

TumCP↓, RIP1↑, ROS↑, Necroptosis↑, Casp3↑, Casp8↑, eff↓, TumCG↓,

2232-

SK,

Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis

-

in-vitro,

ESCC,

EC9706

2.26 ± 0.12 µM

tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,

5331-

TFdiG,

Anti-Cancer Properties of Theaflavins

-

Review,

Var,

NA

AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,

5334-

TFdiG,

Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling

-

in-vitro,

Thyroid,

8505C

21.79 µg/mL.

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1/SREBF1↓, toxicity↑,

3427-

TQ,

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

-

in-vitro,

Var,

NA

ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

3416-

TQ,

Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway

-

in-vitro,

Bladder,

T24/HTB-9

 TQ (20–100 μM) for 24 h

-

in-vitro,

Bladder,

253J

-

in-vitro,

Nor,

SV-HUC-1

TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,

1928-

TQ,

Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,

2085-

TQ,

Anticancer Activities of Nigella Sativa (Black Cumin)

-

Review,

Var,

NA

MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,

2097-

TQ,

Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells

-

in-vitro,

Cerv,

HeLa

 IC50 values for 25, 50, 75 and 100 ug/ml were observed after 72, 48, 24 and 24 h

Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, P53↑, P21↑, TumCP↓, Apoptosis↓, selectivity↑,

2109-

TQ,

Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro

-

in-vitro,

AML,

CEM

1.5 µg/mL

Apoptosis↓, Bcl-2↓, BAX↑, ROS↑, HSP70/HSPA5↑, Casp3↑, Casp8↑,

5221-

TQ,

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

-

in-vitro,

AML,

HL-60

chemoPv↑, Apoptosis↑, MMP↓, Casp8↑, Casp9↑, Bax:Bcl2↑, Cyt‑c↑,

5904-

TV,

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

-

Review,

Var,

NA

-

Review,

Stroke,

NA

-

Review,

Diabetic,

NA

-

Review,

Obesity,

NA

-

Review,

AD,

NA

-

Review,

Arthritis,

NA

*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

5021-

UA,

Anticancer effect of ursolic acid via mitochondria-dependent pathways

-

Review,

Var,

NA

Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

3790-

UA,

Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools

-

Review,

Var,

NA

*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,

Showing Research Papers: 201 to 235 of 235
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 235

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 3, Catalase↓, 7, Catalase↑, 1, GCLM↓, 1, GPx↓, 1, GPx↑, 1, GSH↓, 20, GSH↑, 3, GSH/GSSG↓, 1, GSR↓, 1, GSR↑, 1, GSTs↓, 2, GSTs↑, 1, GSTs↝, 1, H2O2↓, 1, H2O2↑, 4, i-H2O2↑, 1, HO-1↓, 2, HO-1↑, 6, HO-1↝, 1, Iron↓, 1, Iron↑, 1, lipid-P?, 1, lipid-P↓, 3, lipid-P↑, 4, MDA↑, 5, MPO↓, 2, NQO1↓, 1, NQO1↑, 2, NRF2↓, 4, NRF2↑, 7, p‑NRF2↑, 1, RNS↑, 1, ROS?, 3, ROS↓, 8, ROS↑, 106, ROS⇅, 3, ROS∅, 1, i-ROS?, 1, i-ROS↑, 2, mt-ROS↑, 3, SOD↓, 5, SOD↑, 3, SOD1↑, 1, SOD2↓, 2, SOD2↑, 2, TAC↓, 1, TBARS↑, 1, ox-Trx1↑, 1, TrxR↓, 4, TrxR1↓, 1, VitC↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1, IronCh↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2, CDC2↓, 6, CDC25↓, 13, CDC25↑, 1, compIV↓, 1, EGF↓, 1, ETC↓, 1, HSP60/HSPD1↑, 1, mtDam↑, 9, OCR↓, 1, OXPHOS↓, 1, PDH↓, 1, PINK1↑, 1, SDH↓, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 2, ACC↑, 1, ACLY↓, 1, ALAT↓, 4, AMP↑, 1, AMPK↓, 1, AMPK↑, 9, AMPK↝, 1, ATP↓, 4, ATP↝, 1, CAIX/CA9↓, 1, citrate↓, 1, CPT1A↓, 1, ENO1↓, 1, FABP4↓, 1, FASN↓, 2, FASN↑, 2, FBPase↑, 1, glucoNG↑, 1, GlucoseCon↓, 4, Glycolysis↓, 6, GSK‐3β↓, 5, GSK‐3β↑, 4, p‑GSK‐3β↓, 3, H2S↑, 1, HK2↓, 5, lactateProd↓, 5, LDHA↓, 3, LDL↓, 1, PDK1 / PDPK1↓, 1, PFK↓, 2, PFK1↓, 1, PFK2?, 1, PFK2↓, 1, PKM2↓, 3, PKM2∅, 1, p‑S6↓, 1, SCD1↓, 1, SIRT1↓, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 1, TCA↓, 2, TCA↑, 1, Warburg↓, 2, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 14, APAF1↑, 6, Apoptosis↓, 4, Apoptosis↑, 116, mt-Apoptosis↑, 1, ASC↓, 1, ASK1↑, 1, BAD↓, 3, BAD↑, 11, Bak↓, 1, Bak↑, 4, BAX↑, 86, BAX⇅, 1, BAX∅, 1, Bax:Bcl2↑, 15, Bcl-2↓, 80, Bcl-2↑, 4, Bcl-2∅, 2, Bcl-xL↓, 19, Bcl-xL↑, 2, Bcl-xL∅, 1, BID↓, 2, BID↑, 9, cl‑BID↑, 6, BIM↑, 4, BOK↑, 1, Casp↑, 5, Casp↝, 1, Casp1↓, 1, Casp1↑, 2, Casp10↓, 1, Casp10↑, 2, Casp10∅, 1, Casp12↑, 2, Casp2↑, 4, Casp3↓, 3, Casp3↑, 146, Casp3↝, 1, Casp3∅, 1, cl‑Casp3↑, 29, proCasp3↓, 2, proCasp3↑, 2, CASP4↑, 1, Casp6↓, 1, Casp6↑, 1, Casp7↑, 13, cl‑Casp7↑, 4, Casp8↓, 5, Casp8↑, 181, Casp8↝, 1, Casp8∅, 4, cl‑Casp8↑, 30, proCasp8↓, 2, proCasp8↑, 4, pro‑Casp8↑, 1, Casp9?, 1, Casp9↓, 2, Casp9↑, 129, Casp9↝, 1, cl‑Casp9↑, 18, proCasp9↓, 2, proCasp9↑, 2, cFLIP↓, 8, Cyt‑c↑, 70, Cyt‑c↝, 1, Diablo↑, 4, DR5↑, 26, DR5∅, 1, FADD↑, 9, FADD∅, 1, Fas↓, 1, Fas↑, 34, FasL↓, 1, FasL↑, 16, Ferroptosis↑, 1, IAP1↓, 7, IAP2/BIRC3↓, 4, cl‑IAP2/BIRC3↑, 1, ICAD↓, 1, iNOS↓, 5, Mcl-1↓, 18, cl‑Mcl-1↑, 1, MDM2↓, 5, MDM2↑, 1, p‑MDM2↓, 1, MLKL↑, 1, p‑MLKL↓, 1, MOMP↑, 1, NAIP↓, 1, Necroptosis↑, 2, necrosis↑, 2, p38↓, 2, p38↑, 15, p‑p38↓, 1, p‑p38↑, 6, PUMA↑, 3, PUMA↝, 1, Pyro↑, 2, RIP3↑, 1, p‑RIP3↑, 1, survivin↓, 31, TNFR 1↑, 2, TRAIL↑, 9, TRAILR↑, 3, TumCD↓, 1, TumCD↑, 7, XIAP↓, 23, XIAP↑, 1, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 56, Akt↑, 3, p‑Akt↓, 15, AKT1↓, 2, AMPKα↑, 1, CaMKII ↓, 1, CK2↓, 2, cMET↓, 3, cSrc↓, 2, EGFR↓, 16, EGFR↑, 2, p‑EGFR↓, 1, ERK↓, 23, ERK↑, 6, p‑ERK↓, 7, p‑ERK↑, 1, p‑ERK⇅, 1, FOXD3↑, 1, HER2/EBBR2↓, 6, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 1, HRAS↓, 1, IGF-1R↓, 3, IGF-1R↑, 1, IKKα↓, 7, IKKα↑, 1, p‑IKKα↓, 1, p‑IκB↓, 1, JAK1↓, 5, p‑JAK1↓, 1, JAK2↓, 7, p‑JAK2↓, 4, JNK↓, 2, JNK↑, 14, p‑JNK↓, 2, p‑JNK↑, 2, cl‑JNK↑, 1, MAPK↓, 12, MAPK↑, 8, MEK↓, 2, p‑MEK↓, 2, mTOR↓, 28, mTOR↑, 2, mTOR↝, 1, p‑mTOR↓, 3, mTORC2↓, 1, p70S6↓, 1, P70S6K↓, 6, p‑P70S6K↓, 1, P90RSK↓, 1, p‑PDGFR-BB↓, 1, PI3K↓, 40, p‑PI3K↓, 4, PI3K/Akt↓, 1, PI3k/Akt/mTOR↝, 1, PIAS-3↑, 1, PIK3CA↓, 1, PKA↓, 1, PKCδ↓, 5, p‑PKCδ↓, 1, cl‑PKCδ↑, 1, PTEN↓, 2, PTEN↑, 10, Raf↓, 3, RAS↓, 6, RIP1↑, 1, SHP1↓, 1, SHP1↑, 1, Sp1/3/4↓, 3, Src↓, 1, p‑Src↓, 2, STAT↓, 1, STAT3↓, 21, STAT3↑, 1, p‑STAT3↓, 5, STAT6↓, 2, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 5, ATFs↑, 1, cJun↓, 2, cJun↑, 3, p‑cJun↑, 2, cMyc↓, 11, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 3, DNMT3A↓, 1, DNMTs↓, 1, FOXM1↓, 2, FOXO↑, 2, FOXO1↑, 2, FOXO3↓, 1, FOXO3↑, 1, p‑FOXO3↓, 1, FOXO4↑, 1, H3↓, 2, ac‑H3↑, 1, H4↓, 1, ac‑H4↑, 1, HATs↓, 2, HDAC↓, 5, HDAC1↓, 2, HDAC3↓, 1, HES1↓, 1, miR-130a↓, 1, miR-200b↑, 1, miR-200c↑, 1, miR-21↓, 2, Myc↓, 3, MYCN↓, 1, OCT4↓, 2, other↓, 2, other↑, 1, other↝, 3, PCAF↓, 1, SOX2↓, 1, SOX9↓, 1, SUV39H↓, 1, tumCV?, 1, tumCV↓, 36,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↑, 16, eIF2α↓, 1, eIF2α↑, 1, p‑eIF2α↑, 4, ER Stress↓, 2, ER Stress↑, 15, GRP78/BiP↓, 1, GRP78/BiP↑, 8, HSP27↓, 2, HSP70/HSPA5↓, 2, HSP70/HSPA5↑, 1, HSP72↓, 1, HSP90↓, 3, HSPs↓, 1, IRE1↑, 1, PERK↑, 3, UPR↑, 4, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4, ATG5↝, 1, ATG7↑, 1, Beclin-1/ATG6↑, 7, Beclin-1/ATG6↝, 1, CTSB↓, 1, CTSD↓, 1, LC3B↑, 2, LC3B-II↑, 2, LC3I↑, 1, LC3II↑, 6, p62↓, 2, p62↑, 2, PARK2↑, 1, TumAuto↑, 17, TumAuto⇅, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, ATR↑, 1, DFF45↑, 2, DNA-PK↑, 1, DNAdam↑, 35, DNArepair↓, 1, hTERT/TERT↓, 5, p16↑, 2, P53↓, 1, P53↑, 48, p‑P53↑, 4, p53 Wildtype↓, 1, PARP↓, 1, PARP↑, 16, p‑PARP↑, 1, cl‑PARP↓, 2, cl‑PARP↑, 73, cl‑PARP1↑, 2, PCNA↓, 13, SIRT6↓, 1, Telomerase↓, 6, TOP1↓, 2, TOP2↓, 4, TOP2↑, 1, TP53↓, 1, TP53↑, 2, UHRF1↓, 1, γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1, AURKB↑, 1, CDK1↓, 9, CDK1↑, 4, p‑CDK1↓, 2, p‑CDK1↑, 1, CDK2↓, 18, CDK2↑, 2, p‑CDK2↓, 1, CDK4↓, 23, CDK4↑, 2, CDK4∅, 1, CDK4/6↓, 1, CDK6↓, 8, CDK6↑, 3, CDK6∅, 1, CDK8↓, 1, CHK1↓, 1, Cyc↓, 2, cycA1/CCNA1↓, 7, CycB/CCNB1↓, 16, CycB/CCNB1↑, 3, cycD1/CCND1↓, 33, cycD1/CCND1↑, 2, cycD1/CCND1∅, 1, CycD3↓, 1, cycE/CCNE↓, 15, cycE1↓, 1, cycF↑, 1, E2F4↑, 1, E2Fs↓, 2, GADD45A↑, 1, Ki-67↓, 6, mitA↑, 1, p19↑, 1, P21↑, 37, p27/CDKN1B↑, 15, pRB↑, 1, p‑pRB↓, 1, RB1↓, 1, RB1↑, 2, p‑RB1↓, 3, Securin↓, 1, TumCCA?, 1, TumCCA↑, 91, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1, ALDH1A1↓, 1, BMP7/OP1↓, 1, CD133↓, 2, CD24↓, 1, CD34↓, 1, cFos↓, 2, cFos↑, 1, CSCs↓, 9, Diff↑, 2, FGF↓, 1, Gli1↓, 2, HH↓, 1, IGF-1↓, 2, IGFBP3↑, 1, JAG1↓, 1, p‑Jun↑, 1, Ki-67↓, 6, Let-7↑, 1, mTORC1↓, 2, Nanog↓, 2, NICD↓, 1, NOTCH↓, 4, NOTCH1↓, 6, NOTCH3↓, 1, p300↓, 1, Shh↓, 2, Smo↓, 2, STAT1↓, 1, Sufu↑, 1, TAZ↓, 1, TumCG?, 1, TumCG↓, 43, TumCG↑, 1, TumCP↓, 60, tyrosinase↓, 1, Wnt↓, 12, Wnt↑, 2, Wnt/(β-catenin)↓, 1, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg↑, 1, AP-1↓, 5, AXL↓, 1, Ca+2↓, 1, Ca+2↑, 14, Ca+2↝, 4, i-Ca+2↑, 3, cal2↓, 1, cal2↑, 1, CCN2/CTGF↓, 1, Cdc42↓, 1, Cdc42↑, 1, Cofilin↓, 1, COL1↓, 1, COL3A1↓, 1, DLC1↑, 1, E-cadherin↓, 5, E-cadherin↑, 9, EM↑, 1, EMT↓, 18, EMT↑, 1, FAK↓, 7, p‑FAK↓, 2, Fibronectin↓, 1, GLI2↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB4↓, 1, LEF1↓, 1, LIMK2↓, 1, LRP1↓, 1, MET↓, 1, p‑MET↓, 1, MMP1↓, 3, MMP13↓, 1, MMP2↓, 35, MMP3↓, 1, MMP7↓, 3, MMP9↓, 41, MMPs↓, 11, MTA1↓, 1, N-cadherin↓, 10, PAK1↓, 1, PDGF↓, 2, Rac1↓, 1, Rho↓, 2, ROCK1↓, 2, Sharpin↓, 1, Slug?, 1, Slug↓, 8, SMAD3↓, 1, SMAD3↑, 1, p‑SMAD4↓, 1, Snail?, 1, Snail↓, 15, TET1↓, 1, TGF-β↓, 7, TGF-β↑, 1, TIMP1↓, 1, TIMP1↑, 3, TIMP2↓, 3, TIMP2↑, 7, TIMP3↑, 1, TSP-1↑, 1, TumCI↓, 31, TumCI↑, 1, TumCMig↓, 25, TumMeta↓, 16, Twist↓, 6, Tyro3↓, 1, uPA↓, 11, Vim↓, 7, Vim↑, 1, Zeb1↓, 2, Zeb1↑, 1, ZEB2↓, 1, α-tubulin↓, 1, β-catenin/ZEB1↓, 16,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32, CD31/PECAM-1↓, 2, Endoglin↑, 1, HIF-1↓, 2, Hif1a↓, 12, NO↑, 1, VCAM-1↓, 2, VEGF↓, 38, VEGF↑, 1, VEGFR2/KDR/Flk1↓, 5,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, CLDN1↓, 1, CLDN2↓, 1, EPR↑, 1, GLUT1↓, 4, GLUT2↓, 1, memfluid↓, 1, MMP?, 1, MMP↓, 75, MMP↑, 1, MPT↑, 2, TRPM7↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1, CD4+↑, 1, CD44↓, 4, CD8+↑, 1, cDC2↓, 1, COX1↓, 1, COX2/PTGS2↓, 29, COX2/PTGS2↑, 1, CXCL1↓, 1, CXCR2↓, 1, CXCR4↓, 6, DR4↑, 7, DR4∅, 2, DR6↑, 1, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 2, IFN-γ↓, 2, IL1↓, 2, IL10↓, 1, IL12↓, 2, IL17↓, 1, IL1α↓, 1, IL1β↓, 6, IL2↑, 2, IL6↓, 12, IL8↓, 5, Imm↑, 1, Imm↝, 1, Inflam↓, 12, MCP1/CCL2↓, 2, MIP2↓, 1, NF-kB↓, 55, NF-kB↑, 6, p‑NF-kB↓, 2, p‑NF-kB↑, 1, NK cell↑, 1, NLRP3↓, 2, p50↓, 2, p65↓, 3, p‑p65↓, 1, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 8, PSA↓, 2, RAGE↓, 2, T-Cell↝, 1, TCF↑, 1, TLR4↓, 2, TNF-α↓, 14, TNF-α↑, 5, TNF-α∅, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2, TRADD↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1, AR↓, 7, PPARα↓, 1, cl‑PPARα↓, 1, PPARγ↑, 3,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 13, BioAv↑, 25, BioAv↝, 2, ChemoSen↓, 2, ChemoSen↑, 41, CompStab↑, 1, CompStab↝, 1, CYP1A1↓, 1, CYP1B1↑, 1, DDS↑, 1, Dose?, 3, Dose↓, 2, Dose↑, 4, Dose⇅, 1, Dose↝, 13, Dose∅, 3, eff↓, 24, eff↑, 30, eff↝, 8, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 3, Half-Life∅, 1, MDR1↓, 2, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 5, P450↓, 2, P450↝, 1, RadioS↑, 15, selectivity↓, 1, selectivity↑, 51, Synergy↑, 20, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 4, ALP↓, 2, AR↓, 7, ascitic↓, 1, AST↓, 4, CEA↓, 2, EGFR↓, 16, EGFR↑, 2, p‑EGFR↓, 1, FOXM1↓, 2, HER2/EBBR2↓, 6, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 5, IL6↓, 12, LDH↑, 1, Myc↓, 3, NSE↓, 1, PD-L1↓, 1, PSA↓, 2, RAGE↓, 2, TP53↓, 1, TP53↑, 2, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18, antiCG↓, 1, antiD↑, 1, antiNeop↑, 1, AntiTum↑, 4, cachexia↓, 2, cardioP↑, 2, chemoP↑, 8, chemoPv↑, 8, chemoPv⇅, 1, ChemoSideEff↓, 1, hepatoP↑, 2, OS↑, 4, QoL↑, 1, radioP↑, 2, RenoP↑, 4, Risk↓, 2, toxicity↓, 9, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 7, Weight↑, 1, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 3, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 750

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 34, Catalase↑, 17, GPx↑, 13, GSH↑, 15, GSR↑, 2, GSTs↑, 10, H2O2↓, 1, HDL↑, 2, HO-1↑, 5, hyperG↝, 1, Keap1↓, 1, Keap1↑, 1, lipid-P↓, 9, MDA↓, 13, MPO↓, 3, NADH↓, 1, NQO1↑, 2, NRF2↓, 1, NRF2↑, 11, RNS↓, 3, ROS↓, 32, ROS↑, 3, ROS⇅, 1, ROS∅, 1, SOD?, 1, SOD↑, 20, SOD1↑, 1, TBARS↓, 2, uricA↓, 1, VitC↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1, IronCh↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 1, ALAT↓, 8, AMPK↑, 2, ATP↑, 2, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, GSK‐3β↑, 1, H2S↑, 1, HMG-CoA↓, 1, LDL↓, 3, lipidLev↓, 1, SIRT1↑, 4, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5, ASC↓, 1, BAD↓, 1, BAX↓, 8, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↑, 3, Casp1↓, 3, Casp3↓, 10, Casp3↑, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 1, Casp8↓, 5, Casp8↑, 1, cl‑Casp8↓, 1, cl‑Casp8↑, 3, Casp9↓, 4, Casp9↑, 1, cl‑Casp9↑, 1, Cyt‑c↓, 4, Fas↑, 2, iNOS↓, 8, p38↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 1, p‑Akt↑, 2, JNK↓, 1, p‑JNK↓, 1, MAPK↓, 5, MAPK↑, 2, mTOR↑, 1, PI3K↓, 1, PI3K↑, 1, PKCδ↓, 1, RIP1↓, 1, STAT3↑, 1, p‑STAT3↑, 1, STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF4↓, 1, cJun↓, 1, HDAC↓, 1, HDAC3↓, 1, HOTAIR↑, 1, other↓, 1, other↑, 2, other↝, 1, RUNX2↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2, ER Stress↓, 1, GRP78/BiP↓, 1, UPR↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1, P53↓, 2, P53↑, 2, PARP↑, 1, cl‑PARP↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, Ki-67↓, 1, P21↓, 2, P21↑, 3, TumCCA↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Ki-67↓, 1, neuroG↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, BACH1↓, 1, Ca+2?, 1, Ca+2↝, 1, COL1↓, 1, COL1↑, 1, MMP13↓, 1, MMP3↓, 1, PAI-1/SERPINE1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, TGF-β↓, 1, TXNIP↓, 1, α-SMA↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5, NO↑, 1, VCAM-1↓, 1,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1, BBB↓, 1, BBB↑, 2, BBB↝, 1, CLDN1↓, 1, GastroP↑, 4, IBI↑, 1, MMP↓, 2, MMP↑, 3, OCLN↓, 1, OCLN↑, 1, TJ↑, 1, ZO-1↓, 1, ZO-1↑, 3,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1, CD4+↑, 2, CD40↓, 1, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 12, ICAM-1↓, 1, IFN-γ↓, 1, IFN-γ↑, 1, IL10↓, 1, IL10↑, 2, IL13↑, 1, IL18↓, 1, IL1β↓, 9, IL2↓, 1, IL6↓, 12, IL6↑, 1, IL8↓, 2, Imm↑, 4, Inflam↓, 33, IP-10/CXCL-10↓, 1, NF-kB↓, 10, NF-kB↑, 1, NK cell↑, 1, NLRP3↓, 2, PGE2↓, 4, PGE2↑, 1, Th1 response↓, 1, Th2↑, 2, TLR4↓, 3, TNF-α↓, 16, TNF-α↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4, BChE↓, 2, BDNF↑, 2, NGF↑, 2, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 2, BACE/β-secretase↓, 1, XO↝, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1, PPARα↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11, BioAv↑, 9, BioAv↝, 5, BioEnh↑, 1, CYP2E1↓, 2, Dose↝, 6, eff↓, 1, eff↑, 8, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 5, P-gp/ABCB1↓, 1, P450↓, 1, P450↝, 1, selectivity↑, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8, ALP↓, 2, AST↓, 9, BP↓, 3, BUN↓, 1, CEA↓, 1, creat↓, 3, CRP↓, 1, IL6↓, 12, IL6↑, 1, LDH↓, 4, NOS2↓, 1, TG/TAG↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 1, antiAll↑, 7, AntiArt↑, 3, AntiCan↑, 6, antiCG↑, 1, antiD↓, 1, AntiDiabetic↑, 7, antiNeop↑, 1, AntiTum↑, 3, cardioP↑, 16, chemoP↑, 5, chemoPv↑, 1, cognitive↑, 4, hepatoP↑, 16, memory↑, 2, motorD↑, 1, neuroP?, 1, neuroP↑, 17, Obesity↓, 2, Pain↓, 1, radioP↑, 3, RenoP↓, 1, RenoP↑, 4, Stroke↓, 3, toxicity↓, 16, toxicity↝, 1, toxicity∅, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4, AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 5, GutMicro↑, 4, Sepsis↓, 1,
Total Targets: 257

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

11 Apigenin (mainly Parsley)
10 Fisetin
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
5 Silver-NanoParticles
5 Magnolol
4 Phenethyl isothiocyanate
4 Curcumin
4 Emodin
4 Gambogic Acid
4 Morin
4 Luteolin
3 Allyl isothiocyanate
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Benzyl isothiocyanate
3 Photodynamic Therapy
3 Citric Acid
3 Ferulic acid
3 Gallic acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Kaempferol
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Boron
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Fucoidan
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 isoquercitrin
2 Juglone
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Patchouli Oil (Pogostemon cablin)
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Metformin
1 Cisplatin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Chlorophyllin
1 Crocetin
1 Carvone
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Isorhamnetin
1 L-Theanine
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Lutein
1 Matrine
1 Methyl Jasmonate
1 Chemotherapy
1 Mangiferin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:44  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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